Indacaterol (maleate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.120526
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0653153
B2M beta-2-microglobulin 0.0619633
NRXN3 neurexin 3 0.0570828
VEGFA vascular endothelial growth factor A 0.0513238
ELL2 elongation factor, RNA polymerase II, 2 0.0465619
FNIP1 folliculin interacting protein 1 0.0462654
TENT5A terminal nucleotidyltransferase 5A 0.0454529
EFNA5 ephrin-A5 0.0411614
ZCCHC7 zinc finger, CCHC domain containing 7 0.0366899
TENT2 terminal nucleotidyltransferase 2 0.0365802
DST dystonin 0.0334873
TTC3 tetratricopeptide repeat domain 3 0.0324754
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0320729
ZMIZ1 zinc finger, MIZ-type containing 1 0.0318818
MBNL2 muscleblind-like splicing regulator 2 0.0308036
LPP LIM domain containing preferred translocation partner in lipoma 0.0306182
SBF2 SET binding factor 2 0.0305881
CMIP c-Maf inducing protein 0.0305752
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0304255
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0301457
LIMS1 LIM and senescent cell antigen-like domains 1 0.0299777
NALF1 NALCN channel auxiliary factor 1 0.0297978
ZBTB20 zinc finger and BTB domain containing 20 0.0297714
NCOR2 nuclear receptor corepressor 2 0.0294184
FAM13A family with sequence similarity 13, member A 0.029212
MED13L mediator complex subunit 13-like 0.0291636
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0289189
RAD51B RAD51 paralog B 0.0280699
NBAS neuroblastoma amplified sequence 0.0277545
CLIC4 chloride intracellular channel 4 0.0274156
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0273961
ZMYND8 zinc finger, MYND-type containing 8 0.027297
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0272833
PRELID2 PRELI domain containing 2 0.0268753
MAP2K1 mitogen-activated protein kinase kinase 1 0.0263689
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0261724
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0257927
AGO3 argonaute RISC catalytic component 3 0.0257638
GLRX glutaredoxin (thioltransferase) 0.0254075
OSBPL3 oxysterol binding protein-like 3 0.025262
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0250884
CDH13 cadherin 13 0.0249557
F3 coagulation factor III (thromboplastin, tissue factor) 0.0249075
MYH9 myosin, heavy chain 9, non-muscle 0.0248314
PCNX1 pecanex 1 0.0246862
RIN2 Ras and Rab interactor 2 0.024009
UBA6 ubiquitin-like modifier activating enzyme 6 0.0239775
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0237731
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0231312
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0231223
FAM13B family with sequence similarity 13, member B 0.0229934
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0229415
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0227374
NBEAL1 neurobeachin-like 1 0.0226791
XPO1 exportin 1 0.02253
SDK1 sidekick cell adhesion molecule 1 0.0222529
KAZN kazrin, periplakin interacting protein 0.0219216
GGNBP2 gametogenetin binding protein 2 0.0218655
NAV1 neuron navigator 1 0.0217829
EGFR epidermal growth factor receptor 0.0217335
RAB6A RAB6A, member RAS oncogene family 0.0216497
ZNF146 zinc finger protein 146 0.0215483
SNX9 sorting nexin 9 0.0213897
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0212094
DYNC2I1 dynein 2 intermediate chain 1 0.0211
MAML2 mastermind-like 2 (Drosophila) 0.0208279
PDE4D phosphodiesterase 4D, cAMP-specific 0.0207871
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0207186
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0207103
ERRFI1 ERBB receptor feedback inhibitor 1 0.0203528
TMEM167A transmembrane protein 167A 0.0203475
TMEM165 transmembrane protein 165 0.0202863
RSRC2 arginine/serine-rich coiled-coil 2 0.0201792
SOX5 SRY (sex determining region Y)-box 5 0.0200965
TNS3 tensin 3 0.0200773
JAK1 Janus kinase 1 0.0200725
BIRC6 baculoviral IAP repeat containing 6 0.0199932
FMNL2 formin-like 2 0.0198552
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0197309
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0195286
SH3GL1 SH3-domain GRB2-like 1 0.0195069
LOC102724023 ES1 protein homolog, mitochondrial 0.0194676
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0194559
COG6 component of oligomeric golgi complex 6 0.0193878
PID1 phosphotyrosine interaction domain containing 1 0.0193659
BCAR3 breast cancer anti-estrogen resistance 3 0.0193102
PRKCA protein kinase C, alpha 0.0192813
ANKRD11 ankyrin repeat domain 11 0.0191823
YAP1 Yes-associated protein 1 0.0191726
NF1 neurofibromin 1 0.019058
RANBP9 RAN binding protein 9 0.0190537
PHF21A PHD finger protein 21A 0.0190219
MYO1E myosin IE 0.0189278
BUB3 BUB3 mitotic checkpoint protein 0.0189189
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0189161
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0188882
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.018776
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0187374
