| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.24912 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.17088 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.167509 |
| FN1 | fibronectin 1 | 0.161501 |
| DSPP | dentin sialophosphoprotein | 0.160499 |
| ENO1 | enolase 1, (alpha) | 0.139369 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.122568 |
| APOB | apolipoprotein B | 0.118874 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.116331 |
| GPC3 | glypican 3 | 0.111082 |
| EHBP1 | EH domain binding protein 1 | 0.102609 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0955758 |
| SVIL | supervillin | 0.0873957 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0866751 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0857038 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0840881 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0807087 |
| PEG3 | paternally expressed 3 | 0.0787243 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0764877 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0752332 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0742513 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0737797 |
| LDHA | lactate dehydrogenase A | 0.0650567 |
| TF | transferrin | 0.056561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0560868 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0547717 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0542936 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0530331 |
| FAT1 | FAT atypical cadherin 1 | 0.0498526 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.049409 |
| MT2A | metallothionein 2A | 0.0492466 |
| SDC4 | syndecan 4 | 0.0492283 |
| VCL | vinculin | 0.0489985 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0467514 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0462083 |
| ITGAV | integrin, alpha V | 0.0460442 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0453007 |
| CANX | calnexin | 0.044978 |
| ASPH | aspartate beta-hydroxylase | 0.0448273 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0441465 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0424282 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0424081 |
| TMEM123 | transmembrane protein 123 | 0.0411838 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0410213 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0403783 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0400194 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0398385 |
| LOC112694756 | uncharaterized LOC112694756 | 0.039455 |
| ATXN1 | ataxin 1 | 0.0394178 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0390826 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0390341 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0389925 |
| FOXP1 | forkhead box P1 | 0.0388685 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0387729 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0387664 |
| FAM107B | family with sequence similarity 107, member B | 0.0386986 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0375511 |
| KLF6 | Kruppel-like factor 6 | 0.0366929 |
| DST | dystonin | 0.0361431 |
| ZNF644 | zinc finger protein 644 | 0.036046 |
| BCL2L1 | BCL2-like 1 | 0.0360335 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0358948 |
| TRIM26 | tripartite motif containing 26 | 0.0358535 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0353364 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0348298 |
| RPLP0 | ribosomal protein, large, P0 | 0.0347492 |
| A2M | alpha-2-macroglobulin | 0.0346202 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0343403 |
| PHF3 | PHD finger protein 3 | 0.0340905 |
| JMJD1C | jumonji domain containing 1C | 0.0339956 |
| AHSG | alpha-2-HS-glycoprotein | 0.0337905 |
| PTCHD4 | patched domain containing 4 | 0.0337117 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.033577 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0334877 |
| CP | ceruloplasmin (ferroxidase) | 0.0333207 |
| KRT8 | keratin 8, type II | 0.0327299 |
| TPM4 | tropomyosin 4 | 0.0326505 |
| FRMD5 | FERM domain containing 5 | 0.0325807 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0323975 |
| AFDN | afadin, adherens junction formation factor | 0.0322626 |
| CFB | complement factor B | 0.0322106 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0317852 |
| MCL1 | myeloid cell leukemia 1 | 0.0313406 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0312562 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0308936 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0306812 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0303427 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0303359 |
| GK | glycerol kinase | 0.0300664 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0290073 |
| YME1L1 | YME1-like 1 ATPase | 0.0289107 |
| CTSB | cathepsin B | 0.0287773 |
| PGK1 | phosphoglycerate kinase 1 | 0.0287387 |
| EGR1 | early growth response 1 | 0.0286425 |
| RPS24 | ribosomal protein S24 | 0.0284889 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0284511 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0284011 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0283226 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.028114 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0280964 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | -0.0393615 |
| NDRG1 | N-myc downstream regulated 1 | -0.0373613 |
| APOA2 | apolipoprotein A-II | -0.0333796 |
