Indacaterol (maleate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Indacaterol (maleate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Indacaterol (maleate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0575013
ESYT2 extended synaptotagmin-like protein 2 0.0551138
ETNK1 ethanolamine kinase 1 0.0480463
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0462949
OGA O-GlcNAcase 0.0440664
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0418713
ITGA6 integrin, alpha 6 0.0402891
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0400639
UBA6 ubiquitin-like modifier activating enzyme 6 0.0341596
LMO7 LIM domain 7 0.0318961
BRWD3 bromodomain and WD repeat domain containing 3 0.0312402
PDGFA platelet-derived growth factor alpha polypeptide 0.0311404
ANLN anillin, actin binding protein 0.0311367
ERRFI1 ERBB receptor feedback inhibitor 1 0.0311068
TMEM41B transmembrane protein 41B 0.0301228
CEMIP2 cell migration inducing hyaluronidase 2 0.0301066
RICTOR RPTOR independent companion of MTOR, complex 2 0.0297642
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0294999
DSCAM Down syndrome cell adhesion molecule 0.0292313
ITPRID2 ITPR interacting domain containing 2 0.0284048
KMT2C lysine (K)-specific methyltransferase 2C 0.0282585
WDFY2 WD repeat and FYVE domain containing 2 0.02774
ABHD2 abhydrolase domain containing 2 0.0272152
AFDN afadin, adherens junction formation factor 0.0268732
CEP95 centrosomal protein 95kDa 0.0267501
SPRED2 sprouty-related, EVH1 domain containing 2 0.0262362
BIRC6 baculoviral IAP repeat containing 6 0.0259517
COPA coatomer protein complex, subunit alpha 0.0252893
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0249454
SBF2 SET binding factor 2 0.0248966
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0247745
EFNB2 ephrin-B2 0.0245352
CD46 CD46 molecule, complement regulatory protein 0.0243974
USP9X ubiquitin specific peptidase 9, X-linked 0.02392
VCL vinculin 0.0236141
KDM6A lysine (K)-specific demethylase 6A 0.0235564
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0230362
MYH9 myosin, heavy chain 9, non-muscle 0.0230217
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0229228
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0228419
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0226488
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0225528
SUCO SUN domain containing ossification factor 0.0225246
TM9SF2 transmembrane 9 superfamily member 2 0.0220677
ADAM17 ADAM metallopeptidase domain 17 0.021992
ARL5B ADP-ribosylation factor-like 5B 0.0218074
KDM3A lysine (K)-specific demethylase 3A 0.0211445
SETD5 SET domain containing 5 0.0211341
HELZ helicase with zinc finger 0.0208638
SNX9 sorting nexin 9 0.0206978
EEF2 eukaryotic translation elongation factor 2 0.0205647
MACC1 metastasis associated in colon cancer 1 0.020344
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0198465
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0196048
JAG1 jagged 1 0.0192811
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.019239
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.019227
GARS1 glycyl-tRNA synthetase 1 0.0191265
NPTN neuroplastin 0.018894
JMJD1C jumonji domain containing 1C 0.0184014
MARCHF6 membrane associated ring-CH-type finger 6 0.0181931
ZFC3H1 zinc finger, C3H1-type containing 0.0181537
PGK1 phosphoglycerate kinase 1 0.0181517
MORF4L2 mortality factor 4 like 2 0.0180991
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0177855
ANO6 anoctamin 6 0.0174107
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0173658
ZNF654 zinc finger protein 654 0.0173447
SERINC1 serine incorporator 1 0.0170856
NUP58 nucleoporin 58 0.0168647
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0168371
RASA3 RAS p21 protein activator 3 0.0168202
USP3 ubiquitin specific peptidase 3 0.0167509
SPAG9 sperm associated antigen 9 0.0165944
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0165005
ANXA11 annexin A11 0.0164098
MXD1 MAX dimerization protein 1 0.016379
CTNND1 catenin (cadherin-associated protein), delta 1 0.0163384
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0163367
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0161965
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0161569
RLIM ring finger protein, LIM domain interacting 0.0160199
KDM7A lysine (K)-specific demethylase 7A 0.0160024
TOP2B topoisomerase (DNA) II beta 180kDa 0.0159979
GAN gigaxonin 0.0159407
CCDC82 coiled-coil domain containing 82 0.0156784
YME1L1 YME1-like 1 ATPase 0.0155625
USP34 ubiquitin specific peptidase 34 0.0154401
TMCC1 transmembrane and coiled-coil domain family 1 0.0152017
TMEM39A transmembrane protein 39A 0.0151586
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0151088
