Infigratinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Infigratinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.22601
LDHA lactate dehydrogenase A 0.219807
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.197036
ENO1 enolase 1, (alpha) 0.126156
KRT8 keratin 8, type II 0.102963
FTH1 ferritin, heavy polypeptide 1 0.0985748
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0980239
CALR calreticulin 0.0905637
KRT18 keratin 18, type I 0.0886821
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0841244
PKM pyruvate kinase, muscle 0.0817438
FAT1 FAT atypical cadherin 1 0.0729936
CEMIP cell migration inducing protein, hyaluronan binding 0.0718881
PABPC1 poly(A) binding protein, cytoplasmic 1 0.070374
LOC112694756 uncharaterized LOC112694756 0.0612621
MLEC malectin 0.0610281
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0608149
YBX1 Y box binding protein 1 0.0599658
LOC102724023 ES1 protein homolog, mitochondrial 0.0578117
EEF1G eukaryotic translation elongation factor 1 gamma 0.0544481
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0539503
B2M beta-2-microglobulin 0.053617
PCBP2 poly(rC) binding protein 2 0.0516006
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0515586
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0509298
S100A6 S100 calcium binding protein A6 0.0506858
MT2A metallothionein 2A 0.0491336
RPLP1 ribosomal protein, large, P1 0.0489734
AREG amphiregulin 0.0468824
RPL23 ribosomal protein L23 0.0464104
RPS18 ribosomal protein S18 0.0453772
MYO1E myosin IE 0.0451827
TPM3 tropomyosin 3 0.0446782
LGALS3 lectin, galactoside-binding, soluble, 3 0.0443182
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0437074
RPS8 ribosomal protein S8 0.0397896
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0391574
POTEF POTE ankyrin domain family, member F 0.0390863
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0388801
TUBA1B tubulin, alpha 1b 0.0385091
PGK1 phosphoglycerate kinase 1 0.038363
EXT1 exostosin glycosyltransferase 1 0.0381036
KRT19 keratin 19, type I 0.0378704
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0375372
CANX calnexin 0.0366682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.036666
RPL31 ribosomal protein L31 0.0366497
SOX9 SRY (sex determining region Y)-box 9 0.0359358
RPS19 ribosomal protein S19 0.0349884
EEF2 eukaryotic translation elongation factor 2 0.0330391
MCL1 myeloid cell leukemia 1 0.0326546
SPDYA speedy/RINGO cell cycle regulator family member A 0.0321879
GSTP1 glutathione S-transferase pi 1 0.0312405
PDIA6 protein disulfide isomerase family A, member 6 0.0304796
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0304756
RPS17 ribosomal protein S17 0.0295273
RPS4X ribosomal protein S4, X-linked 0.0293846
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0293411
SET SET nuclear proto-oncogene 0.0293213
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0292195
RAN RAN, member RAS oncogene family 0.028875
RACK1 receptor for activated C kinase 1 0.0288508
RPL35A ribosomal protein L35a 0.0281528
CENPF centromere protein F, 350/400kDa 0.0280629
APLP2 amyloid beta (A4) precursor-like protein 2 0.0279697
MARCHF3 membrane associated ring-CH-type finger 3 0.0277014
LDHB lactate dehydrogenase B 0.0271808
SERBP1 SERPINE1 mRNA binding protein 1 0.0270274
KIF5B kinesin family member 5B 0.0262504
VCL vinculin 0.0254896
CD9 CD9 molecule 0.0247323
MT1E metallothionein 1E 0.024399
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0243837
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0241368
NEBL nebulette 0.0240182
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0239178
TPI1 triosephosphate isomerase 1 0.0238897
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0238341
PDIA3 protein disulfide isomerase family A, member 3 0.0237033
TSC22D1 TSC22 domain family, member 1 0.0226278
PDIA4 protein disulfide isomerase family A, member 4 0.0224102
TMSB10 thymosin beta 10 0.0223969
RPL35 ribosomal protein L35 0.0219787
RPS26 ribosomal protein S26 0.021841
ATP5F1A ATP synthase F1 subunit alpha 0.0218095
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0217219
MUC13 mucin 13, cell surface associated 0.021664
EIF4B eukaryotic translation initiation factor 4B 0.0215307
OASL 2'-5'-oligoadenylate synthetase-like 0.0214671
ISG15 ISG15 ubiquitin-like modifier 0.0214263
RPL27A ribosomal protein L27a 0.021395
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0213262
EPHB2 EPH receptor B2 0.0213058
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0211893
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0208311
BTN3A3 butyrophilin, subfamily 3, member A3 0.0208119
SMC1A structural maintenance of chromosomes 1A 0.020796
TRIM2 tripartite motif containing 2 0.0207778
CLDN7 claudin 7 0.0204236
