Infigratinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Infigratinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.200535
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.199614
LMO7 LIM domain 7 0.14592
PDLIM5 PDZ and LIM domain 5 0.119572
DPYD dihydropyrimidine dehydrogenase 0.109351
LDHA lactate dehydrogenase A 0.0939292
PDE4D phosphodiesterase 4D, cAMP-specific 0.0904403
MTSS1 metastasis suppressor 1 0.088851
SLC35F3 solute carrier family 35, member F3 0.0761578
CD44 CD44 molecule (Indian blood group) 0.0699617
INTS6 integrator complex subunit 6 0.0686454
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.068391
MBNL1 muscleblind-like splicing regulator 1 0.0671451
ALCAM activated leukocyte cell adhesion molecule 0.0626671
PALLD palladin, cytoskeletal associated protein 0.059931
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0573904
GRB10 growth factor receptor-bound protein 10 0.0563303
RIGI RNA sensor RIG-I 0.0543771
ANO1 anoctamin 1, calcium activated chloride channel 0.052722
RABGAP1L RAB GTPase activating protein 1-like 0.052363
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0522691
AMOTL1 angiomotin like 1 0.0514388
RASAL2 RAS protein activator like 2 0.0511342
PSD3 pleckstrin and Sec7 domain containing 3 0.0506281
HSPG2 heparan sulfate proteoglycan 2 0.0501824
FOXP1 forkhead box P1 0.0501182
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0499778
PTK2 protein tyrosine kinase 2 0.0493709
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0486441
MACF1 microtubule-actin crosslinking factor 1 0.0479188
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0478168
PLS3 plastin 3 0.0472069
PICALM phosphatidylinositol binding clathrin assembly protein 0.0466818
B2M beta-2-microglobulin 0.0463347
PLEC plectin 0.0458437
APLP2 amyloid beta (A4) precursor-like protein 2 0.0456594
AKAP13 A kinase (PRKA) anchor protein 13 0.0446915
ENO1 enolase 1, (alpha) 0.0441412
EXT1 exostosin glycosyltransferase 1 0.0439697
ZSWIM6 zinc finger, SWIM-type containing 6 0.0438816
VCL vinculin 0.0437161
EFNA5 ephrin-A5 0.0429513
FOXO1 forkhead box O1 0.0428784
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0421234
PRELID2 PRELI domain containing 2 0.0413911
HMGA2 high mobility group AT-hook 2 0.0407763
DOCK5 dedicator of cytokinesis 5 0.0405537
TGM2 transglutaminase 2 0.0404075
MECOM MDS1 and EVI1 complex locus 0.0396751
RAD51B RAD51 paralog B 0.0396429
SAMD9 sterile alpha motif domain containing 9 0.0394928
IFI6 interferon, alpha-inducible protein 6 0.0394145
RCOR1 REST corepressor 1 0.0390173
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0389345
POTEF POTE ankyrin domain family, member F 0.0387836
ACTN4 actinin, alpha 4 0.0385156
FNDC3B fibronectin type III domain containing 3B 0.0384044
RNF217 ring finger protein 217 0.0382918
MYOF myoferlin 0.0382695
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0381925
CDK6 cyclin-dependent kinase 6 0.038184
PRSS23 protease, serine, 23 0.0381817
KIAA1671 KIAA1671 0.0380448
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.037973
EXOC4 exocyst complex component 4 0.03792
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0374985
SIK3 SIK family kinase 3 0.0373478
DST dystonin 0.0372926
SULF2 sulfatase 2 0.0371009
CLIC4 chloride intracellular channel 4 0.0369918
PLXNA2 plexin A2 0.0368919
MCL1 myeloid cell leukemia 1 0.03686
MAML2 mastermind-like 2 (Drosophila) 0.0362627
IFI44L interferon-induced protein 44-like 0.0360598
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.035979
DIAPH1 diaphanous-related formin 1 0.0355826
MBNL2 muscleblind-like splicing regulator 2 0.0355066
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0353032
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0346087
TSC22D1 TSC22 domain family, member 1 0.0338697
BCAR3 breast cancer anti-estrogen resistance 3 0.0338456
SMAD3 SMAD family member 3 0.0336162
DGKH diacylglycerol kinase, eta 0.0335317
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0333285
CSMD2 CUB and Sushi multiple domains 2 0.0332429
SMYD3 SET and MYND domain containing 3 0.0324756
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0320179
NCOR2 nuclear receptor corepressor 2 0.0317056
KLF12 Kruppel-like factor 12 0.0314054
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0309224
CTBP2 C-terminal binding protein 2 0.0306145
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0305682
AOPEP aminopeptidase O (putative) 0.0305007
EGFR epidermal growth factor receptor 0.0300761
HDAC9 histone deacetylase 9 0.0300213
SP100 SP100 nuclear antigen 0.0293297
TRIO trio Rho guanine nucleotide exchange factor 0.0290956
SOX5 SRY (sex determining region Y)-box 5 0.0290314
ASPH aspartate beta-hydroxylase 0.0288902
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0288359

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11936
NDRG1 N-myc downstream regulated 1 -0.0912218
