Indacaterol (maleate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0858953
KRT17 keratin 17, type I 0.0453912
DSCAM Down syndrome cell adhesion molecule 0.0357608
PDLIM5 PDZ and LIM domain 5 0.0280477
NRIP1 nuclear receptor interacting protein 1 0.0264741
EPS8 epidermal growth factor receptor pathway substrate 8 0.0262155
OGA O-GlcNAcase 0.0259006
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0253574
KYNU kynureninase 0.0223931
MYO6 myosin VI 0.0221162
ERRFI1 ERBB receptor feedback inhibitor 1 0.0220506
KLF5 Kruppel-like factor 5 (intestinal) 0.0204351
DAPK1 death-associated protein kinase 1 0.0192176
SMOC1 SPARC related modular calcium binding 1 0.018891
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0184947
KDM3A lysine (K)-specific demethylase 3A 0.0178561
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0174416
STEAP4 STEAP family member 4 0.0170606
KIF13B kinesin family member 13B 0.0170243
INTS6 integrator complex subunit 6 0.0166175
NCOA3 nuclear receptor coactivator 3 0.0161947
KDM6A lysine (K)-specific demethylase 6A 0.0160442
CEP95 centrosomal protein 95kDa 0.0155667
VCL vinculin 0.0151147
ITPRID2 ITPR interacting domain containing 2 0.0148345
TFG TRK-fused gene 0.0147624
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0144608
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0141513
ZFAND3 zinc finger, AN1-type domain 3 0.0141117
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0135307
TC2N tandem C2 domains, nuclear 0.013455
CD2AP CD2-associated protein 0.0132659
SPAG9 sperm associated antigen 9 0.0132111
HBP1 HMG-box transcription factor 1 0.0131958
SENP5 SUMO1/sentrin specific peptidase 5 0.0129772
TM9SF2 transmembrane 9 superfamily member 2 0.0129109
HDLBP high density lipoprotein binding protein 0.0125855
FAM107B family with sequence similarity 107, member B 0.0125829
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0125788
DSPP dentin sialophosphoprotein 0.012549
FAM13A family with sequence similarity 13, member A 0.0125488
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.012511
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0124639
CLINT1 clathrin interactor 1 0.0122972
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0122159
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0120035
PTPRR protein tyrosine phosphatase, receptor type, R 0.0119586
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0119178
ELL2 elongation factor, RNA polymerase II, 2 0.0117686
SEC23A Sec23 homolog A (S. cerevisiae) 0.0115157
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0114793
TRA2A transformer 2 alpha homolog (Drosophila) 0.0114655
TMF1 TATA element modulatory factor 1 0.0114199
COPA coatomer protein complex, subunit alpha 0.0113337
COG6 component of oligomeric golgi complex 6 0.0112829
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0110269
RANBP9 RAN binding protein 9 0.0109031
CUL3 cullin 3 0.010899
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0106939
AFF4 AF4/FMR2 family, member 4 0.0106509
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0105942
MARCHF6 membrane associated ring-CH-type finger 6 0.0105607
FNDC3B fibronectin type III domain containing 3B 0.0104965
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0104608
BIRC6 baculoviral IAP repeat containing 6 0.0103483
EIF4A2 eukaryotic translation initiation factor 4A2 0.0102953
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0102147
SUCO SUN domain containing ossification factor 0.0102084
RCOR1 REST corepressor 1 0.0101877
ARRDC3 arrestin domain containing 3 0.0100334
USP53 ubiquitin specific peptidase 53 0.00996543
COPB1 coatomer protein complex, subunit beta 1 0.00995211
ECT2 epithelial cell transforming 2 0.00985725
SEC31A SEC31 homolog A (S. cerevisiae) 0.00965075
BCAR3 breast cancer anti-estrogen resistance 3 0.00947414
TTC3 tetratricopeptide repeat domain 3 0.0093933
BZW1 basic leucine zipper and W2 domains 1 0.00935459
MAPK8 mitogen-activated protein kinase 8 0.00934982
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.00932676
RIMKLB ribosomal modification protein rimK-like family member B 0.00932101
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00912043
PUM2 pumilio RNA-binding family member 2 0.00906898
NTN4 netrin 4 0.00904173
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.00897554
CANX calnexin 0.00896051
AFF1 AF4/FMR2 family, member 1 0.00889491
NECTIN2 nectin cell adhesion molecule 2 0.00886944
PMM2 phosphomannomutase 2 0.00886453
NSD3 nuclear receptor binding SET domain protein 3 0.00884711
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00884635
ATOSA atos homolog A 0.00869191
NEK7 NIMA-related kinase 7 0.00868113
ABHD17C abhydrolase domain containing 17C 0.00866217
