Indacaterol (maleate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.130822
ELL2 elongation factor, RNA polymerase II, 2 0.10874
B2M beta-2-microglobulin 0.0938295
UGCG UDP-glucose ceramide glucosyltransferase 0.087875
RB1CC1 RB1-inducible coiled-coil 1 0.0646874
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.059364
OGA O-GlcNAcase 0.0582167
FMNL2 formin-like 2 0.0558741
ADM adrenomedullin 0.0516579
GOLGA4 golgin A4 0.0502058
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.04991
JMJD1C jumonji domain containing 1C 0.0477748
ANLN anillin, actin binding protein 0.0413732
ARRDC3 arrestin domain containing 3 0.0408838
ATP13A3 ATPase type 13A3 0.0403243
SPAG9 sperm associated antigen 9 0.0398808
UBA6 ubiquitin-like modifier activating enzyme 6 0.0390864
FNIP1 folliculin interacting protein 1 0.0389218
SOD2 superoxide dismutase 2, mitochondrial 0.038209
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0358323
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0352676
NGLY1 N-glycanase 1 0.0346983
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0337956
MXI1 MAX interactor 1, dimerization protein 0.0336994
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0317671
CADM1 cell adhesion molecule 1 0.0314481
BCLAF1 BCL2-associated transcription factor 1 0.0307319
ESYT2 extended synaptotagmin-like protein 2 0.0296413
CCNL1 cyclin L1 0.0292206
PHIP pleckstrin homology domain interacting protein 0.0283112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0280987
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.027814
CDK19 cyclin-dependent kinase 19 0.027493
STC1 stanniocalcin 1 0.0273365
PCBP3 poly(rC) binding protein 3 0.0272515
VEGFA vascular endothelial growth factor A 0.0262215
SDC4 syndecan 4 0.0261002
SUCO SUN domain containing ossification factor 0.0260118
HELZ helicase with zinc finger 0.0255738
DSCAM Down syndrome cell adhesion molecule 0.0252391
MAP2K1 mitogen-activated protein kinase kinase 1 0.0252019
TENT5A terminal nucleotidyltransferase 5A 0.0247466
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0245568
USP47 ubiquitin specific peptidase 47 0.0241434
RAB8B RAB8B, member RAS oncogene family 0.0240398
MMP12 matrix metallopeptidase 12 0.0232639
SNX9 sorting nexin 9 0.0231774
YTHDC1 YTH domain containing 1 0.0230742
MSN moesin 0.0228693
RAB6A RAB6A, member RAS oncogene family 0.0224744
TMEM41B transmembrane protein 41B 0.0224524
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.022191
FNDC3B fibronectin type III domain containing 3B 0.0220796
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0220478
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0219028
RAP1B RAP1B, member of RAS oncogene family 0.0218992
MYOF myoferlin 0.0213398
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0206619
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0205843
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0205666
AKAP12 A kinase (PRKA) anchor protein 12 0.0205095
PIAS1 protein inhibitor of activated STAT, 1 0.0202922
WTAP Wilms tumor 1 associated protein 0.0200696
RASA2 RAS p21 protein activator 2 0.0197435
WDR45B WD repeat domain 45B 0.0194937
CACUL1 CDK2-associated, cullin domain 1 0.0191897
COPA coatomer protein complex, subunit alpha 0.0190622
AMPD3 adenosine monophosphate deaminase 3 0.0189556
PTBP3 polypyrimidine tract binding protein 3 0.0188955
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0188929
UBE2H ubiquitin-conjugating enzyme E2H 0.0186872
NPEPPS aminopeptidase puromycin sensitive 0.0185594
ETNK1 ethanolamine kinase 1 0.0185229
PCBP2 poly(rC) binding protein 2 0.0184814
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0184167
NRIP1 nuclear receptor interacting protein 1 0.0182902
ANKRD10 ankyrin repeat domain 10 0.0182655
DOCK5 dedicator of cytokinesis 5 0.0182505
SEC23A Sec23 homolog A (S. cerevisiae) 0.01819
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0181819
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.0181556
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0180538
RAI1 retinoic acid induced 1 0.0177976
CHD1 chromodomain helicase DNA binding protein 1 0.0177765
CEP250 centrosomal protein 250kDa 0.0177551
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0176425
KMT2E lysine (K)-specific methyltransferase 2E 0.0176003
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0175696
NT5C2 5'-nucleotidase, cytosolic II 0.0173323
EPS8 epidermal growth factor receptor pathway substrate 8 0.0172251
XPO1 exportin 1 0.0172146
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0172002
RTN4 reticulon 4 0.0171202
TRA2A transformer 2 alpha homolog (Drosophila) 0.0169912
MARCHF6 membrane associated ring-CH-type finger 6 0.0168608
SNX13 sorting nexin 13 0.0168509
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0168109
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0166456
