Indacaterol (maleate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A 0.121278
TRIO trio Rho guanine nucleotide exchange factor 0.103237
ITCH itchy E3 ubiquitin protein ligase 0.0799947
B2M beta-2-microglobulin 0.0797972
SUCO SUN domain containing ossification factor 0.067323
MYH9 myosin, heavy chain 9, non-muscle 0.0653158
GOLGA4 golgin A4 0.0648951
OGA O-GlcNAcase 0.0624543
TMSB4X thymosin beta 4, X-linked 0.0570504
LMO7 LIM domain 7 0.0561532
KRT17 keratin 17, type I 0.0557812
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0557249
EZR ezrin 0.0530171
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0508374
MSN moesin 0.0481664
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0463852
RBM39 RNA binding motif protein 39 0.0454769
PGK1 phosphoglycerate kinase 1 0.045082
KDM3A lysine (K)-specific demethylase 3A 0.0427081
MTSS1 metastasis suppressor 1 0.0422629
SQSTM1 sequestosome 1 0.0412081
KDM6A lysine (K)-specific demethylase 6A 0.0406939
SDC4 syndecan 4 0.0393514
SQLE squalene epoxidase 0.039276
KRT6A keratin 6A, type II 0.0377178
SLK STE20-like kinase 0.0371339
LAMC2 laminin, gamma 2 0.037021
KIAA1217 KIAA1217 0.0358494
ARRDC3 arrestin domain containing 3 0.0347903
COPA coatomer protein complex, subunit alpha 0.034692
ANKRD33B ankyrin repeat domain 33B 0.0345441
ESYT2 extended synaptotagmin-like protein 2 0.0338378
FNIP1 folliculin interacting protein 1 0.0334107
OPTN optineurin 0.033195
SLMAP sarcolemma associated protein 0.0324061
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0323398
TNIP1 TNFAIP3 interacting protein 1 0.0322263
FOXO3 forkhead box O3 0.0320428
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0319174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0319033
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315875
ARHGAP21 Rho GTPase activating protein 21 0.0310922
HOOK2 hook microtubule-tethering protein 2 0.0305247
NRIP1 nuclear receptor interacting protein 1 0.0303623
PICALM phosphatidylinositol binding clathrin assembly protein 0.0303134
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0301581
CEMIP cell migration inducing protein, hyaluronan binding 0.0297415
RNF145 ring finger protein 145 0.0297125
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0296469
ELL2 elongation factor, RNA polymerase II, 2 0.0296405
AKAP13 A kinase (PRKA) anchor protein 13 0.0294693
CTNND1 catenin (cadherin-associated protein), delta 1 0.029374
NCOR2 nuclear receptor corepressor 2 0.0293122
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0287277
RNF19B ring finger protein 19B 0.0283603
EEF2 eukaryotic translation elongation factor 2 0.0283085
TPM3 tropomyosin 3 0.0282877
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0282433
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0282406
FNDC3B fibronectin type III domain containing 3B 0.0281541
MXI1 MAX interactor 1, dimerization protein 0.0278819
ANKRD10 ankyrin repeat domain 10 0.0275079
HELZ helicase with zinc finger 0.0274246
RAB6A RAB6A, member RAS oncogene family 0.0272145
RPL14 ribosomal protein L14 0.026497
CLIC4 chloride intracellular channel 4 0.0263632
MEGF6 multiple EGF-like-domains 6 0.026189
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0258252
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0256992
NAV2 neuron navigator 2 0.0253419
CD46 CD46 molecule, complement regulatory protein 0.0250504
TMF1 TATA element modulatory factor 1 0.0247071
ZNF292 zinc finger protein 292 0.0245223
TTC3 tetratricopeptide repeat domain 3 0.0244959
KMT2E lysine (K)-specific methyltransferase 2E 0.0243416
TRA2A transformer 2 alpha homolog (Drosophila) 0.0243167
SRP54 signal recognition particle 54kDa 0.0241332
IQGAP1 IQ motif containing GTPase activating protein 1 0.0241086
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0239732
ANLN anillin, actin binding protein 0.0239513
KIF16B kinesin family member 16B 0.0238972
CDC73 cell division cycle 73 0.0238639
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0237722
PDLIM5 PDZ and LIM domain 5 0.0236891
SEC24A SEC24 family member A 0.0236305
FLNB filamin B, beta 0.023103
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0229334
SPAG9 sperm associated antigen 9 0.0229042
MCL1 myeloid cell leukemia 1 0.022896
TM9SF2 transmembrane 9 superfamily member 2 0.0228843
VCL vinculin 0.0228452
VMP1 vacuole membrane protein 1 0.0227547
EIF4A2 eukaryotic translation initiation factor 4A2 0.0227025
RICTOR RPTOR independent companion of MTOR, complex 2 0.0225251
INSIG2 insulin induced gene 2 0.0224037
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0223729
RASA3 RAS p21 protein activator 3 0.0223271
PPARG peroxisome proliferator-activated receptor gamma 0.022216
PMM2 phosphomannomutase 2 0.0221717
ADAM17 ADAM metallopeptidase domain 17 0.0220396

