Imiquimod (maleate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KDM6A lysine (K)-specific demethylase 6A 0.0809211
IL6 interleukin 6 0.0722905
KYNU kynureninase 0.0652186
NAMPT nicotinamide phosphoribosyltransferase 0.0610868
WTAP Wilms tumor 1 associated protein 0.0600785
KMT2E lysine (K)-specific methyltransferase 2E 0.0598386
PDE4D phosphodiesterase 4D, cAMP-specific 0.0562121
RSAD2 radical S-adenosyl methionine domain containing 2 0.0560314
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0559851
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0505201
TRA2A transformer 2 alpha homolog (Drosophila) 0.0464074
KMT2C lysine (K)-specific methyltransferase 2C 0.0448244
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.044695
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0422999
UBC ubiquitin C 0.0419493
FNDC3A fibronectin type III domain containing 3A 0.0415094
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0411597
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0392544
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0380133
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0363981
SKIC3 SKI3 subunit of superkiller complex 0.0363841
ANKHD1 ankyrin repeat and KH domain containing 1 0.0363818
COPA coatomer protein complex, subunit alpha 0.0349252
PTMA prothymosin, alpha 0.0342545
SOD2 superoxide dismutase 2, mitochondrial 0.0339436
RHEB Ras homolog enriched in brain 0.0334762
UGCG UDP-glucose ceramide glucosyltransferase 0.0334567
RHOBTB3 Rho-related BTB domain containing 3 0.0324981
PRELID2 PRELI domain containing 2 0.032441
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323194
ZFR zinc finger RNA binding protein 0.0309174
MATR3 matrin 3 0.03028
RAB10 RAB10, member RAS oncogene family 0.0300981
CXCL3 chemokine (C-X-C motif) ligand 3 0.0298888
TSC22D2 TSC22 domain family, member 2 0.0298458
NAP1L1 nucleosome assembly protein 1-like 1 0.0297292
UBA6 ubiquitin-like modifier activating enzyme 6 0.029542
SLC38A1 solute carrier family 38, member 1 0.0294399
H3-3B H3.3 histone B 0.0293613
AGO3 argonaute RISC catalytic component 3 0.0293508
TM9SF2 transmembrane 9 superfamily member 2 0.0288081
GOLGA4 golgin A4 0.0282609
KDM3B lysine (K)-specific demethylase 3B 0.0282369
USP9X ubiquitin specific peptidase 9, X-linked 0.0282189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0276542
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0276411
PUM2 pumilio RNA-binding family member 2 0.0270668
ABLIM1 actin binding LIM protein 1 0.0270412
OXSR1 oxidative stress responsive 1 0.0270407
RND3 Rho family GTPase 3 0.0269684
RYBP RING1 and YY1 binding protein 0.0268314
FAM13A family with sequence similarity 13, member A 0.0266361
SEC24A SEC24 family member A 0.0264231
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0264151
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0263467
SUCO SUN domain containing ossification factor 0.0262307
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0261603
NDFIP1 Nedd4 family interacting protein 1 0.0260958
SEM1 SEM1 26S proteasome subunit 0.0260012
BIRC3 baculoviral IAP repeat containing 3 0.0259303
RLIM ring finger protein, LIM domain interacting 0.0259139
MXD1 MAX dimerization protein 1 0.0257953
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0257569
PNPLA8 patatin-like phospholipase domain containing 8 0.025513
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0254957
GPBP1 GC-rich promoter binding protein 1 0.0252159
ANXA5 annexin A5 0.0251485
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0251299
PRKCSH protein kinase C substrate 80K-H 0.0250846
OSBPL8 oxysterol binding protein-like 8 0.0246312
MYO1E myosin IE 0.0245738
RBM6 RNA binding motif protein 6 0.024484
TNIP1 TNFAIP3 interacting protein 1 0.0243244
STC2 stanniocalcin 2 0.0242855
RAD23B RAD23 homolog B (S. cerevisiae) 0.0242571
EPAS1 endothelial PAS domain protein 1 0.0241502
FNDC3B fibronectin type III domain containing 3B 0.0239988
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0239563
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0238674
SEPTIN7 septin 7 0.0238522
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0237851
ADAM17 ADAM metallopeptidase domain 17 0.0235912
QKI QKI, KH domain containing, RNA binding 0.0234808
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0233901
PRRC1 proline-rich coiled-coil 1 0.023291
ZCCHC7 zinc finger, CCHC domain containing 7 0.0232526
KDM3A lysine (K)-specific demethylase 3A 0.0231723
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.0231619
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0231529
TMSB4X thymosin beta 4, X-linked 0.0231424
RNF145 ring finger protein 145 0.0230474
UBE2B ubiquitin-conjugating enzyme E2B 0.022903
RPN2 ribophorin II 0.0228946
PCBP2 poly(rC) binding protein 2 0.0225889
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0225299
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0224495
