Imiquimod (maleate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.19663
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.117084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.106665
ZNF292 zinc finger protein 292 0.089468
FNDC3B fibronectin type III domain containing 3B 0.0778048
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0733565
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0661931
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0656137
CD109 CD109 molecule 0.0649902
RNF145 ring finger protein 145 0.062428
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0617712
RICTOR RPTOR independent companion of MTOR, complex 2 0.0608225
PTK2 protein tyrosine kinase 2 0.0599608
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0599195
HELZ helicase with zinc finger 0.0598359
SUCO SUN domain containing ossification factor 0.0595775
WAC WW domain containing adaptor with coiled-coil 0.0583206
TFG TRK-fused gene 0.0562376
MCTP2 multiple C2 domains, transmembrane 2 0.0544206
ETNK1 ethanolamine kinase 1 0.0532009
COPA coatomer protein complex, subunit alpha 0.0530801
UBA6 ubiquitin-like modifier activating enzyme 6 0.0521408
TPR translocated promoter region, nuclear basket protein 0.0512302
CENPF centromere protein F, 350/400kDa 0.0510901
EPS8 epidermal growth factor receptor pathway substrate 8 0.0504496
KMT2E lysine (K)-specific methyltransferase 2E 0.0495674
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0483435
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0476701
OGA O-GlcNAcase 0.047564
KMT2C lysine (K)-specific methyltransferase 2C 0.0473176
FAM13A family with sequence similarity 13, member A 0.0465463
AHR aryl hydrocarbon receptor 0.0463295
GOLGA4 golgin A4 0.0462862
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0454296
NRIP1 nuclear receptor interacting protein 1 0.0446761
NUP58 nucleoporin 58 0.0446693
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0437273
MKI67 marker of proliferation Ki-67 0.0436403
CDC73 cell division cycle 73 0.0435247
TXNRD1 thioredoxin reductase 1 0.0434002
TRIO trio Rho guanine nucleotide exchange factor 0.0429471
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0429189
PRRC2C proline-rich coiled-coil 2C 0.042705
YME1L1 YME1-like 1 ATPase 0.0427012
MYH9 myosin, heavy chain 9, non-muscle 0.0426082
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0425191
SEC23A Sec23 homolog A (S. cerevisiae) 0.0422963
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0422024
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0412487
RUNX2 runt-related transcription factor 2 0.0408493
TENT2 terminal nucleotidyltransferase 2 0.0407171
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0387297
JMJD1C jumonji domain containing 1C 0.0374969
NEK7 NIMA-related kinase 7 0.0372272
DSCAM Down syndrome cell adhesion molecule 0.0369833
ZFAND3 zinc finger, AN1-type domain 3 0.036795
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0361465
ARID4B AT rich interactive domain 4B (RBP1-like) 0.036029
DST dystonin 0.0358944
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0357966
FNBP1 formin binding protein 1 0.0357855
PUM2 pumilio RNA-binding family member 2 0.0356839
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0356066
CAB39 calcium binding protein 39 0.0355261
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.035191
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0350227
PTBP3 polypyrimidine tract binding protein 3 0.0345475
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0345287
RAB1A RAB1A, member RAS oncogene family 0.0344311
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0343713
ETV6 ets variant 6 0.0342297
SLTM SAFB-like, transcription modulator 0.0340174
TMEM156 transmembrane protein 156 0.0339939
PRELID2 PRELI domain containing 2 0.0337995
ADD3 adducin 3 (gamma) 0.0337573
MIS18BP1 MIS18 binding protein 1 0.0334954
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0334635
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.033422
SNX9 sorting nexin 9 0.0331206
RTN4 reticulon 4 0.0330576
TPM3 tropomyosin 3 0.0327239
KDM5B lysine (K)-specific demethylase 5B 0.0326132
H1-0 H1.0 linker histone 0.0323877
BIRC6 baculoviral IAP repeat containing 6 0.0323754
CLINT1 clathrin interactor 1 0.032354
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0321746
LCORL ligand dependent nuclear receptor corepressor-like 0.0321486
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0319695
MARCHF6 membrane associated ring-CH-type finger 6 0.0317685
OSMR oncostatin M receptor 0.0316398
ERBIN erbb2 interacting protein 0.0314884
TM9SF3 transmembrane 9 superfamily member 3 0.0313906
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0311056
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0309777
XPO1 exportin 1 0.0309055
