Indacaterol (maleate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Indacaterol (maleate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0661375
MCL1 myeloid cell leukemia 1 0.033826
OGA O-GlcNAcase 0.0331518
ESYT2 extended synaptotagmin-like protein 2 0.0328174
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0310678
ERRFI1 ERBB receptor feedback inhibitor 1 0.0305205
KMT2E lysine (K)-specific methyltransferase 2E 0.0290177
CD109 CD109 molecule 0.0282767
FAM13A family with sequence similarity 13, member A 0.0282743
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0276523
ZNF292 zinc finger protein 292 0.0273859
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271227
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0267063
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.026088
RNF145 ring finger protein 145 0.0253408
CHD1L chromodomain helicase DNA binding protein 1-like 0.0243005
KDM6A lysine (K)-specific demethylase 6A 0.0239027
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.023127
MSN moesin 0.0230922
FNDC3B fibronectin type III domain containing 3B 0.022613
RTN4 reticulon 4 0.0225884
SUCO SUN domain containing ossification factor 0.0224412
NBAS neuroblastoma amplified sequence 0.0220216
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0216932
COPA coatomer protein complex, subunit alpha 0.021643
KMT2C lysine (K)-specific methyltransferase 2C 0.0214319
HELZ helicase with zinc finger 0.0212935
NUP58 nucleoporin 58 0.0211577
SDK1 sidekick cell adhesion molecule 1 0.0204995
NGLY1 N-glycanase 1 0.0203617
ELL2 elongation factor, RNA polymerase II, 2 0.0197932
AGFG1 ArfGAP with FG repeats 1 0.0196439
FNIP1 folliculin interacting protein 1 0.0187454
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0183336
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0183102
USP34 ubiquitin specific peptidase 34 0.0178862
BIRC6 baculoviral IAP repeat containing 6 0.0176773
ATP13A3 ATPase type 13A3 0.0175583
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0175111
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0168671
ZMYM2 zinc finger, MYM-type 2 0.0167638
CD46 CD46 molecule, complement regulatory protein 0.0163455
PICALM phosphatidylinositol binding clathrin assembly protein 0.0162294
ITPRID2 ITPR interacting domain containing 2 0.016182
SP3 Sp3 transcription factor 0.0161303
FMNL2 formin-like 2 0.0160693
ADAM9 ADAM metallopeptidase domain 9 0.0157398
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0156566
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0156088
CUL3 cullin 3 0.0153221
PDGFA platelet-derived growth factor alpha polypeptide 0.0147232
DTNA dystrobrevin, alpha 0.0142584
TPD52 tumor protein D52 0.0142144
CEP170 centrosomal protein 170kDa 0.0141896
LIMCH1 LIM and calponin homology domains 1 0.0141876
RAI1 retinoic acid induced 1 0.0139785
AVL9 AVL9 homolog (S. cerevisiase) 0.0139283
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0136045
VMP1 vacuole membrane protein 1 0.0135942
INSIG2 insulin induced gene 2 0.0135915
FAM219A family with sequence similarity 219, member A 0.0135758
USP9X ubiquitin specific peptidase 9, X-linked 0.0133654
SAMD4A sterile alpha motif domain containing 4A 0.0133385
TFG TRK-fused gene 0.0132769
PTEN phosphatase and tensin homolog 0.0129312
ZFC3H1 zinc finger, C3H1-type containing 0.0128905
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.012558
GOLGA4 golgin A4 0.0122951
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0122444
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0119941
STC2 stanniocalcin 2 0.0119898
EIF4B eukaryotic translation initiation factor 4B 0.0118876
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0118184
TPM3 tropomyosin 3 0.0118037
TRA2A transformer 2 alpha homolog (Drosophila) 0.0116904
FLNB filamin B, beta 0.0116709
DPY19L1 dpy-19-like 1 (C. elegans) 0.0116224
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0116194
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0115922
USP37 ubiquitin specific peptidase 37 0.0114949
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0112293
ANO6 anoctamin 6 0.0111263
SREBF2 sterol regulatory element binding transcription factor 2 0.0111057
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0111017
ANXA5 annexin A5 0.011037
DSCAM Down syndrome cell adhesion molecule 0.0109767
PCBP2 poly(rC) binding protein 2 0.0109243
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0108879
PIAS2 protein inhibitor of activated STAT, 2 0.0106843
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0106575
GSK3B glycogen synthase kinase 3 beta 0.0106355
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0105565
MXI1 MAX interactor 1, dimerization protein 0.0104559
SNX13 sorting nexin 13 0.0104531
SEC23A Sec23 homolog A (S. cerevisiae) 0.0103717
