Imiquimod (maleate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.119994
FNDC3B fibronectin type III domain containing 3B 0.0856944
SOD2 superoxide dismutase 2, mitochondrial 0.0814553
TRIO trio Rho guanine nucleotide exchange factor 0.0780566
MYH9 myosin, heavy chain 9, non-muscle 0.076706
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0740874
FRMD4A FERM domain containing 4A 0.0642299
NAMPT nicotinamide phosphoribosyltransferase 0.0610988
CADM1 cell adhesion molecule 1 0.0576944
USP9X ubiquitin specific peptidase 9, X-linked 0.0528855
COL6A3 collagen, type VI, alpha 3 0.0511065
TENT5A terminal nucleotidyltransferase 5A 0.0490514
DST dystonin 0.048497
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0425934
MKI67 marker of proliferation Ki-67 0.0417454
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.040681
SPTBN1 spectrin, beta, non-erythrocytic 1 0.040495
NAV2 neuron navigator 2 0.0387964
TNIP1 TNFAIP3 interacting protein 1 0.0385723
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0384868
SMAD3 SMAD family member 3 0.0383798
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0377482
FN1 fibronectin 1 0.0374016
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0364237
RTN4 reticulon 4 0.0359278
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0348883
ANLN anillin, actin binding protein 0.034649
CENPF centromere protein F, 350/400kDa 0.0343579
VCL vinculin 0.0339193
SPAG9 sperm associated antigen 9 0.0325703
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0309512
ATP13A3 ATPase type 13A3 0.0309093
FNIP1 folliculin interacting protein 1 0.0306959
ZNF292 zinc finger protein 292 0.0305884
KDM6A lysine (K)-specific demethylase 6A 0.0300702
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0300035
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0299231
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.029761
QKI QKI, KH domain containing, RNA binding 0.0294997
BIRC2 baculoviral IAP repeat containing 2 0.0292208
UBA6 ubiquitin-like modifier activating enzyme 6 0.029217
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289035
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0285973
PRELID2 PRELI domain containing 2 0.0282459
MYOF myoferlin 0.0270536
RB1CC1 RB1-inducible coiled-coil 1 0.0269347
CKAP5 cytoskeleton associated protein 5 0.0268122
ZFAND3 zinc finger, AN1-type domain 3 0.0268111
PDE10A phosphodiesterase 10A 0.0267226
KYNU kynureninase 0.0267042
NRXN3 neurexin 3 0.0265498
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0260955
OGA O-GlcNAcase 0.0258475
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0256641
ELL2 elongation factor, RNA polymerase II, 2 0.0256392
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0249641
HELZ helicase with zinc finger 0.0248369
UBE2H ubiquitin-conjugating enzyme E2H 0.024815
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0245432
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0244132
USP47 ubiquitin specific peptidase 47 0.0238731
FRMD5 FERM domain containing 5 0.0234622
BICC1 BicC family RNA binding protein 1 0.0232467
TSC22D2 TSC22 domain family, member 2 0.0231926
TNS3 tensin 3 0.0230406
MED13L mediator complex subunit 13-like 0.0229531
TRIP12 thyroid hormone receptor interactor 12 0.0225343
NEK7 NIMA-related kinase 7 0.0223448
AFDN afadin, adherens junction formation factor 0.0222473
GLS2 glutaminase 2 (liver, mitochondrial) 0.0222334
VMP1 vacuole membrane protein 1 0.0221353
LCORL ligand dependent nuclear receptor corepressor-like 0.0220136
IGF2R insulin-like growth factor 2 receptor 0.0214483
WAC WW domain containing adaptor with coiled-coil 0.0213948
BRWD3 bromodomain and WD repeat domain containing 3 0.0204842
LPP LIM domain containing preferred translocation partner in lipoma 0.0204482
COL8A1 collagen, type VIII, alpha 1 0.0203053
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0202875
VCAN versican 0.0199407
ITSN2 intersectin 2 0.0199299
ZFC3H1 zinc finger, C3H1-type containing 0.0197959
XRN1 5'-3' exoribonuclease 1 0.0197536
MX1 MX dynamin-like GTPase 1 0.0196924
THBS1 thrombospondin 1 0.0196519
DIAPH3 diaphanous-related formin 3 0.019391
GSK3B glycogen synthase kinase 3 beta 0.0193896
EPS8 epidermal growth factor receptor pathway substrate 8 0.0192179
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0191737
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0191335
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0191182
LCOR ligand dependent nuclear receptor corepressor 0.0188896
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0186802
TNPO1 transportin 1 0.0186287
TFG TRK-fused gene 0.0186192
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0185955
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0184661
