Indacaterol (maleate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.0965682
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0886124
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0628497
VCL vinculin 0.0619582
GOLGA4 golgin A4 0.0574692
EZR ezrin 0.0500253
UBE2H ubiquitin-conjugating enzyme E2H 0.0455571
PRSS3 protease, serine, 3 0.0447159
FLNB filamin B, beta 0.0408181
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0394538
DSCAM Down syndrome cell adhesion molecule 0.03865
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0370321
MYO6 myosin VI 0.0362461
RBM39 RNA binding motif protein 39 0.035807
SHROOM3 shroom family member 3 0.0354414
CEP95 centrosomal protein 95kDa 0.0347255
LAMB3 laminin, beta 3 0.0346325
PTPRR protein tyrosine phosphatase, receptor type, R 0.0342985
ITGA6 integrin, alpha 6 0.0329576
ABHD17C abhydrolase domain containing 17C 0.0326789
RHPN2 rhophilin, Rho GTPase binding protein 2 0.032656
LRRC1 leucine rich repeat containing 1 0.0321909
PLAC8 placenta-specific 8 0.0321468
RPL14 ribosomal protein L14 0.0321373
GARS1 glycyl-tRNA synthetase 1 0.0317641
MYOF myoferlin 0.0312991
OGA O-GlcNAcase 0.030413
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0304011
KMT2C lysine (K)-specific methyltransferase 2C 0.0302457
PRELID2 PRELI domain containing 2 0.0301484
ANXA11 annexin A11 0.0289077
MON2 MON2 homolog (S. cerevisiae) 0.0287921
MARCHF6 membrane associated ring-CH-type finger 6 0.0283939
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0280319
ACTN4 actinin, alpha 4 0.0280218
TRIM2 tripartite motif containing 2 0.0279993
USP3 ubiquitin specific peptidase 3 0.0277803
PLAUR plasminogen activator, urokinase receptor 0.027282
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.027114
ESYT2 extended synaptotagmin-like protein 2 0.0266513
CTNND1 catenin (cadherin-associated protein), delta 1 0.0261694
EIF4B eukaryotic translation initiation factor 4B 0.0260309
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0258541
CDK19 cyclin-dependent kinase 19 0.0255692
ETNK1 ethanolamine kinase 1 0.0255158
DSG3 desmoglein 3 0.0253335
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0252269
SLMAP sarcolemma associated protein 0.0250311
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0248072
TMEM41B transmembrane protein 41B 0.0246781
ITPRID2 ITPR interacting domain containing 2 0.0245834
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0244373
NKTR natural killer cell triggering receptor 0.0242559
RAP1B RAP1B, member of RAS oncogene family 0.0230077
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0227783
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.022583
USP53 ubiquitin specific peptidase 53 0.0224347
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0223301
ANLN anillin, actin binding protein 0.0219587
TRA2A transformer 2 alpha homolog (Drosophila) 0.0218628
TJP1 tight junction protein 1 0.0218537
SBF2 SET binding factor 2 0.0216921
ZFC3H1 zinc finger, C3H1-type containing 0.0216396
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0215999
NF1 neurofibromin 1 0.0212892
OSBPL3 oxysterol binding protein-like 3 0.0211742
BAIAP2L1 BAI1-associated protein 2-like 1 0.0207461
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0207277
RRBP1 ribosome binding protein 1 0.0204994
LAMA4 laminin, alpha 4 0.0204838
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0204096
MED13L mediator complex subunit 13-like 0.0196563
ZMYM2 zinc finger, MYM-type 2 0.0193858
RAB1A RAB1A, member RAS oncogene family 0.0192115
AFDN afadin, adherens junction formation factor 0.0191449
TUT4 terminal uridylyl transferase 4 0.0191208
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.019106
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0190521
CDC42SE2 CDC42 small effector 2 0.0187769
COG5 component of oligomeric golgi complex 5 0.0187388
RAB6A RAB6A, member RAS oncogene family 0.0185117
DSPP dentin sialophosphoprotein 0.0185036
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.018358
SCAF8 SR-related CTD-associated factor 8 0.0183487
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0183051
THOC2 THO complex 2 0.0181081
STRN3 striatin, calmodulin binding protein 3 0.0180251
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0179394
RLF rearranged L-myc fusion 0.0178542
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0178013
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0177483
DGKD diacylglycerol kinase, delta 130kDa 0.0175729
TTC3 tetratricopeptide repeat domain 3 0.0173887
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0172703
PTEN phosphatase and tensin homolog 0.0172459
AKAP9 A kinase (PRKA) anchor protein 9 0.0171049
KLF3 Kruppel-like factor 3 (basic) 0.0170371
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0169832
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0169559
