Imiquimod (maleate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.091224
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0871069
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0801861
ZNF292 zinc finger protein 292 0.0798902
CENPF centromere protein F, 350/400kDa 0.0750092
TPX2 TPX2, microtubule-associated 0.0737545
YAP1 Yes-associated protein 1 0.0706189
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0691699
SMC4 structural maintenance of chromosomes 4 0.0606099
TXNRD1 thioredoxin reductase 1 0.0601383
DSCAM Down syndrome cell adhesion molecule 0.0596831
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0594732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.058981
CKAP2 cytoskeleton associated protein 2 0.0579033
GOLGA4 golgin A4 0.0561394
CALU calumenin 0.056098
NUP58 nucleoporin 58 0.0540985
KIAA1958 KIAA1958 0.0534372
ECT2 epithelial cell transforming 2 0.0534361
ANLN anillin, actin binding protein 0.0494932
KIF5B kinesin family member 5B 0.048006
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0479522
RPL4 ribosomal protein L4 0.0463767
MKI67 marker of proliferation Ki-67 0.0461302
KIAA1328 KIAA1328 0.045798
MIS18BP1 MIS18 binding protein 1 0.0453513
CLTC clathrin, heavy chain (Hc) 0.0439443
DIAPH3 diaphanous-related formin 3 0.0427575
APOLD1 apolipoprotein L domain containing 1 0.0417355
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0413082
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0403047
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0400324
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0395822
HJURP Holliday junction recognition protein 0.0391351
LCORL ligand dependent nuclear receptor corepressor-like 0.0387723
NIPBL Nipped-B homolog (Drosophila) 0.0381209
TBC1D5 TBC1 domain family, member 5 0.0377147
YBX3 Y box binding protein 3 0.0375904
AURKA aurora kinase A 0.0375445
HSPA8 heat shock 70kDa protein 8 0.0373998
CANX calnexin 0.0371157
RRBP1 ribosome binding protein 1 0.0367911
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0367792
MBNL2 muscleblind-like splicing regulator 2 0.0365447
SPAG9 sperm associated antigen 9 0.0364335
COPB1 coatomer protein complex, subunit beta 1 0.036084
FAM13A family with sequence similarity 13, member A 0.0360195
FXR1 fragile X mental retardation, autosomal homolog 1 0.0353998
TOP2B topoisomerase (DNA) II beta 180kDa 0.0353883
CEP250 centrosomal protein 250kDa 0.0350747
PHIP pleckstrin homology domain interacting protein 0.0350175
RPL37A ribosomal protein L37a 0.0342932
SNX14 sorting nexin 14 0.033992
STRBP spermatid perinuclear RNA binding protein 0.033614
CKAP5 cytoskeleton associated protein 5 0.033517
RNF145 ring finger protein 145 0.0333323
ERRFI1 ERBB receptor feedback inhibitor 1 0.0332074
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0331999
NGLY1 N-glycanase 1 0.0330929
PDE4D phosphodiesterase 4D, cAMP-specific 0.0329571
CEP95 centrosomal protein 95kDa 0.0325541
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0325139
MATR3 matrin 3 0.0324737
HELZ helicase with zinc finger 0.0324435
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0322233
SNX13 sorting nexin 13 0.0321477
SRPK2 SRSF protein kinase 2 0.0317774
DEK DEK proto-oncogene 0.0317426
RAD21 RAD21 homolog (S. pombe) 0.0314198
MARCHF6 membrane associated ring-CH-type finger 6 0.0313887
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0312146
GIGYF2 GRB10 interacting GYF protein 2 0.0311718
TFG TRK-fused gene 0.0311668
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0310704
FGFR2 fibroblast growth factor receptor 2 0.0306862
WDR43 WD repeat domain 43 0.0306321
WAC WW domain containing adaptor with coiled-coil 0.0303351
DNER delta/notch-like EGF repeat containing 0.0303238
DHDDS dehydrodolichyl diphosphate synthase 0.0302943
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0302089
TENT2 terminal nucleotidyltransferase 2 0.0300913
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0296821
PRR11 proline rich 11 0.0296731
FANCI Fanconi anemia, complementation group I 0.0295278
NAMPT nicotinamide phosphoribosyltransferase 0.0294431
XPO1 exportin 1 0.0292719
EEF2 eukaryotic translation elongation factor 2 0.0292343
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0292091
ZNF670 zinc finger protein 670 0.0289281
CLINT1 clathrin interactor 1 0.0289065
BIRC2 baculoviral IAP repeat containing 2 0.0286691
AHCTF1 AT hook containing transcription factor 1 0.0285338
IARS1 isoleucyl-tRNA synthetase 1 0.0285111
SCLT1 sodium channel and clathrin linker 1 0.0284802
PBX3 pre-B-cell leukemia homeobox 3 0.0277112
UBQLN1 ubiquilin 1 0.02763
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0274525
RABGAP1 RAB GTPase activating protein 1 0.0271947
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0271331
CHD1 chromodomain helicase DNA binding protein 1 0.0271298

decreased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.13215
TMSB10 thymosin beta 10 -0.102733
ANGPTL4 angiopoietin-like 4 -0.0953956
