Infigratinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Infigratinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.160561
NRG1 neuregulin 1 0.14838
LSAMP limbic system-associated membrane protein 0.121774
NALF1 NALCN channel auxiliary factor 1 0.110086
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.105853
EXT1 exostosin glycosyltransferase 1 0.0985173
ZSWIM6 zinc finger, SWIM-type containing 6 0.0769131
FMN1 formin 1 0.0760814
PTPRD protein tyrosine phosphatase, receptor type, D 0.0754542
TLE4 transducin-like enhancer of split 4 0.0575297
THSD4 thrombospondin, type I, domain containing 4 0.0565949
PRKCA protein kinase C, alpha 0.0543308
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0517876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0499703
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0497815
BCAS3 breast carcinoma amplified sequence 3 0.0488416
LINGO2 leucine rich repeat and Ig domain containing 2 0.0440596
SLIT2 slit homolog 2 (Drosophila) 0.0423587
TIMP3 TIMP metallopeptidase inhibitor 3 0.0404435
ANTXR1 anthrax toxin receptor 1 0.0401906
MCL1 myeloid cell leukemia 1 0.039909
VMP1 vacuole membrane protein 1 0.0389748
ZBTB20 zinc finger and BTB domain containing 20 0.0383624
ZNF804A zinc finger protein 804A 0.0383229
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0381592
TPM1 tropomyosin 1 (alpha) 0.0375552
CPED1 cadherin-like and PC-esterase domain containing 1 0.0374896
BPTF bromodomain PHD finger transcription factor 0.0356199
NPAS2 neuronal PAS domain protein 2 0.035479
LPP LIM domain containing preferred translocation partner in lipoma 0.0346629
UNC5C unc-5 homolog C (C. elegans) 0.0333077
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327809
CUX1 cut-like homeobox 1 0.0327311
BICD1 bicaudal D homolog 1 (Drosophila) 0.0326199
EGR1 early growth response 1 0.0318619
RNF213 ring finger protein 213 0.0317084
HSPH1 heat shock 105kDa/110kDa protein 1 0.0315194
TPM4 tropomyosin 4 0.0315178
GREM2 gremlin 2, DAN family BMP antagonist 0.0314634
FRMD4A FERM domain containing 4A 0.0314105
ACTG1 actin gamma 1 0.0310885
MSI2 musashi RNA-binding protein 2 0.0299458
CADM2 cell adhesion molecule 2 0.0297549
NREP neuronal regeneration related protein 0.0289086
PLAT plasminogen activator, tissue 0.0288926
INTS6 integrator complex subunit 6 0.0283366
RPL23 ribosomal protein L23 0.0282431
MACF1 microtubule-actin crosslinking factor 1 0.0281844
VIM vimentin 0.0280848
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0280492
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0277864
EXOC4 exocyst complex component 4 0.0275684
ASPH aspartate beta-hydroxylase 0.0273333
RAD51B RAD51 paralog B 0.0273185
TPT1 tumor protein, translationally-controlled 1 0.026624
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.026006
SYT1 synaptotagmin I 0.0259686
PDLIM5 PDZ and LIM domain 5 0.0259128
FERMT2 fermitin family member 2 0.0258451
CDH13 cadherin 13 0.0256737
MYO1E myosin IE 0.0253592
ATXN1 ataxin 1 0.0250989
AKAP12 A kinase (PRKA) anchor protein 12 0.0243892
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0242601
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0240801
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0240684
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238421
FNDC3A fibronectin type III domain containing 3A 0.0237901
CANX calnexin 0.0236159
RIGI RNA sensor RIG-I 0.0235486
LIMCH1 LIM and calponin homology domains 1 0.0234021
MAPK10 mitogen-activated protein kinase 10 0.0233704
SLITRK6 SLIT and NTRK-like family, member 6 0.0231731
RPL37A ribosomal protein L37a 0.0230954
EFNA5 ephrin-A5 0.0230362
KLHL13 kelch-like family member 13 0.0226424
GLCCI1 glucocorticoid induced 1 0.0224631
DNM3 dynamin 3 0.0222672
PBX1 pre-B-cell leukemia homeobox 1 0.0219381
COL4A5 collagen, type IV, alpha 5 0.0219258
RPS12 ribosomal protein S12 0.0216671
AUTS2 autism susceptibility candidate 2 0.0216445
PDZRN3 PDZ domain containing ring finger 3 0.0216025
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0215224
RPTOR regulatory associated protein of MTOR, complex 1 0.0214305
N4BP2L2 NEDD4 binding protein 2-like 2 0.021355
THBS1 thrombospondin 1 0.0212697
LRP1B low density lipoprotein receptor-related protein 1B 0.0212162
MAML2 mastermind-like 2 (Drosophila) 0.0210892
AHR aryl hydrocarbon receptor 0.0210704
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0209592
CNTN4 contactin 4 0.0208574
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0207988
RPL35A ribosomal protein L35a 0.0207023
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0205599
TCF12 transcription factor 12 0.0200813
DACH2 dachshund family transcription factor 2 0.0199873
PACS1 phosphofurin acidic cluster sorting protein 1 0.019937
DNAH14 dynein, axonemal, heavy chain 14 0.0199075
UBAP2 ubiquitin associated protein 2 0.0198958

decreased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 -0.0208738
FAM13A family with sequence similarity 13, member A -0.0194874
GOLGA4 golgin A4 -0.0184221
HELZ helicase with zinc finger -0.0174551
OGA O-GlcNAcase -0.0172355