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0169503

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.21147
RPLP1 ribosomal protein, large, P1 -0.139917
RPS6 ribosomal protein S6 -0.136857
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127342
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.118897
RPS8 ribosomal protein S8 -0.116107
RPS27A ribosomal protein S27a -0.114502
RPS12 ribosomal protein S12 -0.104385
PDE4D phosphodiesterase 4D, cAMP-specific -0.102997
UBC ubiquitin C -0.0976991
PKM pyruvate kinase, muscle -0.0853941
RPL23 ribosomal protein L23 -0.0846779
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0790967
RPS19 ribosomal protein S19 -0.0776002
EEF2 eukaryotic translation elongation factor 2 -0.0771386
RPLP0 ribosomal protein, large, P0 -0.0757188
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0739366
TPT1 tumor protein, translationally-controlled 1 -0.0732983
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0727498
RPS25 ribosomal protein S25 -0.0716624
PTMA prothymosin, alpha -0.0700215
RPS23 ribosomal protein S23 -0.0695543
PDIA3 protein disulfide isomerase family A, member 3 -0.0687068
RPL37A ribosomal protein L37a -0.0678692
LOC112694756 uncharaterized LOC112694756 -0.0665053
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0662943
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0657715
RACK1 receptor for activated C kinase 1 -0.0656629
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0650908
RPLP2 ribosomal protein, large, P2 -0.0649953
POTEF POTE ankyrin domain family, member F -0.0641097
RPL9 ribosomal protein L9 -0.0599701
RPL11 ribosomal protein L11 -0.0594458
LDHA lactate dehydrogenase A -0.0593758
MYO1E myosin IE -0.0591678
ACTG1 actin gamma 1 -0.0588826
RPS17 ribosomal protein S17 -0.0581309
RPS13 ribosomal protein S13 -0.0575781
FAT1 FAT atypical cadherin 1 -0.0561637
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0556273
RPL31 ribosomal protein L31 -0.0540204
RPL26 ribosomal protein L26 -0.0537052
RPL34 ribosomal protein L34 -0.0533786
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.051451
RPS3 ribosomal protein S3 -0.05092
EEF1G eukaryotic translation elongation factor 1 gamma -0.0503759
PCBP2 poly(rC) binding protein 2 -0.0502992
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0492584
ENO1 enolase 1, (alpha) -0.0487112
RPL28 ribosomal protein L28 -0.0475316
RPL12 ribosomal protein L12 -0.0467613
INTS6 integrator complex subunit 6 -0.0463754
RPL35A ribosomal protein L35a -0.0462065
RPL37 ribosomal protein L37 -0.0452939
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0449857
SLC38A2 solute carrier family 38, member 2 -0.0448182
KRT18 keratin 18, type I -0.0445087
RPS14 ribosomal protein S14 -0.0437865
RPS27 ribosomal protein S27 -0.0421299
RPS11 ribosomal protein S11 -0.0411947
RPS5 ribosomal protein S5 -0.0406383
RPS20 ribosomal protein S20 -0.0406313
RPS16 ribosomal protein S16 -0.0403262
HLA-B major histocompatibility complex, class I, B -0.0402296
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0399332
RPL8 ribosomal protein L8 -0.0397865
RPS29 ribosomal protein S29 -0.0394347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0386643
TMSB10 thymosin beta 10 -0.038622
PTPRB protein tyrosine phosphatase, receptor type, B -0.0377295
CATSPERB catsper channel auxiliary subunit beta -0.0377139
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.036383
ASPH aspartate beta-hydroxylase -0.0362357
RPL4 ribosomal protein L4 -0.036196
LRRC23 leucine rich repeat containing 23 -0.0358681
RPS24 ribosomal protein S24 -0.0357876
F3 coagulation factor III (thromboplastin, tissue factor) -0.0357502
EGFR epidermal growth factor receptor -0.0352103
RIMKLB ribosomal modification protein rimK-like family member B -0.0350535
RPL36 ribosomal protein L36 -0.0347922
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0343688
RNF213 ring finger protein 213 -0.0334181
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0331832
NAP1L1 nucleosome assembly protein 1-like 1 -0.0326891
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0326344
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0319932
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0317653
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.030925
RPL19 ribosomal protein L19 -0.0308288
RPL30 ribosomal protein L30 -0.0307655
AGR2 anterior gradient 2 -0.029752
CAV2 caveolin 2 -0.0295092
RPL3 ribosomal protein L3 -0.0294409
RPL7 ribosomal protein L7 -0.0289368
HMGA1 high mobility group AT-hook 1 -0.0288962
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0288367
APLP2 amyloid beta (A4) precursor-like protein 2 -0.028409
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.028385
RPS4X ribosomal protein S4, X-linked -0.0282029
RPL21 ribosomal protein L21 -0.0279913