INTS6 integrator complex subunit 6 0.0187234

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.288901
TMSB10 thymosin beta 10 -0.212137
COL6A3 collagen, type VI, alpha 3 -0.175513
MT2A metallothionein 2A -0.131371
VIM vimentin -0.119776
TGFBI transforming growth factor, beta-induced, 68kDa -0.118164
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.107388
HLA-B major histocompatibility complex, class I, B -0.095731
UBC ubiquitin C -0.0789777
AHNAK AHNAK nucleoprotein -0.0704773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0641653
SDC4 syndecan 4 -0.0626716
TXNIP thioredoxin interacting protein -0.0608461
PTMA prothymosin, alpha -0.0599206
SEC31A SEC31 homolog A (S. cerevisiae) -0.0572238
ANXA2 annexin A2 -0.056883
CALU calumenin -0.0548179
SRPK2 SRSF protein kinase 2 -0.0547482
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.054691
FN1 fibronectin 1 -0.0513813
SMAD3 SMAD family member 3 -0.0446945
ENO1 enolase 1, (alpha) -0.0427582
COL1A1 collagen, type I, alpha 1 -0.04223
NDRG1 N-myc downstream regulated 1 -0.0416584
WTAP Wilms tumor 1 associated protein -0.0414281
FTL ferritin, light polypeptide -0.0412141
LDHA lactate dehydrogenase A -0.0407451
CAV1 caveolin 1, caveolae protein, 22kDa -0.0406101
COL1A2 collagen, type I, alpha 2 -0.0399248
H3-3B H3.3 histone B -0.0392755
LOXL2 lysyl oxidase-like 2 -0.0383782
TAGLN2 transgelin 2 -0.0377825
FNDC3A fibronectin type III domain containing 3A -0.0376372
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0370207
CALD1 caldesmon 1 -0.0365678
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0365524
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0362631
EEF2 eukaryotic translation elongation factor 2 -0.0356536
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0353345
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0352313
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0350848
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0344682
CLTC clathrin, heavy chain (Hc) -0.0343543
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0338038
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0335623
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.033361
GANAB glucosidase, alpha; neutral AB -0.0330869
FLNA filamin A, alpha -0.0329289
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0328543
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.032313
PDIA3 protein disulfide isomerase family A, member 3 -0.0321165
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0319341
RPLP1 ribosomal protein, large, P1 -0.031783
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0317174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0315152
RAB10 RAB10, member RAS oncogene family -0.0303569
ZEB2 zinc finger E-box binding homeobox 2 -0.0301421
USP34 ubiquitin specific peptidase 34 -0.0300726
CD44 CD44 molecule (Indian blood group) -0.0298987
CDK6 cyclin-dependent kinase 6 -0.0298828
LONP2 lon peptidase 2, peroxisomal -0.0298728
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0295456
SPAG9 sperm associated antigen 9 -0.0294707
TRIO trio Rho guanine nucleotide exchange factor -0.0292958
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0286775
TPM4 tropomyosin 4 -0.0281831
CCNI cyclin I -0.0275945
WAC WW domain containing adaptor with coiled-coil -0.0274794
RUNX2 runt-related transcription factor 2 -0.0274634
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0273692
ANKRD12 ankyrin repeat domain 12 -0.027201
RBM25 RNA binding motif protein 25 -0.0270093
GRB10 growth factor receptor-bound protein 10 -0.0268413
SOS1 son of sevenless homolog 1 (Drosophila) -0.0266719
LOC112694756 uncharaterized LOC112694756 -0.0266061
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0265668
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0265466
SOS2 son of sevenless homolog 2 (Drosophila) -0.0264027
RLIM ring finger protein, LIM domain interacting -0.0261606
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0261446
ANXA5 annexin A5 -0.0261173
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0261065
UBE2H ubiquitin-conjugating enzyme E2H -0.025817
FKBP10 FK506 binding protein 10, 65 kDa -0.0256106
FAT1 FAT atypical cadherin 1 -0.0254999
EXOC4 exocyst complex component 4 -0.0253494
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0252932
ZNF609 zinc finger protein 609 -0.025136
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0250324
SFTPA2 surfactant protein A2 -0.0248693
RTN4 reticulon 4 -0.0244062
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0242206
RPS27A ribosomal protein S27a -0.0242042
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0241521
ECE1 endothelin converting enzyme 1 -0.0240994
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.024062
TPR translocated promoter region, nuclear basket protein -0.0239499
CSDE1 cold shock domain containing E1, RNA-binding -0.0238499
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0238097
AHR aryl hydrocarbon receptor -0.0237602