Imiquimod (maleate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.0951363
NAV2 neuron navigator 2 0.0917715
SDK1 sidekick cell adhesion molecule 1 0.0900897
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0703628
VCL vinculin 0.0664143
AKAP12 A kinase (PRKA) anchor protein 12 0.0631407
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0618592
INTS6 integrator complex subunit 6 0.0603448
CCND1 cyclin D1 0.0577323
ASPH aspartate beta-hydroxylase 0.0572206
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0559614
FRMD5 FERM domain containing 5 0.0495282
ANO1 anoctamin 1, calcium activated chloride channel 0.0485289
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0460495
FLNB filamin B, beta 0.04577
ETNK1 ethanolamine kinase 1 0.0457626
PTMA prothymosin, alpha 0.0447305
RAD51B RAD51 paralog B 0.0443715
GMDS GDP-mannose 4,6-dehydratase 0.043426
MACF1 microtubule-actin crosslinking factor 1 0.0426228
BACE2 beta-site APP-cleaving enzyme 2 0.0424589
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.041691
KRT18 keratin 18, type I 0.0415889
MAML2 mastermind-like 2 (Drosophila) 0.0402313
EXOC4 exocyst complex component 4 0.0390871
CDK6 cyclin-dependent kinase 6 0.0371421
FNIP1 folliculin interacting protein 1 0.0369368
CUX1 cut-like homeobox 1 0.0364189
ERRFI1 ERBB receptor feedback inhibitor 1 0.034759
ZCCHC7 zinc finger, CCHC domain containing 7 0.0346567
ARHGAP32 Rho GTPase activating protein 32 0.0327618
AHNAK AHNAK nucleoprotein 0.0325703
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0325565
TRIO trio Rho guanine nucleotide exchange factor 0.0316282
FNDC3B fibronectin type III domain containing 3B 0.0315793
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0311859
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0310593
SKAP1 src kinase associated phosphoprotein 1 0.0307391
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0305478
TNIK TRAF2 and NCK interacting kinase 0.0302609
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0301454
FMNL2 formin-like 2 0.0298675
MED13 mediator complex subunit 13 0.0297787
RCOR1 REST corepressor 1 0.0290076
MRPS6 mitochondrial ribosomal protein S6 0.0289317
CTBP2 C-terminal binding protein 2 0.0288335
ITPRID2 ITPR interacting domain containing 2 0.0287813
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0287536
HSPA8 heat shock 70kDa protein 8 0.0282408
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0277916
NPAS2 neuronal PAS domain protein 2 0.0272354
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0271267
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0271036
LPP LIM domain containing preferred translocation partner in lipoma 0.0270007
KRT8 keratin 8, type II 0.026905
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0268107
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0267029
ATXN1 ataxin 1 0.0262524
LRMDA leucine rich melanocyte differentiation associated 0.0261853
KDM6A lysine (K)-specific demethylase 6A 0.026073
DOCK9 dedicator of cytokinesis 9 0.0257698
ANLN anillin, actin binding protein 0.025423
TAS2R14 taste receptor, type 2, member 14 0.0253953
SLMAP sarcolemma associated protein 0.0253893
HDAC4 histone deacetylase 4 0.0253555
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0253506
UBAP2 ubiquitin associated protein 2 0.0248922
HSPH1 heat shock 105kDa/110kDa protein 1 0.0247368
DST dystonin 0.0246891
MYOF myoferlin 0.0246157
GTF2IRD1 GTF2I repeat domain containing 1 0.0244891
ADGRL2 adhesion G protein-coupled receptor L2 0.024476
RASA2 RAS p21 protein activator 2 0.0244304
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0241619
ANKRD10 ankyrin repeat domain 10 0.0240167
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0240015
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0239117
USP34 ubiquitin specific peptidase 34 0.023891
WAC WW domain containing adaptor with coiled-coil 0.0237972
BIRC6 baculoviral IAP repeat containing 6 0.0236588
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0236561
PDLIM5 PDZ and LIM domain 5 0.0235957
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0235775
OSBPL10 oxysterol binding protein-like 10 0.0233342
SAMD4A sterile alpha motif domain containing 4A 0.0232893
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0232166
ANXA3 annexin A3 0.0231932
CD44 CD44 molecule (Indian blood group) 0.0230965
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0230067
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0230009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0229612
PPARG peroxisome proliferator-activated receptor gamma 0.0226626
CCNY cyclin Y 0.0225978
SQSTM1 sequestosome 1 0.0225941
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0221877
