Indacaterol (maleate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0795733
OGA O-GlcNAcase 0.0672726
QKI QKI, KH domain containing, RNA binding 0.0542837
TMSB4X thymosin beta 4, X-linked 0.0520209
SSBP2 single-stranded DNA binding protein 2 0.0456551
SUCO SUN domain containing ossification factor 0.0447332
RNF145 ring finger protein 145 0.0440848
TOP2B topoisomerase (DNA) II beta 180kDa 0.0439248
NAMPT nicotinamide phosphoribosyltransferase 0.0416503
MEOX2 mesenchyme homeobox 2 0.0408629
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0408379
B2M beta-2-microglobulin 0.0390094
AKAP9 A kinase (PRKA) anchor protein 9 0.0389182
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0374603
HELZ helicase with zinc finger 0.0350209
KDM6A lysine (K)-specific demethylase 6A 0.0329944
VEGFA vascular endothelial growth factor A 0.0325739
DSCAM Down syndrome cell adhesion molecule 0.0310339
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0307869
EEF2 eukaryotic translation elongation factor 2 0.0307502
RBM39 RNA binding motif protein 39 0.0303299
RYBP RING1 and YY1 binding protein 0.0300498
NFIA nuclear factor I/A 0.0295291
PELI1 pellino E3 ubiquitin protein ligase 1 0.029418
TM9SF3 transmembrane 9 superfamily member 3 0.0293994
ARHGAP21 Rho GTPase activating protein 21 0.0292364
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0290576
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289104
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.028887
RAB18 RAB18, member RAS oncogene family 0.0286542
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0285247
MEST mesoderm specific transcript 0.028424
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0283353
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0282119
CALR calreticulin 0.0279229
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0279155
KMT2E lysine (K)-specific methyltransferase 2E 0.02785
CAMTA1 calmodulin binding transcription activator 1 0.0278037
TRA2A transformer 2 alpha homolog (Drosophila) 0.027586
RAB6A RAB6A, member RAS oncogene family 0.0273258
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0271261
SMAP1 small ArfGAP 1 0.0263886
NCKAP1 NCK-associated protein 1 0.0263456
CCNL1 cyclin L1 0.026172
TFG TRK-fused gene 0.0261111
SEC23A Sec23 homolog A (S. cerevisiae) 0.0260905
APP amyloid beta (A4) precursor protein 0.0260669
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0258711
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0250492
RHEB Ras homolog enriched in brain 0.0250488
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0249475
TPD52 tumor protein D52 0.0248322
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.024761
CKAP5 cytoskeleton associated protein 5 0.0243339
DENND4C DENN/MADD domain containing 4C 0.0242491
CD46 CD46 molecule, complement regulatory protein 0.0242063
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0241867
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0241638
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.0241588
KDM3A lysine (K)-specific demethylase 3A 0.0241153
SRSF11 serine/arginine-rich splicing factor 11 0.0240096
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0238742
NPEPPS aminopeptidase puromycin sensitive 0.0237106
USP3 ubiquitin specific peptidase 3 0.0236374
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.023437
ZNF608 zinc finger protein 608 0.0232821
GOLGA4 golgin A4 0.0230902
ZFAND6 zinc finger, AN1-type domain 6 0.0230461
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0230032
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.022937
FOXJ3 forkhead box J3 0.0229029
PDS5B PDS5 cohesin associated factor B 0.0228836
PTEN phosphatase and tensin homolog 0.0228681
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0227292
PNISR PNN-interacting serine/arginine-rich protein 0.0223684
CASC3 cancer susceptibility candidate 3 0.0219592
EPS8 epidermal growth factor receptor pathway substrate 8 0.0219336
NPTN neuroplastin 0.0219067
TCP1 t-complex 1 0.0217776
WTAP Wilms tumor 1 associated protein 0.0215553
SPPL3 signal peptide peptidase like 3 0.0215494
RLF rearranged L-myc fusion 0.0215315
PPME1 protein phosphatase methylesterase 1 0.0215048
GIGYF2 GRB10 interacting GYF protein 2 0.0214269
KMT2C lysine (K)-specific methyltransferase 2C 0.0214181
DST dystonin 0.0213002
FAR1 fatty acyl CoA reductase 1 0.0212954
RTN4 reticulon 4 0.0208775
COPA coatomer protein complex, subunit alpha 0.0206802
SKIL SKI-like proto-oncogene 0.0206179
TBK1 TANK-binding kinase 1 0.0204976
MATR3 matrin 3 0.0201999
MKRN1 makorin ring finger protein 1 0.0201988
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0201702
ATG3 autophagy related 3 0.0201
ANLN anillin, actin binding protein 0.0200925
ELL2 elongation factor, RNA polymerase II, 2 0.0199878
PCBP2 poly(rC) binding protein 2 0.019896
