| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An imidazoquinoline that has formula C14H16N4. (Chemical Entities of Biological Interest Ontology, CHEBI_36704) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/57469 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Imiquimod relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BBS9 | Bardet-Biedl syndrome 9 | 1.31 |
| NPHP3 | nephronophthisis 3 (adolescent) | 1.14 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 1.13 |
| BCOR | BCL6 corepressor | 1.01 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.95 |
| DHFR | dihydrofolate reductase | 0.92 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.84 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.73 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.6 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.57 |
| MANEAL | mannosidase, endo-alpha-like | 0.56 |
| CFAP57 | cilia and flagella associated protein 57 | 0.51 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 0.49 |
| NIN | ninein (GSK3B interacting protein) | 0.49 |
| CNST | consortin, connexin sorting protein | 0.49 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.48 |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.47 |
| BAIAP2 | BAI1-associated protein 2 | 0.44 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.44 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.43 |
| NLGN2 | neuroligin 2 | 0.43 |
| B2M | beta-2-microglobulin | 0.43 |
| DOCK3 | dedicator of cytokinesis 3 | 0.42 |
| TMEM94 | transmembrane protein 94 | 0.42 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.4 |
| DOLPP1 | dolichyldiphosphatase 1 | 0.39 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.39 |
| RPL30 | ribosomal protein L30 | 0.39 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.38 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | 0.38 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.37 |
| ASB3 | ankyrin repeat and SOCS box containing 3 | 0.37 |
| RPL36A | ribosomal protein L36a | 0.37 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.37 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.36 |
| KSR2 | kinase suppressor of ras 2 | 0.36 |
| KLHL20 | kelch-like family member 20 | 0.36 |
| GLI2 | GLI family zinc finger 2 | 0.36 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.36 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.35 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.35 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.34 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.34 |
| ZNF274 | zinc finger protein 274 | 0.33 |
| FZD1 | frizzled class receptor 1 | 0.33 |
| LIPH | lipase, member H | 0.33 |
| APLF | aprataxin and PNKP like factor | 0.32 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.32 |
| PDZD11 | PDZ domain containing 11 | 0.32 |
| NAF1 | nuclear assembly factor 1 ribonucleoprotein | 0.32 |
| ZNF436 | zinc finger protein 436 | 0.31 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.31 |
| NHEJ1 | nonhomologous end-joining factor 1 | 0.31 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.31 |
| DST | dystonin | 0.3 |
| ZNF197 | zinc finger protein 197 | 0.3 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.3 |
| HDDC3 | HD domain containing 3 | 0.3 |
| ETAA1 | Ewing tumor-associated antigen 1 | 0.3 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | 0.3 |
| RIN3 | Ras and Rab interactor 3 | 0.29 |
| NPHP4 | nephronophthisis 4 | 0.29 |
| TNNI3 | troponin I type 3 (cardiac) | 0.29 |
| ZNF777 | zinc finger protein 777 | 0.28 |
| TRAK2 | trafficking protein, kinesin binding 2 | 0.28 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.28 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.28 |
| DNAL1 | dynein, axonemal, light chain 1 | 0.28 |
| ZNF282 | zinc finger protein 282 | 0.28 |
| CDK6 | cyclin-dependent kinase 6 | 0.28 |
| AXIN2 | axin 2 | 0.28 |
| MATR3 | matrin 3 | 0.28 |
| HPS1 | Hermansky-Pudlak syndrome 1 | 0.28 |
| TRIB3 | tribbles pseudokinase 3 | 0.28 |
| FZD2 | frizzled class receptor 2 | 0.27 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.27 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.27 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.27 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.27 |
| METTL6 | methyltransferase like 6 | 0.26 |
| TANK | TRAF family member-associated NFKB activator | 0.26 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 0.26 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.26 |
| ZBTB48 | zinc finger and BTB domain containing 48 | 0.26 |
| EGR1 | early growth response 1 | 0.26 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.25 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.25 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.25 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | 0.25 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.25 |
| ALPK1 | alpha-kinase 1 | 0.25 |
| ZBTB39 | zinc finger and BTB domain containing 39 | 0.25 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.25 |
| R3HDM4 | R3H domain containing 4 | 0.24 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.24 |
| SH2D4A | SH2 domain containing 4A | 0.24 |
