Imiquimod (maleate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (maleate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (maleate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.0927155
JARID2 jumonji, AT rich interactive domain 2 0.0919664
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.075468
ATP13A3 ATPase type 13A3 0.0673603
EGFR epidermal growth factor receptor 0.0643149
SOD2 superoxide dismutase 2, mitochondrial 0.0596988
PDE4D phosphodiesterase 4D, cAMP-specific 0.0587468
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0573213
FNDC3B fibronectin type III domain containing 3B 0.0553973
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0538067
FAM13A family with sequence similarity 13, member A 0.0485488
SETD5 SET domain containing 5 0.0450132
FMNL2 formin-like 2 0.0429094
RNF145 ring finger protein 145 0.0385688
CALD1 caldesmon 1 0.0382681
FAT1 FAT atypical cadherin 1 0.0365383
CALU calumenin 0.036319
MSI2 musashi RNA-binding protein 2 0.035828
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0344527
NGLY1 N-glycanase 1 0.0339033
MEIS1 Meis homeobox 1 0.0333012
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0331271
IER3 immediate early response 3 0.0328417
SEC31A SEC31 homolog A (S. cerevisiae) 0.0325669
PDE8A phosphodiesterase 8A 0.0305423
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0301503
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0296058
USP3 ubiquitin specific peptidase 3 0.0274884
COL5A2 collagen, type V, alpha 2 0.0271829
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0270657
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0267483
RAB8B RAB8B, member RAS oncogene family 0.0267027
GSK3B glycogen synthase kinase 3 beta 0.0266615
MYOF myoferlin 0.0265148
COG6 component of oligomeric golgi complex 6 0.0262765
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0257665
WAC WW domain containing adaptor with coiled-coil 0.0257656
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0255878
ZCCHC7 zinc finger, CCHC domain containing 7 0.025439
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0252978
SREBF2 sterol regulatory element binding transcription factor 2 0.024994
RICTOR RPTOR independent companion of MTOR, complex 2 0.0249099
PTBP3 polypyrimidine tract binding protein 3 0.0245446
APOLD1 apolipoprotein L domain containing 1 0.0244219
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0243535
PLIN2 perilipin 2 0.0240739
NBAS neuroblastoma amplified sequence 0.0236552
COPB1 coatomer protein complex, subunit beta 1 0.023636
H1-0 H1.0 linker histone 0.0233228
HELZ helicase with zinc finger 0.0229027
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0225205
MARCHF6 membrane associated ring-CH-type finger 6 0.0223156
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0220985
FOXO3 forkhead box O3 0.022031
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.021995
ELF2 E74-like factor 2 (ets domain transcription factor) 0.021779
PRELID2 PRELI domain containing 2 0.0214722
HOMER2 homer scaffolding protein 2 0.0214233
MMP12 matrix metallopeptidase 12 0.0212464
HSPG2 heparan sulfate proteoglycan 2 0.0209807
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0208672
PCBP3 poly(rC) binding protein 3 0.0202633
MRPS6 mitochondrial ribosomal protein S6 0.0201928
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0200416
TM9SF3 transmembrane 9 superfamily member 3 0.0196753
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0196521
ANXA5 annexin A5 0.0195637
COL4A1 collagen, type IV, alpha 1 0.0195367
SAMD4A sterile alpha motif domain containing 4A 0.0194508
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0193266
SCAF4 SR-related CTD-associated factor 4 0.0188242
LPP LIM domain containing preferred translocation partner in lipoma 0.0186868
CDC27 cell division cycle 27 0.0185158
BRWD1 bromodomain and WD repeat domain containing 1 0.0184216
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0183537
TNPO1 transportin 1 0.0182342
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0180558
RAB1A RAB1A, member RAS oncogene family 0.0179379
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0179217
EPAS1 endothelial PAS domain protein 1 0.0178469
CEP350 centrosomal protein 350kDa 0.0178174
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0176989
GPBP1 GC-rich promoter binding protein 1 0.0176633
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0176466
GJD3 gap junction protein, delta 3, 31.9kDa 0.0175929
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0175587
SFXN1 sideroflexin 1 0.0175576
ADAM17 ADAM metallopeptidase domain 17 0.0175189
UBE2H ubiquitin-conjugating enzyme E2H 0.0174622
SHB Src homology 2 domain containing adaptor protein B 0.0174446
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0174359
BIRC6 baculoviral IAP repeat containing 6 0.0173357
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0173246
VEGFC vascular endothelial growth factor C 0.0173215
