Impaired Insulin Secretion Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0948379
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Genes

88 genes associated with the disease Impaired Insulin Secretion in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX5 arachidonate 5-lipoxygenase
BTC betacellulin
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CAMP cathelicidin antimicrobial peptide
CAPN10 calpain 10
CDK8 cyclin-dependent kinase 8
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DBP D site of albumin promoter (albumin D-box) binding protein
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
G6PC2 glucose-6-phosphatase, catalytic, 2
G6PD glucose-6-phosphate dehydrogenase
GATA6 GATA binding protein 6
GCG glucagon
GCK glucokinase (hexokinase 4)
GIP gastric inhibitory polypeptide
GLP1R glucagon-like peptide 1 receptor
HHEX hematopoietically expressed homeobox
HNF4A hepatocyte nuclear factor 4, alpha
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INS insulin
INSR insulin receptor
KAT2B K(lysine) acetyltransferase 2B
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KRT16 keratin 16, type I
LDB1 LIM domain binding 1
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LRP1 low density lipoprotein receptor-related protein 1
MTNR1B melatonin receptor 1B
MYRIP myosin VIIA and Rab interacting protein
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAEP progestagen-associated endometrial protein
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PREP prolyl endopeptidase
PRL prolactin
PTK2B protein tyrosine kinase 2 beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RBP4 retinol binding protein 4, plasma
REST RE1-silencing transcription factor
RIT2 Ras-like without CAAX 2
SFRP4 secreted frizzled-related protein 4
SIDT2 SID1 transmembrane family, member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC30A10 solute carrier family 30, member 10
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A5 solute carrier family 39 (zinc transporter), member 5
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS2 suppressor of cytokine signaling 2
SORCS1 sortilin-related VPS10 domain containing receptor 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAAR1 trace amine associated receptor 1
TARDBP TAR DNA binding protein
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAM transcription factor A, mitochondrial
TFB1M transcription factor B1, mitochondrial
TMEM163 transmembrane protein 163
TPD52 tumor protein D52
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZGLP1 zinc finger, GATA-like protein 1
ZRANB3 zinc finger, RAN-binding domain containing 3