RBM39 RNA binding motif protein 39 0.0166213
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.0165539

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.191091
VIM vimentin -0.176316
GLIS3 GLIS family zinc finger 3 -0.145697
FRMD4A FERM domain containing 4A -0.131571
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.123322
BICC1 BicC family RNA binding protein 1 -0.10252
CD44 CD44 molecule (Indian blood group) -0.101919
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100483
EXT1 exostosin glycosyltransferase 1 -0.0921945
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0850845
COL6A3 collagen, type VI, alpha 3 -0.0720184
HMGA2 high mobility group AT-hook 2 -0.0715778
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0694303
HLA-B major histocompatibility complex, class I, B -0.0655463
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0642496
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0641274
ANXA2 annexin A2 -0.062436
TPT1 tumor protein, translationally-controlled 1 -0.0622379
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0614172
TGFBI transforming growth factor, beta-induced, 68kDa -0.0596953
TMSB10 thymosin beta 10 -0.0594952
THBS1 thrombospondin 1 -0.0582358
NAV1 neuron navigator 1 -0.0572025
RPS24 ribosomal protein S24 -0.0554408
AHNAK AHNAK nucleoprotein -0.0552168
TPM1 tropomyosin 1 (alpha) -0.0539023
RNF213 ring finger protein 213 -0.0522975
TNS3 tensin 3 -0.0522874
CDH13 cadherin 13 -0.0514061
PTPRK protein tyrosine phosphatase, receptor type, K -0.0512835
ZMYND8 zinc finger, MYND-type containing 8 -0.0503446
LOC112694756 uncharaterized LOC112694756 -0.0497606
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0494404
RAD51B RAD51 paralog B -0.0488305
VCL vinculin -0.0482086
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0480457
RPS6 ribosomal protein S6 -0.0478076
RIGI RNA sensor RIG-I -0.0466486
ACTG1 actin gamma 1 -0.0464222
SMAD3 SMAD family member 3 -0.04525
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0447826
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0438616
ZBTB20 zinc finger and BTB domain containing 20 -0.0429895
FTH1 ferritin, heavy polypeptide 1 -0.0429737
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0428757
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0423785
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0421387
NAP1L1 nucleosome assembly protein 1-like 1 -0.0414784
TUBB tubulin, beta class I -0.0409088
TRIO trio Rho guanine nucleotide exchange factor -0.040743
RPL23 ribosomal protein L23 -0.0407105
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0406428
RRBP1 ribosome binding protein 1 -0.0404654
DST dystonin -0.040452
RAI14 retinoic acid induced 14 -0.0396582
RPL35A ribosomal protein L35a -0.0396222
PSD3 pleckstrin and Sec7 domain containing 3 -0.0385893
CTSD cathepsin D -0.0383868
LDHA lactate dehydrogenase A -0.0371062
SFRP1 secreted frizzled-related protein 1 -0.0366523
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0359193
TPM4 tropomyosin 4 -0.0357931
EGFR epidermal growth factor receptor -0.0357544
ASPH aspartate beta-hydroxylase -0.0352981
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0351477
DIAPH2 diaphanous-related formin 2 -0.0338768
FLNA filamin A, alpha -0.0334087
RPL26 ribosomal protein L26 -0.033374
ATXN1 ataxin 1 -0.0332435
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0331974
CANX calnexin -0.0327197
LPP LIM domain containing preferred translocation partner in lipoma -0.0327148
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0326954
RPS8 ribosomal protein S8 -0.0325953
COL5A1 collagen, type V, alpha 1 -0.0325879
RPLP1 ribosomal protein, large, P1 -0.0325835
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0322177
FRMD5 FERM domain containing 5 -0.0322026
GNAS GNAS complex locus -0.0321717
RACK1 receptor for activated C kinase 1 -0.0317354
RPS4X ribosomal protein S4, X-linked -0.0313362
SVIL supervillin -0.0311644
UTRN utrophin -0.0308809
HLA-E major histocompatibility complex, class I, E -0.0304546
RPL11 ribosomal protein L11 -0.0304098
SQSTM1 sequestosome 1 -0.0302887
SMYD3 SET and MYND domain containing 3 -0.0301835
EXOC4 exocyst complex component 4 -0.0299936
MX1 MX dynamin-like GTPase 1 -0.0298758
ENO1 enolase 1, (alpha) -0.0298147
C6ORF62 chromosome 6 open reading frame 62 -0.0297144
DPYD dihydropyrimidine dehydrogenase -0.02908
VCAN versican -0.0289827
FAM20C family with sequence similarity 20, member C -0.0289182
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0288
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0287458
QKI QKI, KH domain containing, RNA binding -0.028412
HLA-A major histocompatibility complex, class I, A -0.0281837
ARID1B AT rich interactive domain 1B (SWI1-like) -0.027946
MAML2 mastermind-like 2 (Drosophila) -0.0278891