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0896655
TPT1 tumor protein, translationally-controlled 1 -0.0672909
NAMPT nicotinamide phosphoribosyltransferase -0.0635753
GOLGA4 golgin A4 -0.053461
FTL ferritin, light polypeptide -0.0507418
CLU clusterin -0.0475156
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0455784
HSPA1A heat shock 70kDa protein 1A -0.0389821
PTMA prothymosin, alpha -0.0352237
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0351369
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0346529
STC1 stanniocalcin 1 -0.0334288
OGA O-GlcNAcase -0.0306736
MT2A metallothionein 2A -0.0305726
H1-0 H1.0 linker histone -0.0297428
RPS21 ribosomal protein S21 -0.0284803
KDM3A lysine (K)-specific demethylase 3A -0.0280599
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0268791
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264817
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0261516
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0245308
UBE2B ubiquitin-conjugating enzyme E2B -0.0234583
IGF2 insulin-like growth factor 2 -0.0224866
NPEPPS aminopeptidase puromycin sensitive -0.021791
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0216139
CUL4B cullin 4B -0.0209568
GARS1 glycyl-tRNA synthetase 1 -0.0208689
RPS6 ribosomal protein S6 -0.0205495
WSB1 WD repeat and SOCS box containing 1 -0.0201327
GNAS GNAS complex locus -0.0199097
PRRC2C proline-rich coiled-coil 2C -0.0196226
HMOX1 heme oxygenase 1 -0.0195887
RTN4 reticulon 4 -0.0194615
SQSTM1 sequestosome 1 -0.0193731
PDGFB platelet-derived growth factor beta polypeptide -0.0191482
ADM adrenomedullin -0.0191079
DENND4C DENN/MADD domain containing 4C -0.0191005
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0188245
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0188008
CSTB cystatin B (stefin B) -0.0185131
SUCO SUN domain containing ossification factor -0.0184843
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0184714
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0184546
RBM39 RNA binding motif protein 39 -0.0182311
RLF rearranged L-myc fusion -0.0181506
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0178114
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.017574
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0170856
NPC1 Niemann-Pick disease, type C1 -0.0169942
SKIC3 SKI3 subunit of superkiller complex -0.0168735
HSPB1 heat shock 27kDa protein 1 -0.0168504
ANLN anillin, actin binding protein -0.0167699
PNISR PNN-interacting serine/arginine-rich protein -0.016714
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0165211
ZMYND8 zinc finger, MYND-type containing 8 -0.0165196
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0163266
RSL1D1 ribosomal L1 domain containing 1 -0.0162329
PLAT plasminogen activator, tissue -0.0161323
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.01601
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0158503
CAVIN1 caveolae associated protein 1 -0.0156894
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0156828
RPS2 ribosomal protein S2 -0.0156764
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.015643
DSTN destrin (actin depolymerizing factor) -0.0156305
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0153809
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0149563
PTGR1 prostaglandin reductase 1 -0.0148235
USP3 ubiquitin specific peptidase 3 -0.01477
MT1X metallothionein 1X -0.0147465
RPL7A ribosomal protein L7a -0.0147149
EIF1 eukaryotic translation initiation factor 1 -0.0144983
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0144061
TMSB10 thymosin beta 10 -0.0142858
RPL11 ribosomal protein L11 -0.0141794
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0141598
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0139567
RB1CC1 RB1-inducible coiled-coil 1 -0.013675
VDAC1 voltage-dependent anion channel 1 -0.0135763
RPL13A ribosomal protein L13a -0.0134635
BZW2 basic leucine zipper and W2 domains 2 -0.0133816
ARHGAP5 Rho GTPase activating protein 5 -0.013354
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0133289
SLC38A1 solute carrier family 38, member 1 -0.0133188
HSPA8 heat shock 70kDa protein 8 -0.013279
RPLP2 ribosomal protein, large, P2 -0.0131788
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0131067
TMEM263 transmembrane protein 263 -0.0130805
RPS3 ribosomal protein S3 -0.0130674
FAM13A family with sequence similarity 13, member A -0.0130419
HM13 histocompatibility (minor) 13 -0.0129924
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0129101
TM9SF2 transmembrane 9 superfamily member 2 -0.012862
XPO1 exportin 1 -0.0128417
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0127998
NKTR natural killer cell triggering receptor -0.0127517
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0125659
STIP1 stress-induced phosphoprotein 1 -0.0123814