Indacaterol (maleate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.102758
FAM13A family with sequence similarity 13, member A 0.0796297
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0791658
RNF145 ring finger protein 145 0.0782902
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.077281
CCNL1 cyclin L1 0.0639528
TFG TRK-fused gene 0.0627002
DSCAM Down syndrome cell adhesion molecule 0.0622418
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0609642
FXR1 fragile X mental retardation, autosomal homolog 1 0.0596218
PTMA prothymosin, alpha 0.0595526
TSC22D2 TSC22 domain family, member 2 0.0582622
KMT2E lysine (K)-specific methyltransferase 2E 0.0582118
NDRG1 N-myc downstream regulated 1 0.0569288
MARCHF6 membrane associated ring-CH-type finger 6 0.0562513
SLC38A1 solute carrier family 38, member 1 0.0531907
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0530637
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0526577
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0493415
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0491412
RBM39 RNA binding motif protein 39 0.0472766
RHEB Ras homolog enriched in brain 0.0467159
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0456003
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0442889
MATR3 matrin 3 0.0433318
MSMO1 methylsterol monooxygenase 1 0.0429368
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0425938
CLINT1 clathrin interactor 1 0.0424544
CD46 CD46 molecule, complement regulatory protein 0.0419012
QKI QKI, KH domain containing, RNA binding 0.0413277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0413112
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0410498
RBM25 RNA binding motif protein 25 0.0406922
YBX3 Y box binding protein 3 0.0405772
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0400258
KDM6A lysine (K)-specific demethylase 6A 0.0393315
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0392871
ZNF292 zinc finger protein 292 0.039085
GARS1 glycyl-tRNA synthetase 1 0.0378957
GPBP1 GC-rich promoter binding protein 1 0.0373995
USP3 ubiquitin specific peptidase 3 0.0367751
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0361171
PAPOLA poly(A) polymerase alpha 0.0358348
RYBP RING1 and YY1 binding protein 0.0357635
COPA coatomer protein complex, subunit alpha 0.0345405
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0344507
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0340756
ADAM9 ADAM metallopeptidase domain 9 0.0339231
SSBP2 single-stranded DNA binding protein 2 0.0336727
EPS8 epidermal growth factor receptor pathway substrate 8 0.0332825
BHLHE40 basic helix-loop-helix family, member e40 0.033262
HMGB2 high mobility group box 2 0.0328498
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0327661
WTAP Wilms tumor 1 associated protein 0.0327077
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0326055
ZNF148 zinc finger protein 148 0.0325213
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.032514
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0324214
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0323054
TMEM131L transmembrane 131 like 0.0318262
B2M beta-2-microglobulin 0.0314273
PRRC1 proline-rich coiled-coil 1 0.0313179
PELI1 pellino E3 ubiquitin protein ligase 1 0.0309933
RLF rearranged L-myc fusion 0.0306941
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0300859
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0298736
CHD1 chromodomain helicase DNA binding protein 1 0.0297253
LRRC1 leucine rich repeat containing 1 0.0296676
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0295532
RAD23B RAD23 homolog B (S. cerevisiae) 0.0292981
ECT2 epithelial cell transforming 2 0.0290012
MSN moesin 0.0289288
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0287921
RYK receptor-like tyrosine kinase 0.0287571
PUM1 pumilio RNA-binding family member 1 0.0285216
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0283671
PARD3 par-3 family cell polarity regulator 0.0282619
SEC23A Sec23 homolog A (S. cerevisiae) 0.0280911
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0278017
TNIP1 TNFAIP3 interacting protein 1 0.0277527
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0274286
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0272664
RNASE3 ribonuclease, RNase A family, 3 0.0266335
TRA2A transformer 2 alpha homolog (Drosophila) 0.0264101
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.026304
SUCO SUN domain containing ossification factor 0.0260602
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0253342
RSRC2 arginine/serine-rich coiled-coil 2 0.0253128
BCLAF1 BCL2-associated transcription factor 1 0.0251173
ARRDC3 arrestin domain containing 3 0.0250781
TPM3 tropomyosin 3 0.0250709
ANLN anillin, actin binding protein 0.025062
KDM1A lysine (K)-specific demethylase 1A 0.0250531
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0250316
HELZ helicase with zinc finger 0.0247381
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0245246
