| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3715 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Indomethacin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 1.21 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.66 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.58 |
| ZMYM6 | zinc finger, MYM-type 6 | 0.55 |
| METTL22 | methyltransferase like 22 | 0.55 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.53 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.52 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.49 |
| GRAMD1A | GRAM domain containing 1A | 0.47 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 0.46 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.46 |
| PLEC | plectin | 0.46 |
| RNF170 | ring finger protein 170 | 0.43 |
| CDCA4 | cell division cycle associated 4 | 0.43 |
| OTX1 | orthodenticle homeobox 1 | 0.4 |
| EMB | embigin | 0.39 |
| CHPF | chondroitin polymerizing factor | 0.37 |
| SPATA7 | spermatogenesis associated 7 | 0.35 |
| LGALSL | lectin, galactoside-binding-like | 0.34 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.34 |
| MSMO1 | methylsterol monooxygenase 1 | 0.34 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.33 |
| CHRD | chordin | 0.33 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.32 |
| SLC38A7 | solute carrier family 38, member 7 | 0.32 |
| HPCAL4 | hippocalcin like 4 | 0.32 |
| ZNF431 | zinc finger protein 431 | 0.32 |
| ZNF264 | zinc finger protein 264 | 0.31 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.31 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | 0.3 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.3 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.3 |
| TOX2 | TOX high mobility group box family member 2 | 0.29 |
| YAP1 | Yes-associated protein 1 | 0.29 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.29 |
| ERMARD | ER membrane-associated RNA degradation | 0.29 |
| MSH5 | mutS homolog 5 | 0.28 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | 0.28 |
| PIMREG | PICALM interacting mitotic regulator | 0.28 |
| FAM124A | family with sequence similarity 124A | 0.28 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 0.28 |
| BORA | bora, aurora kinase A activator | 0.28 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.28 |
| FADS1 | fatty acid desaturase 1 | 0.28 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.28 |
| CRCP | CGRP receptor component | 0.28 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 0.27 |
| SPICE1 | spindle and centriole associated protein 1 | 0.27 |
| SEPTIN4 | septin 4 | 0.27 |
| TYK2 | tyrosine kinase 2 | 0.27 |
| FRMPD1 | FERM and PDZ domain containing 1 | 0.26 |
| ART5 | ADP-ribosyltransferase 5 | 0.26 |
| SORT1 | sortilin 1 | 0.26 |
| JUN | jun proto-oncogene | 0.26 |
| EHF | ets homologous factor | 0.26 |
| TUBD1 | tubulin, delta 1 | 0.26 |
| UBOX5 | U-box domain containing 5 | 0.26 |
| RAB11A | RAB11A, member RAS oncogene family | 0.25 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.25 |
| RMDN2 | regulator of microtubule dynamics 2 | 0.25 |
| TDRD9 | tudor domain containing 9 | 0.25 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.25 |
| ONECUT3 | one cut homeobox 3 | 0.25 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.24 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | 0.24 |
| CFAP97 | cilia and flagella associated protein 97 | 0.24 |
| COX5A | cytochrome c oxidase subunit Va | 0.24 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | 0.24 |
| SYN2 | synapsin II | 0.24 |
| SMO | smoothened, frizzled class receptor | 0.24 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.24 |
| SP100 | SP100 nuclear antigen | 0.24 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.24 |
| PML | promyelocytic leukemia | 0.24 |
| AOC1 | amine oxidase, copper containing 1 | 0.24 |
| ZNF367 | zinc finger protein 367 | 0.23 |
| FAM126B | family with sequence similarity 126, member B | 0.23 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.23 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.23 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 0.23 |
| TRO | trophinin | 0.23 |
| ATAD3B | ATPase family, AAA domain containing 3B | 0.23 |
| LYRM2 | LYR motif containing 2 | 0.23 |
| RPL35A | ribosomal protein L35a | 0.23 |
| ZNF12 | zinc finger protein 12 | 0.23 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.22 |
| MIGA2 | mitoguardin 2 | 0.22 |
| SPATA2L | spermatogenesis associated 2-like | 0.22 |
| SRXN1 | sulfiredoxin 1 | 0.22 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.22 |
| C14ORF93 | chromosome 14 open reading frame 93 | 0.22 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.22 |
| FLII | flightless I homolog (Drosophila) | 0.22 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.22 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.22 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.22 |
| JDP2 | Jun dimerization protein 2 | 0.22 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.22 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.22 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF555 | zinc finger protein 555 | -2.44 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -2.19 |
