Indacaterol (maleate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.0615442
DSCAM Down syndrome cell adhesion molecule 0.0411
NRIP1 nuclear receptor interacting protein 1 0.0362897
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0322401
IFNGR1 interferon gamma receptor 1 0.0306454
RNF43 ring finger protein 43 0.0288356
PTBP3 polypyrimidine tract binding protein 3 0.0285075
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0282003
ZMYM2 zinc finger, MYM-type 2 0.0278182
PRELID2 PRELI domain containing 2 0.0274125
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.026764
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0256624
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.025085
FNIP1 folliculin interacting protein 1 0.0239414
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0233346
SREBF2 sterol regulatory element binding transcription factor 2 0.023242
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0230396
USP54 ubiquitin specific peptidase 54 0.0208698
PHF3 PHD finger protein 3 0.0202168
MCTP2 multiple C2 domains, transmembrane 2 0.0196066
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0191831
PTEN phosphatase and tensin homolog 0.019112
TC2N tandem C2 domains, nuclear 0.0175338
ARGLU1 arginine and glutamate rich 1 0.0173438
DENND4C DENN/MADD domain containing 4C 0.0170713
OGA O-GlcNAcase 0.016996
CD46 CD46 molecule, complement regulatory protein 0.0168692
RBM26 RNA binding motif protein 26 0.01667
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0166337
EHF ets homologous factor 0.0166246
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0165233
SPRED1 sprouty-related, EVH1 domain containing 1 0.01642
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0162637
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0161359
PDZD8 PDZ domain containing 8 0.0159014
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0158731
RABGAP1 RAB GTPase activating protein 1 0.015716
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0156697
RNF149 ring finger protein 149 0.0155828
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0153837
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0153218
USPL1 ubiquitin specific peptidase like 1 0.0151563
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0151548
ZDHHC20 zinc finger, DHHC-type containing 20 0.0149698
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.014953
CCDC14 coiled-coil domain containing 14 0.0147564
TENT2 terminal nucleotidyltransferase 2 0.0146812
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0145709
IL20RA interleukin 20 receptor, alpha 0.0145668
USP3 ubiquitin specific peptidase 3 0.0145188
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0142877
TJP2 tight junction protein 2 0.0142675
ZNF160 zinc finger protein 160 0.0142483
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0141768
LCOR ligand dependent nuclear receptor corepressor 0.0141377
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0141185
GRK3 G protein-coupled receptor kinase 3 0.0139081
PUM2 pumilio RNA-binding family member 2 0.0137361
TMEM62 transmembrane protein 62 0.0135199
TOP2A topoisomerase (DNA) II alpha 170kDa 0.013487
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0133555
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.013341
RHOBTB3 Rho-related BTB domain containing 3 0.0132147
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0132138
SPRED2 sprouty-related, EVH1 domain containing 2 0.0131822
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0131147
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0129545
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0129327
SUCO SUN domain containing ossification factor 0.0128995
ETNK1 ethanolamine kinase 1 0.0126527
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0126475
TNRC6A trinucleotide repeat containing 6A 0.012544
DIAPH3 diaphanous-related formin 3 0.0124793
TBPL1 TBP-like 1 0.0122986
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0122505
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0121013
KIF16B kinesin family member 16B 0.0117493
ARRDC3 arrestin domain containing 3 0.0117224
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0116989
ARHGAP32 Rho GTPase activating protein 32 0.0116324
COG6 component of oligomeric golgi complex 6 0.0115733
EIF4B eukaryotic translation initiation factor 4B 0.0115275
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0114875
ANLN anillin, actin binding protein 0.011438
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0113901
MEIS2 Meis homeobox 2 0.0113003
ESYT2 extended synaptotagmin-like protein 2 0.0112693
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0111918
ZMYND8 zinc finger, MYND-type containing 8 0.011162
STK24 serine/threonine kinase 24 0.0111559
SP3 Sp3 transcription factor 0.0110483
XPO1 exportin 1 0.0109508
LRRC1 leucine rich repeat containing 1 0.0108932
HELZ helicase with zinc finger 0.010716