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.202942
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.140004
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136955
TIMP3 TIMP metallopeptidase inhibitor 3 -0.128894
TPT1 tumor protein, translationally-controlled 1 -0.0969246
AHNAK AHNAK nucleoprotein -0.0962594
DPYD dihydropyrimidine dehydrogenase -0.0945054
CD44 CD44 molecule (Indian blood group) -0.0879683
CAV1 caveolin 1, caveolae protein, 22kDa -0.0844213
POTEF POTE ankyrin domain family, member F -0.0810397
FOXP1 forkhead box P1 -0.0747664
S100A10 S100 calcium binding protein A10 -0.071375
RPL11 ribosomal protein L11 -0.0666402
MT2A metallothionein 2A -0.0651374
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0643575
PTMA prothymosin, alpha -0.0624131
RPS21 ribosomal protein S21 -0.0615003
RPS6 ribosomal protein S6 -0.0608386
RPS8 ribosomal protein S8 -0.0588774
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0584126
RPLP1 ribosomal protein, large, P1 -0.0571257
NRG1 neuregulin 1 -0.0550241
LOC112694756 uncharaterized LOC112694756 -0.0546641
TMSB10 thymosin beta 10 -0.0527905
H1-0 H1.0 linker histone -0.0527658
RPS24 ribosomal protein S24 -0.0520564
RPLP2 ribosomal protein, large, P2 -0.0520271
IFITM3 interferon induced transmembrane protein 3 -0.0500593
RPS25 ribosomal protein S25 -0.0471551
SAMD9 sterile alpha motif domain containing 9 -0.0458545
RPS19 ribosomal protein S19 -0.0455521
RPLP0 ribosomal protein, large, P0 -0.0454936
RPL23 ribosomal protein L23 -0.0447385
ITGA6 integrin, alpha 6 -0.0444771
SULF2 sulfatase 2 -0.0443465
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0442015
RPL35A ribosomal protein L35a -0.0421681
GNAS GNAS complex locus -0.0412863
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0411978
SLC38A2 solute carrier family 38, member 2 -0.0402798
OSMR oncostatin M receptor -0.0398218
VDAC1 voltage-dependent anion channel 1 -0.0388692
RABGAP1L RAB GTPase activating protein 1-like -0.0387679
PODXL podocalyxin-like -0.038645
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0377275
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0375661
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0372173
IGF2 insulin-like growth factor 2 -0.037203
IFITM1 interferon induced transmembrane protein 1 -0.0371713
ARHGAP29 Rho GTPase activating protein 29 -0.0369133
RPS13 ribosomal protein S13 -0.0361293
PRSS23 protease, serine, 23 -0.0361184
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0361123
S100A6 S100 calcium binding protein A6 -0.0345634
MKI67 marker of proliferation Ki-67 -0.0340612
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0337091
EMP1 epithelial membrane protein 1 -0.0336565
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0334555
ASPH aspartate beta-hydroxylase -0.0334112
MYOF myoferlin -0.0328067
RPL27A ribosomal protein L27a -0.0327131
LDHA lactate dehydrogenase A -0.0322993
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0321914
PLAT plasminogen activator, tissue -0.0319071
RPS23 ribosomal protein S23 -0.0317579
RPL35 ribosomal protein L35 -0.0315568
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.03136
PDIA3 protein disulfide isomerase family A, member 3 -0.0313543
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0308298
SULF1 sulfatase 1 -0.0307641
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0305887
TXNIP thioredoxin interacting protein -0.0305231
IFI16 interferon, gamma-inducible protein 16 -0.0304143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0302878
MBNL1 muscleblind-like splicing regulator 1 -0.0298537
RPL8 ribosomal protein L8 -0.0298309
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.029304
RPL19 ribosomal protein L19 -0.0286915
CDK6 cyclin-dependent kinase 6 -0.0284368
HLA-B major histocompatibility complex, class I, B -0.0282708
RPL12 ribosomal protein L12 -0.0282457
SYPL1 synaptophysin-like 1 -0.0280267
RPL32 ribosomal protein L32 -0.0279086
IGFBP4 insulin-like growth factor binding protein 4 -0.0279032
FNDC3A fibronectin type III domain containing 3A -0.0278874
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0278505
HMGB1 high mobility group box 1 -0.0274064
RPL26 ribosomal protein L26 -0.0272869
MACF1 microtubule-actin crosslinking factor 1 -0.027109
RPS27A ribosomal protein S27a -0.0269613
ACTN4 actinin, alpha 4 -0.0268695
FTL ferritin, light polypeptide -0.0268195
RPL36A ribosomal protein L36a -0.0263335
S100A2 S100 calcium binding protein A2 -0.026222
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0260635
CYB5R3 cytochrome b5 reductase 3 -0.0259919
RPL9 ribosomal protein L9 -0.0259825
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0257701
RPL31 ribosomal protein L31 -0.0256087
CENPF centromere protein F, 350/400kDa -0.0255867