Infigratinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Infigratinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.177057
NLGN1 neuroligin 1 0.150176
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.13926
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133178
HMGA2 high mobility group AT-hook 2 0.112094
PDE4D phosphodiesterase 4D, cAMP-specific 0.102123
VIM vimentin 0.0977273
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0950689
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0842692
CALR calreticulin 0.0735593
PCDH7 protocadherin 7 0.0716803
CANX calnexin 0.0701862
LDHA lactate dehydrogenase A 0.0691201
EHBP1 EH domain binding protein 1 0.0689544
YAP1 Yes-associated protein 1 0.0672399
AHNAK AHNAK nucleoprotein 0.0646521
ASPH aspartate beta-hydroxylase 0.0620512
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0599117
DST dystonin 0.0587284
ENO1 enolase 1, (alpha) 0.0571504
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0529938
NHSL1 NHS-like 1 0.0518272
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0517275
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0509224
ADIPOR2 adiponectin receptor 2 0.0497804
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0491206
INTS6 integrator complex subunit 6 0.0490004
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.047401
MACF1 microtubule-actin crosslinking factor 1 0.0473274
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0453958
NAP1L1 nucleosome assembly protein 1-like 1 0.0448721
ANXA1 annexin A1 0.0441678
RIMS2 regulating synaptic membrane exocytosis 2 0.0439546
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0421051
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0398958
TPI1 triosephosphate isomerase 1 0.0381866
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0369179
BIRC3 baculoviral IAP repeat containing 3 0.0357542
RASAL2 RAS protein activator like 2 0.0354727
CMIP c-Maf inducing protein 0.0351756
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0343729
ZNF804A zinc finger protein 804A 0.0340857
ZSWIM6 zinc finger, SWIM-type containing 6 0.0340093
MSRB3 methionine sulfoxide reductase B3 0.0335663
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0334737
LPP LIM domain containing preferred translocation partner in lipoma 0.0332615
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0329455
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0319306
RAB7A RAB7A, member RAS oncogene family 0.0307317
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0306429
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.030563
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0303754
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0302025
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0301168
CUX1 cut-like homeobox 1 0.0294927
TPM4 tropomyosin 4 0.0292926
TPM3 tropomyosin 3 0.029178
HSPA8 heat shock 70kDa protein 8 0.0289213
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0289086
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0283448
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0283268
MTAP methylthioadenosine phosphorylase 0.0279038
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0278319
PDGFC platelet derived growth factor C 0.0275166
LOC112694756 uncharaterized LOC112694756 0.0273819
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.026334
DENND5A DENN/MADD domain containing 5A 0.0259973
ETV6 ets variant 6 0.0256367
CLDN1 claudin 1 0.0253811
HSPH1 heat shock 105kDa/110kDa protein 1 0.0252943
DTNA dystrobrevin, alpha 0.0252045
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0250111
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0249426
PGK1 phosphoglycerate kinase 1 0.0248934
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.024842
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0248174
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0247147
AKAP12 A kinase (PRKA) anchor protein 12 0.0243286
EIF4B eukaryotic translation initiation factor 4B 0.024232
CHD4 chromodomain helicase DNA binding protein 4 0.0241357
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0240226
ANXA2 annexin A2 0.0238751
EXOC4 exocyst complex component 4 0.0238388
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0237236
HDAC9 histone deacetylase 9 0.0235801
R3HDM2 R3H domain containing 2 0.0232985
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0232418
EEF1G eukaryotic translation elongation factor 1 gamma 0.0231857
LRMDA leucine rich melanocyte differentiation associated 0.0231102
DOCK1 dedicator of cytokinesis 1 0.0229089
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0226404
CCDC47 coiled-coil domain containing 47 0.0226207
CEP112 centrosomal protein 112kDa 0.0225602
RPS12 ribosomal protein S12 0.0225202
NEBL nebulette 0.0222303
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0217821
LRRC23 leucine rich repeat containing 23 0.0217643
