Imiquimod (maleate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 0.0870902
NALF1 NALCN channel auxiliary factor 1 0.0866829
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0766748
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0650448
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0603389
NAMPT nicotinamide phosphoribosyltransferase 0.0571485
JAM3 junctional adhesion molecule 3 0.0523504
SINHCAF SIN3-HDAC complex associated factor 0.0493282
ERRFI1 ERBB receptor feedback inhibitor 1 0.0446358
HSPH1 heat shock 105kDa/110kDa protein 1 0.0424505
FHIT fragile histidine triad 0.0416757
GMDS GDP-mannose 4,6-dehydratase 0.0413611
FAM13A family with sequence similarity 13, member A 0.0410212
PCBP3 poly(rC) binding protein 3 0.0406556
PACS1 phosphofurin acidic cluster sorting protein 1 0.036785
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0364077
ENO1 enolase 1, (alpha) 0.0354664
NRG1 neuregulin 1 0.035153
RPL4 ribosomal protein L4 0.0344964
DTNA dystrobrevin, alpha 0.0341506
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0324445
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0323498
SNTG1 syntrophin, gamma 1 0.0321888
FAT1 FAT atypical cadherin 1 0.0319913
HMGB3 high mobility group box 3 0.0314415
ESRRG estrogen-related receptor gamma 0.0304682
FNDC3B fibronectin type III domain containing 3B 0.0302733
APP amyloid beta (A4) precursor protein 0.0301662
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0292249
SASH1 SAM and SH3 domain containing 1 0.0291357
SSBP2 single-stranded DNA binding protein 2 0.0286495
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0279636
TRIO trio Rho guanine nucleotide exchange factor 0.0275992
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0275695
ZNF292 zinc finger protein 292 0.0273518
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0267397
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0265443
TCF12 transcription factor 12 0.0264512
CA8 carbonic anhydrase VIII 0.0263523
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0257507
PTK2 protein tyrosine kinase 2 0.0250874
SAMD12 sterile alpha motif domain containing 12 0.0249118
NRXN1 neurexin 1 0.0247351
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0245704
HELZ helicase with zinc finger 0.02399
TXNRD1 thioredoxin reductase 1 0.0239075
H1-0 H1.0 linker histone 0.022557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0220989
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0219744
PSD3 pleckstrin and Sec7 domain containing 3 0.0219217
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0219005
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0218897
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0218012
MACF1 microtubule-actin crosslinking factor 1 0.0217816
NUP58 nucleoporin 58 0.0216673
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0215478
JMJD1C jumonji domain containing 1C 0.0214705
YME1L1 YME1-like 1 ATPase 0.0210389
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.021025
FOXO3 forkhead box O3 0.0207322
CHD7 chromodomain helicase DNA binding protein 7 0.0206213
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0203431
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0201605
PGK1 phosphoglycerate kinase 1 0.0199266
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0196962
DGKB diacylglycerol kinase, beta 90kDa 0.0196294
FGF14 fibroblast growth factor 14 0.0195581
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0193146
MSI2 musashi RNA-binding protein 2 0.0192567
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0192194
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0191856
SETD2 SET domain containing 2 0.0191481
RIT2 Ras-like without CAAX 2 0.019116
BBX bobby sox homolog (Drosophila) 0.019017
SYT1 synaptotagmin I 0.0189971
RAD23B RAD23 homolog B (S. cerevisiae) 0.0189639
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0188146
PUM1 pumilio RNA-binding family member 1 0.0187318
RORA RAR-related orphan receptor A 0.0186711
TM9SF3 transmembrane 9 superfamily member 3 0.0186027
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.018464
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0183618
HDAC9 histone deacetylase 9 0.018359
WDR75 WD repeat domain 75 0.0183129
MCTP1 multiple C2 domains, transmembrane 1 0.0182769
HILPDA hypoxia inducible lipid droplet-associated 0.0181718
JAZF1 JAZF zinc finger 1 0.0180813
NCKAP5 NCK-associated protein 5 0.0180728
MEF2A myocyte enhancer factor 2A 0.01806
NDRG1 N-myc downstream regulated 1 0.0180271
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0180195
KDM5B lysine (K)-specific demethylase 5B 0.0179656
MED13L mediator complex subunit 13-like 0.017886
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0177928
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0175647
EFNA5 ephrin-A5 0.0175419
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0173679
