Indacaterol (maleate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0732991
TM4SF1 transmembrane 4 L six family member 1 0.0688404
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0523805
PDE4D phosphodiesterase 4D, cAMP-specific 0.0393503
PM20D1 peptidase M20 domain containing 1 0.0393134
GRAMD1B GRAM domain containing 1B 0.0363193
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0315893
OSMR oncostatin M receptor 0.0297119
TXNRD1 thioredoxin reductase 1 0.0291361
CAMTA1 calmodulin binding transcription activator 1 0.027643
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0270543
VMP1 vacuole membrane protein 1 0.0260793
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0255479
HSPA8 heat shock 70kDa protein 8 0.0249345
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0248728
EXT1 exostosin glycosyltransferase 1 0.0236094
LPP LIM domain containing preferred translocation partner in lipoma 0.0230994
UBASH3B ubiquitin associated and SH3 domain containing B 0.0223529
IQGAP1 IQ motif containing GTPase activating protein 1 0.0219773
VCL vinculin 0.0218767
SDC4 syndecan 4 0.0204618
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0203616
DGKD diacylglycerol kinase, delta 130kDa 0.0202806
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0200928
NCEH1 neutral cholesterol ester hydrolase 1 0.0199277
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0197072
IGF1R insulin-like growth factor 1 receptor 0.0193275
ASPH aspartate beta-hydroxylase 0.0190309
RRM2 ribonucleotide reductase M2 0.0186583
THSD4 thrombospondin, type I, domain containing 4 0.0184734
DOCK5 dedicator of cytokinesis 5 0.0183631
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0182381
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0180026
YBX3 Y box binding protein 3 0.0177831
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0177444
TPM4 tropomyosin 4 0.0172424
ZBTB20 zinc finger and BTB domain containing 20 0.017189
SP3 Sp3 transcription factor 0.0169167
LAMC2 laminin, gamma 2 0.0168683
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0167496
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0166212
EHBP1 EH domain binding protein 1 0.0164411
TTC28 tetratricopeptide repeat domain 28 0.0163897
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0163752
RPL41 ribosomal protein L41 0.0163387
RSL1D1 ribosomal L1 domain containing 1 0.0161135
SUCO SUN domain containing ossification factor 0.0160765
HDLBP high density lipoprotein binding protein 0.0157355
NCOA7 nuclear receptor coactivator 7 0.0156726
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0153738
UBAP2L ubiquitin associated protein 2-like 0.0152992
TMSB4X thymosin beta 4, X-linked 0.0152522
ITPRID2 ITPR interacting domain containing 2 0.0149974
ERRFI1 ERBB receptor feedback inhibitor 1 0.0149323
MYH9 myosin, heavy chain 9, non-muscle 0.0148865
TM9SF3 transmembrane 9 superfamily member 3 0.0148306
NAMPT nicotinamide phosphoribosyltransferase 0.0147812
DLG1 discs, large homolog 1 (Drosophila) 0.014753
WDR43 WD repeat domain 43 0.0145994
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0145508
SPIDR scaffolding protein involved in DNA repair 0.0144947
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0143878
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0143428
AHNAK AHNAK nucleoprotein 0.0142724
APP amyloid beta (A4) precursor protein 0.0142039
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0139905
GLIS3 GLIS family zinc finger 3 0.0138198
CAVIN1 caveolae associated protein 1 0.0137966
ANGPTL4 angiopoietin-like 4 0.013733
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.013706
CFLAR CASP8 and FADD-like apoptosis regulator 0.013702
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.013629
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.0135737
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0135672
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0134601
NOL10 nucleolar protein 10 0.013452
GDI2 GDP dissociation inhibitor 2 0.0134209
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0132853
MEMO1 mediator of cell motility 1 0.0132679
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0132467
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0132286
ARL5B ADP-ribosylation factor-like 5B 0.0131537
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0130681
SERINC1 serine incorporator 1 0.0130234
FAF1 Fas (TNFRSF6) associated factor 1 0.012589
WDPCP WD repeat containing planar cell polarity effector 0.0124787
WIPF2 WAS/WASL interacting protein family, member 2 0.0123145
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0122144
NFE2L2 nuclear factor, erythroid 2-like 2 0.0122013
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0121276
RNF121 ring finger protein 121 0.0121051
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0120884
CALU calumenin 0.0119629
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0119338
KYNU kynureninase 0.011771
CTNND1 catenin (cadherin-associated protein), delta 1 0.011747
BZW1 basic leucine zipper and W2 domains 1 0.0116674
