Indacaterol (maleate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0585971
VCL vinculin 0.0533517
STK24 serine/threonine kinase 24 0.0522819
LMO7 LIM domain 7 0.0500167
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0479061
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0449974
ERRFI1 ERBB receptor feedback inhibitor 1 0.0433382
RTN4 reticulon 4 0.0393112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0391649
SPRED2 sprouty-related, EVH1 domain containing 2 0.0371717
PLAUR plasminogen activator, urokinase receptor 0.0370311
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0364063
ARHGAP32 Rho GTPase activating protein 32 0.0363602
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0345374
MCL1 myeloid cell leukemia 1 0.0317682
SMAD3 SMAD family member 3 0.0312982
MYO6 myosin VI 0.030189
JMJD1C jumonji domain containing 1C 0.0294916
SLC45A4 solute carrier family 45, member 4 0.0287632
DSCAM Down syndrome cell adhesion molecule 0.0285615
MYH9 myosin, heavy chain 9, non-muscle 0.0277063
ANXA11 annexin A11 0.0268308
ITPRID2 ITPR interacting domain containing 2 0.0267927
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.026792
VMP1 vacuole membrane protein 1 0.0264251
ACTN4 actinin, alpha 4 0.0255972
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.025303
B2M beta-2-microglobulin 0.024056
MSN moesin 0.02381
FRY furry homolog (Drosophila) 0.0233539
SEPTIN9 septin 9 0.0231575
HKDC1 hexokinase domain containing 1 0.0228
PRELID2 PRELI domain containing 2 0.0225818
TMEM41B transmembrane protein 41B 0.0218306
NAMPT nicotinamide phosphoribosyltransferase 0.0215973
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0215947
ANKRD11 ankyrin repeat domain 11 0.0209482
RAD51B RAD51 paralog B 0.0209103
TM9SF3 transmembrane 9 superfamily member 3 0.020719
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0205778
IL6ST interleukin 6 signal transducer 0.0199014
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0198627
CTNND1 catenin (cadherin-associated protein), delta 1 0.019832
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0195704
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.019395
TXNRD1 thioredoxin reductase 1 0.0193424
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.019183
SAMD12 sterile alpha motif domain containing 12 0.0190735
FNDC3B fibronectin type III domain containing 3B 0.018689
BCL2L1 BCL2-like 1 0.0184718
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0183775
SMOX spermine oxidase 0.0183561
LIPH lipase, member H 0.0182355
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0181027
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0180748
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0178499
DST dystonin 0.0177223
CHKA choline kinase alpha 0.0176755
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0176351
ANKRD10 ankyrin repeat domain 10 0.0174817
CTTNBP2NL CTTNBP2 N-terminal like 0.01745
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0169546
DSPP dentin sialophosphoprotein 0.0169523
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0166268
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0165771
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0165512
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0164599
PPL periplakin 0.0164327
WDFY3 WD repeat and FYVE domain containing 3 0.0164108
PTEN phosphatase and tensin homolog 0.0163878
NPC1 Niemann-Pick disease, type C1 0.0163674
KDM6A lysine (K)-specific demethylase 6A 0.0158922
ELF2 E74-like factor 2 (ets domain transcription factor) 0.015887
ZNF292 zinc finger protein 292 0.015837
FNIP1 folliculin interacting protein 1 0.015826
CDK19 cyclin-dependent kinase 19 0.0157509
MYH14 myosin, heavy chain 14, non-muscle 0.0157348
CCSER1 coiled-coil serine-rich protein 1 0.0156916
VEGFA vascular endothelial growth factor A 0.0154813
EIF4B eukaryotic translation initiation factor 4B 0.0153545
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.015325
RBM47 RNA binding motif protein 47 0.0152984
BCAR3 breast cancer anti-estrogen resistance 3 0.0152594
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0152562
ZMYM2 zinc finger, MYM-type 2 0.0151811
WASL Wiskott-Aldrich syndrome-like 0.0150493
EPB41 erythrocyte membrane protein band 4.1 0.0149032
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0147083
ARGLU1 arginine and glutamate rich 1 0.0146025
NCOR2 nuclear receptor corepressor 2 0.0145899
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0145592
PDE4D phosphodiesterase 4D, cAMP-specific 0.0144761
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0142973
USP54 ubiquitin specific peptidase 54 0.0142883