| ARHGAP44 | Rho GTPase activating protein 44 | -1.9 |
| NPHP3 | nephronophthisis 3 (adolescent) | -1.35 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | -1.17 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -1.14 |
| PCTP | phosphatidylcholine transfer protein | -0.93 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.8 |
| ZNF175 | zinc finger protein 175 | -0.8 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.75 |
| RYK | receptor-like tyrosine kinase | -0.74 |
| ZNF808 | zinc finger protein 808 | -0.56 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -0.56 |
| RNF130 | ring finger protein 130 | -0.55 |
| ZNF195 | zinc finger protein 195 | -0.53 |
| MAST2 | microtubule associated serine/threonine kinase 2 | -0.53 |
| TMEM102 | transmembrane protein 102 | -0.52 |
| ACVR2A | activin A receptor, type IIA | -0.51 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.5 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | -0.49 |
| COQ4 | coenzyme Q4 | -0.48 |
| FAM110C | family with sequence similarity 110, member C | -0.46 |
| BCL10 | B-cell CLL/lymphoma 10 | -0.45 |
| GLI2 | GLI family zinc finger 2 | -0.44 |
| AXIN2 | axin 2 | -0.44 |
| RWDD2B | RWD domain containing 2B | -0.43 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.43 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.42 |
| WTAP | Wilms tumor 1 associated protein | -0.42 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.41 |
| DENND5A | DENN/MADD domain containing 5A | -0.41 |
| TMEM9 | transmembrane protein 9 | -0.4 |
| NEB | nebulin | -0.39 |
| THAP9 | THAP domain containing 9 | -0.39 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.39 |
| CDK10 | cyclin-dependent kinase 10 | -0.38 |
| TMEM184C | transmembrane protein 184C | -0.38 |
| CCDC158 | coiled-coil domain containing 158 | -0.38 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.38 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.38 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.37 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | -0.37 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.36 |
| ZYX | zyxin | -0.36 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.36 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | -0.36 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | -0.35 |
| COL6A3 | collagen, type VI, alpha 3 | -0.35 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.35 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.35 |
| MT2A | metallothionein 2A | -0.35 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.35 |
| NCOA1 | nuclear receptor coactivator 1 | -0.35 |
| ZSCAN20 | zinc finger and SCAN domain containing 20 | -0.34 |
| SLC22A18 | solute carrier family 22, member 18 | -0.34 |
| ZNF503 | zinc finger protein 503 | -0.34 |
| CEP68 | centrosomal protein 68kDa | -0.34 |
| KMT5B | lysine methyltransferase 5B | -0.33 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.33 |
| TMEM160 | transmembrane protein 160 | -0.32 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.32 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.32 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.32 |
| CCNQ | cyclin Q | -0.32 |
| RARG | retinoic acid receptor, gamma | -0.32 |
| COQ5 | coenzyme Q5 homolog, methyltransferase (S. cerevisiae) | -0.32 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.32 |
| ZBED6 | zinc finger, BED-type containing 6 | -0.32 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.31 |
| NGFR | nerve growth factor receptor | -0.31 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.31 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.31 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.31 |
| EGR1 | early growth response 1 | -0.3 |
| ZNF114 | zinc finger protein 114 | -0.3 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | -0.3 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.3 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | -0.3 |
| TP73 | tumor protein p73 | -0.3 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | -0.29 |
| CASZ1 | castor zinc finger 1 | -0.29 |
| TMEM175 | transmembrane protein 175 | -0.29 |
| SESN1 | sestrin 1 | -0.29 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | -0.29 |
| SOX13 | SRY (sex determining region Y)-box 13 | -0.29 |
| PON3 | paraoxonase 3 | -0.29 |
| CEP112 | centrosomal protein 112kDa | -0.28 |
| BAHD1 | bromo adjacent homology domain containing 1 | -0.28 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.28 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.28 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -0.28 |
| NRBF2 | nuclear receptor binding factor 2 | -0.28 |
| LAMA1 | laminin, alpha 1 | -0.28 |
| AMOT | angiomotin | -0.28 |
| GAB1 | GRB2-associated binding protein 1 | -0.28 |
| PPP1R16A | protein phosphatase 1, regulatory subunit 16A | -0.28 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.28 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.28 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.28 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.27 |