BIRC2 baculoviral IAP repeat containing 2 0.011667
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0115946
MORF4L1 mortality factor 4 like 1 0.0115938

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.288805
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.276194
FTL ferritin, light polypeptide -0.191222
FTH1 ferritin, heavy polypeptide 1 -0.160919
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.157448
VIM vimentin -0.0949188
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.090134
TMSB10 thymosin beta 10 -0.088314
POTEF POTE ankyrin domain family, member F -0.0761426
EIF1 eukaryotic translation initiation factor 1 -0.0744058
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0717292
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0650654
RPL19 ribosomal protein L19 -0.0619695
RPLP1 ribosomal protein, large, P1 -0.0611505
RPL23 ribosomal protein L23 -0.0582781
IGF2 insulin-like growth factor 2 -0.0538648
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0525707
PKM pyruvate kinase, muscle -0.0513764
RPS8 ribosomal protein S8 -0.0493253
PFN1 profilin 1 -0.0472879
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.044562
RPS12 ribosomal protein S12 -0.0443862
FGB fibrinogen beta chain -0.0436409
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0435663
RPS6 ribosomal protein S6 -0.0429739
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0428301
IGFBP3 insulin-like growth factor binding protein 3 -0.0408666
KDM5B lysine (K)-specific demethylase 5B -0.0396595
PCBP2 poly(rC) binding protein 2 -0.0392025
KTN1 kinectin 1 (kinesin receptor) -0.0391243
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0387165
RPS19 ribosomal protein S19 -0.0380432
RPS20 ribosomal protein S20 -0.0375729
HMGA1 high mobility group AT-hook 1 -0.0375376
PDIA3 protein disulfide isomerase family A, member 3 -0.0374331
RPS25 ribosomal protein S25 -0.0373886
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.036343
RPL37A ribosomal protein L37a -0.0359225
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0358781
RBM25 RNA binding motif protein 25 -0.035436
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.034557
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0343944
RPL36 ribosomal protein L36 -0.0342199
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0337559
RBM39 RNA binding motif protein 39 -0.0333301
S100A6 S100 calcium binding protein A6 -0.0331967
HLA-A major histocompatibility complex, class I, A -0.0316406
ACTG1 actin gamma 1 -0.0315108
NDRG1 N-myc downstream regulated 1 -0.0307782
YBX1 Y box binding protein 1 -0.0304384
BZW2 basic leucine zipper and W2 domains 2 -0.028997
RPL31 ribosomal protein L31 -0.0289032
UGCG UDP-glucose ceramide glucosyltransferase -0.0286249
GNAS GNAS complex locus -0.0286049
PDIA6 protein disulfide isomerase family A, member 6 -0.0282793
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0282203
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0275527
RSRC2 arginine/serine-rich coiled-coil 2 -0.0274601
RPL28 ribosomal protein L28 -0.0273952
ZNF207 zinc finger protein 207 -0.0271027
RPL35A ribosomal protein L35a -0.0269211
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0262996
ERBIN erbb2 interacting protein -0.0262755
RPS23 ribosomal protein S23 -0.0261838
TPD52 tumor protein D52 -0.0261108
FMNL2 formin-like 2 -0.0259567
ZFAND3 zinc finger, AN1-type domain 3 -0.0258533
RPL37 ribosomal protein L37 -0.0252166
EEF2 eukaryotic translation elongation factor 2 -0.0248107
IL6 interleukin 6 -0.02442
LOC112694756 uncharaterized LOC112694756 -0.023875
KIF5B kinesin family member 5B -0.0238366
RPL8 ribosomal protein L8 -0.0238333
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0237058
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0234797
LDHA lactate dehydrogenase A -0.0234294
FBXO11 F-box protein 11 -0.0233224
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229684
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0229043
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0227805
HLA-B major histocompatibility complex, class I, B -0.022736
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0222527
ANXA1 annexin A1 -0.0220019
FNBP1L formin binding protein 1-like -0.0218531
PARD3 par-3 family cell polarity regulator -0.0218524
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0217023
RPL11 ribosomal protein L11 -0.02161
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0215939
PTK2 protein tyrosine kinase 2 -0.0214995
RCC1 regulator of chromosome condensation 1 -0.021363
IFRD1 interferon-related developmental regulator 1 -0.0211827
RPS29 ribosomal protein S29 -0.0210111
RPLP0 ribosomal protein, large, P0 -0.0209502
BTBD7 BTB (POZ) domain containing 7 -0.0208798
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0206182
NRG1 neuregulin 1 -0.0205929
RPS17 ribosomal protein S17 -0.0205566
RUNX1 runt-related transcription factor 1 -0.0204336
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0203838
RPLP2 ribosomal protein, large, P2 -0.0203266