Indacaterol (maleate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.0835441
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0708114
STC2 stanniocalcin 2 0.0552318
CD109 CD109 molecule 0.0547618
TMEM156 transmembrane protein 156 0.0527783
AKAP12 A kinase (PRKA) anchor protein 12 0.048036
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0453513
NRG1 neuregulin 1 0.0442115
MYH9 myosin, heavy chain 9, non-muscle 0.0407551
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.03986
VEGFA vascular endothelial growth factor A 0.0387914
ENO2 enolase 2 (gamma, neuronal) 0.0324736
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0319892
LIMCH1 LIM and calponin homology domains 1 0.0300743
RTN4 reticulon 4 0.0296621
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0288722
FAM13A family with sequence similarity 13, member A 0.0271818
KLHL5 kelch-like family member 5 0.0265003
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256453
GOLGA4 golgin A4 0.025103
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0248283
TM9SF3 transmembrane 9 superfamily member 3 0.0244604
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0243916
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.023867
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0236529
OGA O-GlcNAcase 0.0236069
PTBP3 polypyrimidine tract binding protein 3 0.023061
GPC6 glypican 6 0.0228762
ANKRD11 ankyrin repeat domain 11 0.0224636
CHD1L chromodomain helicase DNA binding protein 1-like 0.0223735
SOS1 son of sevenless homolog 1 (Drosophila) 0.0223216
WAC WW domain containing adaptor with coiled-coil 0.0222028
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.021998
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0218146
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0218096
PDLIM5 PDZ and LIM domain 5 0.0211359
BCLAF1 BCL2-associated transcription factor 1 0.0208318
TPM3 tropomyosin 3 0.0206336
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205523
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0200352
ANXA5 annexin A5 0.0197621
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0196315
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0194157
PLIN2 perilipin 2 0.0193053
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0193042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0191142
CDYL chromodomain protein, Y-like 0.0190347
OSMR oncostatin M receptor 0.0189567
CDCP1 CUB domain containing protein 1 0.0189292
PRRC2C proline-rich coiled-coil 2C 0.0188617
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0185963
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0184031
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0183578
ZNF292 zinc finger protein 292 0.0180335
HIPK2 homeodomain interacting protein kinase 2 0.0178974
NKTR natural killer cell triggering receptor 0.0176667
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0174095
TMEM165 transmembrane protein 165 0.0173655
ATP13A3 ATPase type 13A3 0.0173432
ADAM9 ADAM metallopeptidase domain 9 0.0172451
KDM6A lysine (K)-specific demethylase 6A 0.0172119
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0169994
UGCG UDP-glucose ceramide glucosyltransferase 0.0169425
PTBP2 polypyrimidine tract binding protein 2 0.0168172
WDR45B WD repeat domain 45B 0.0165315
MRPS6 mitochondrial ribosomal protein S6 0.016506
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0163943
ZNF841 zinc finger protein 841 0.0163577
SUCO SUN domain containing ossification factor 0.0162584
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0162282
TRIP12 thyroid hormone receptor interactor 12 0.0162221
FAM168B family with sequence similarity 168, member B 0.0158709
SNX9 sorting nexin 9 0.0158516
HMGB3 high mobility group box 3 0.0157611
NPC1 Niemann-Pick disease, type C1 0.0157179
SSH1 slingshot protein phosphatase 1 0.0156584
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0155238
RAI14 retinoic acid induced 14 0.0155123
TENT2 terminal nucleotidyltransferase 2 0.0153421
CEP95 centrosomal protein 95kDa 0.0153141
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0153029
ZMYM2 zinc finger, MYM-type 2 0.0152921
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0152114
SLMAP sarcolemma associated protein 0.0151809
KLC1 kinesin light chain 1 0.0151786
EGFR epidermal growth factor receptor 0.0151663
BIRC6 baculoviral IAP repeat containing 6 0.0151015
XPO1 exportin 1 0.0150602
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0150402
PGK1 phosphoglycerate kinase 1 0.0150072
FBXL5 F-box and leucine-rich repeat protein 5 0.0149904
LRP5 low density lipoprotein receptor-related protein 5 0.0149814
RNF145 ring finger protein 145 0.0147995
RAB8B RAB8B, member RAS oncogene family 0.0147217
ADAM17 ADAM metallopeptidase domain 17 0.0147144
ZFP36L1 ZFP36 ring finger protein-like 1 0.0146733