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0172894
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0170451
ELOVL5 ELOVL fatty acid elongase 5 0.016996

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.153893
PTMA prothymosin, alpha -0.119272
MT2A metallothionein 2A -0.0680757
VGF VGF nerve growth factor inducible -0.0644018
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0629409
RPL26 ribosomal protein L26 -0.0607649
RPS6 ribosomal protein S6 -0.0595736
LOC112694756 uncharaterized LOC112694756 -0.059249
RPS3 ribosomal protein S3 -0.0541125
CALCA calcitonin-related polypeptide alpha -0.0533904
RPS21 ribosomal protein S21 -0.0503151
RPL37A ribosomal protein L37a -0.0495916
NAP1L1 nucleosome assembly protein 1-like 1 -0.0446652
S100A9 S100 calcium binding protein A9 -0.0438543
CPE carboxypeptidase E -0.0431014
RPS27 ribosomal protein S27 -0.0427547
RPS8 ribosomal protein S8 -0.0427514
NCOR1 nuclear receptor corepressor 1 -0.0426945
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0414543
IFI6 interferon, alpha-inducible protein 6 -0.0413205
RPL11 ribosomal protein L11 -0.0400598
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0396552
RPL7 ribosomal protein L7 -0.0379974
RPL23 ribosomal protein L23 -0.0371094
RPL32 ribosomal protein L32 -0.0363657
FUS FUS RNA binding protein -0.0359375
RPS25 ribosomal protein S25 -0.0356834
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0353563
RPL38 ribosomal protein L38 -0.0333995
ATP5F1B ATP synthase F1 subunit beta -0.0325984
CAMTA1 calmodulin binding transcription activator 1 -0.0324752
RAD21 RAD21 homolog (S. pombe) -0.03213
RPL30 ribosomal protein L30 -0.0320127
RPLP1 ribosomal protein, large, P1 -0.0314042
POTEF POTE ankyrin domain family, member F -0.0311311
EGR1 early growth response 1 -0.0309802
ACTG1 actin gamma 1 -0.0307858
RPS19 ribosomal protein S19 -0.0307613
RPS5 ribosomal protein S5 -0.0301331
RPL8 ribosomal protein L8 -0.0298729
RPS16 ribosomal protein S16 -0.0292488
ISG15 ISG15 ubiquitin-like modifier -0.0289675
RPL37 ribosomal protein L37 -0.0289086
TMSB10 thymosin beta 10 -0.0285688
RPL19 ribosomal protein L19 -0.0280329
RPL7A ribosomal protein L7a -0.0274145
RPS20 ribosomal protein S20 -0.0273145
PCM1 pericentriolar material 1 -0.0269156
RPS29 ribosomal protein S29 -0.0268416
RPL36AL ribosomal protein L36a-like -0.0266035
ANKHD1 ankyrin repeat and KH domain containing 1 -0.026113
RPL5 ribosomal protein L5 -0.0260533
RPS23 ribosomal protein S23 -0.0257798
RBM25 RNA binding motif protein 25 -0.0257492
RPS17 ribosomal protein S17 -0.0256473
EEF2 eukaryotic translation elongation factor 2 -0.0256306
RPL34 ribosomal protein L34 -0.0251556
NIPBL Nipped-B homolog (Drosophila) -0.0250728
PNN pinin, desmosome associated protein -0.0247001
RPL18 ribosomal protein L18 -0.0244966
RPS12 ribosomal protein S12 -0.0244787
RACK1 receptor for activated C kinase 1 -0.0243517
COX6C cytochrome c oxidase subunit VIc -0.023938
RPL35A ribosomal protein L35a -0.0236283
EIF1 eukaryotic translation initiation factor 1 -0.0232603
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.02312
TPR translocated promoter region, nuclear basket protein -0.0229966
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0229243
TNRC6C trinucleotide repeat containing 6C -0.0229046
TPT1 tumor protein, translationally-controlled 1 -0.0228603
KIAA1958 KIAA1958 -0.0228566
STC1 stanniocalcin 1 -0.0227899
RPL12 ribosomal protein L12 -0.0221404
RPS27A ribosomal protein S27a -0.0221023
CSPP1 centrosome and spindle pole associated protein 1 -0.0219647
RPS2 ribosomal protein S2 -0.0217731
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.021586
TENT5A terminal nucleotidyltransferase 5A -0.0215177
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0214671
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0211605
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0211435
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0210876
RPL36 ribosomal protein L36 -0.0210503
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0210348
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0206721
ZC3H15 zinc finger CCCH-type containing 15 -0.020594
RPL31 ribosomal protein L31 -0.020477
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0203998
SIK2 salt-inducible kinase 2 -0.0202621
KTN1 kinectin 1 (kinesin receptor) -0.0200751
B2M beta-2-microglobulin -0.0199489
TUFM Tu translation elongation factor, mitochondrial -0.0197338
PKM pyruvate kinase, muscle -0.0197225
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0196752
PEX5L peroxisomal biogenesis factor 5-like -0.019626
FTL ferritin, light polypeptide -0.0195264
ATP5F1E ATP synthase F1 subunit epsilon -0.0194726
SMC3 structural maintenance of chromosomes 3 -0.0193053
PDE4D phosphodiesterase 4D, cAMP-specific -0.0192404
MIS18BP1 MIS18 binding protein 1 -0.0191975