ADAM17 ADAM metallopeptidase domain 17 0.0103078
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0102889
YEATS2 YEATS domain containing 2 0.0102761
SETD5 SET domain containing 5 0.0102726
EFNA5 ephrin-A5 0.0102686

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.251546
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.223127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.207491
PDE4D phosphodiesterase 4D, cAMP-specific -0.196895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.130516
FN1 fibronectin 1 -0.123108
PDE10A phosphodiesterase 10A -0.120339
TMSB10 thymosin beta 10 -0.108014
TPT1 tumor protein, translationally-controlled 1 -0.10624
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.105989
PTMA prothymosin, alpha -0.101021
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0989658
RPLP1 ribosomal protein, large, P1 -0.0969698
VIM vimentin -0.0908547
FTL ferritin, light polypeptide -0.0844383
PSD3 pleckstrin and Sec7 domain containing 3 -0.0827737
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.081907
COL5A2 collagen, type V, alpha 2 -0.0733666
SMYD3 SET and MYND domain containing 3 -0.0701006
RPS24 ribosomal protein S24 -0.0658695
TFPI2 tissue factor pathway inhibitor 2 -0.0657378
RPS6 ribosomal protein S6 -0.063338
RPLP0 ribosomal protein, large, P0 -0.0632535
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0618248
RPS8 ribosomal protein S8 -0.0603689
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0600551
TM4SF1 transmembrane 4 L six family member 1 -0.0587451
EIF1 eukaryotic translation initiation factor 1 -0.0583257
RPL12 ribosomal protein L12 -0.0581786
NALF1 NALCN channel auxiliary factor 1 -0.0579513
TXNRD1 thioredoxin reductase 1 -0.0578793
RPL26 ribosomal protein L26 -0.0574352
RPL35A ribosomal protein L35a -0.0561315
GDA guanine deaminase -0.0557271
NAMPT nicotinamide phosphoribosyltransferase -0.0554673
RPL19 ribosomal protein L19 -0.0530006
ACTG1 actin gamma 1 -0.052993
RPL23 ribosomal protein L23 -0.0504057
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.049736
CDH13 cadherin 13 -0.0494691
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0485873
RPL31 ribosomal protein L31 -0.0476927
RPS19 ribosomal protein S19 -0.0470232
GNAS GNAS complex locus -0.0460247
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0459942
RPL37A ribosomal protein L37a -0.044362
S100A6 S100 calcium binding protein A6 -0.0435603
RPL11 ribosomal protein L11 -0.0429277
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0416095
S100A10 S100 calcium binding protein A10 -0.0415519
MAML3 mastermind-like 3 (Drosophila) -0.0414433
RPL34 ribosomal protein L34 -0.0413812
NCOA7 nuclear receptor coactivator 7 -0.0410591
RACK1 receptor for activated C kinase 1 -0.0409612
NAP1L1 nucleosome assembly protein 1-like 1 -0.0407663
LOC112694756 uncharaterized LOC112694756 -0.0407496
RPS4X ribosomal protein S4, X-linked -0.0404673
PRKN parkin RBR E3 ubiquitin protein ligase -0.0402114
RPS23 ribosomal protein S23 -0.0397434
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0397328
RPS27A ribosomal protein S27a -0.0395711
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0386883
P3H2 prolyl 3-hydroxylase 2 -0.0386488
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0385461
LDHA lactate dehydrogenase A -0.0381125
RPS16 ribosomal protein S16 -0.0379532
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0376996
CANX calnexin -0.0376873
ANTXR1 anthrax toxin receptor 1 -0.0371388
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0365832
HLA-B major histocompatibility complex, class I, B -0.0364469
BZW1 basic leucine zipper and W2 domains 1 -0.0361708
RPL36A ribosomal protein L36a -0.0359979
TBXT T-box transcription factor T -0.035545
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0351433
RPL13A ribosomal protein L13a -0.0337409
RPLP2 ribosomal protein, large, P2 -0.0335729
RPL9 ribosomal protein L9 -0.0335689
RPS25 ribosomal protein S25 -0.0331702
RPL38 ribosomal protein L38 -0.0330661
COL4A5 collagen, type IV, alpha 5 -0.0329372
KYNU kynureninase -0.0327618
RPL7A ribosomal protein L7a -0.0323802
RPS21 ribosomal protein S21 -0.0321565
VDAC1 voltage-dependent anion channel 1 -0.031995
RPS14 ribosomal protein S14 -0.0319263
RPS29 ribosomal protein S29 -0.0316996
RPL36 ribosomal protein L36 -0.0313397
RPL35 ribosomal protein L35 -0.0305202
PALLD palladin, cytoskeletal associated protein -0.0299352
RPS12 ribosomal protein S12 -0.029537
RPL37 ribosomal protein L37 -0.0292708
RPS13 ribosomal protein S13 -0.0291788
RPS27 ribosomal protein S27 -0.0285648
RPL32 ribosomal protein L32 -0.0284638
PBX1 pre-B-cell leukemia homeobox 1 -0.0283074
UBC ubiquitin C -0.028257
RPS3 ribosomal protein S3 -0.0281688
BASP1 brain abundant, membrane attached signal protein 1 -0.0274523
RPS28 ribosomal protein S28 -0.026833