HELZ helicase with zinc finger 0.0146248
CTNND1 catenin (cadherin-associated protein), delta 1 0.0142649
RBM6 RNA binding motif protein 6 0.014184
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0140452

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.513609
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.165225
FN1 fibronectin 1 -0.103603
FTH1 ferritin, heavy polypeptide 1 -0.101905
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.101346
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0905683
MT2A metallothionein 2A -0.0836235
EXT1 exostosin glycosyltransferase 1 -0.0813861
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0740559
RPL26 ribosomal protein L26 -0.0688083
SQSTM1 sequestosome 1 -0.0680801
RPLP1 ribosomal protein, large, P1 -0.062775
NAMPT nicotinamide phosphoribosyltransferase -0.0608966
TPT1 tumor protein, translationally-controlled 1 -0.0571473
RACK1 receptor for activated C kinase 1 -0.0567117
CANX calnexin -0.0566618
LMNA lamin A/C -0.0563971
GLIS3 GLIS family zinc finger 3 -0.0559302
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0553378
FTL ferritin, light polypeptide -0.0549535
RPS24 ribosomal protein S24 -0.0545279
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0521464
S100A10 S100 calcium binding protein A10 -0.0520414
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0516295
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0512947
GNAS GNAS complex locus -0.0501433
RPS6 ribosomal protein S6 -0.0492941
RPS20 ribosomal protein S20 -0.0489181
RPL35A ribosomal protein L35a -0.0484846
LOC112694756 uncharaterized LOC112694756 -0.0461495
RPS19 ribosomal protein S19 -0.0445881
HLA-B major histocompatibility complex, class I, B -0.0422609
VIM vimentin -0.0408642
PTMA prothymosin, alpha -0.0399472
ARF1 ADP-ribosylation factor 1 -0.0395615
NDRG1 N-myc downstream regulated 1 -0.0379604
RPL11 ribosomal protein L11 -0.0374362
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0369925
RPL12 ribosomal protein L12 -0.0369342
H1-0 H1.0 linker histone -0.0365512
RPS8 ribosomal protein S8 -0.0364427
SOD2 superoxide dismutase 2, mitochondrial -0.0355013
ANKRD28 ankyrin repeat domain 28 -0.0354187
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0351178
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.033895
RPS29 ribosomal protein S29 -0.0338131
RPL23 ribosomal protein L23 -0.0337047
EIF1 eukaryotic translation initiation factor 1 -0.0332039
RPL9 ribosomal protein L9 -0.0331494
RPLP0 ribosomal protein, large, P0 -0.0325405
TMSB10 thymosin beta 10 -0.032503
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0324499
PDE4D phosphodiesterase 4D, cAMP-specific -0.0323324
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0319064
NCOA7 nuclear receptor coactivator 7 -0.031684
MBD5 methyl-CpG binding domain protein 5 -0.0316006
TPI1 triosephosphate isomerase 1 -0.0314477
RPL30 ribosomal protein L30 -0.0313538
AHR aryl hydrocarbon receptor -0.0311893
RPS16 ribosomal protein S16 -0.0311035
RPS27A ribosomal protein S27a -0.0308819
RPL38 ribosomal protein L38 -0.0301931
RPS5 ribosomal protein S5 -0.0300824
RPL28 ribosomal protein L28 -0.0295404
RPS12 ribosomal protein S12 -0.0294508
TAS2R14 taste receptor, type 2, member 14 -0.0290274
RPL37 ribosomal protein L37 -0.0287286
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0281004
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0280559
RPL19 ribosomal protein L19 -0.0280204
RPS25 ribosomal protein S25 -0.0269725
UGDH UDP-glucose 6-dehydrogenase -0.0263686
RPS21 ribosomal protein S21 -0.026111
INTS6 integrator complex subunit 6 -0.0259262
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0256599
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0256521
MORF4L2 mortality factor 4 like 2 -0.0254984
EMP1 epithelial membrane protein 1 -0.025365
AEBP2 AE binding protein 2 -0.0251977
RPL37A ribosomal protein L37a -0.0251825
ALCAM activated leukocyte cell adhesion molecule -0.0251807
RPL34 ribosomal protein L34 -0.0249612
RPL32 ribosomal protein L32 -0.0247933
S100A6 S100 calcium binding protein A6 -0.0244666
TMEM263 transmembrane protein 263 -0.0241473
RPS27 ribosomal protein S27 -0.0240041
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0238668
RPL36 ribosomal protein L36 -0.0237647
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0237297
RAD21 RAD21 homolog (S. pombe) -0.0235325
RPL31 ribosomal protein L31 -0.0231961
MBNL1 muscleblind-like splicing regulator 1 -0.0231317
ASPH aspartate beta-hydroxylase -0.0229857
RPS11 ribosomal protein S11 -0.0229041
RNF213 ring finger protein 213 -0.0228976
HMGA1 high mobility group AT-hook 1 -0.0228174
MTDH metadherin -0.0227698
CALU calumenin -0.0226664
DSTN destrin (actin depolymerizing factor) -0.0224932
RPS23 ribosomal protein S23 -0.0224256