Indacaterol (maleate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.131658
TXNRD1 thioredoxin reductase 1 0.100534
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.090409
CAPRIN2 caprin family member 2 0.0864503
RAI1 retinoic acid induced 1 0.0845871
SLC38A2 solute carrier family 38, member 2 0.0748824
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.070275
EZR ezrin 0.0701083
SPAG9 sperm associated antigen 9 0.0698871
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0609832
KMT2E lysine (K)-specific methyltransferase 2E 0.0586683
RTN4 reticulon 4 0.0564718
FMNL2 formin-like 2 0.0545757
OGA O-GlcNAcase 0.0493328
TOP1 topoisomerase (DNA) I 0.0490716
TMEM41B transmembrane protein 41B 0.0490366
ADAM17 ADAM metallopeptidase domain 17 0.0487951
CENPF centromere protein F, 350/400kDa 0.0485124
JMJD1C jumonji domain containing 1C 0.0482929
EREG epiregulin 0.0468469
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0453471
GARS1 glycyl-tRNA synthetase 1 0.0447572
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0442957
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.043993
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0436695
MYH9 myosin, heavy chain 9, non-muscle 0.0433407
BIRC6 baculoviral IAP repeat containing 6 0.043151
ARHGAP5 Rho GTPase activating protein 5 0.0405591
TM4SF1 transmembrane 4 L six family member 1 0.0391526
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0387855
KMT2C lysine (K)-specific methyltransferase 2C 0.0386038
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0382705
ZNF292 zinc finger protein 292 0.0382566
FNIP1 folliculin interacting protein 1 0.0371792
MKI67 marker of proliferation Ki-67 0.036309
NUP58 nucleoporin 58 0.0359585
XPO1 exportin 1 0.035766
ANLN anillin, actin binding protein 0.0356318
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0353114
TRIP12 thyroid hormone receptor interactor 12 0.0348734
ANKRD11 ankyrin repeat domain 11 0.0348302
ARRDC3 arrestin domain containing 3 0.0348131
HOOK2 hook microtubule-tethering protein 2 0.034373
MACF1 microtubule-actin crosslinking factor 1 0.0333925
USP34 ubiquitin specific peptidase 34 0.0332367
APP amyloid beta (A4) precursor protein 0.0330659
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0329837
MARCHF6 membrane associated ring-CH-type finger 6 0.0329709
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0329185
VCL vinculin 0.0327485
CLTC clathrin, heavy chain (Hc) 0.0326843
SPRED2 sprouty-related, EVH1 domain containing 2 0.0326318
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0325641
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0323241
FLNB filamin B, beta 0.0321601
ATP13A3 ATPase type 13A3 0.0318409
PUM2 pumilio RNA-binding family member 2 0.0316844
TMSB4X thymosin beta 4, X-linked 0.0315628
ADGRG6 adhesion G protein-coupled receptor G6 0.0311472
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0311436
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0306973
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0306457
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0301757
WDR45B WD repeat domain 45B 0.0300754
USP9X ubiquitin specific peptidase 9, X-linked 0.0298689
UPP1 uridine phosphorylase 1 0.0297816
POM121 POM121 transmembrane nucleoporin 0.0296249
GSK3B glycogen synthase kinase 3 beta 0.0291635
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0291378
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0290559
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0289681
SNX14 sorting nexin 14 0.0288678
H1-0 H1.0 linker histone 0.0288394
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0286413
DENND5A DENN/MADD domain containing 5A 0.0284298
RHEB Ras homolog enriched in brain 0.0279272
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0278325
SRPK2 SRSF protein kinase 2 0.0275243
PTBP2 polypyrimidine tract binding protein 2 0.0273795
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0271932
STRN3 striatin, calmodulin binding protein 3 0.0270929
ZEB1 zinc finger E-box binding homeobox 1 0.0269856
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0269826
TM9SF3 transmembrane 9 superfamily member 3 0.0268744
ETNK1 ethanolamine kinase 1 0.0268628
RBM39 RNA binding motif protein 39 0.02664
ERBIN erbb2 interacting protein 0.0263297
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0259511
SUCO SUN domain containing ossification factor 0.0259108
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0258238
AHNAK AHNAK nucleoprotein 0.025579
NCOR1 nuclear receptor corepressor 1 0.0255369
COG5 component of oligomeric golgi complex 5 0.0255273
KDM3A lysine (K)-specific demethylase 3A 0.0254864
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0254171
SETD5 SET domain containing 5 0.0253713
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0252989