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0173203
NT5C2 5'-nucleotidase, cytosolic II 0.0172862
RYBP RING1 and YY1 binding protein 0.0172749
NKTR natural killer cell triggering receptor 0.017139
USP12 ubiquitin specific peptidase 12 0.0171346
SNX9 sorting nexin 9 0.0170705

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.265205
FN1 fibronectin 1 -0.150484
NALF1 NALCN channel auxiliary factor 1 -0.118055
HLA-B major histocompatibility complex, class I, B -0.115865
TMSB10 thymosin beta 10 -0.0993771
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0927098
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0888007
MYO10 myosin X -0.0822351
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0806572
COL6A1 collagen, type VI, alpha 1 -0.080032
B2M beta-2-microglobulin -0.0784548
FTL ferritin, light polypeptide -0.0774027
PRKG1 protein kinase, cGMP-dependent, type I -0.0728737
ACTG1 actin gamma 1 -0.069783
INHBA inhibin, beta A -0.0680792
AKAP12 A kinase (PRKA) anchor protein 12 -0.065678
HMGA2 high mobility group AT-hook 2 -0.0616841
NAV1 neuron navigator 1 -0.0588856
RPS8 ribosomal protein S8 -0.0588076
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0571075
CD44 CD44 molecule (Indian blood group) -0.0548088
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0540988
RPL23 ribosomal protein L23 -0.0538933
RPS6 ribosomal protein S6 -0.053558
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0530219
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0525821
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0521982
EIF1 eukaryotic translation initiation factor 1 -0.0510728
MT2A metallothionein 2A -0.0509994
TPM4 tropomyosin 4 -0.0484529
CALR calreticulin -0.0475288
RPS12 ribosomal protein S12 -0.0457072
COL1A1 collagen, type I, alpha 1 -0.0455271
MYH9 myosin, heavy chain 9, non-muscle -0.0450289
RPL37A ribosomal protein L37a -0.0434801
CAVIN1 caveolae associated protein 1 -0.0429359
TPT1 tumor protein, translationally-controlled 1 -0.0429041
NDRG1 N-myc downstream regulated 1 -0.0428912
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0424071
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0417296
NAP1L1 nucleosome assembly protein 1-like 1 -0.0414901
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0405494
COL6A3 collagen, type VI, alpha 3 -0.0397899
RPL26 ribosomal protein L26 -0.0397229
RPLP1 ribosomal protein, large, P1 -0.0396931
SLIT2 slit homolog 2 (Drosophila) -0.0396266
VEGFA vascular endothelial growth factor A -0.0394211
ZEB1 zinc finger E-box binding homeobox 1 -0.0377106
GPHN gephyrin -0.037273
MSN moesin -0.0364556
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0363066
GLIS3 GLIS family zinc finger 3 -0.036156
RPL32 ribosomal protein L32 -0.0360527
RAI14 retinoic acid induced 14 -0.0356971
RPL31 ribosomal protein L31 -0.0354869
PTMA prothymosin, alpha -0.0351465
RPL38 ribosomal protein L38 -0.0351035
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0345647
OXR1 oxidation resistance 1 -0.0341859
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0340256
MMP1 matrix metallopeptidase 1 -0.0336913
RPS27 ribosomal protein S27 -0.0329206
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0327184
CLMP CXADR-like membrane protein -0.0326872
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0320609
TXNIP thioredoxin interacting protein -0.032017
COL6A2 collagen, type VI, alpha 2 -0.030766
CD59 CD59 molecule, complement regulatory protein -0.0307511
HLA-A major histocompatibility complex, class I, A -0.0307491
FBN1 fibrillin 1 -0.0306518
RPS23 ribosomal protein S23 -0.0306169
RPS2 ribosomal protein S2 -0.0299345
RPS13 ribosomal protein S13 -0.0293683
FRMD4A FERM domain containing 4A -0.0292729
RPLP2 ribosomal protein, large, P2 -0.0290763
HAS2 hyaluronan synthase 2 -0.0288795
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0284684
KTN1 kinectin 1 (kinesin receptor) -0.0284455
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0280343
P4HB prolyl 4-hydroxylase, beta polypeptide -0.028019
ARHGAP24 Rho GTPase activating protein 24 -0.0278992
LOC112694756 uncharaterized LOC112694756 -0.0277196
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.027699
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0275119
RPL9 ribosomal protein L9 -0.0275118
SDCCAG8 serologically defined colon cancer antigen 8 -0.0274743
ASPH aspartate beta-hydroxylase -0.0274629
SASH1 SAM and SH3 domain containing 1 -0.0272005
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0269968
RPL7 ribosomal protein L7 -0.0269429
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0268579
RPL34 ribosomal protein L34 -0.0267877
RPS17 ribosomal protein S17 -0.0259778
SAMD3 sterile alpha motif domain containing 3 -0.0258583
SFTPA2 surfactant protein A2 -0.0257405
RPL35A ribosomal protein L35a -0.0257128
ARHGAP5 Rho GTPase activating protein 5 -0.0255192
RPL28 ribosomal protein L28 -0.0253102
WNT5A wingless-type MMTV integration site family, member 5A -0.0252555
RPL11 ribosomal protein L11 -0.0252421