| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Infigratinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.214722 |
| COL6A3 | collagen, type VI, alpha 3 | 0.17799 |
| LDHA | lactate dehydrogenase A | 0.148446 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.148262 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.147668 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.129159 |
| MT2A | metallothionein 2A | 0.117264 |
| ENO1 | enolase 1, (alpha) | 0.111529 |
| ASPH | aspartate beta-hydroxylase | 0.099334 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0819266 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0770676 |
| PKM | pyruvate kinase, muscle | 0.0682838 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.065109 |
| COL1A2 | collagen, type I, alpha 2 | 0.064382 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0629621 |
| SMAD3 | SMAD family member 3 | 0.061392 |
| B2M | beta-2-microglobulin | 0.0602234 |
| CD44 | CD44 molecule (Indian blood group) | 0.0570693 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.056709 |
| VEGFA | vascular endothelial growth factor A | 0.0558011 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0532407 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0511544 |
| CALR | calreticulin | 0.0495407 |
| COL5A1 | collagen, type V, alpha 1 | 0.0478624 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0478464 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0468429 |
| ECE1 | endothelin converting enzyme 1 | 0.0450409 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0444839 |
| PLEC | plectin | 0.0443263 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0426999 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0422083 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0418758 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0410023 |
| NAV1 | neuron navigator 1 | 0.039766 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.039275 |
| GLIS3 | GLIS family zinc finger 3 | 0.0391783 |
| RIGI | RNA sensor RIG-I | 0.0388928 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0387234 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0386435 |
| VCAN | versican | 0.038509 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0384103 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0383535 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0378215 |
| FAT1 | FAT atypical cadherin 1 | 0.0367202 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0361587 |
| AXL | AXL receptor tyrosine kinase | 0.0353926 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0352398 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0352166 |
| TMSB4X | thymosin beta 4, X-linked | 0.0343934 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0342187 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0327148 |
| POTEF | POTE ankyrin domain family, member F | 0.0326189 |
| CALD1 | caldesmon 1 | 0.032135 |
| TPI1 | triosephosphate isomerase 1 | 0.0307227 |
| RUNX1 | runt-related transcription factor 1 | 0.0306782 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0303755 |
| YBX1 | Y box binding protein 1 | 0.0302963 |
| VCL | vinculin | 0.0301752 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0300126 |
| HMGA2 | high mobility group AT-hook 2 | 0.0296927 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0294089 |
| MSN | moesin | 0.0293536 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0287019 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0281689 |
| PGK1 | phosphoglycerate kinase 1 | 0.0276048 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0274177 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0270131 |
| CNTN5 | contactin 5 | 0.0267361 |
| TPM4 | tropomyosin 4 | 0.0257695 |
| RPS18 | ribosomal protein S18 | 0.0257049 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0254153 |
| VEGFC | vascular endothelial growth factor C | 0.0251207 |
| MYO10 | myosin X | 0.0250827 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.025064 |
| ANXA2 | annexin A2 | 0.0249627 |
| JAG1 | jagged 1 | 0.0249377 |
| SFTPA2 | surfactant protein A2 | 0.0249043 |
| SVIL | supervillin | 0.0248583 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0246998 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0245191 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0244552 |
| ATP13A3 | ATPase type 13A3 | 0.0241319 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0240704 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0240424 |
| COL1A1 | collagen, type I, alpha 1 | 0.0240224 |
| TAGLN2 | transgelin 2 | 0.0239575 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0239271 |
| APP | amyloid beta (A4) precursor protein | 0.0238328 |
| ITGAV | integrin, alpha V | 0.0237041 |
| NRP1 | neuropilin 1 | 0.0234725 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0231453 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0229572 |
| FAM20C | family with sequence similarity 20, member C | 0.022859 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0228256 |
| IL6ST | interleukin 6 signal transducer | 0.022813 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0226147 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0225905 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0225155 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0224001 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0223332 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.202079 |
| NDRG1 | N-myc downstream regulated 1 | -0.155488 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.127936 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.108095 |
| CADM1 | cell adhesion molecule 1 | -0.0902307 |
| CDH13 | cadherin 13 | -0.0878837 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0792902 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0703744 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0656377 |
| MTDH | metadherin | -0.0622522 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0611775 |
| IER3 | immediate early response 3 | -0.0588647 |
| UBC | ubiquitin C | -0.0574738 |
| FTL | ferritin, light polypeptide | -0.0572531 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.056496 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0525472 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0517989 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.047824 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0475278 |
| RPS8 | ribosomal protein S8 | -0.0455453 |
| ADM | adrenomedullin | -0.0451498 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0435305 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0427883 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0412225 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0399347 |
| LOX | lysyl oxidase | -0.0385188 |
| RND3 | Rho family GTPase 3 | -0.0383676 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.038097 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0359002 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0356936 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0356093 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0356029 |
| MAP4 | microtubule-associated protein 4 | -0.0354306 |
| GOLGA4 | golgin A4 | -0.0329779 |
| RPL35A | ribosomal protein L35a | -0.0329102 |
| SQSTM1 | sequestosome 1 | -0.0324647 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0323453 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.031654 |
| HM13 | histocompatibility (minor) 13 | -0.031215 |
| GOLGB1 | golgin B1 | -0.0303467 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0302681 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0295217 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0292875 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0291049 |
| RPS6 | ribosomal protein S6 | -0.0289993 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.028877 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0288668 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0287847 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0286947 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0280745 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0277518 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0274893 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0274238 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0273073 |
| CDK13 | cyclin-dependent kinase 13 | -0.0269962 |
| FNIP1 | folliculin interacting protein 1 | -0.0268356 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0257079 |
| SEC24D | SEC24 family member D | -0.0250267 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0242935 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0242477 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0242421 |
| ANO10 | anoctamin 10 | -0.0238239 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0237464 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0234605 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.023416 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.023407 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0230039 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0226747 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0224317 |
| SETD5 | SET domain containing 5 | -0.022162 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.021332 |
| CMIP | c-Maf inducing protein | -0.0213282 |
| CLMP | CXADR-like membrane protein | -0.0210686 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0210017 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0204335 |
| CLINT1 | clathrin interactor 1 | -0.0203699 |
| HMBOX1 | homeobox containing 1 | -0.02018 |
| TRAM1 | translocation associated membrane protein 1 | -0.0201785 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0200018 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0196932 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.019674 |
| HDLBP | high density lipoprotein binding protein | -0.0196433 |
| PDE10A | phosphodiesterase 10A | -0.0195586 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0194767 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0194363 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0193983 |
| FMNL2 | formin-like 2 | -0.0193797 |
| NKTR | natural killer cell triggering receptor | -0.0193711 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0193005 |
| RTN3 | reticulon 3 | -0.0192192 |
| RPL37A | ribosomal protein L37a | -0.0191778 |
| RLF | rearranged L-myc fusion | -0.0189962 |
| ANXA1 | annexin A1 | -0.0188933 |
| HSPA1B | heat shock 70kDa protein 1B | -0.0188749 |
| QKI | QKI, KH domain containing, RNA binding | -0.0188316 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0187584 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0186731 |
| ATF4 | activating transcription factor 4 | -0.0186308 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0185582 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0185361 |