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0221497
CACUL1 CDK2-associated, cullin domain 1 0.0220021
IRF1 interferon regulatory factor 1 0.021902
CYLD cylindromatosis (turban tumor syndrome) 0.0218839

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.334376
COL1A1 collagen, type I, alpha 1 -0.169562
IGFBP3 insulin-like growth factor binding protein 3 -0.160844
FN1 fibronectin 1 -0.152487
COL1A2 collagen, type I, alpha 2 -0.133222
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.124521
TIMP3 TIMP metallopeptidase inhibitor 3 -0.114582
LOX lysyl oxidase -0.113838
LOXL2 lysyl oxidase-like 2 -0.103341
HLA-B major histocompatibility complex, class I, B -0.0879784
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0876771
MT2A metallothionein 2A -0.0845383
PRSS23 protease, serine, 23 -0.0836279
GLIS3 GLIS family zinc finger 3 -0.0720061
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0660414
TGFBI transforming growth factor, beta-induced, 68kDa -0.0634709
CALD1 caldesmon 1 -0.06306
ANKRD11 ankyrin repeat domain 11 -0.0629788
NRXN3 neurexin 3 -0.0623373
CALU calumenin -0.0616341
HLA-C major histocompatibility complex, class I, C -0.0611675
CDK6 cyclin-dependent kinase 6 -0.0609066
PSD3 pleckstrin and Sec7 domain containing 3 -0.058878
COL6A1 collagen, type VI, alpha 1 -0.055285
TPM1 tropomyosin 1 (alpha) -0.0548651
COL3A1 collagen, type III, alpha 1 -0.0534192
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0520151
PLCB4 phospholipase C, beta 4 -0.0515918
TTC3 tetratricopeptide repeat domain 3 -0.050251
COL6A2 collagen, type VI, alpha 2 -0.0489741
MT1X metallothionein 1X -0.0478014
COL5A1 collagen, type V, alpha 1 -0.0475646
RRBP1 ribosome binding protein 1 -0.0471122
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0470879
HIPK2 homeodomain interacting protein kinase 2 -0.0467211
COL5A2 collagen, type V, alpha 2 -0.0457659
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.045025
SLC38A2 solute carrier family 38, member 2 -0.0450119
IGFBP7 insulin-like growth factor binding protein 7 -0.0441979
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0435224
TMSB10 thymosin beta 10 -0.0430867
STC1 stanniocalcin 1 -0.0423902
EGFR epidermal growth factor receptor -0.0421342
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0420429
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0407878
TPM4 tropomyosin 4 -0.0407092
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0406237
AHNAK AHNAK nucleoprotein -0.0404983
ACTG1 actin gamma 1 -0.0385445
TNNC1 troponin C type 1 (slow) -0.0384029
F3 coagulation factor III (thromboplastin, tissue factor) -0.038214
SMYD3 SET and MYND domain containing 3 -0.0371239
SCARB2 scavenger receptor class B, member 2 -0.0367008
LAMA4 laminin, alpha 4 -0.0364127
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0361032
CHD9 chromodomain helicase DNA binding protein 9 -0.0359754
SAMD4A sterile alpha motif domain containing 4A -0.0351237
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0350358
CDH13 cadherin 13 -0.0349433
SEC24D SEC24 family member D -0.0346134
NRP1 neuropilin 1 -0.0341268
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0338194
VCL vinculin -0.0335736
HIP1 huntingtin interacting protein 1 -0.0328844
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0328256
AKAP12 A kinase (PRKA) anchor protein 12 -0.0327651
MAP4 microtubule-associated protein 4 -0.032736
TMEM165 transmembrane protein 165 -0.0326827
EGR1 early growth response 1 -0.0325349
SMAD3 SMAD family member 3 -0.0324847
ARHGAP24 Rho GTPase activating protein 24 -0.0324266
FRMD4A FERM domain containing 4A -0.0318079
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0314651
COL4A1 collagen, type IV, alpha 1 -0.0313197
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0310702
CAVIN1 caveolae associated protein 1 -0.0310511
EXT1 exostosin glycosyltransferase 1 -0.0307909
PXDN peroxidasin -0.0306453
PTPRG protein tyrosine phosphatase, receptor type, G -0.030226
ERBIN erbb2 interacting protein -0.0295349
VEGFC vascular endothelial growth factor C -0.029415
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291867
MYH9 myosin, heavy chain 9, non-muscle -0.029098
PDLIM5 PDZ and LIM domain 5 -0.0290429
BBS9 Bardet-Biedl syndrome 9 -0.0290008
LAMB1 laminin, beta 1 -0.0287839
RAB1A RAB1A, member RAS oncogene family -0.0285404
HMGA2 high mobility group AT-hook 2 -0.0283767
EXOC6B exocyst complex component 6B -0.0281736
DST dystonin -0.0278362
CTSB cathepsin B -0.0278291
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0275396
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0273363
RSF1 remodeling and spacing factor 1 -0.0271335
MEF2A myocyte enhancer factor 2A -0.0270825
SDK1 sidekick cell adhesion molecule 1 -0.0270555
BCAR3 breast cancer anti-estrogen resistance 3 -0.027015
AHR aryl hydrocarbon receptor -0.0269483
SETD5 SET domain containing 5 -0.0267837
EIF5B eukaryotic translation initiation factor 5B -0.0265451