RRM2 ribonucleotide reductase M2 0.0217493
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0217016
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0216586

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.198209
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0526311
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0510921
ATP5F1B ATP synthase F1 subunit beta -0.0481541
PFN1 profilin 1 -0.0382757
TMEM41B transmembrane protein 41B -0.036507
CPOX coproporphyrinogen oxidase -0.0345212
RPS21 ribosomal protein S21 -0.0338979
TMSB10 thymosin beta 10 -0.0338178
CCNL1 cyclin L1 -0.0325884
ZNF292 zinc finger protein 292 -0.0284602
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0270925
ANKRD12 ankyrin repeat domain 12 -0.0267584
NKTR natural killer cell triggering receptor -0.0264984
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0257881
RPS2 ribosomal protein S2 -0.0239102
XPO1 exportin 1 -0.0237455
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.023735
KLHL24 kelch-like family member 24 -0.0229952
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0228606
PNISR PNN-interacting serine/arginine-rich protein -0.0226651
PNN pinin, desmosome associated protein -0.0223432
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.021922
POTEF POTE ankyrin domain family, member F -0.0217743
RBM25 RNA binding motif protein 25 -0.0217634
HMGA1 high mobility group AT-hook 1 -0.0214023
EDN1 endothelin 1 -0.0213328
RPS6 ribosomal protein S6 -0.0212988
ZBTB20 zinc finger and BTB domain containing 20 -0.0203704
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0201006
KDM3A lysine (K)-specific demethylase 3A -0.0195346
THOC2 THO complex 2 -0.0195265
AKAP9 A kinase (PRKA) anchor protein 9 -0.0195229
CEP95 centrosomal protein 95kDa -0.0195057
ADAM17 ADAM metallopeptidase domain 17 -0.0194664
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0193448
BIRC6 baculoviral IAP repeat containing 6 -0.01864
RTN4 reticulon 4 -0.0184703
RB1CC1 RB1-inducible coiled-coil 1 -0.0184076
WDR43 WD repeat domain 43 -0.0182694
TNPO1 transportin 1 -0.0181512
SRSF11 serine/arginine-rich splicing factor 11 -0.0180267
TBK1 TANK-binding kinase 1 -0.0178483
NCOR1 nuclear receptor corepressor 1 -0.017578
MIS18BP1 MIS18 binding protein 1 -0.0172063
CHD1 chromodomain helicase DNA binding protein 1 -0.0170497
KIF5B kinesin family member 5B -0.0168108
RBM27 RNA binding motif protein 27 -0.0163675
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0163299
YBX3 Y box binding protein 3 -0.0163078
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0162232
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0161904
PRRC2C proline-rich coiled-coil 2C -0.0161262
PUM2 pumilio RNA-binding family member 2 -0.0159037
CCN2 cellular communication network factor 2 -0.0158033
MGAT4C MGAT4 family, member C -0.0157414
FBXL20 F-box and leucine-rich repeat protein 20 -0.0156424
CDK19 cyclin-dependent kinase 19 -0.0155604
BIRC2 baculoviral IAP repeat containing 2 -0.0153593
ATP11A ATPase, class VI, type 11A -0.0152547
CEP192 centrosomal protein 192kDa -0.0150478
GOLGA4 golgin A4 -0.0150103
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0149363
SETD5 SET domain containing 5 -0.0148234
SP3 Sp3 transcription factor -0.0147692
RNF145 ring finger protein 145 -0.0147508
CXADR coxsackie virus and adenovirus receptor -0.0147487
OXR1 oxidation resistance 1 -0.0147472
SRRM1 serine/arginine repetitive matrix 1 -0.0146582
BTG3 BTG family, member 3 -0.0145628
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0144615
RPL11 ribosomal protein L11 -0.0144337
NEK7 NIMA-related kinase 7 -0.0143997
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.014347
CDCA2 cell division cycle associated 2 -0.0141428
THOC1 THO complex 1 -0.0140817
RSF1 remodeling and spacing factor 1 -0.0140425
SLC49A4 solute carrier family 49 member 4 -0.0139964
OGA O-GlcNAcase -0.0139817
TCERG1 transcription elongation regulator 1 -0.0139503
ADNP activity-dependent neuroprotector homeobox -0.0138363
TNRC6A trinucleotide repeat containing 6A -0.013833
MATR3 matrin 3 -0.0138134
GARS1 glycyl-tRNA synthetase 1 -0.01381
RPS13 ribosomal protein S13 -0.0137039
RPL8 ribosomal protein L8 -0.0136923
PRKCI protein kinase C, iota -0.0135334
GCG glucagon -0.0134373
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0132765
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0132722
RBMX RNA binding motif protein, X-linked -0.0132251
BCAS3 breast carcinoma amplified sequence 3 -0.0131549
WDR45B WD repeat domain 45B -0.0131427
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0130687
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0130186
UBA6 ubiquitin-like modifier activating enzyme 6 -0.012971
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0128921
TRA2A transformer 2 alpha homolog (Drosophila) -0.012827
R3HDM1 R3H domain containing 1 -0.0126264
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0126169