TANK TRAF family member-associated NFKB activator 0.0142615
AATF apoptosis antagonizing transcription factor 0.0141942
MAPK8 mitogen-activated protein kinase 8 0.0141617
OGA O-GlcNAcase 0.0141503
PPARG peroxisome proliferator-activated receptor gamma 0.0141368
TNS1 tensin 1 0.0141272

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.211774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.167457
RPLP1 ribosomal protein, large, P1 -0.126855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126778
TPT1 tumor protein, translationally-controlled 1 -0.118754
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117672
RPL23 ribosomal protein L23 -0.0940777
RPS19 ribosomal protein S19 -0.0828944
RPS6 ribosomal protein S6 -0.0811189
LOC112694756 uncharaterized LOC112694756 -0.0750794
FTH1 ferritin, heavy polypeptide 1 -0.073429
TMSB10 thymosin beta 10 -0.0724437
PTMA prothymosin, alpha -0.0719533
RAD21 RAD21 homolog (S. pombe) -0.0673269
RPS8 ribosomal protein S8 -0.0666032
RPL35A ribosomal protein L35a -0.0653478
RPLP0 ribosomal protein, large, P0 -0.0621843
RPL11 ribosomal protein L11 -0.0594788
AHNAK AHNAK nucleoprotein -0.0589951
PDIA3 protein disulfide isomerase family A, member 3 -0.0584662
RPS5 ribosomal protein S5 -0.0548745
KRT18 keratin 18, type I -0.0544014
RPS16 ribosomal protein S16 -0.0532558
S100A10 S100 calcium binding protein A10 -0.052816
RPL27A ribosomal protein L27a -0.0528012
RPL34 ribosomal protein L34 -0.0514092
RPS3 ribosomal protein S3 -0.0510047
S100A6 S100 calcium binding protein A6 -0.0492496
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0485329
RPL19 ribosomal protein L19 -0.0482838
FBXO32 F-box protein 32 -0.0482579
ANXA2 annexin A2 -0.0475157
CANX calnexin -0.0473357
LDHA lactate dehydrogenase A -0.0471437
RPL12 ribosomal protein L12 -0.047136
NDRG1 N-myc downstream regulated 1 -0.0469249
ACTG1 actin gamma 1 -0.046437
AGR2 anterior gradient 2 -0.0463856
RPL28 ribosomal protein L28 -0.045881
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0453719
RPL8 ribosomal protein L8 -0.0443967
RPS11 ribosomal protein S11 -0.0438983
EIF1 eukaryotic translation initiation factor 1 -0.043683
RPS24 ribosomal protein S24 -0.0433642
RPLP2 ribosomal protein, large, P2 -0.0432269
RPL18 ribosomal protein L18 -0.0424685
RPS13 ribosomal protein S13 -0.0422311
HMGA1 high mobility group AT-hook 1 -0.0416456
RPS21 ribosomal protein S21 -0.0400415
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0397842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0396489
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0395706
RTN3 reticulon 3 -0.0388703
EMP1 epithelial membrane protein 1 -0.0377538
RPS25 ribosomal protein S25 -0.0376477
RPL13A ribosomal protein L13a -0.0358197
RACK1 receptor for activated C kinase 1 -0.0356105
ASTN2 astrotactin 2 -0.0351627
GNAS GNAS complex locus -0.0350802
RPL26 ribosomal protein L26 -0.0347441
HMGB1 high mobility group box 1 -0.0347162
PDIA4 protein disulfide isomerase family A, member 4 -0.0345469
KDM3A lysine (K)-specific demethylase 3A -0.0339247
EXPH5 exophilin 5 -0.0338904
LYZ lysozyme -0.0335773
RPL9 ribosomal protein L9 -0.0333141
TPI1 triosephosphate isomerase 1 -0.0330332
RPL7 ribosomal protein L7 -0.0325781
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0322066
ARF1 ADP-ribosylation factor 1 -0.0319421
KRT20 keratin 20, type I -0.0319146
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0315544
EPCAM epithelial cell adhesion molecule -0.0308761
RPL30 ribosomal protein L30 -0.0298747
UBC ubiquitin C -0.0295083
MYL12B myosin, light chain 12B, regulatory -0.0293225
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290569
MBNL2 muscleblind-like splicing regulator 2 -0.029049
RRBP1 ribosome binding protein 1 -0.0288257
RPL32 ribosomal protein L32 -0.0287139
MORF4L2 mortality factor 4 like 2 -0.0284819
TMEM123 transmembrane protein 123 -0.0283425
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0280247
RPS23 ribosomal protein S23 -0.0279433
RPS12 ribosomal protein S12 -0.0277641
RPL35 ribosomal protein L35 -0.0273046
RPS4X ribosomal protein S4, X-linked -0.0271869
RPL31 ribosomal protein L31 -0.0267858
HM13 histocompatibility (minor) 13 -0.0264207
JUN jun proto-oncogene -0.0263449
KLF6 Kruppel-like factor 6 -0.026256
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.026131
RPS20 ribosomal protein S20 -0.0259883
SQSTM1 sequestosome 1 -0.025864
UBE2B ubiquitin-conjugating enzyme E2B -0.0252772
LMNA lamin A/C -0.0252705
ATF3 activating transcription factor 3 -0.0251029
NF1 neurofibromin 1 -0.0250886
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0250508
RPL36 ribosomal protein L36 -0.0246548