Indacaterol (maleate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0787844
OGA O-GlcNAcase 0.0643141
FMNL2 formin-like 2 0.0616678
SNX14 sorting nexin 14 0.060123
ZCCHC7 zinc finger, CCHC domain containing 7 0.0581603
SPAG9 sperm associated antigen 9 0.0574133
B2M beta-2-microglobulin 0.0477905
SUCO SUN domain containing ossification factor 0.047449
VCL vinculin 0.0463051
FBL fibrillarin 0.0421297
TRA2A transformer 2 alpha homolog (Drosophila) 0.0408952
TMEM41B transmembrane protein 41B 0.0395652
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0365411
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.034515
BIRC6 baculoviral IAP repeat containing 6 0.0341702
ADAM17 ADAM metallopeptidase domain 17 0.0340843
DDIT4 DNA-damage-inducible transcript 4 0.0319109
WDR45B WD repeat domain 45B 0.0307019
GARS1 glycyl-tRNA synthetase 1 0.030235
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0299085
KDM3A lysine (K)-specific demethylase 3A 0.029692
COPA coatomer protein complex, subunit alpha 0.0296272
DGKD diacylglycerol kinase, delta 130kDa 0.0295489
TM9SF3 transmembrane 9 superfamily member 3 0.0291188
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.028762
PGK1 phosphoglycerate kinase 1 0.0282398
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0268003
USP3 ubiquitin specific peptidase 3 0.0262911
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0259119
GOLGA4 golgin A4 0.0255819
UBA2 ubiquitin-like modifier activating enzyme 2 0.0254355
RNMT RNA (guanine-7-) methyltransferase 0.0252207
SRP54 signal recognition particle 54kDa 0.024785
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0240278
CTBP2 C-terminal binding protein 2 0.023951
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0236771
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0234026
WDR43 WD repeat domain 43 0.022982
NUP58 nucleoporin 58 0.02286
DCAF13 DDB1 and CUL4 associated factor 13 0.0228428
EEF2 eukaryotic translation elongation factor 2 0.022063
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 0.0219582
TMSB4X thymosin beta 4, X-linked 0.0217135
DENND5A DENN/MADD domain containing 5A 0.0216463
PDGFA platelet-derived growth factor alpha polypeptide 0.0216449
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0215847
RAB1A RAB1A, member RAS oncogene family 0.021282
ATP13A3 ATPase type 13A3 0.0212394
ARF4 ADP-ribosylation factor 4 0.0211201
SEC24A SEC24 family member A 0.0210017
TPD52 tumor protein D52 0.0207883
ADM adrenomedullin 0.0206033
NOP58 NOP58 ribonucleoprotein 0.0205386
FOXJ3 forkhead box J3 0.0203039
CA8 carbonic anhydrase VIII 0.0202909
TTC3 tetratricopeptide repeat domain 3 0.0199417
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019821
RB1CC1 RB1-inducible coiled-coil 1 0.0197684
MYH9 myosin, heavy chain 9, non-muscle 0.0196657
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0196202
ELL2 elongation factor, RNA polymerase II, 2 0.0195802
TFG TRK-fused gene 0.0195328
MARCHF6 membrane associated ring-CH-type finger 6 0.0194805
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0194069
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0193727
EIF4B eukaryotic translation initiation factor 4B 0.019167
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0187046
JMJD1C jumonji domain containing 1C 0.0186441
RPL14 ribosomal protein L14 0.0186165
RLF rearranged L-myc fusion 0.0184994
SAFB2 scaffold attachment factor B2 0.0183288
MATR3 matrin 3 0.0182791
TBC1D23 TBC1 domain family, member 23 0.0181971
ESYT2 extended synaptotagmin-like protein 2 0.0180124
PDE7A phosphodiesterase 7A 0.0179069
UBE2O ubiquitin-conjugating enzyme E2O 0.0176378
RAB6A RAB6A, member RAS oncogene family 0.0175077
MLF1 myeloid leukemia factor 1 0.01742
MARK3 MAP/microtubule affinity-regulating kinase 3 0.017313
CRY1 cryptochrome circadian clock 1 0.0170711
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0169941
ZMYM2 zinc finger, MYM-type 2 0.0169098
ELOVL5 ELOVL fatty acid elongase 5 0.0169015
RASA3 RAS p21 protein activator 3 0.0168225
DDIT3 DNA-damage-inducible transcript 3 0.0166069
UBA6 ubiquitin-like modifier activating enzyme 6 0.0165825
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0165427
CCNL1 cyclin L1 0.016385
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0162461
GADD45B growth arrest and DNA-damage-inducible, beta 0.016207
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0162051
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0161802
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0161676
AHDC1 AT hook, DNA binding motif, containing 1 0.0161016
BRD2 bromodomain containing 2 0.0160071
MCL1 myeloid cell leukemia 1 0.0159698
ANLN anillin, actin binding protein 0.0159315
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0158499
LOC102724023 ES1 protein homolog, mitochondrial 0.015811
RAB18 RAB18, member RAS oncogene family 0.0158037

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.158733
CD44 CD44 molecule (Indian blood group) -0.136497
