Infertility Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility. (Experimental Factor Ontology, EFO_0000545)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D007246
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Genes

137 genes/proteins associated with the disease Infertility from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KL klotho 2.88009
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.88009
LEPR leptin receptor 2.88009
TTC19 tetratricopeptide repeat domain 19 2.88009
IFNG interferon, gamma 1.67202
GSR glutathione reductase 1.48273
GPX1 glutathione peroxidase 1 1.47787
SOD1 superoxide dismutase 1, soluble 1.45273
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.43293
IL1B interleukin 1, beta 1.42321
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.42183
MAPK1 mitogen-activated protein kinase 1 1.39702
CAT catalase 1.381
IL4 interleukin 4 1.3699
ACHE acetylcholinesterase (Yt blood group) 1.36447
BDNF brain-derived neurotrophic factor 1.35098
TNF tumor necrosis factor 1.34926
ENO1 enolase 1, (alpha) 1.3443
ACTB actin, beta 1.33612
BCL2L1 BCL2-like 1 1.32993
BCL2 B-cell CLL/lymphoma 2 1.32993
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.32074
CCL2 chemokine (C-C motif) ligand 2 1.31626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.30117
FABP3 fatty acid binding protein 3, muscle and heart 1.29843
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.29781
CYCS cytochrome c, somatic 1.2861
NQO1 NAD(P)H dehydrogenase, quinone 1 1.28119
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.27905
GCLC glutamate-cysteine ligase, catalytic subunit 1.27875
SERBP1 SERPINE1 mRNA binding protein 1 1.25619
NOS2 nitric oxide synthase 2, inducible 1.25494
STAR steroidogenic acute regulatory protein 1.25432
GSK3A glycogen synthase kinase 3 alpha 1.25214
CCND1 cyclin D1 1.2456
SOD2 superoxide dismutase 2, mitochondrial 1.2415
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.23837
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.23584
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.23584
PRDX4 peroxiredoxin 4 1.23552
LDHA lactate dehydrogenase A 1.23106
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.22469
ATF3 activating transcription factor 3 1.21695
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 1.21631
EEF1G eukaryotic translation elongation factor 1 gamma 1.21337
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.20881
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.20654
FOS FBJ murine osteosarcoma viral oncogene homolog 1.1977
DHPS deoxyhypusine synthase 1.19542
IL10 interleukin 10 1.18948
GSTP1 glutathione S-transferase pi 1 1.18915
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.18849
GSK3B glycogen synthase kinase 3 beta 1.18849
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.18783
CCND2 cyclin D2 1.18652
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.18521
ARF5 ADP-ribosylation factor 5 1.18126
C3 complement component 3 1.17596
MAPK3 mitogen-activated protein kinase 3 1.17464
ZEB1 zinc finger E-box binding homeobox 1 1.17235
DDIT4 DNA-damage-inducible transcript 4 1.17202
RPL14 ribosomal protein L14 1.15661
NACA nascent polypeptide-associated complex alpha subunit 1.14575
HMOX1 heme oxygenase 1 1.14234
ERBB3 erb-b2 receptor tyrosine kinase 3 1.14234
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 1.13518
PHGDH phosphoglycerate dehydrogenase 1.13177
FSHB follicle stimulating hormone, beta polypeptide 1.13143
RBP1 retinol binding protein 1, cellular 1.13143
BAX BCL2-associated X protein 1.13041
MT3 metallothionein 3 1.12703
HSPA4 heat shock 70kDa protein 4 1.1253
IL2 interleukin 2 1.12461
ENO2 enolase 2 (gamma, neuronal) 1.12323
G6PD glucose-6-phosphate dehydrogenase 1.11911
VEGFA vascular endothelial growth factor A 1.11809
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.11741
PHB prohibitin 1.11741
VIM vimentin 1.1129
MCL1 myeloid cell leukemia 1 1.10769
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.10665
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.10665
PARP1 poly (ADP-ribose) polymerase 1 1.10562
MGP matrix Gla protein 1.09998
NAMPT nicotinamide phosphoribosyltransferase 1.09646
EGFR epidermal growth factor receptor 1.09611
ESR1 estrogen receptor 1 1.09471
FAM107A family with sequence similarity 107, member A 1.09401
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.09154
EEF2 eukaryotic translation elongation factor 2 1.09119
HSPA1A heat shock 70kDa protein 1A 1.09083
ZFP36 ZFP36 ring finger protein 1.09083
HSPB1 heat shock 27kDa protein 1 1.08975
PGD phosphogluconate dehydrogenase 1.08266
PDIA3 protein disulfide isomerase family A, member 3 1.08266
MAPK8 mitogen-activated protein kinase 8 1.08196
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.08091
NRTN neurturin 1.0784
SHBG sex hormone-binding globulin 1.07732
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.07589
PRDX2 peroxiredoxin 2 1.07447
PDGFA platelet-derived growth factor alpha polypeptide 1.07057
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 1.06333
TRAF4 TNF receptor-associated factor 4 1.06333
CCS copper chaperone for superoxide dismutase 1.06333
MAPK11 mitogen-activated protein kinase 11 1.06297
CALR calreticulin 1.06116
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.06116
DNM1L dynamin 1-like 1.06008
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.05648
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.0561
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.0561
ABHD4 abhydrolase domain containing 4 1.05573
CREB1 cAMP responsive element binding protein 1 1.04831
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 1.04721
STAT5B signal transducer and activator of transcription 5B 1.04611
TGFA transforming growth factor, alpha 1.04574
LEP leptin 1.03159
NFE2L2 nuclear factor, erythroid 2-like 2 1.03009
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 1.02933
TP53 tumor protein p53 1.02858
GPX3 glutathione peroxidase 3 1.02821
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 1.02671
ALPL alkaline phosphatase, liver/bone/kidney 1.02299
CAPG capping protein (actin filament), gelsolin-like 1.02114
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 1.0189
DLD dihydrolipoamide dehydrogenase 1.01852
GRB2 growth factor receptor-bound protein 2 1.01852
RBBP4 retinoblastoma binding protein 4 1.01814
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.01549
GADD45A growth arrest and DNA-damage-inducible, alpha 1.01512
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 1.01474
FBLN1 fibulin 1 1.01474
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.01286
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.01286
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.01099
CTSB cathepsin B 1.01062