| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Imiquimod (maleate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Imiquimod (maleate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0905658 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0859584 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0556709 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0518053 |
| HELZ | helicase with zinc finger | 0.0390975 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0387349 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0386949 |
| NOTCH2 | notch 2 | 0.0385057 |
| MSN | moesin | 0.0365502 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0360632 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0358389 |
| PRELID2 | PRELI domain containing 2 | 0.0334752 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0313668 |
| ZNF292 | zinc finger protein 292 | 0.030916 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0305555 |
| NBAS | neuroblastoma amplified sequence | 0.0296203 |
| FMNL2 | formin-like 2 | 0.0288223 |
| OGA | O-GlcNAcase | 0.0284056 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0281728 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0280318 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0275536 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0273567 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0269861 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0267726 |
| RPL3 | ribosomal protein L3 | 0.0267632 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0265561 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0265082 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0262356 |
| NAV2 | neuron navigator 2 | 0.0259702 |
| ATP13A3 | ATPase type 13A3 | 0.0259328 |
| NCKAP1 | NCK-associated protein 1 | 0.0255537 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0253242 |
| NGLY1 | N-glycanase 1 | 0.0252376 |
| TPM3 | tropomyosin 3 | 0.0252078 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0246687 |
| TFG | TRK-fused gene | 0.0246587 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0242509 |
| SPAG9 | sperm associated antigen 9 | 0.0240604 |
| SUCO | SUN domain containing ossification factor | 0.0240412 |
| FMN1 | formin 1 | 0.0235085 |
| AFDN | afadin, adherens junction formation factor | 0.0234217 |
| TRIM33 | tripartite motif containing 33 | 0.0223463 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.021952 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0219327 |
| RLIM | ring finger protein, LIM domain interacting | 0.0213507 |
| USP3 | ubiquitin specific peptidase 3 | 0.0213478 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0211836 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0206191 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0205699 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0205336 |
| CDK19 | cyclin-dependent kinase 19 | 0.0202471 |
| USP32 | ubiquitin specific peptidase 32 | 0.0201808 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0201597 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0200368 |
| RNF145 | ring finger protein 145 | 0.019843 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0197242 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0194725 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.019199 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0191623 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.01907 |
| TXNRD1 | thioredoxin reductase 1 | 0.0189672 |
| MEMO1 | mediator of cell motility 1 | 0.0188431 |
| EP300 | E1A binding protein p300 | 0.0188404 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0186977 |
| RTN4 | reticulon 4 | 0.0186839 |
| NEK7 | NIMA-related kinase 7 | 0.0185421 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0185384 |
| GOLGA4 | golgin A4 | 0.018498 |
| SBF2 | SET binding factor 2 | 0.0184722 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0184319 |
| CLIC4 | chloride intracellular channel 4 | 0.0183961 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0183625 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0183078 |
| COPA | coatomer protein complex, subunit alpha | 0.0182094 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.018088 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0179276 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0178093 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0177731 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0174122 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0171185 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.017116 |
| ANK2 | ankyrin 2, neuronal | 0.0170959 |
| CLINT1 | clathrin interactor 1 | 0.0170958 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0170095 |
| ABI1 | abl-interactor 1 | 0.0168977 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.01689 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0168716 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.016479 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0162606 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.01621 |
| CORO1C | coronin, actin binding protein, 1C | 0.0161872 |
| POM121 | POM121 transmembrane nucleoporin | 0.0161184 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0161041 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0157757 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0157508 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0157197 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0156187 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0155661 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0155225 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0154032 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.224247 |