TRA2B transformer 2 beta homolog (Drosophila) 0.0242473
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0241807
YTHDC1 YTH domain containing 1 0.0240961
ANXA5 annexin A5 0.0240782

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.194641
ACTG1 actin gamma 1 -0.190268
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180864
SAMD4A sterile alpha motif domain containing 4A -0.128179
LPP LIM domain containing preferred translocation partner in lipoma -0.126386
POTEF POTE ankyrin domain family, member F -0.12419
EXT1 exostosin glycosyltransferase 1 -0.111127
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0948708
EFNA5 ephrin-A5 -0.0860396
KRT7 keratin 7, type II -0.0819671
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0788192
TMSB10 thymosin beta 10 -0.0775694
CCND1 cyclin D1 -0.0748804
LAMB3 laminin, beta 3 -0.0746729
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.073859
TPT1 tumor protein, translationally-controlled 1 -0.0704951
IFI27 interferon, alpha-inducible protein 27 -0.068961
GRB10 growth factor receptor-bound protein 10 -0.0679813
IFI16 interferon, gamma-inducible protein 16 -0.0648994
LAMC2 laminin, gamma 2 -0.0634958
DTNA dystrobrevin, alpha -0.0630482
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0622978
NAV2 neuron navigator 2 -0.0613986
VCL vinculin -0.0607013
CSTB cystatin B (stefin B) -0.059053
LIMCH1 LIM and calponin homology domains 1 -0.055522
FBXO32 F-box protein 32 -0.0554884
ALCAM activated leukocyte cell adhesion molecule -0.0538617
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0530197
AHNAK AHNAK nucleoprotein -0.0527056
TRIO trio Rho guanine nucleotide exchange factor -0.0519719
LDHA lactate dehydrogenase A -0.0503258
IFI6 interferon, alpha-inducible protein 6 -0.0498682
FTL ferritin, light polypeptide -0.0486191
ARHGAP5 Rho GTPase activating protein 5 -0.048413
MYO1E myosin IE -0.0477984
FNIP1 folliculin interacting protein 1 -0.0472947
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0469662
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0468058
RNF213 ring finger protein 213 -0.0465874
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0454082
GNAS GNAS complex locus -0.0442895
SQSTM1 sequestosome 1 -0.0442065
ANXA2 annexin A2 -0.0441888
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0440293
RAI14 retinoic acid induced 14 -0.0429608
SMAD3 SMAD family member 3 -0.0428096
S100A10 S100 calcium binding protein A10 -0.0426804
PLSCR1 phospholipid scramblase 1 -0.0425118
GOLGB1 golgin B1 -0.0425094
BLZF1 basic leucine zipper nuclear factor 1 -0.0422832
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0420787
AHNAK2 AHNAK nucleoprotein 2 -0.0417298
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0415578
RPL35A ribosomal protein L35a -0.0415521
ARHGAP20 Rho GTPase activating protein 20 -0.0411099
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0409256
MX1 MX dynamin-like GTPase 1 -0.0399098
UBE2H ubiquitin-conjugating enzyme E2H -0.0396399
MAP1B microtubule-associated protein 1B -0.0393894
SEC31A SEC31 homolog A (S. cerevisiae) -0.0391904
PDLIM5 PDZ and LIM domain 5 -0.0386208
SP100 SP100 nuclear antigen -0.0385605
EIF1 eukaryotic translation initiation factor 1 -0.0383982
NIPBL Nipped-B homolog (Drosophila) -0.0379978
MX2 MX dynamin-like GTPase 2 -0.0379882
RPL23 ribosomal protein L23 -0.0375403
PLEC plectin -0.0374266
SVIL supervillin -0.0373731
SH3KBP1 SH3-domain kinase binding protein 1 -0.0371792
RPL30 ribosomal protein L30 -0.0368961
RIGI RNA sensor RIG-I -0.0367867
RCOR1 REST corepressor 1 -0.0362402
KRT19 keratin 19, type I -0.0362353
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0358831
PATJ PATJ crumbs cell polarity complex component -0.0357348
HMGA1 high mobility group AT-hook 1 -0.0357316
TPM4 tropomyosin 4 -0.0356613
ETV6 ets variant 6 -0.0356538
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0355526
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0355191
F3 coagulation factor III (thromboplastin, tissue factor) -0.0350794
ZBTB20 zinc finger and BTB domain containing 20 -0.0350724
RAB7A RAB7A, member RAS oncogene family -0.0349784
ATXN1 ataxin 1 -0.034856
ERBIN erbb2 interacting protein -0.034745
HLA-A major histocompatibility complex, class I, A -0.0341416
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0339275
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0337504
RACK1 receptor for activated C kinase 1 -0.0337203
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0335127
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0331806
INTS6 integrator complex subunit 6 -0.0331404
FBXL2 F-box and leucine-rich repeat protein 2 -0.0330571
IGFBP3 insulin-like growth factor binding protein 3 -0.0328251
HLA-B major histocompatibility complex, class I, B -0.0322916
ZNF217 zinc finger protein 217 -0.0322442
MAML2 mastermind-like 2 (Drosophila) -0.0320001
BASP1 brain abundant, membrane attached signal protein 1 -0.0319238
NF1 neurofibromin 1 -0.0318237