NPEPPS aminopeptidase puromycin sensitive -0.0168579
WDR45B WD repeat domain 45B -0.0165862
IGF2 insulin-like growth factor 2 -0.0163023
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0161787
FNBP1 formin binding protein 1 -0.0152156
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0125932
USP3 ubiquitin specific peptidase 3 -0.0124912
MAP1B microtubule-associated protein 1B -0.0124883
NCOR2 nuclear receptor corepressor 2 -0.0122092
TENT5A terminal nucleotidyltransferase 5A -0.0121165
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0119187
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0118984
NDRG1 N-myc downstream regulated 1 -0.0116499
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0115923
RNF145 ring finger protein 145 -0.0113489
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0112086
RTN4 reticulon 4 -0.0109297
CD36 CD36 molecule (thrombospondin receptor) -0.0107739
PHIP pleckstrin homology domain interacting protein -0.00993943
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00985395
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0097646
MIS18BP1 MIS18 binding protein 1 -0.00975251
ESYT2 extended synaptotagmin-like protein 2 -0.00941031
CHD1 chromodomain helicase DNA binding protein 1 -0.00939346
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00917423
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.00899691
FOXO3 forkhead box O3 -0.00869211
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.00857865
NBAS neuroblastoma amplified sequence -0.00845424
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00829892
CASC3 cancer susceptibility candidate 3 -0.00829876
SREBF2 sterol regulatory element binding transcription factor 2 -0.0082233
HAS2 hyaluronan synthase 2 -0.00814744
RBM25 RNA binding motif protein 25 -0.00814466
CDC27 cell division cycle 27 -0.00810136
RARA retinoic acid receptor, alpha -0.00809501
ACBD3 acyl-CoA binding domain containing 3 -0.00802306
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.00801795
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0079836
DENND4C DENN/MADD domain containing 4C -0.0079688
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00781516
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0077924
NUP58 nucleoporin 58 -0.00774782
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.00773673
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0076656
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.00761709
KMT2E lysine (K)-specific methyltransferase 2E -0.0075828
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00757559
USP9Y ubiquitin specific peptidase 9, Y-linked -0.00755622
RNMT RNA (guanine-7-) methyltransferase -0.00750437
RB1CC1 RB1-inducible coiled-coil 1 -0.00747264
SUCO SUN domain containing ossification factor -0.00746438
IARS1 isoleucyl-tRNA synthetase 1 -0.00738802
MARCHF6 membrane associated ring-CH-type finger 6 -0.00737908
CDON cell adhesion associated, oncogene regulated -0.00731932
SETD5 SET domain containing 5 -0.00730269
USPL1 ubiquitin specific peptidase like 1 -0.00726744
NEK7 NIMA-related kinase 7 -0.00722373
RAB6A RAB6A, member RAS oncogene family -0.00721333
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.00709495
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00705244
KMT2C lysine (K)-specific methyltransferase 2C -0.00701023
KCTD3 potassium channel tetramerization domain containing 3 -0.0069685
GARS1 glycyl-tRNA synthetase 1 -0.00696575
BHLHE40 basic helix-loop-helix family, member e40 -0.00694219
PCTP phosphatidylcholine transfer protein -0.00692584
PRPF8 pre-mRNA processing factor 8 -0.0068844
DISP1 dispatched homolog 1 (Drosophila) -0.00686795
BRWD1 bromodomain and WD repeat domain containing 1 -0.00681061
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00680289
ZNF148 zinc finger protein 148 -0.00672914
CKAP5 cytoskeleton associated protein 5 -0.00672208
ELP2 elongator acetyltransferase complex subunit 2 -0.00670537
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.00669241
PRTG protogenin -0.00658287
ZNF654 zinc finger protein 654 -0.00655749
PDS5B PDS5 cohesin associated factor B -0.00653698
SLMAP sarcolemma associated protein -0.00647046
YEATS2 YEATS domain containing 2 -0.0064574
DSCAM Down syndrome cell adhesion molecule -0.00644089
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00643378
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0064143
WDR43 WD repeat domain 43 -0.00640109
SRP54 signal recognition particle 54kDa -0.00635845
SH3PXD2B SH3 and PX domains 2B -0.0063337
TOB1 transducer of ERBB2, 1 -0.00630726
NKTR natural killer cell triggering receptor -0.00628684
NAMPT nicotinamide phosphoribosyltransferase -0.0062777
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.00619748
MXI1 MAX interactor 1, dimerization protein -0.00618501
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.00617564
WSB1 WD repeat and SOCS box containing 1 -0.0061675
MINDY3 MINDY lysine 48 deubiquitinase 3 -0.00615601
RFX7 regulatory factor X, 7 -0.00612683
MICU3 mitochondrial calcium uptake family, member 3 -0.00610785