ADAM9 ADAM metallopeptidase domain 9 0.0252736
TNPO1 transportin 1 0.024852
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0248253

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.184024
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162443
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.128336
HLA-B major histocompatibility complex, class I, B -0.12122
TP63 tumor protein p63 -0.119268
CD44 CD44 molecule (Indian blood group) -0.105248
RPS8 ribosomal protein S8 -0.104598
CADM2 cell adhesion molecule 2 -0.0984151
TPT1 tumor protein, translationally-controlled 1 -0.0965274
MT2A metallothionein 2A -0.0962121
RPL35A ribosomal protein L35a -0.087578
RPS6 ribosomal protein S6 -0.0872216
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0811635
RPL26 ribosomal protein L26 -0.0751183
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0741874
FTL ferritin, light polypeptide -0.0741217
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0728696
TMSB10 thymosin beta 10 -0.0712135
RPS19 ribosomal protein S19 -0.0710226
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0708475
RPL12 ribosomal protein L12 -0.0689485
RPL37A ribosomal protein L37a -0.0651344
DST dystonin -0.0627244
RPL36 ribosomal protein L36 -0.0617076
RPL31 ribosomal protein L31 -0.0596797
CFAP299 cilia and flagella associated protein 299 -0.0576048
RPLP1 ribosomal protein, large, P1 -0.0573821
RIGI RNA sensor RIG-I -0.0564991
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0561478
TNS3 tensin 3 -0.0557031
RPS12 ribosomal protein S12 -0.0549596
SP100 SP100 nuclear antigen -0.0544802
RPL28 ribosomal protein L28 -0.0512144
RPL37 ribosomal protein L37 -0.0511409
FTH1 ferritin, heavy polypeptide 1 -0.0494228
RNF213 ring finger protein 213 -0.0493313
RPS3 ribosomal protein S3 -0.0490848
HMGA1 high mobility group AT-hook 1 -0.0474029
PDE10A phosphodiesterase 10A -0.0473077
RPS25 ribosomal protein S25 -0.047289
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0449383
PSD3 pleckstrin and Sec7 domain containing 3 -0.0440473
DPYD dihydropyrimidine dehydrogenase -0.0435722
RACK1 receptor for activated C kinase 1 -0.0433037
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0432408
RPL36A ribosomal protein L36a -0.0427215
RPS23 ribosomal protein S23 -0.0410887
RPL9 ribosomal protein L9 -0.0410621
LOC112694756 uncharaterized LOC112694756 -0.0405527
RPLP2 ribosomal protein, large, P2 -0.0400632
DNER delta/notch-like EGF repeat containing -0.0399372
RPS10 ribosomal protein S10 -0.0393804
RPL23 ribosomal protein L23 -0.0392434
IFIH1 interferon induced with helicase C domain 1 -0.0391801
CSMD3 CUB and Sushi multiple domains 3 -0.039022
RPL11 ribosomal protein L11 -0.0387185
RPLP0 ribosomal protein, large, P0 -0.0383319
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.038028
EHBP1 EH domain binding protein 1 -0.0375296
RPS27A ribosomal protein S27a -0.0372943
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0364572
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0364492
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035253
POTEF POTE ankyrin domain family, member F -0.0349581
EXOC4 exocyst complex component 4 -0.0344923
NPAS2 neuronal PAS domain protein 2 -0.0343803
RPS27 ribosomal protein S27 -0.033746
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0330392
RPS28 ribosomal protein S28 -0.0328272
RPL38 ribosomal protein L38 -0.0328225
RPS29 ribosomal protein S29 -0.0320972
RPL7A ribosomal protein L7a -0.0317697
EPHA4 EPH receptor A4 -0.031704
RPS20 ribosomal protein S20 -0.0312659
EFNA5 ephrin-A5 -0.0307922
SDK1 sidekick cell adhesion molecule 1 -0.0305903
IFITM1 interferon induced transmembrane protein 1 -0.0303492
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.030015
RPS24 ribosomal protein S24 -0.0299698
RPL35 ribosomal protein L35 -0.0296887
LPP LIM domain containing preferred translocation partner in lipoma -0.0296215
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.029484
GNAS GNAS complex locus -0.0293635
INTS6 integrator complex subunit 6 -0.0292307
RPL19 ribosomal protein L19 -0.0289149
PLSCR1 phospholipid scramblase 1 -0.0288204
RPS14 ribosomal protein S14 -0.0285287
RPL27 ribosomal protein L27 -0.0283668
RPL34 ribosomal protein L34 -0.0282825
RPL27A ribosomal protein L27a -0.0278274
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273069
MT1E metallothionein 1E -0.0273048
HLA-A major histocompatibility complex, class I, A -0.0268428
HLA-E major histocompatibility complex, class I, E -0.0260425
WSB1 WD repeat and SOCS box containing 1 -0.0258526
TGM2 transglutaminase 2 -0.0255236
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0249718
TRIM56 tripartite motif containing 56 -0.0249482
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0247299
IFI6 interferon, alpha-inducible protein 6 -0.0247055