| FTL | ferritin, light polypeptide | -0.0293983 |
| HMGA1 | high mobility group AT-hook 1 | -0.0254897 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0160152 |
| BAG3 | BCL2-associated athanogene 3 | -0.0128191 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0124592 |
| RPL37A | ribosomal protein L37a | -0.0119999 |
| NABP1 | nucleic acid binding protein 1 | -0.0112804 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0112215 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0111572 |
| EGFR | epidermal growth factor receptor | -0.0110319 |
| HSPA1B | heat shock 70kDa protein 1B | -0.0109907 |
| PRELID2 | PRELI domain containing 2 | -0.0109727 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0106402 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0100994 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00996321 |
| FKTN | fukutin | -0.00996211 |
| DTNA | dystrobrevin, alpha | -0.00985058 |
| PHF21A | PHD finger protein 21A | -0.0092875 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00924746 |
| HSPE1 | heat shock 10kDa protein 1 | -0.00874114 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00848754 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00824535 |
| LAMB3 | laminin, beta 3 | -0.00819565 |
| PRDM2 | PR domain containing 2, with ZNF domain | -0.00815506 |
| INTS6 | integrator complex subunit 6 | -0.00786572 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00786201 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.00767756 |
| RPS29 | ribosomal protein S29 | -0.00767086 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | -0.00766558 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.00752197 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0074146 |
| CACYBP | calcyclin binding protein | -0.00738492 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00728249 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00725428 |
| NOP56 | NOP56 ribonucleoprotein | -0.00709093 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00700949 |
| ATP9A | ATPase, class II, type 9A | -0.00691049 |
| LRRC23 | leucine rich repeat containing 23 | -0.00688717 |
| SEC24D | SEC24 family member D | -0.00677027 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.00676335 |
| CDC7 | cell division cycle 7 | -0.00673345 |
| TFF1 | trefoil factor 1 | -0.00670316 |
| TMEM165 | transmembrane protein 165 | -0.00649656 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00647813 |
| TXNDC11 | thioredoxin domain containing 11 | -0.00647762 |
| DNM2 | dynamin 2 | -0.00641515 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.0063511 |
| IL32 | interleukin 32 | -0.00632867 |
| MAP7D2 | MAP7 domain containing 2 | -0.00629964 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00619741 |
| GXYLT1 | glucoside xylosyltransferase 1 | -0.00618088 |
| VRK2 | vaccinia related kinase 2 | -0.00611805 |
| GTF2B | general transcription factor IIB | -0.00610019 |
| EFNA5 | ephrin-A5 | -0.00608117 |
| STK32C | serine/threonine kinase 32C | -0.0060621 |
| COL5A1 | collagen, type V, alpha 1 | -0.0060561 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.00603399 |
| STPG4 | sperm-tail PG-rich repeat containing 4 | -0.00599413 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.00589776 |
| SEC23IP | SEC23 interacting protein | -0.00589023 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.00584047 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.00582791 |
| PDE8A | phosphodiesterase 8A | -0.00582243 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.00580413 |
| NUP98 | nucleoporin 98kDa | -0.00579932 |
| TENM3 | teneurin transmembrane protein 3 | -0.00577631 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) | -0.00573622 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00573139 |
| ATG14 | autophagy related 14 | -0.00572952 |
| CEP43 | centrosomal protein 43 | -0.00572772 |
| RASAL2 | RAS protein activator like 2 | -0.00572459 |
| MT1G | metallothionein 1G | -0.00572115 |
| ABHD3 | abhydrolase domain containing 3 | -0.00571169 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.00570205 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00569593 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | -0.00569495 |
| RPL7A | ribosomal protein L7a | -0.00568092 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00567283 |
| OXSR1 | oxidative stress responsive 1 | -0.00565507 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.00564477 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0056364 |
| ZNF782 | zinc finger protein 782 | -0.00563325 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.00560749 |
| CKMT2 | creatine kinase, mitochondrial 2 (sarcomeric) | -0.00560157 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.00559408 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.00556477 |
| TARS3 | threonyl-tRNA synthetase 3 | -0.00552877 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.00547251 |
| LURAP1L | leucine rich adaptor protein 1-like | -0.00546781 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.00545051 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.00544891 |
| RSRP1 | arginine/serine-rich protein 1 | -0.00542322 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00541463 |
| PGM1 | phosphoglucomutase 1 | -0.00541456 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.00540653 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.00540626 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.00540488 |
