Indacaterol (maleate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.13731
IGF2 insulin-like growth factor 2 0.0558487
FNDC3B fibronectin type III domain containing 3B 0.0401289
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0366422
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0347268
INSIG2 insulin induced gene 2 0.0343508
JMJD1C jumonji domain containing 1C 0.0276191
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0269594
ELL2 elongation factor, RNA polymerase II, 2 0.0264
GOLGA4 golgin A4 0.0262257
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0258041
DSPP dentin sialophosphoprotein 0.0248461
DTNA dystrobrevin, alpha 0.0247805
PTBP3 polypyrimidine tract binding protein 3 0.024647
VEGFA vascular endothelial growth factor A 0.0244268
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0242882
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0228001
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0219463
KDM7A lysine (K)-specific demethylase 7A 0.0217583
KIF1B kinesin family member 1B 0.0213353
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0209318
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0209123
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0206993
RYBP RING1 and YY1 binding protein 0.0200706
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0199412
WDR45B WD repeat domain 45B 0.0197071
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0187723
PEG3 paternally expressed 3 0.0176576
MXI1 MAX interactor 1, dimerization protein 0.017592
KTN1 kinectin 1 (kinesin receptor) 0.0171196
ZMYM2 zinc finger, MYM-type 2 0.0170714
FAM13A family with sequence similarity 13, member A 0.0170231
FTH1 ferritin, heavy polypeptide 1 0.0169727
BHLHE40 basic helix-loop-helix family, member e40 0.0167246
QKI QKI, KH domain containing, RNA binding 0.0165545
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0163031
ZNF292 zinc finger protein 292 0.0162923
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0160302
KMT2C lysine (K)-specific methyltransferase 2C 0.0159948
ESYT2 extended synaptotagmin-like protein 2 0.0159647
GRK3 G protein-coupled receptor kinase 3 0.0159543
MYO1B myosin IB 0.0155754
WDFY2 WD repeat and FYVE domain containing 2 0.0151057
MALT1 MALT1 paracaspase 0.0150029
SCARB1 scavenger receptor class B, member 1 0.0147219
NAMPT nicotinamide phosphoribosyltransferase 0.0144545
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0144278
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0143741
TPST1 tyrosylprotein sulfotransferase 1 0.0143153
RICTOR RPTOR independent companion of MTOR, complex 2 0.0142871
CRY1 cryptochrome circadian clock 1 0.0141981
DENND4A DENN/MADD domain containing 4A 0.0140917
RBM33 RNA binding motif protein 33 0.0140506
FKTN fukutin 0.0138747
CYTH1 cytohesin 1 0.0138154
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136946
TRA2A transformer 2 alpha homolog (Drosophila) 0.0136804
NDRG1 N-myc downstream regulated 1 0.013624
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0136127
CHKA choline kinase alpha 0.0134945
NGLY1 N-glycanase 1 0.0134705
PCGF5 polycomb group ring finger 5 0.0134698
HELZ helicase with zinc finger 0.0132586
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0132251
USP47 ubiquitin specific peptidase 47 0.0131415
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.013064
UBA6 ubiquitin-like modifier activating enzyme 6 0.0130162
WAC WW domain containing adaptor with coiled-coil 0.012891
PDHX pyruvate dehydrogenase complex, component X 0.0128763
PHF21A PHD finger protein 21A 0.0127265
RLF rearranged L-myc fusion 0.0126898
TPD52 tumor protein D52 0.0126293
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0125047
RSRC2 arginine/serine-rich coiled-coil 2 0.0124714
TUT4 terminal uridylyl transferase 4 0.0124555
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0124246
CCNL1 cyclin L1 0.0122623
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0121378
SBF2 SET binding factor 2 0.0120667
SPAG9 sperm associated antigen 9 0.0119937
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0119043
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.01189
CNOT2 CCR4-NOT transcription complex, subunit 2 0.01169
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0114905
TNS1 tensin 1 0.0114646
RAB6A RAB6A, member RAS oncogene family 0.0114435
NPEPPS aminopeptidase puromycin sensitive 0.0114071
ANKRD10 ankyrin repeat domain 10 0.0111486
MTUS1 microtubule associated tumor suppressor 1 0.0110967
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0110615
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0108675
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0108342
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0108012
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0107515
LYZ lysozyme 0.0106785
WWC1 WW and C2 domain containing 1 0.0106255
DLC1 DLC1 Rho GTPase activating protein 0.0105386