ZMYM2 zinc finger, MYM-type 2 0.00854434
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00838908
USP3 ubiquitin specific peptidase 3 0.00837808
TTC17 tetratricopeptide repeat domain 17 0.00828695
TMEM39A transmembrane protein 39A 0.00818266
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.00815228
IGFBP3 insulin-like growth factor binding protein 3 0.00809325

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.305211
RPS6 ribosomal protein S6 -0.113503
HMGA1 high mobility group AT-hook 1 -0.113409
TMSB10 thymosin beta 10 -0.110813
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.10465
POTEF POTE ankyrin domain family, member F -0.0956814
KRT19 keratin 19, type I -0.0902382
RPL23 ribosomal protein L23 -0.0853339
RPLP1 ribosomal protein, large, P1 -0.0838233
MT2A metallothionein 2A -0.0821696
RPS19 ribosomal protein S19 -0.0815451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0805955
RPL35A ribosomal protein L35a -0.0782371
IFI27 interferon, alpha-inducible protein 27 -0.0676091
RPS8 ribosomal protein S8 -0.0640508
ACTG1 actin gamma 1 -0.0638241
LY6E lymphocyte antigen 6 complex, locus E -0.057174
RPS3 ribosomal protein S3 -0.0537201
RPS13 ribosomal protein S13 -0.0534965
LOC102724023 ES1 protein homolog, mitochondrial -0.0525406
HLA-A major histocompatibility complex, class I, A -0.0518475
RPL19 ribosomal protein L19 -0.0513842
MUC4 mucin 4, cell surface associated -0.0498152
EIF1 eukaryotic translation initiation factor 1 -0.0487322
FOSL1 FOS-like antigen 1 -0.0487066
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.048688
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0485945
RPL28 ribosomal protein L28 -0.0470303
RACK1 receptor for activated C kinase 1 -0.0467429
LOC112694756 uncharaterized LOC112694756 -0.0466802
FTL ferritin, light polypeptide -0.0463679
NDRG1 N-myc downstream regulated 1 -0.0461337
RPL12 ribosomal protein L12 -0.0458614
HLA-B major histocompatibility complex, class I, B -0.0444413
RPL8 ribosomal protein L8 -0.0444388
LDHA lactate dehydrogenase A -0.0439567
TXNIP thioredoxin interacting protein -0.0427263
RPS14 ribosomal protein S14 -0.041488
RPS23 ribosomal protein S23 -0.0408273
RPL34 ribosomal protein L34 -0.0408205
RPLP2 ribosomal protein, large, P2 -0.0406317
RPL11 ribosomal protein L11 -0.0402501
RPL37A ribosomal protein L37a -0.0400514
RPS15 ribosomal protein S15 -0.0398236
RPL35 ribosomal protein L35 -0.0397859
TPT1 tumor protein, translationally-controlled 1 -0.0395605
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.039413
EGR1 early growth response 1 -0.0393604
RPS29 ribosomal protein S29 -0.0392956
RPL36 ribosomal protein L36 -0.0390396
LAMA4 laminin, alpha 4 -0.0386365
RPL31 ribosomal protein L31 -0.0379459
S100A6 S100 calcium binding protein A6 -0.0375914
PTMA prothymosin, alpha -0.0372012
TPI1 triosephosphate isomerase 1 -0.0366589
RPL37 ribosomal protein L37 -0.0365781
LAMB3 laminin, beta 3 -0.0362553
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0359848
IFITM3 interferon induced transmembrane protein 3 -0.0359282
RPL32 ribosomal protein L32 -0.0354781
CLDN4 claudin 4 -0.0352939
RPS12 ribosomal protein S12 -0.0348875
KRT18 keratin 18, type I -0.0347887
KRT7 keratin 7, type II -0.0347773
RPS21 ribosomal protein S21 -0.0345971
B2M beta-2-microglobulin -0.0344147
RPS25 ribosomal protein S25 -0.0342967
CD44 CD44 molecule (Indian blood group) -0.0340975
PKM pyruvate kinase, muscle -0.0339717
SVIL supervillin -0.0339475
TAPBP TAP binding protein (tapasin) -0.0338571
S100A9 S100 calcium binding protein A9 -0.0336847
RNF213 ring finger protein 213 -0.0336192
RPS27 ribosomal protein S27 -0.0327841
RPS5 ribosomal protein S5 -0.0325319
EZR ezrin -0.0323967
TPM4 tropomyosin 4 -0.0322437
RPS4X ribosomal protein S4, X-linked -0.0316934
EMP1 epithelial membrane protein 1 -0.0314846
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.030973
RPLP0 ribosomal protein, large, P0 -0.0304554
IFITM1 interferon induced transmembrane protein 1 -0.0301599
RPL5 ribosomal protein L5 -0.0300876
PCBP2 poly(rC) binding protein 2 -0.0299133
MUC16 mucin 16, cell surface associated -0.0297283
MX1 MX dynamin-like GTPase 1 -0.0292564
TRIO trio Rho guanine nucleotide exchange factor -0.0291994
DEK DEK proto-oncogene -0.0291026
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.028909
RPL30 ribosomal protein L30 -0.028634
RPL9 ribosomal protein L9 -0.0283128
ENO1 enolase 1, (alpha) -0.0280116
ANXA2 annexin A2 -0.0274121
CDCP1 CUB domain containing protein 1 -0.0273765
PRRC2C proline-rich coiled-coil 2C -0.0270421
BRD4 bromodomain containing 4 -0.0269086
S100A10 S100 calcium binding protein A10 -0.0267827
RUNX1 runt-related transcription factor 1 -0.0266388
RPL36A ribosomal protein L36a -0.0265434
RPL18 ribosomal protein L18 -0.0265157