| TBC1D31 | TBC1 domain family, member 31 | 0.24 |
| CEP128 | centrosomal protein 128kDa | 0.24 |
| MAGEA12 | melanoma antigen family A12 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP1R2B | PPP1R2 family member B | -0.93 |
| LDHD | lactate dehydrogenase D | -0.72 |
| HAL | histidine ammonia-lyase | -0.64 |
| GPATCH2L | G patch domain containing 2-like | -0.59 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.58 |
| MIEF1 | mitochondrial elongation factor 1 | -0.51 |
| TADA2B | transcriptional adaptor 2B | -0.48 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.48 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -0.47 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.47 |
| DEAF1 | DEAF1 transcription factor | -0.47 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.47 |
| CLIC3 | chloride intracellular channel 3 | -0.46 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.44 |
| OSTF1 | osteoclast stimulating factor 1 | -0.43 |
| MAF1 | MAF1 homolog (S. cerevisiae) | -0.43 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | -0.43 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | -0.41 |
| HS6ST1 | heparan sulfate 6-O-sulfotransferase 1 | -0.41 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.4 |
| JOSD1 | Josephin domain containing 1 | -0.39 |
| FN1 | fibronectin 1 | -0.39 |
| ZNF771 | zinc finger protein 771 | -0.38 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | -0.38 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.38 |
| ETNK2 | ethanolamine kinase 2 | -0.37 |
| TMC4 | transmembrane channel-like 4 | -0.36 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.36 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.36 |
| ZNF14 | zinc finger protein 14 | -0.36 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.36 |
| FAM8A1 | family with sequence similarity 8, member A1 | -0.36 |
| KLHL9 | kelch-like family member 9 | -0.36 |
| COMMD6 | COMM domain containing 6 | -0.35 |
| RNF26 | ring finger protein 26 | -0.35 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.35 |
| TMEM104 | transmembrane protein 104 | -0.34 |
| OPTN | optineurin | -0.34 |
| PTK6 | protein tyrosine kinase 6 | -0.34 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.34 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.34 |
| CD58 | CD58 molecule | -0.33 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.33 |
| CCNI | cyclin I | -0.33 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.32 |
| ARG2 | arginase 2 | -0.32 |
| CPE | carboxypeptidase E | -0.32 |
| TMC6 | transmembrane channel-like 6 | -0.31 |
| ABCB11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | -0.31 |
| ANKRD39 | ankyrin repeat domain 39 | -0.31 |
| PRR3 | proline rich 3 | -0.31 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.31 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.31 |
| GM2A | GM2 ganglioside activator | -0.3 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.3 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -0.3 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.3 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.3 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.3 |
| CA8 | carbonic anhydrase VIII | -0.29 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.29 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.29 |
| ZNF414 | zinc finger protein 414 | -0.29 |
| ATE1 | arginyltransferase 1 | -0.29 |
| ERG28 | ergosterol biosynthesis 28 homolog | -0.29 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.29 |
| PRKCG | protein kinase C, gamma | -0.29 |
| KCTD21 | potassium channel tetramerization domain containing 21 | -0.29 |
| CTSL | cathepsin L | -0.29 |
| FXN | frataxin | -0.29 |
| TMEM134 | transmembrane protein 134 | -0.28 |
| BSDC1 | BSD domain containing 1 | -0.28 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.28 |
| MCOLN1 | mucolipin 1 | -0.28 |
| MT1X | metallothionein 1X | -0.28 |
| MSLN | mesothelin | -0.28 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.28 |
| HINFP | histone H4 transcription factor | -0.28 |
| ABLIM2 | actin binding LIM protein family, member 2 | -0.28 |
| HLA-F | major histocompatibility complex, class I, F | -0.28 |
| APOE | apolipoprotein E | -0.28 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | -0.27 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | -0.27 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.27 |
| MIGA2 | mitoguardin 2 | -0.27 |
| STK16 | serine/threonine kinase 16 | -0.27 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | -0.27 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.27 |
| MROH6 | maestro heat-like repeat family member 6 | -0.27 |
| USP20 | ubiquitin specific peptidase 20 | -0.27 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.27 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.27 |
| TP53 | tumor protein p53 | -0.27 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -0.27 |
| CBR3 | carbonyl reductase 3 | -0.27 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.26 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.26 |
| MED8 | mediator complex subunit 8 | -0.26 |
| ARSD | arylsulfatase D | -0.26 |
| INVS | inversin | -0.26 |
