Indacaterol (maleate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CALD1 caldesmon 1 0.128842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.119165
PABPC1 poly(A) binding protein, cytoplasmic 1 0.096177
RPL14 ribosomal protein L14 0.080258
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.075911
LPP LIM domain containing preferred translocation partner in lipoma 0.071185
RPS6 ribosomal protein S6 0.0711556
B2M beta-2-microglobulin 0.0659838
RB1CC1 RB1-inducible coiled-coil 1 0.0653812
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0607079
DSCAM Down syndrome cell adhesion molecule 0.0552011
PBX3 pre-B-cell leukemia homeobox 3 0.0544124
ENO2 enolase 2 (gamma, neuronal) 0.0522569
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0520594
TPM4 tropomyosin 4 0.0495345
CRY1 cryptochrome circadian clock 1 0.0485378
ZNF292 zinc finger protein 292 0.0480103
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0471042
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0452806
OGA O-GlcNAcase 0.0446406
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0439188
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0438357
BIRC6 baculoviral IAP repeat containing 6 0.0432896
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0431933
FNIP1 folliculin interacting protein 1 0.0429271
HDAC9 histone deacetylase 9 0.0428426
FHIT fragile histidine triad 0.042426
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0405973
FRMD4A FERM domain containing 4A 0.0402276
MT2A metallothionein 2A 0.0400274
PRRC2C proline-rich coiled-coil 2C 0.0399134
GOLGA4 golgin A4 0.0390321
IARS1 isoleucyl-tRNA synthetase 1 0.038832
RPS12 ribosomal protein S12 0.0384149
SBF2 SET binding factor 2 0.0383256
KMT2C lysine (K)-specific methyltransferase 2C 0.0382445
FNDC3B fibronectin type III domain containing 3B 0.037798
CALR calreticulin 0.0376028
LCORL ligand dependent nuclear receptor corepressor-like 0.0372771
AKAP9 A kinase (PRKA) anchor protein 9 0.0362813
RNF145 ring finger protein 145 0.036106
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0352502
FMNL2 formin-like 2 0.0347977
CUL3 cullin 3 0.0345666
RPL37 ribosomal protein L37 0.0345597
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0342609
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0341809
ZMYM2 zinc finger, MYM-type 2 0.0341612
OSBPL8 oxysterol binding protein-like 8 0.0340521
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0333841
KTN1 kinectin 1 (kinesin receptor) 0.0330415
SRSF11 serine/arginine-rich splicing factor 11 0.0329876
PHF3 PHD finger protein 3 0.0326988
EEF1G eukaryotic translation elongation factor 1 gamma 0.0322903
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0321935
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0319642
RPL35A ribosomal protein L35a 0.0317778
RPS17 ribosomal protein S17 0.0316084
MCTP1 multiple C2 domains, transmembrane 1 0.0311043
DGKI diacylglycerol kinase, iota 0.0310461
EFL1 elongation factor like GTPase 1 0.0310409
RAB7A RAB7A, member RAS oncogene family 0.0309622
TMSB10 thymosin beta 10 0.0308323
TBK1 TANK-binding kinase 1 0.0301083
NAP1L1 nucleosome assembly protein 1-like 1 0.0299919
RPS3 ribosomal protein S3 0.0299716
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0297006
TM9SF3 transmembrane 9 superfamily member 3 0.0295801
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0293008
FTL ferritin, light polypeptide 0.0292751
RPL5 ribosomal protein L5 0.0289257
EEF2 eukaryotic translation elongation factor 2 0.0287275
TPD52 tumor protein D52 0.0285117
GCC2 GRIP and coiled-coil domain containing 2 0.0284733
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0283993
RPL31 ribosomal protein L31 0.0283435
NUDC nudC nuclear distribution protein 0.0281732
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0281388
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0280357
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.0279897
MEF2A myocyte enhancer factor 2A 0.0279694
FOXO3 forkhead box O3 0.0279459
CD2AP CD2-associated protein 0.0278357
RPS19 ribosomal protein S19 0.0277888
ITCH itchy E3 ubiquitin protein ligase 0.0276941
UHMK1 U2AF homology motif (UHM) kinase 1 0.0276487
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0275976
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0274751
RPS21 ribosomal protein S21 0.0274742
IWS1 IWS1 homolog (S. cerevisiae) 0.0271702
DLC1 DLC1 Rho GTPase activating protein 0.0270977
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0270292
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0268678
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0268217
RPLP2 ribosomal protein, large, P2 0.0268126
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0267588
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0264517
COPA coatomer protein complex, subunit alpha 0.0263679
SAMD4A sterile alpha motif domain containing 4A 0.0261195
AFF1 AF4/FMR2 family, member 1 0.0260936

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135153
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109788