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0104218
CD109 CD109 molecule 0.0103793
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0103752

decreased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.103055
ENO1 enolase 1, (alpha) -0.0997488
RPS27A ribosomal protein S27a -0.0963861
APOB apolipoprotein B -0.0955359
FN1 fibronectin 1 -0.0944429
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0940481
GPC3 glypican 3 -0.0898152
UBC ubiquitin C -0.0877733
MT2A metallothionein 2A -0.0828105
TPT1 tumor protein, translationally-controlled 1 -0.0783344
IGFBP1 insulin-like growth factor binding protein 1 -0.0782012
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0681389
TM4SF1 transmembrane 4 L six family member 1 -0.0633297
RPS24 ribosomal protein S24 -0.0587103
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0551222
TMSB10 thymosin beta 10 -0.0548322
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529754
SVIL supervillin -0.0520249
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0514302
RPL23 ribosomal protein L23 -0.0509041
RPL11 ribosomal protein L11 -0.0504909
LOC112694756 uncharaterized LOC112694756 -0.0463821
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0444747
RPL37A ribosomal protein L37a -0.042481
RPLP1 ribosomal protein, large, P1 -0.0405801
RPS12 ribosomal protein S12 -0.0403451
AKAP12 A kinase (PRKA) anchor protein 12 -0.0401987
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0400974
SLC38A2 solute carrier family 38, member 2 -0.0398872
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.038532
CFB complement factor B -0.0380468
NKD1 naked cuticle homolog 1 (Drosophila) -0.0380242
RPS8 ribosomal protein S8 -0.037637
NAP1L1 nucleosome assembly protein 1-like 1 -0.0374807
FBF1 Fas (TNFRSF6) binding factor 1 -0.0371011
SMAD3 SMAD family member 3 -0.036617
JUN jun proto-oncogene -0.0364605
EEF2 eukaryotic translation elongation factor 2 -0.0359371
RPLP2 ribosomal protein, large, P2 -0.0346839
AHNAK AHNAK nucleoprotein -0.033674
FAM107B family with sequence similarity 107, member B -0.0331375
FAT1 FAT atypical cadherin 1 -0.0324038
MRTFA myocardin related transcription factor A -0.0314095
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0306839
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.030531
PTMA prothymosin, alpha -0.0301703
RNF213 ring finger protein 213 -0.029834
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0293509
ATXN1 ataxin 1 -0.0292517
PARD3 par-3 family cell polarity regulator -0.0292104
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0289674
DNAH17 dynein, axonemal, heavy chain 17 -0.028931
BCL2L1 BCL2-like 1 -0.0288253
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288104
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0285087
RPL9 ribosomal protein L9 -0.0284355
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.027151
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0270626
ASPH aspartate beta-hydroxylase -0.0267912
KRT8 keratin 8, type II -0.0265735
RIGI RNA sensor RIG-I -0.0263783
ISG15 ISG15 ubiquitin-like modifier -0.0263667
RPS29 ribosomal protein S29 -0.0262368
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0261999
UBASH3B ubiquitin associated and SH3 domain containing B -0.0255854
MCL1 myeloid cell leukemia 1 -0.025582
RACK1 receptor for activated C kinase 1 -0.0255185
RRBP1 ribosome binding protein 1 -0.0253862
RPL36A ribosomal protein L36a -0.0253793
SPATS2L spermatogenesis associated, serine-rich 2-like -0.025242
VCL vinculin -0.0248932
AMBP alpha-1-microglobulin/bikunin precursor -0.0246187
PTPRF protein tyrosine phosphatase, receptor type, F -0.0243698
RPL35A ribosomal protein L35a -0.0242101
ZFAND3 zinc finger, AN1-type domain 3 -0.0240737
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0239101
RPS19 ribosomal protein S19 -0.0236669
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0235146
MYH9 myosin, heavy chain 9, non-muscle -0.0233981
ACTG1 actin gamma 1 -0.023263
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0231985
APOE apolipoprotein E -0.0230829
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0228895
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0227773
RPS13 ribosomal protein S13 -0.0221405
RPL12 ribosomal protein L12 -0.0221267
LRMDA leucine rich melanocyte differentiation associated -0.0221057
IFI6 interferon, alpha-inducible protein 6 -0.0219903
PKM pyruvate kinase, muscle -0.0217813
GPC6 glypican 6 -0.0213355
CALR calreticulin -0.0211784
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0211195
RPL38 ribosomal protein L38 -0.0207693
EHBP1 EH domain binding protein 1 -0.0207646
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0207588
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.020729
RPL26 ribosomal protein L26 -0.0207138
ACTN4 actinin, alpha 4 -0.0206573
ZMYND8 zinc finger, MYND-type containing 8 -0.0201903
VMP1 vacuole membrane protein 1 -0.0198871