ZC3H11A zinc finger CCCH-type containing 11A 0.0305218
DLG1 discs, large homolog 1 (Drosophila) 0.030478
SMOX spermine oxidase 0.0304239
ZFR zinc finger RNA binding protein 0.0302897
ELL2 elongation factor, RNA polymerase II, 2 0.0302216

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.204578
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201469
FN1 fibronectin 1 -0.192193
TMSB10 thymosin beta 10 -0.118519
HMGA2 high mobility group AT-hook 2 -0.094841
HLA-B major histocompatibility complex, class I, B -0.0930485
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.082842
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0711831
FTL ferritin, light polypeptide -0.0700411
PTMA prothymosin, alpha -0.0682984
INTS6 integrator complex subunit 6 -0.0647244
S100A6 S100 calcium binding protein A6 -0.0613646
MT2A metallothionein 2A -0.0611513
TPT1 tumor protein, translationally-controlled 1 -0.0602473
NDRG1 N-myc downstream regulated 1 -0.0574012
AEBP2 AE binding protein 2 -0.056733
IFI27 interferon, alpha-inducible protein 27 -0.0559897
ACTG1 actin gamma 1 -0.0556894
SQSTM1 sequestosome 1 -0.0543154
RPL35A ribosomal protein L35a -0.0537192
VCL vinculin -0.0535567
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0531867
RPL26 ribosomal protein L26 -0.0500148
VIM vimentin -0.0473641
MRPS6 mitochondrial ribosomal protein S6 -0.0471885
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0438703
RPL31 ribosomal protein L31 -0.0424492
RPS24 ribosomal protein S24 -0.0407845
RPL9 ribosomal protein L9 -0.0406313
STC2 stanniocalcin 2 -0.0405745
SOX4 SRY (sex determining region Y)-box 4 -0.0404923
PALLD palladin, cytoskeletal associated protein -0.040243
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0398055
RPLP1 ribosomal protein, large, P1 -0.0380403
LMNA lamin A/C -0.0374405
RPL23 ribosomal protein L23 -0.037395
EGR1 early growth response 1 -0.0357499
FTH1 ferritin, heavy polypeptide 1 -0.0349507
RPL37A ribosomal protein L37a -0.0344143
CANX calnexin -0.0341334
RPL34 ribosomal protein L34 -0.0339098
LRRC23 leucine rich repeat containing 23 -0.0336427
IFI6 interferon, alpha-inducible protein 6 -0.033278
LIMCH1 LIM and calponin homology domains 1 -0.033102
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0327893
LOC102724023 ES1 protein homolog, mitochondrial -0.0324019
RPS19 ribosomal protein S19 -0.0321141
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0320104
IGFBP3 insulin-like growth factor binding protein 3 -0.0319211
RASAL2 RAS protein activator like 2 -0.0319184
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0318588
B2M beta-2-microglobulin -0.0318134
SLC35F3 solute carrier family 35, member F3 -0.0298294
RPS29 ribosomal protein S29 -0.02979
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0296487
HLA-A major histocompatibility complex, class I, A -0.0287531
RPS20 ribosomal protein S20 -0.0286044
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0284296
RPS6 ribosomal protein S6 -0.0284031
TENM4 teneurin transmembrane protein 4 -0.0281299
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0279745
S100A10 S100 calcium binding protein A10 -0.0276793
RPS8 ribosomal protein S8 -0.0274015
TMSB4X thymosin beta 4, X-linked -0.0272791
RPL38 ribosomal protein L38 -0.0268294
RPS27 ribosomal protein S27 -0.0267646
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0266037
CALR calreticulin -0.0264069
CTSD cathepsin D -0.0260701
RPS25 ribosomal protein S25 -0.0260253
RNF213 ring finger protein 213 -0.0258264
DNAH5 dynein, axonemal, heavy chain 5 -0.0255825
HMGA1 high mobility group AT-hook 1 -0.0255275
RPL36 ribosomal protein L36 -0.0254056
RPL37 ribosomal protein L37 -0.0252967
GNAS GNAS complex locus -0.0251316
RACK1 receptor for activated C kinase 1 -0.0250231
EIF1 eukaryotic translation initiation factor 1 -0.0249108
SFTPA2 surfactant protein A2 -0.0248957
S100A9 S100 calcium binding protein A9 -0.0246707
RPL12 ribosomal protein L12 -0.0244376
LOX lysyl oxidase -0.0243174
IER3 immediate early response 3 -0.0242496
LOC112694756 uncharaterized LOC112694756 -0.023682
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0233383
RPS21 ribosomal protein S21 -0.0229134
RPS23 ribosomal protein S23 -0.0227831
RPL28 ribosomal protein L28 -0.0225869
ARF1 ADP-ribosylation factor 1 -0.0222276
SFRP1 secreted frizzled-related protein 1 -0.0221855
TFPI2 tissue factor pathway inhibitor 2 -0.022176
LOXL2 lysyl oxidase-like 2 -0.0221138
POTEF POTE ankyrin domain family, member F -0.0220264
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0219236
SOX5 SRY (sex determining region Y)-box 5 -0.0213956
AHRR aryl-hydrocarbon receptor repressor -0.0213069
RPS12 ribosomal protein S12 -0.0212245
RAI14 retinoic acid induced 14 -0.0212045
RPS3 ribosomal protein S3 -0.0211638
IGFBP5 insulin-like growth factor binding protein 5 -0.0209731