TPT1 tumor protein, translationally-controlled 1 -0.0863987
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.085593
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0851088
DST dystonin -0.0811616
FNDC3B fibronectin type III domain containing 3B -0.0797789
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0780579
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0773692
CD44 CD44 molecule (Indian blood group) -0.070547
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0702543
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0696914
HMGA2 high mobility group AT-hook 2 -0.0696853
PRKCA protein kinase C, alpha -0.0689659
POTEF POTE ankyrin domain family, member F -0.0633298
FTH1 ferritin, heavy polypeptide 1 -0.0614585
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0607626
PRR16 proline rich 16 -0.0591541
NALCN sodium leak channel, non selective -0.05734
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0570053
PRSS23 protease, serine, 23 -0.0562289
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0512038
HLA-B major histocompatibility complex, class I, B -0.0511911
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0507029
RAI14 retinoic acid induced 14 -0.0505051
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0500721
AKAP12 A kinase (PRKA) anchor protein 12 -0.0496821
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0481776
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0481436
EXT1 exostosin glycosyltransferase 1 -0.048093
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0469988
PODXL podocalyxin-like -0.0468422
ZBTB20 zinc finger and BTB domain containing 20 -0.0468121
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.046421
ZFHX3 zinc finger homeobox 3 -0.0458596
EGR1 early growth response 1 -0.0454819
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0453271
IGFBP3 insulin-like growth factor binding protein 3 -0.0444277
ACTG1 actin gamma 1 -0.0441054
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0439855
NDRG1 N-myc downstream regulated 1 -0.0433456
FLNB filamin B, beta -0.0433283
SH3KBP1 SH3-domain kinase binding protein 1 -0.0432973
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0429471
SVIL supervillin -0.0429032
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0428495
BPTF bromodomain PHD finger transcription factor -0.041739
DPYD dihydropyrimidine dehydrogenase -0.0415962
HLA-A major histocompatibility complex, class I, A -0.0414003
S100A6 S100 calcium binding protein A6 -0.0412879
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0411271
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0405182
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0404739
SLC38A2 solute carrier family 38, member 2 -0.0403268
WARS1 tryptophanyl-tRNA synthetase 1 -0.0398924
AEBP2 AE binding protein 2 -0.0394492
B2M beta-2-microglobulin -0.0388598
PCED1B PC-esterase domain containing 1B -0.0383992
NT5E 5'-nucleotidase, ecto (CD73) -0.0382649
SDC4 syndecan 4 -0.0374057
ACER3 alkaline ceramidase 3 -0.0369914
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0369818
RORA RAR-related orphan receptor A -0.0364142
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0363238
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0359368
NPAS2 neuronal PAS domain protein 2 -0.0355553
PLEK2 pleckstrin 2 -0.0355267
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0353695
ENO2 enolase 2 (gamma, neuronal) -0.0351389
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0351307
FNDC3A fibronectin type III domain containing 3A -0.0351057
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0347719
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0341265
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0338338
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0336838
OSMR oncostatin M receptor -0.0330881
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.033056
PARD3 par-3 family cell polarity regulator -0.0327645
GPC5 glypican 5 -0.0326279
FMNL2 formin-like 2 -0.0323858
OASL 2'-5'-oligoadenylate synthetase-like -0.0320694
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0318212
IGF2 insulin-like growth factor 2 -0.0315536
IGFBP4 insulin-like growth factor binding protein 4 -0.0312576
VCL vinculin -0.0312162
CUX1 cut-like homeobox 1 -0.0311236
SASH1 SAM and SH3 domain containing 1 -0.0306635
MACF1 microtubule-actin crosslinking factor 1 -0.0306313
JARID2 jumonji, AT rich interactive domain 2 -0.0300419
EGFR epidermal growth factor receptor -0.0295678
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0293661
PTPRG protein tyrosine phosphatase, receptor type, G -0.0291803
ARHGAP18 Rho GTPase activating protein 18 -0.0288931
CCDC50 coiled-coil domain containing 50 -0.0288926
PRH1 proline-rich protein HaeIII subfamily 1 -0.0288758
LAMB1 laminin, beta 1 -0.0288575
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.028699
IFI44 interferon-induced protein 44 -0.0284794
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0283932