| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Infigratinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.113353 |
| LDHA | lactate dehydrogenase A | 0.0898687 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0764901 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0705485 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0669236 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0646593 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0597266 |
| AHNAK | AHNAK nucleoprotein | 0.056034 |
| CANX | calnexin | 0.0523729 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0509158 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0446407 |
| CALR | calreticulin | 0.0421293 |
| UBC | ubiquitin C | 0.0409368 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0381618 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0360332 |
| SQSTM1 | sequestosome 1 | 0.0358869 |
| PKM | pyruvate kinase, muscle | 0.0352921 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0344741 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0338758 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0333747 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0332498 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0328381 |
| LOX | lysyl oxidase | 0.0326435 |
| COPA | coatomer protein complex, subunit alpha | 0.0324631 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0320814 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.031422 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0312099 |
| RUNX1 | runt-related transcription factor 1 | 0.0311962 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0305231 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0299743 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0295528 |
| DST | dystonin | 0.0286243 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0286156 |
| NDRG1 | N-myc downstream regulated 1 | 0.0272366 |
| CD109 | CD109 molecule | 0.026924 |
| ANXA2 | annexin A2 | 0.0266821 |
| FBN1 | fibrillin 1 | 0.0265746 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0264854 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0264211 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0257046 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0256801 |
| TPM3 | tropomyosin 3 | 0.0256447 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0255445 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0254015 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0252093 |
| ADM | adrenomedullin | 0.0247992 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0245577 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0245376 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0243788 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0243147 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0242991 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.024203 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0241258 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0238117 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0237875 |
| ATP13A3 | ATPase type 13A3 | 0.0237733 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0234211 |
| INSIG2 | insulin induced gene 2 | 0.0231327 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0231011 |
| SUCO | SUN domain containing ossification factor | 0.0229106 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0228789 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0227723 |
| HELZ | helicase with zinc finger | 0.0226966 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0224553 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0224114 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0223872 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0223575 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0221621 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0220748 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0218404 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0216421 |
| INSIG1 | insulin induced gene 1 | 0.0215333 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0210269 |
| MB21D2 | Mab-21 domain containing 2 | 0.0207036 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0198497 |
| RNF24 | ring finger protein 24 | 0.0197538 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0197007 |
| CTBP2 | C-terminal binding protein 2 | 0.0196046 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0195 |
| APP | amyloid beta (A4) precursor protein | 0.0194361 |
| GOLGA4 | golgin A4 | 0.0193733 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0193042 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0187775 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0187716 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0187678 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0184243 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0183199 |
| SPAG9 | sperm associated antigen 9 | 0.0183121 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0182794 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0179928 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0179255 |
| MSI2 | musashi RNA-binding protein 2 | 0.017889 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0178768 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0177965 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0174906 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0173981 |
| HIP1 | huntingtin interacting protein 1 | 0.0172 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0171723 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0170387 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0170077 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.216387 |
| VIM | vimentin | -0.187314 |
| MT2A | metallothionein 2A | -0.143698 |
| PLAT | plasminogen activator, tissue | -0.108422 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0851661 |
| HLA-B | major histocompatibility complex, class I, B | -0.0782225 |
| PODXL | podocalyxin-like | -0.0606164 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0523132 |
| MT1X | metallothionein 1X | -0.0475049 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0457701 |
| SUCNR1 | succinate receptor 1 | -0.0442092 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0435877 |
| NAV1 | neuron navigator 1 | -0.0432774 |
| FN1 | fibronectin 1 | -0.0407551 |
| CSTB | cystatin B (stefin B) | -0.0387575 |
| PRSS23 | protease, serine, 23 | -0.035621 |
| PTMA | prothymosin, alpha | -0.0343923 |
| S100A10 | S100 calcium binding protein A10 | -0.0342371 |
| HLA-C | major histocompatibility complex, class I, C | -0.0333598 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0326771 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0319509 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0319096 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0309025 |
| MX2 | MX dynamin-like GTPase 2 | -0.0308638 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0303195 |
| LMNA | lamin A/C | -0.0302935 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0296934 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0286783 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.026822 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0262501 |
| MAP1B | microtubule-associated protein 1B | -0.0260977 |
| COL3A1 | collagen, type III, alpha 1 | -0.0260026 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0258937 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0246498 |
| RPS19 | ribosomal protein S19 | -0.0246273 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0244811 |
| RPL35A | ribosomal protein L35a | -0.0242589 |
| S100A4 | S100 calcium binding protein A4 | -0.0236227 |
| RNF213 | ring finger protein 213 | -0.0227341 |
| COL1A2 | collagen, type I, alpha 2 | -0.0227182 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0223302 |
| CAVIN1 | caveolae associated protein 1 | -0.0220411 |
| RPLP2 | ribosomal protein, large, P2 | -0.0216612 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0215973 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0215784 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0210603 |
| FRMD4A | FERM domain containing 4A | -0.0207276 |
| B2M | beta-2-microglobulin | -0.0207246 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0205991 |
| CD81 | CD81 molecule | -0.019584 |
| CTSB | cathepsin B | -0.0194776 |
| S100A6 | S100 calcium binding protein A6 | -0.0193038 |
| RPS21 | ribosomal protein S21 | -0.0189746 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0189273 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0188282 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0187905 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0182366 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0181777 |
| KRT81 | keratin 81, type II | -0.0181711 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0181255 |
| RRBP1 | ribosome binding protein 1 | -0.0180536 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0179924 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.017781 |
| MYADM | myeloid-associated differentiation marker | -0.0177703 |
| S100A11 | S100 calcium binding protein A11 | -0.0174154 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0173822 |
| RPL23 | ribosomal protein L23 | -0.0172081 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0171881 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0171816 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0171777 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0169347 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0169192 |
| RPL36 | ribosomal protein L36 | -0.0168099 |
| CD44 | CD44 molecule (Indian blood group) | -0.0166028 |
| PRRC2C | proline-rich coiled-coil 2C | -0.016545 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0163746 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0162645 |
| RPS6 | ribosomal protein S6 | -0.0162299 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0162268 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0162168 |
| BPTF | bromodomain PHD finger transcription factor | -0.016097 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0160941 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0157602 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0157319 |
| RPS15 | ribosomal protein S15 | -0.0156782 |
| ACTG1 | actin gamma 1 | -0.0156598 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.015508 |
| RBM25 | RNA binding motif protein 25 | -0.0152686 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0152422 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.015126 |
| RPLP1 | ribosomal protein, large, P1 | -0.0150972 |
| RPL37A | ribosomal protein L37a | -0.0150798 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.01482 |
| S100A9 | S100 calcium binding protein A9 | -0.0143513 |
| SERF2 | small EDRK-rich factor 2 | -0.0143267 |
| MRC2 | mannose receptor, C type 2 | -0.0142129 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0141361 |
| STC1 | stanniocalcin 1 | -0.0138806 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.013849 |
| NPR2 | natriuretic peptide receptor 2 | -0.013761 |