ACTG1 actin gamma 1 -0.105231
STC1 stanniocalcin 1 -0.0888459
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0867458
POTEF POTE ankyrin domain family, member F -0.0861567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0857397
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0735067
AHNAK AHNAK nucleoprotein -0.0728472
LOC112694756 uncharaterized LOC112694756 -0.0690125
FRMD6 FERM domain containing 6 -0.0682582
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0673901
SPRY4 sprouty homolog 4 (Drosophila) -0.0620271
AGO2 argonaute RISC catalytic component 2 -0.0619537
ARHGAP22 Rho GTPase activating protein 22 -0.0596483
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0587376
SGMS2 sphingomyelin synthase 2 -0.0542717
GPHN gephyrin -0.0501643
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.04925
ZNF438 zinc finger protein 438 -0.0485694
ZEB1 zinc finger E-box binding homeobox 1 -0.047527
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0463487
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0462095
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0461414
RPL7 ribosomal protein L7 -0.0456357
EXT1 exostosin glycosyltransferase 1 -0.0431266
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0416692
RAD21 RAD21 homolog (S. pombe) -0.041446
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0412003
UBC ubiquitin C -0.040386
CD44 CD44 molecule (Indian blood group) -0.0394681
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0394052
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.03922
HMGA1 high mobility group AT-hook 1 -0.0390203
C2CD2 C2 calcium-dependent domain containing 2 -0.0389124
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0387584
CDK17 cyclin-dependent kinase 17 -0.0375861
SPIDR scaffolding protein involved in DNA repair -0.0368737
EGR1 early growth response 1 -0.0362426
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0360007
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0359534
WNK1 WNK lysine deficient protein kinase 1 -0.035706
SAMD9 sterile alpha motif domain containing 9 -0.0356461
TUBB4B tubulin, beta 4B class IVb -0.0355987
UPP1 uridine phosphorylase 1 -0.0355904
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0355888
CLTC clathrin, heavy chain (Hc) -0.0345302
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0344952
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0344886
NABP1 nucleic acid binding protein 1 -0.0332251
PKM pyruvate kinase, muscle -0.0317729
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0315986
RPS2 ribosomal protein S2 -0.0314965
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0314522
EFNB2 ephrin-B2 -0.0314011
ILF3 interleukin enhancer binding factor 3, 90kDa -0.030611
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0305587
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0298928
RUNX1 runt-related transcription factor 1 -0.0297798
SMYD3 SET and MYND domain containing 3 -0.0294247
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0291327
MKI67 marker of proliferation Ki-67 -0.0290775
JUN jun proto-oncogene -0.0289981
CAPN2 calpain 2, (m/II) large subunit -0.0289916
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0286602
TASOR2 transcription activation suppressor family member 2 -0.028599
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -0.0280319
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0274006
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0270823
RPLP0 ribosomal protein, large, P0 -0.0267778
H1-4 H1.4 linker histone, cluster member -0.025552
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0254807
SERBP1 SERPINE1 mRNA binding protein 1 -0.0254573
CORO1C coronin, actin binding protein, 1C -0.0254482
PRPF8 pre-mRNA processing factor 8 -0.0250627
BIRC2 baculoviral IAP repeat containing 2 -0.0249104
HMGA2 high mobility group AT-hook 2 -0.0247729
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0246939
AKAP12 A kinase (PRKA) anchor protein 12 -0.0246301
RBM39 RNA binding motif protein 39 -0.0245721
MTAP methylthioadenosine phosphorylase -0.0245487
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0245377
ADAR adenosine deaminase, RNA-specific -0.0244945
MX1 MX dynamin-like GTPase 1 -0.0244801
ANXA2 annexin A2 -0.0243317
KLF10 Kruppel-like factor 10 -0.0242978
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0239045
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0238188
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.023702
R3HDM1 R3H domain containing 1 -0.0236712
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0235301
TRA2B transformer 2 beta homolog (Drosophila) -0.0235186
ZBTB38 zinc finger and BTB domain containing 38 -0.0235064
ATAD2 ATPase family, AAA domain containing 2 -0.0233254
SLC38A2 solute carrier family 38, member 2 -0.0231993
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0227275
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.022625
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0225232
RPLP1 ribosomal protein, large, P1 -0.0224916
STK4 serine/threonine kinase 4 -0.0224578