RBM39 RNA binding motif protein 39 0.0150276
WDR45B WD repeat domain 45B 0.0149137
TENT2 terminal nucleotidyltransferase 2 0.0148758
KIF16B kinesin family member 16B 0.0148253
ZNF292 zinc finger protein 292 0.0148129
EPS8 epidermal growth factor receptor pathway substrate 8 0.0147577
PDE8A phosphodiesterase 8A 0.014637
ABI1 abl-interactor 1 0.0146084
ARRDC3 arrestin domain containing 3 0.0145759

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.216279
PTMA prothymosin, alpha -0.181505
TPT1 tumor protein, translationally-controlled 1 -0.156193
RPL35A ribosomal protein L35a -0.147411
RPS6 ribosomal protein S6 -0.138108
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128425
TMSB10 thymosin beta 10 -0.120487
CCND1 cyclin D1 -0.097243
RPS8 ribosomal protein S8 -0.0942157
RPL23 ribosomal protein L23 -0.093649
NKD1 naked cuticle homolog 1 (Drosophila) -0.0908136
RPS19 ribosomal protein S19 -0.0903659
RPLP1 ribosomal protein, large, P1 -0.0884914
RPL37A ribosomal protein L37a -0.0851274
FTL ferritin, light polypeptide -0.0822529
SDK1 sidekick cell adhesion molecule 1 -0.0791124
RPL26 ribosomal protein L26 -0.0753128
ACTG1 actin gamma 1 -0.073102
RPL31 ribosomal protein L31 -0.0694805
RPLP2 ribosomal protein, large, P2 -0.0674867
RPS24 ribosomal protein S24 -0.0635905
CDH13 cadherin 13 -0.0622522
RAD51B RAD51 paralog B -0.0622209
RPS25 ribosomal protein S25 -0.061465
RPS13 ribosomal protein S13 -0.0606351
PDE4D phosphodiesterase 4D, cAMP-specific -0.060618
WWOX WW domain containing oxidoreductase -0.060495
VIM vimentin -0.0598502
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0593437
RPS12 ribosomal protein S12 -0.0586361
MT2A metallothionein 2A -0.0586033
RPS3 ribosomal protein S3 -0.0577445
RPS27A ribosomal protein S27a -0.0576179
RPL12 ribosomal protein L12 -0.0566563
HMGA1 high mobility group AT-hook 1 -0.0557722
CDK6 cyclin-dependent kinase 6 -0.0546504
RPL19 ribosomal protein L19 -0.0540827
RPL9 ribosomal protein L9 -0.0539263
RPL11 ribosomal protein L11 -0.0532259
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.052652
KRT18 keratin 18, type I -0.0509899
RPS23 ribosomal protein S23 -0.0509715
NAV2 neuron navigator 2 -0.0495837
RPL36A ribosomal protein L36a -0.0485007
RPL5 ribosomal protein L5 -0.0468953
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0455056
RPL28 ribosomal protein L28 -0.045435
LDHA lactate dehydrogenase A -0.0452757
EIF5B eukaryotic translation initiation factor 5B -0.045073
RBP1 retinol binding protein 1, cellular -0.0448232
RPS14 ribosomal protein S14 -0.0443647
RPS17 ribosomal protein S17 -0.044009
RPS16 ribosomal protein S16 -0.0436727
RPL35 ribosomal protein L35 -0.0431443
RPL34 ribosomal protein L34 -0.0429925
INTS6 integrator complex subunit 6 -0.0426167
RPL38 ribosomal protein L38 -0.0423509
RPS5 ribosomal protein S5 -0.0416171
EXOC4 exocyst complex component 4 -0.0415065
RPS29 ribosomal protein S29 -0.0406195
RPLP0 ribosomal protein, large, P0 -0.0400737
ADGRL2 adhesion G protein-coupled receptor L2 -0.0399064
RPS11 ribosomal protein S11 -0.0396006
RPS21 ribosomal protein S21 -0.0394475
HMGB1 high mobility group box 1 -0.0392253
SKAP1 src kinase associated phosphoprotein 1 -0.0382286
RPL7A ribosomal protein L7a -0.0380307
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.037242
TUBA1B tubulin, alpha 1b -0.0369144
RPL36 ribosomal protein L36 -0.0366498
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0365474
RPL27A ribosomal protein L27a -0.0363797
FHIT fragile histidine triad -0.0362265
BPTF bromodomain PHD finger transcription factor -0.0361805
MYO1D myosin ID -0.036029
POTEF POTE ankyrin domain family, member F -0.035858
RACK1 receptor for activated C kinase 1 -0.0353115
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0352662
PA2G4 proliferation-associated 2G4, 38kDa -0.0352578
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0350571
MRPS6 mitochondrial ribosomal protein S6 -0.0344611
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.034173
TPI1 triosephosphate isomerase 1 -0.0337132
S100A10 S100 calcium binding protein A10 -0.0334446
NOP56 NOP56 ribonucleoprotein -0.0332553
PFN1 profilin 1 -0.0328992
ENO1 enolase 1, (alpha) -0.032396
RPL37 ribosomal protein L37 -0.0319757
TUBB4B tubulin, beta 4B class IVb -0.0319477
RPL32 ribosomal protein L32 -0.0315699
RPS10 ribosomal protein S10 -0.0313095
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0312137
RPS15 ribosomal protein S15 -0.0306115
RPS20 ribosomal protein S20 -0.0304504
CBX3 chromobox homolog 3 -0.0303614
AHNAK AHNAK nucleoprotein -0.0301343
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0298102
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0292694
RPL7 ribosomal protein L7 -0.0290199
RPL27 ribosomal protein L27 -0.0290099