Indacaterol (maleate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.128762
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0967466
FNBP1 formin binding protein 1 0.0841793
HELZ helicase with zinc finger 0.0801778
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0689459
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0674951
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0652312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0648706
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0633847
ZFC3H1 zinc finger, C3H1-type containing 0.0611726
PLAT plasminogen activator, tissue 0.0593198
MARCHF6 membrane associated ring-CH-type finger 6 0.0569535
NPEPPS aminopeptidase puromycin sensitive 0.0555008
EXT1 exostosin glycosyltransferase 1 0.0545297
TENT5A terminal nucleotidyltransferase 5A 0.0535287
SREBF2 sterol regulatory element binding transcription factor 2 0.0529655
B2M beta-2-microglobulin 0.0527511
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0516897
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0498079
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0493486
PRRC2C proline-rich coiled-coil 2C 0.0493018
KDM3A lysine (K)-specific demethylase 3A 0.0481317
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0472955
GPBP1 GC-rich promoter binding protein 1 0.0467616
GOLGA4 golgin A4 0.046716
OGA O-GlcNAcase 0.0453539
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0453267
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0447962
COL1A1 collagen, type I, alpha 1 0.0426557
EIF4A2 eukaryotic translation initiation factor 4A2 0.0422044
HILPDA hypoxia inducible lipid droplet-associated 0.0421745
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0416908
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0400769
ARHGAP9 Rho GTPase activating protein 9 0.0388874
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0388542
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0386126
COL3A1 collagen, type III, alpha 1 0.0383164
VMP1 vacuole membrane protein 1 0.037402
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0369238
MKI67 marker of proliferation Ki-67 0.0352905
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0350124
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0346599
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0333003
CDC27 cell division cycle 27 0.0332723
TLE4 transducin-like enhancer of split 4 0.033204
UBA6 ubiquitin-like modifier activating enzyme 6 0.0329482
ARHGAP5 Rho GTPase activating protein 5 0.0328589
APP amyloid beta (A4) precursor protein 0.0323693
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.032191
POM121 POM121 transmembrane nucleoporin 0.0317157
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0313657
FNBP4 formin binding protein 4 0.030851
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0303972
RNMT RNA (guanine-7-) methyltransferase 0.0302547
PIAS1 protein inhibitor of activated STAT, 1 0.0301104
WIPF2 WAS/WASL interacting protein family, member 2 0.0296538
NRIP1 nuclear receptor interacting protein 1 0.0290663
RBM25 RNA binding motif protein 25 0.0290034
HAND2 heart and neural crest derivatives expressed 2 0.0290007
ZMYM2 zinc finger, MYM-type 2 0.0289588
USP34 ubiquitin specific peptidase 34 0.0288732
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0282231
SSBP3 single stranded DNA binding protein 3 0.0281827
TPX2 TPX2, microtubule-associated 0.0280403
CENPF centromere protein F, 350/400kDa 0.027616
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0274917
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0271662
RNF169 ring finger protein 169 0.0271186
RSL1D1 ribosomal L1 domain containing 1 0.0268175
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0268154
HMGB2 high mobility group box 2 0.0265751
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.026318
NUF2 NUF2, NDC80 kinetochore complex component 0.026247
SMAD3 SMAD family member 3 0.026215
YTHDC1 YTH domain containing 1 0.0261394
IPMK inositol polyphosphate multikinase 0.0259507
SOCS5 suppressor of cytokine signaling 5 0.0259105
TENT2 terminal nucleotidyltransferase 2 0.0257063
MSMO1 methylsterol monooxygenase 1 0.0254432
TOX thymocyte selection-associated high mobility group box 0.0252059
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248506
FNIP1 folliculin interacting protein 1 0.0248322
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0247253
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0246833
UBE3C ubiquitin protein ligase E3C 0.0246745
RUNX1 runt-related transcription factor 1 0.0245652
BCLAF1 BCL2-associated transcription factor 1 0.0244374
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0244275
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0242753
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0238734
CYTH1 cytohesin 1 0.023814
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0237565
RAD51B RAD51 paralog B 0.0237554
PANK3 pantothenate kinase 3 0.0237511
TMEM123 transmembrane protein 123 0.0237295
ANGPTL4 angiopoietin-like 4 0.0237111