| NLGN1 | neuroligin 1 | -0.1376 |
| LSAMP | limbic system-associated membrane protein | -0.129027 |
| RPL35A | ribosomal protein L35a | -0.114975 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111645 |
| PTMA | prothymosin, alpha | -0.0985922 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0973757 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0819464 |
| FRMD4A | FERM domain containing 4A | -0.078686 |
| RPS6 | ribosomal protein S6 | -0.0783779 |
| FN1 | fibronectin 1 | -0.0746034 |
| FTL | ferritin, light polypeptide | -0.0736059 |
| NRG3 | neuregulin 3 | -0.0729839 |
| RPS3 | ribosomal protein S3 | -0.0682701 |
| RPLP1 | ribosomal protein, large, P1 | -0.0681586 |
| TMSB10 | thymosin beta 10 | -0.0674616 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0606686 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0589992 |
| RPL31 | ribosomal protein L31 | -0.0585677 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0559033 |
| HLA-B | major histocompatibility complex, class I, B | -0.0555899 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0552982 |
| RPL38 | ribosomal protein L38 | -0.0534902 |
| RPS8 | ribosomal protein S8 | -0.0500391 |
| B2M | beta-2-microglobulin | -0.0495171 |
| APOD | apolipoprotein D | -0.0492966 |
| CCND1 | cyclin D1 | -0.0487705 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0463287 |
| RPL11 | ribosomal protein L11 | -0.0440992 |
| RPL23 | ribosomal protein L23 | -0.0439503 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0429631 |
| RPS23 | ribosomal protein S23 | -0.0429308 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0411835 |
| RPLP2 | ribosomal protein, large, P2 | -0.0409891 |
| RPS13 | ribosomal protein S13 | -0.0407309 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.039675 |
| PRAME | preferentially expressed antigen in melanoma | -0.0384259 |
| RPL36A | ribosomal protein L36a | -0.0382957 |
| RPL37A | ribosomal protein L37a | -0.0373771 |
| RPL34 | ribosomal protein L34 | -0.0366425 |
| RPS14 | ribosomal protein S14 | -0.0364136 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0361446 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0357461 |
| ENO1 | enolase 1, (alpha) | -0.0356932 |
| RNF213 | ring finger protein 213 | -0.0356219 |
| HMGA1 | high mobility group AT-hook 1 | -0.0351231 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0347621 |
| RPS16 | ribosomal protein S16 | -0.0344179 |
| RPL9 | ribosomal protein L9 | -0.0337706 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0335797 |
| RPS24 | ribosomal protein S24 | -0.033558 |
| TNNC1 | troponin C type 1 (slow) | -0.0332152 |
| RPL37 | ribosomal protein L37 | -0.0330517 |
| PKM | pyruvate kinase, muscle | -0.0330211 |
| RPS29 | ribosomal protein S29 | -0.0330124 |
| RPS12 | ribosomal protein S12 | -0.032394 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0323811 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0322315 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0316548 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0316406 |
| S100A9 | S100 calcium binding protein A9 | -0.0315856 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0313952 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0312228 |
| ACTG1 | actin gamma 1 | -0.0308331 |
| CTSD | cathepsin D | -0.0307441 |
| RPS19 | ribosomal protein S19 | -0.0306617 |
| BPTF | bromodomain PHD finger transcription factor | -0.030513 |
| RACK1 | receptor for activated C kinase 1 | -0.0304585 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.030192 |
| SQSTM1 | sequestosome 1 | -0.0300474 |
| RPS27A | ribosomal protein S27a | -0.0299621 |
| HLA-A | major histocompatibility complex, class I, A | -0.029873 |
| RPS21 | ribosomal protein S21 | -0.0295467 |
| PMEL | premelanosome protein | -0.0293836 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0292386 |
| RPL36 | ribosomal protein L36 | -0.028577 |
| LMNA | lamin A/C | -0.0280469 |
| IER3 | immediate early response 3 | -0.0278314 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0278236 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0276376 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.027625 |
| SP100 | SP100 nuclear antigen | -0.0274947 |
| CUX1 | cut-like homeobox 1 | -0.0271389 |
| TPI1 | triosephosphate isomerase 1 | -0.0268751 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0268626 |
| TRIM56 | tripartite motif containing 56 | -0.0267051 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0265227 |
| RPL32 | ribosomal protein L32 | -0.0264301 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0260397 |
| RPS11 | ribosomal protein S11 | -0.0259831 |
| RPS17 | ribosomal protein S17 | -0.0255247 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0251857 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0248756 |
| RPS25 | ribosomal protein S25 | -0.0244922 |
| RPS10 | ribosomal protein S10 | -0.0243294 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | -0.0242971 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0241121 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0241111 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0239201 |
| GNAS | GNAS complex locus | -0.0238886 |