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0220939
MYH9 myosin, heavy chain 9, non-muscle 0.0220847
LIMS1 LIM and senescent cell antigen-like domains 1 0.0219408
ITGA6 integrin, alpha 6 0.0218478
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0217282

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.349691
RPS6 ribosomal protein S6 -0.147498
TMSB10 thymosin beta 10 -0.138627
RPL35A ribosomal protein L35a -0.109496
RPLP1 ribosomal protein, large, P1 -0.0996813
MT2A metallothionein 2A -0.0952648
RPL23 ribosomal protein L23 -0.0831588
RPS19 ribosomal protein S19 -0.0753838
EGR1 early growth response 1 -0.0742968
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0742456
RPLP2 ribosomal protein, large, P2 -0.0742206
EEF2 eukaryotic translation elongation factor 2 -0.0725517
RPL12 ribosomal protein L12 -0.0712738
RPL32 ribosomal protein L32 -0.0682496
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0658142
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0648587
RPS3 ribosomal protein S3 -0.0648286
VIM vimentin -0.0642289
RPL11 ribosomal protein L11 -0.0616877
RPS4X ribosomal protein S4, X-linked -0.0602859
EIF1 eukaryotic translation initiation factor 1 -0.056732
RPL5 ribosomal protein L5 -0.0567234
SOX4 SRY (sex determining region Y)-box 4 -0.0542419
RPL19 ribosomal protein L19 -0.0536847
RPL36 ribosomal protein L36 -0.0529647
RPS24 ribosomal protein S24 -0.0516035
RPL7 ribosomal protein L7 -0.0515741
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0505721
RPL18 ribosomal protein L18 -0.0497953
RPLP0 ribosomal protein, large, P0 -0.0493566
RPS13 ribosomal protein S13 -0.0487766
RPS23 ribosomal protein S23 -0.0480557
RPL26 ribosomal protein L26 -0.0468641
RPS12 ribosomal protein S12 -0.0458128
EZR ezrin -0.0454921
RPL8 ribosomal protein L8 -0.0447251
SMC4 structural maintenance of chromosomes 4 -0.0439239
LOC112694756 uncharaterized LOC112694756 -0.0424726
RPL34 ribosomal protein L34 -0.0422787
RPL9 ribosomal protein L9 -0.0405964
RPS8 ribosomal protein S8 -0.0401826
RACK1 receptor for activated C kinase 1 -0.0398927
RPS11 ribosomal protein S11 -0.0397723
RPL37 ribosomal protein L37 -0.0397213
RPL28 ribosomal protein L28 -0.0393329
RPS20 ribosomal protein S20 -0.0387949
RPL36A ribosomal protein L36a -0.0383478
PGK1 phosphoglycerate kinase 1 -0.0382371
NKD1 naked cuticle homolog 1 (Drosophila) -0.0375143
ACTN4 actinin, alpha 4 -0.0373247
MT1X metallothionein 1X -0.0371069
RPL13A ribosomal protein L13a -0.0368539
MYL12B myosin, light chain 12B, regulatory -0.0357676
TPI1 triosephosphate isomerase 1 -0.0353121
RPL27A ribosomal protein L27a -0.0350777
DUSP6 dual specificity phosphatase 6 -0.0350011
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0347481
PFN1 profilin 1 -0.0347418
RPS21 ribosomal protein S21 -0.0344828
FOXP1 forkhead box P1 -0.0344528
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0338905
RPL35 ribosomal protein L35 -0.0338879
ACTG1 actin gamma 1 -0.0334896
HMGA1 high mobility group AT-hook 1 -0.033469
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0333028
RPS29 ribosomal protein S29 -0.0331598
RPS14 ribosomal protein S14 -0.0328523
RPS5 ribosomal protein S5 -0.032261
SEC61G Sec61 gamma subunit -0.0322122
EMP1 epithelial membrane protein 1 -0.0319544
SLC38A1 solute carrier family 38, member 1 -0.0317678
GARS1 glycyl-tRNA synthetase 1 -0.0314649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0313161
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0310259
TXNIP thioredoxin interacting protein -0.0308586
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0305449
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0301149
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0297412
PCLO piccolo presynaptic cytomatrix protein -0.0292866
YBX3 Y box binding protein 3 -0.0292409
PCBP2 poly(rC) binding protein 2 -0.0289228
RPS16 ribosomal protein S16 -0.0288565
CBX3 chromobox homolog 3 -0.0282874
CENPF centromere protein F, 350/400kDa -0.0282134
JUN jun proto-oncogene -0.0281909
RPL7A ribosomal protein L7a -0.0281213
CEMIP2 cell migration inducing hyaluronidase 2 -0.0280774
AKAP9 A kinase (PRKA) anchor protein 9 -0.0280496
EEF1G eukaryotic translation elongation factor 1 gamma -0.0277331
NACA nascent polypeptide-associated complex alpha subunit -0.0277128
GNAS GNAS complex locus -0.0272502
RPL30 ribosomal protein L30 -0.0271391
NIPBL Nipped-B homolog (Drosophila) -0.0269789
RPS15 ribosomal protein S15 -0.0269632
LOC102724023 ES1 protein homolog, mitochondrial -0.0268442
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0267544
SYT1 synaptotagmin I -0.0265939
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0264764
NAP1L1 nucleosome assembly protein 1-like 1 -0.0262903
PRRC2C proline-rich coiled-coil 2C -0.0255274