WDFY3 WD repeat and FYVE domain containing 3 0.0106994
MECOM MDS1 and EVI1 complex locus 0.0106832
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0106819
FKBP9 FK506 binding protein 9, 63 kDa 0.0105635
TUBGCP3 tubulin, gamma complex associated protein 3 0.010558
STEAP2 STEAP family member 2, metalloreductase 0.0104017

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.165008
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133733
PTMA prothymosin, alpha -0.114814
ANXA2 annexin A2 -0.111937
LCN2 lipocalin 2 -0.109677
EGR1 early growth response 1 -0.105552
EPSTI1 epithelial stromal interaction 1 (breast) -0.104569
RNF213 ring finger protein 213 -0.0926232
FTL ferritin, light polypeptide -0.0882936
HLA-B major histocompatibility complex, class I, B -0.0870057
AREG amphiregulin -0.0819993
INTS6 integrator complex subunit 6 -0.0797855
LYZ lysozyme -0.0793566
PKM pyruvate kinase, muscle -0.0783909
B2M beta-2-microglobulin -0.0766092
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0753011
ACTG1 actin gamma 1 -0.070983
SP100 SP100 nuclear antigen -0.0702964
IFI6 interferon, alpha-inducible protein 6 -0.0692527
IFI27 interferon, alpha-inducible protein 27 -0.0683535
LMO7 LIM domain 7 -0.0680776
RAB7A RAB7A, member RAS oncogene family -0.0678133
PERP PERP, TP53 apoptosis effector -0.067643
TMSB10 thymosin beta 10 -0.0672056
RPS6 ribosomal protein S6 -0.0660357
RPL35A ribosomal protein L35a -0.0641999
MX1 MX dynamin-like GTPase 1 -0.0640653
MX2 MX dynamin-like GTPase 2 -0.06243
LOC102724023 ES1 protein homolog, mitochondrial -0.0612492
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0609058
EZR ezrin -0.0581704
RPL23 ribosomal protein L23 -0.0551422
GMDS GDP-mannose 4,6-dehydratase -0.0534095
C6ORF132 chromosome 6 open reading frame 132 -0.0518644
GCLC glutamate-cysteine ligase, catalytic subunit -0.0512983
EIF1 eukaryotic translation initiation factor 1 -0.0494891
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0479194
XAF1 XIAP associated factor 1 -0.046292
NDRG1 N-myc downstream regulated 1 -0.046275
RPLP1 ribosomal protein, large, P1 -0.0455871
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0454927
RIGI RNA sensor RIG-I -0.0449317
HLA-C major histocompatibility complex, class I, C -0.0437517
RPS8 ribosomal protein S8 -0.043634
MCL1 myeloid cell leukemia 1 -0.043618
SQSTM1 sequestosome 1 -0.0431475
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0430922
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0426366
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0425603
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.042266
MT2A metallothionein 2A -0.0422565
UBC ubiquitin C -0.0420918
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0408474
VCL vinculin -0.0405441
RPL19 ribosomal protein L19 -0.0395583
HLA-A major histocompatibility complex, class I, A -0.0395527
EXT1 exostosin glycosyltransferase 1 -0.0393184
POTEF POTE ankyrin domain family, member F -0.0391714
FTH1 ferritin, heavy polypeptide 1 -0.0389379
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0388516
ENO1 enolase 1, (alpha) -0.0382303
RPL34 ribosomal protein L34 -0.0374025
RPL31 ribosomal protein L31 -0.0370638
RPS3 ribosomal protein S3 -0.036543
IGFBP3 insulin-like growth factor binding protein 3 -0.0364045
S100A6 S100 calcium binding protein A6 -0.0362951
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0362777
HLA-E major histocompatibility complex, class I, E -0.0360089
LOC112694756 uncharaterized LOC112694756 -0.0359565
S100A10 S100 calcium binding protein A10 -0.0352395
IFITM3 interferon induced transmembrane protein 3 -0.0346606
JUN jun proto-oncogene -0.0346109
RPS24 ribosomal protein S24 -0.0344996
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0343652
MYO1E myosin IE -0.0341527
TM4SF1 transmembrane 4 L six family member 1 -0.0340349
RPL11 ribosomal protein L11 -0.0332555
AKAP13 A kinase (PRKA) anchor protein 13 -0.0330918
SLC38A1 solute carrier family 38, member 1 -0.0330436
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0329034
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0323891
KRT19 keratin 19, type I -0.0321908
RPLP0 ribosomal protein, large, P0 -0.0321685
RPL9 ribosomal protein L9 -0.032066
RPS29 ribosomal protein S29 -0.0319595
VDAC1 voltage-dependent anion channel 1 -0.0318404
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0316653
RPS19 ribosomal protein S19 -0.0314729
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0313001
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0311723
TPI1 triosephosphate isomerase 1 -0.0308445
RPL37A ribosomal protein L37a -0.0308413
TJP1 tight junction protein 1 -0.0303712
TM4SF19 transmembrane 4 L six family member 19 -0.0302841
ZNF292 zinc finger protein 292 -0.0301041
RPS13 ribosomal protein S13 -0.0300456
DSTN destrin (actin depolymerizing factor) -0.0295113
PARD3 par-3 family cell polarity regulator -0.0294434
LDHA lactate dehydrogenase A -0.0292242
RPL37 ribosomal protein L37 -0.0290777