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0236115
YME1L1 YME1-like 1 ATPase 0.0235779
DLG1 discs, large homolog 1 (Drosophila) 0.0235753
FAM13A family with sequence similarity 13, member A 0.0235665

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.1253
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0777221
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0721304
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0705014
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0685491
ACTG1 actin gamma 1 -0.064807
SYT1 synaptotagmin I -0.0607828
PTPRD protein tyrosine phosphatase, receptor type, D -0.0584561
IGF2 insulin-like growth factor 2 -0.0567677
TRIO trio Rho guanine nucleotide exchange factor -0.0555405
BCAS3 breast carcinoma amplified sequence 3 -0.0509851
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.050605
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0503484
THSD4 thrombospondin, type I, domain containing 4 -0.0501709
LSAMP limbic system-associated membrane protein -0.048887
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0471359
RNF213 ring finger protein 213 -0.0427468
SLITRK6 SLIT and NTRK-like family, member 6 -0.0423408
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0416388
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0416127
POTEF POTE ankyrin domain family, member F -0.0415186
FRMD4A FERM domain containing 4A -0.0402342
ANGPT1 angiopoietin 1 -0.0400656
RPLP1 ribosomal protein, large, P1 -0.0393006
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0387062
TPM1 tropomyosin 1 (alpha) -0.0386835
GNAS GNAS complex locus -0.0386022
LPIN1 lipin 1 -0.0365794
RPL23 ribosomal protein L23 -0.0365253
TRIB2 tribbles pseudokinase 2 -0.0363828
FN1 fibronectin 1 -0.0348409
UNC5C unc-5 homolog C (C. elegans) -0.034766
LOC112694756 uncharaterized LOC112694756 -0.0347475
MRTFA myocardin related transcription factor A -0.0344294
RHOA ras homolog family member A -0.0338672
BPTF bromodomain PHD finger transcription factor -0.0338023
RPL34 ribosomal protein L34 -0.0336728
CADM2 cell adhesion molecule 2 -0.033583
IGFBP3 insulin-like growth factor binding protein 3 -0.0327973
CEP112 centrosomal protein 112kDa -0.0321191
CEMIP cell migration inducing protein, hyaluronan binding -0.0314201
DNAH14 dynein, axonemal, heavy chain 14 -0.0311518
ATRNL1 attractin-like 1 -0.0306708
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0304811
LIMCH1 LIM and calponin homology domains 1 -0.0298432
ENO1 enolase 1, (alpha) -0.0298109
KLHL13 kelch-like family member 13 -0.0297177
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0296195
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0293974
DNM3 dynamin 3 -0.0293505
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0288846
NRP1 neuropilin 1 -0.0281919
GPC5 glypican 5 -0.0281343
CPED1 cadherin-like and PC-esterase domain containing 1 -0.028122
CNTN4 contactin 4 -0.0275851
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0274398
ANTXR1 anthrax toxin receptor 1 -0.0270465
RPS17 ribosomal protein S17 -0.027017
FHIT fragile histidine triad -0.0266632
TENM4 teneurin transmembrane protein 4 -0.0265087
IARS1 isoleucyl-tRNA synthetase 1 -0.0264523
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0261005
MCL1 myeloid cell leukemia 1 -0.0259766
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0258949
PDE4D phosphodiesterase 4D, cAMP-specific -0.0258574
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0257841
FTH1 ferritin, heavy polypeptide 1 -0.0255879
ZNF644 zinc finger protein 644 -0.0255447
PHKB phosphorylase kinase, beta -0.025358
EGR1 early growth response 1 -0.0251719
SLMAP sarcolemma associated protein -0.0251651
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0249929
N4BP2L2 NEDD4 binding protein 2-like 2 -0.024503
HMGA1 high mobility group AT-hook 1 -0.0241641
CUX1 cut-like homeobox 1 -0.0241635
GLI3 GLI family zinc finger 3 -0.0240561
LMAN1 lectin, mannose-binding, 1 -0.0240377
SMYD3 SET and MYND domain containing 3 -0.0236398
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0235775
CDK6 cyclin-dependent kinase 6 -0.0235637
PDZRN3 PDZ domain containing ring finger 3 -0.0234568
SLIT2 slit homolog 2 (Drosophila) -0.023134
AFF3 AF4/FMR2 family, member 3 -0.0229235
GMDS GDP-mannose 4,6-dehydratase -0.0227523
RPL36 ribosomal protein L36 -0.0225335
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0225134
ENAH enabled homolog (Drosophila) -0.0222699
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0221852
RPS6 ribosomal protein S6 -0.0219843
RARA retinoic acid receptor, alpha -0.0219657
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0218614
MAML2 mastermind-like 2 (Drosophila) -0.0217616
S100A6 S100 calcium binding protein A6 -0.0217463
SFSWAP splicing factor, suppressor of white-apricot family -0.0216604
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0215412
LDHB lactate dehydrogenase B -0.0213861
SBF2 SET binding factor 2 -0.0213246
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0212544
RPS27 ribosomal protein S27 -0.0211823
MATR3 matrin 3 -0.0210995