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.019851
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0197078

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.228627
CADM2 cell adhesion molecule 2 -0.175054
PRKG1 protein kinase, cGMP-dependent, type I -0.155753
PEG10 paternally expressed 10 -0.139587
MGP matrix Gla protein -0.137319
HMGA2 high mobility group AT-hook 2 -0.12691
PDE4D phosphodiesterase 4D, cAMP-specific -0.123034
TRIO trio Rho guanine nucleotide exchange factor -0.105769
ACTG1 actin gamma 1 -0.105373
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.104899
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0960735
TSHZ2 teashirt zinc finger homeobox 2 -0.091755
FGFR1 fibroblast growth factor receptor 1 -0.0737289
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0724641
RANBP17 RAN binding protein 17 -0.0660055
HMGA1 high mobility group AT-hook 1 -0.0637606
RPS8 ribosomal protein S8 -0.0619871
MAP1B microtubule-associated protein 1B -0.0603906
SLC38A2 solute carrier family 38, member 2 -0.059774
RPLP1 ribosomal protein, large, P1 -0.0551023
MSRB3 methionine sulfoxide reductase B3 -0.0551005
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.054729
JMJD1C jumonji domain containing 1C -0.0540106
GMDS GDP-mannose 4,6-dehydratase -0.0538778
ZFHX3 zinc finger homeobox 3 -0.0530299
LDHA lactate dehydrogenase A -0.0519539
ZBTB20 zinc finger and BTB domain containing 20 -0.0489791
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0487327
COL1A2 collagen, type I, alpha 2 -0.047911
RPS24 ribosomal protein S24 -0.0476885
LOC112694756 uncharaterized LOC112694756 -0.0470594
KPNB1 karyopherin (importin) beta 1 -0.0469082
IER3 immediate early response 3 -0.0465918
RPL35A ribosomal protein L35a -0.046342
NBEA neurobeachin -0.0456922
TPM4 tropomyosin 4 -0.0455158
SOX4 SRY (sex determining region Y)-box 4 -0.0451417
TPK1 thiamin pyrophosphokinase 1 -0.0447171
RSU1 Ras suppressor protein 1 -0.0431155
TCF12 transcription factor 12 -0.0417831
TPT1 tumor protein, translationally-controlled 1 -0.0410837
TSC22D1 TSC22 domain family, member 1 -0.041024
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0406589
SEPTIN11 septin 11 -0.040617
CUX1 cut-like homeobox 1 -0.0406153
RPL37A ribosomal protein L37a -0.0404089
FNDC3B fibronectin type III domain containing 3B -0.0399316
DLG1 discs, large homolog 1 (Drosophila) -0.0398174
LPP LIM domain containing preferred translocation partner in lipoma -0.039626
RPS6 ribosomal protein S6 -0.0395586
PDE10A phosphodiesterase 10A -0.0387452
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0378232
RPL34 ribosomal protein L34 -0.0377168
MYOF myoferlin -0.0374646
WSB1 WD repeat and SOCS box containing 1 -0.0372914
RPLP0 ribosomal protein, large, P0 -0.0370809
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0366764
DOCK3 dedicator of cytokinesis 3 -0.0363105
RACK1 receptor for activated C kinase 1 -0.0356057
KAZN kazrin, periplakin interacting protein -0.0346397
TTC28 tetratricopeptide repeat domain 28 -0.0341285
PARD3 par-3 family cell polarity regulator -0.0340611
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0327945
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0326556
SERBP1 SERPINE1 mRNA binding protein 1 -0.0322841
IPO7 importin 7 -0.0321682
TBCA tubulin folding cofactor A -0.0319455
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0318744
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0315049
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.031358
CDK6 cyclin-dependent kinase 6 -0.031304
RPS23 ribosomal protein S23 -0.0299821
FBXL7 F-box and leucine-rich repeat protein 7 -0.029692
VDAC1 voltage-dependent anion channel 1 -0.0295292
RPLP2 ribosomal protein, large, P2 -0.0294457
AOPEP aminopeptidase O (putative) -0.0294059
RPL37 ribosomal protein L37 -0.0292268
GTF2IRD1 GTF2I repeat domain containing 1 -0.028903
IGF2R insulin-like growth factor 2 receptor -0.0285712
DOCK1 dedicator of cytokinesis 1 -0.0278744
POTEF POTE ankyrin domain family, member F -0.0275517
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0273216
HDAC8 histone deacetylase 8 -0.0273044
PHF14 PHD finger protein 14 -0.0271737
FOXC1 forkhead box C1 -0.0271381
TCEAL9 transcription elongation factor A like 9 -0.0271166
TPI1 triosephosphate isomerase 1 -0.0269074
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0266902
ATP11A ATPase, class VI, type 11A -0.0266031
ARB2A ARB2 cotranscriptional regulator A -0.0265633
ANO6 anoctamin 6 -0.0264721
THSD4 thrombospondin, type I, domain containing 4 -0.0264444
HMGB1 high mobility group box 1 -0.0262946
TRIM9 tripartite motif containing 9 -0.0262917
RAI1 retinoic acid induced 1 -0.0261932
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0261076
NHSL1 NHS-like 1 -0.0260071
LOXL2 lysyl oxidase-like 2 -0.0259871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0256952