DST dystonin -0.127432
AKAP12 A kinase (PRKA) anchor protein 12 -0.104294
SLC35F3 solute carrier family 35, member F3 -0.101018
EGFR epidermal growth factor receptor -0.0956152
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0891198
CARD18 caspase recruitment domain family, member 18 -0.0848311
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0837118
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0822672
ZNF780B zinc finger protein 780B -0.0806384
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0797407
ACTN4 actinin, alpha 4 -0.0774145
ASPH aspartate beta-hydroxylase -0.0767994
AHNAK AHNAK nucleoprotein -0.0748156
SAMD4B sterile alpha motif domain containing 4B -0.072661
THSD4 thrombospondin, type I, domain containing 4 -0.0669864
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0668646
VIM vimentin -0.0650729
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0647419
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0646994
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614907
ARHGAP29 Rho GTPase activating protein 29 -0.0614735
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.061015
SDK1 sidekick cell adhesion molecule 1 -0.0577577
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0561168
MACF1 microtubule-actin crosslinking factor 1 -0.0537321
EXOC4 exocyst complex component 4 -0.0499085
EHBP1 EH domain binding protein 1 -0.0497836
MAP1B microtubule-associated protein 1B -0.0496741
UBASH3B ubiquitin associated and SH3 domain containing B -0.0496529
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.048906
ZBTB20 zinc finger and BTB domain containing 20 -0.0482081
LOC112694756 uncharaterized LOC112694756 -0.0481546
SMYD3 SET and MYND domain containing 3 -0.0477855
LPP LIM domain containing preferred translocation partner in lipoma -0.0469954
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0465843
PHF14 PHD finger protein 14 -0.0464467
EFNA5 ephrin-A5 -0.0461255
RASAL2 RAS protein activator like 2 -0.0450107
RABGAP1L RAB GTPase activating protein 1-like -0.0447799
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0433694
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0433087
MYO9A myosin IXA -0.0425758
PTK2 protein tyrosine kinase 2 -0.042476
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0420051
WWTR1 WW domain containing transcription regulator 1 -0.041865
PDIA3 protein disulfide isomerase family A, member 3 -0.0417633
SLC38A2 solute carrier family 38, member 2 -0.0409009
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0404576
UTRN utrophin -0.0404097
CENPF centromere protein F, 350/400kDa -0.0403045
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0394533
SFTPA2 surfactant protein A2 -0.0384502
ATXN1 ataxin 1 -0.0382621
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0381537
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0377691
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0374772
FBXL17 F-box and leucine-rich repeat protein 17 -0.037262
MAML3 mastermind-like 3 (Drosophila) -0.0370771
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0368702
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0368321
MBD5 methyl-CpG binding domain protein 5 -0.036586
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.0363776
NF1 neurofibromin 1 -0.0359511
ATM ATM serine/threonine kinase -0.0353654
TNS3 tensin 3 -0.0352926
RAD51B RAD51 paralog B -0.0351034
PTPRK protein tyrosine phosphatase, receptor type, K -0.0346681
BICD1 bicaudal D homolog 1 (Drosophila) -0.034545
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -0.0340949
ATP9B ATPase, class II, type 9B -0.0339028
OSMR oncostatin M receptor -0.0337495
CD59 CD59 molecule, complement regulatory protein -0.0331302
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0325895
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0324631
ATG7 autophagy related 7 -0.0324376
CTSD cathepsin D -0.0322999
FRMD5 FERM domain containing 5 -0.0321348
RPLP1 ribosomal protein, large, P1 -0.0321095
MKI67 marker of proliferation Ki-67 -0.0320421
FER fer (fps/fes related) tyrosine kinase -0.0319952
DSTN destrin (actin depolymerizing factor) -0.0318464
RPL11 ribosomal protein L11 -0.0317927
DOCK1 dedicator of cytokinesis 1 -0.0316332
HMGA1 high mobility group AT-hook 1 -0.031538
NT5E 5'-nucleotidase, ecto (CD73) -0.0314016
RNF213 ring finger protein 213 -0.0313818
SPIDR scaffolding protein involved in DNA repair -0.0312759
LDHA lactate dehydrogenase A -0.0309423
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0307432
PRSS23 protease, serine, 23 -0.0307044
HMGA2 high mobility group AT-hook 2 -0.0297927
SMAD3 SMAD family member 3 -0.0296861
ARID1B AT rich interactive domain 1B (SWI1-like) -0.029547
DIAPH2 diaphanous-related formin 2 -0.0294993
ATG10 autophagy related 10 -0.0293777
POTEF POTE ankyrin domain family, member F -0.0293312
DOCK5 dedicator of cytokinesis 5 -0.029191
MYADM myeloid-associated differentiation marker -0.0289881