GOLGA4 golgin A4 0.0184224
ARHGAP29 Rho GTPase activating protein 29 0.0180726
AFAP1 actin filament associated protein 1 0.0180179
PTK2 protein tyrosine kinase 2 0.0179657

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.343914
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.214252
FTL ferritin, light polypeptide -0.142799
TMSB10 thymosin beta 10 -0.113063
HLA-B major histocompatibility complex, class I, B -0.113056
AKAP12 A kinase (PRKA) anchor protein 12 -0.110714
NDRG1 N-myc downstream regulated 1 -0.100545
FTH1 ferritin, heavy polypeptide 1 -0.0955613
IGFBP3 insulin-like growth factor binding protein 3 -0.0927121
RPS6 ribosomal protein S6 -0.0812005
TPT1 tumor protein, translationally-controlled 1 -0.0808281
MT2A metallothionein 2A -0.079132
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0748428
IER3 immediate early response 3 -0.06904
RPS12 ribosomal protein S12 -0.0668546
RPL23 ribosomal protein L23 -0.0636583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0625869
ADM adrenomedullin -0.0623685
EIF1 eukaryotic translation initiation factor 1 -0.0607573
RPL37A ribosomal protein L37a -0.0576877
RPS24 ribosomal protein S24 -0.0534526
RPL35A ribosomal protein L35a -0.0527111
LDHA lactate dehydrogenase A -0.0526186
BTG1 B-cell translocation gene 1, anti-proliferative -0.0496139
RPS3 ribosomal protein S3 -0.049373
RPLP2 ribosomal protein, large, P2 -0.0488968
RPS8 ribosomal protein S8 -0.0471709
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0465261
RPS19 ribosomal protein S19 -0.046429
ZMYND8 zinc finger, MYND-type containing 8 -0.0463517
RPS4X ribosomal protein S4, X-linked -0.0461908
HLA-A major histocompatibility complex, class I, A -0.0448176
RPLP1 ribosomal protein, large, P1 -0.0448089
B2M beta-2-microglobulin -0.0447216
RPS23 ribosomal protein S23 -0.0442236
RPL36A ribosomal protein L36a -0.0436334
LOC112694756 uncharaterized LOC112694756 -0.0425509
VEGFA vascular endothelial growth factor A -0.0419691
ENO1 enolase 1, (alpha) -0.0404802
IFITM3 interferon induced transmembrane protein 3 -0.0398398
RPS13 ribosomal protein S13 -0.0397109
RPL12 ribosomal protein L12 -0.039042
STC1 stanniocalcin 1 -0.0387049
EGR1 early growth response 1 -0.0367753
HMGA2 high mobility group AT-hook 2 -0.036136
SLC38A1 solute carrier family 38, member 1 -0.0357577
HMGA1 high mobility group AT-hook 1 -0.0356252
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0356169
GNAS GNAS complex locus -0.0352344
RPL26 ribosomal protein L26 -0.0351227
S100A9 S100 calcium binding protein A9 -0.0350874
RPL19 ribosomal protein L19 -0.0337812
RPL9 ribosomal protein L9 -0.0332015
ACTG1 actin gamma 1 -0.0326049
RPL36 ribosomal protein L36 -0.03255
PTMA prothymosin, alpha -0.0324076
IFITM1 interferon induced transmembrane protein 1 -0.0322157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0320913
RPL11 ribosomal protein L11 -0.0320163
CTSD cathepsin D -0.0318367
RACK1 receptor for activated C kinase 1 -0.0316334
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0304662
CDH13 cadherin 13 -0.0300931
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0298839
RPS10 ribosomal protein S10 -0.0297597
PLIN2 perilipin 2 -0.0294871
RPL7A ribosomal protein L7a -0.0293273
RPS14 ribosomal protein S14 -0.0291173
TMSB4X thymosin beta 4, X-linked -0.02904
RPL28 ribosomal protein L28 -0.0290081
RPS29 ribosomal protein S29 -0.028872
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0283797
RPS25 ribosomal protein S25 -0.0283249
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0281662
RPL31 ribosomal protein L31 -0.0279403
LOX lysyl oxidase -0.0272307
NAP1L1 nucleosome assembly protein 1-like 1 -0.0268071
RPL38 ribosomal protein L38 -0.026346
IFI6 interferon, alpha-inducible protein 6 -0.0257156
SFTPA2 surfactant protein A2 -0.0257069
RPL32 ribosomal protein L32 -0.0257049
CD44 CD44 molecule (Indian blood group) -0.0256388
TGFBI transforming growth factor, beta-induced, 68kDa -0.0256157
MORF4L2 mortality factor 4 like 2 -0.0248675
TPM4 tropomyosin 4 -0.0248594
LOXL2 lysyl oxidase-like 2 -0.0248593
RPL5 ribosomal protein L5 -0.0247248
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0245517
RPS21 ribosomal protein S21 -0.0244341
EEF1G eukaryotic translation elongation factor 1 gamma -0.0242742
ASTN2 astrotactin 2 -0.0241228
LOC102724023 ES1 protein homolog, mitochondrial -0.023826
RPL27A ribosomal protein L27a -0.0238054
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0236154
PKM pyruvate kinase, muscle -0.0233998
RPL30 ribosomal protein L30 -0.022707
RPS20 ribosomal protein S20 -0.0226635
RPL35 ribosomal protein L35 -0.0226408
RPL37 ribosomal protein L37 -0.0226275
ENO2 enolase 2 (gamma, neuronal) -0.0225717