RPLP0 ribosomal protein, large, P0 0.0203887

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.161499
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.13551
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.125772
TPT1 tumor protein, translationally-controlled 1 -0.1211
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0862679
FLNB filamin B, beta -0.0852418
FTL ferritin, light polypeptide -0.0760571
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0747948
TXNRD1 thioredoxin reductase 1 -0.0735513
ASPH aspartate beta-hydroxylase -0.0732785
ALCAM activated leukocyte cell adhesion molecule -0.0625007
GREB1L growth regulation by estrogen in breast cancer-like -0.0609745
NCOR1 nuclear receptor corepressor 1 -0.0595074
ITGA6 integrin, alpha 6 -0.05597
ANTXR2 anthrax toxin receptor 2 -0.0538244
FERMT1 fermitin family member 1 -0.0514483
ONECUT3 one cut homeobox 3 -0.0491863
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0489687
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0485759
PCDHB16 protocadherin beta 16 -0.0484421
NALF1 NALCN channel auxiliary factor 1 -0.0464639
H1-0 H1.0 linker histone -0.0459134
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0458445
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0428292
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0423666
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0406367
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0402666
JMJD1C jumonji domain containing 1C -0.0401391
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0394386
RPS6 ribosomal protein S6 -0.0385392
PNISR PNN-interacting serine/arginine-rich protein -0.0382936
NDRG1 N-myc downstream regulated 1 -0.0371539
RBM39 RNA binding motif protein 39 -0.0370648
ZFAND3 zinc finger, AN1-type domain 3 -0.0367662
NFIA nuclear factor I/A -0.0366122
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0360738
ANXA2 annexin A2 -0.0356823
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.035512
ACTG1 actin gamma 1 -0.0346181
ARHGAP5 Rho GTPase activating protein 5 -0.0344078
PATJ PATJ crumbs cell polarity complex component -0.0341259
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0338779
SLC35F3 solute carrier family 35, member F3 -0.0332604
MAML3 mastermind-like 3 (Drosophila) -0.0330042
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0329805
MGST1 microsomal glutathione S-transferase 1 -0.0329697
HSPA8 heat shock 70kDa protein 8 -0.032659
CCSER1 coiled-coil serine-rich protein 1 -0.0322927
RPS2 ribosomal protein S2 -0.0319316
SLC38A2 solute carrier family 38, member 2 -0.0318333
FOXO1 forkhead box O1 -0.0317253
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0315806
SBF2 SET binding factor 2 -0.0313583
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0313424
H1-4 H1.4 linker histone, cluster member -0.0308156
ANKRD11 ankyrin repeat domain 11 -0.0307804
DSG2 desmoglein 2 -0.0307246
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.030632
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0304353
EHBP1 EH domain binding protein 1 -0.0296931
RNF217 ring finger protein 217 -0.0295954
FAM13A family with sequence similarity 13, member A -0.0291971
ABHD17C abhydrolase domain containing 17C -0.0287569
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0287098
GCC2 GRIP and coiled-coil domain containing 2 -0.0285682
ARL15 ADP-ribosylation factor-like 15 -0.0278825
EPCAM epithelial cell adhesion molecule -0.0276914
SETD5 SET domain containing 5 -0.0272843
FRMD5 FERM domain containing 5 -0.0271202
FER fer (fps/fes related) tyrosine kinase -0.0270933
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0268674
PRRC2C proline-rich coiled-coil 2C -0.0268575
BACE2 beta-site APP-cleaving enzyme 2 -0.0268285
SMYD3 SET and MYND domain containing 3 -0.0268186
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0267775
ZMYM2 zinc finger, MYM-type 2 -0.026585
PPARG peroxisome proliferator-activated receptor gamma -0.0264426
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.026417
LAMC2 laminin, gamma 2 -0.0263352
ATXN1 ataxin 1 -0.0259666
SSH2 slingshot protein phosphatase 2 -0.0258338
TRIO trio Rho guanine nucleotide exchange factor -0.0257639
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.025502
LAMA4 laminin, alpha 4 -0.0253838
EIF1 eukaryotic translation initiation factor 1 -0.0253519
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0252723
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0252658
TCF12 transcription factor 12 -0.0252485
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0252411
GARS1 glycyl-tRNA synthetase 1 -0.0250932
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0249505
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0249493
CADPS Ca++-dependent secretion activator -0.0248938
GPHN gephyrin -0.0248684
PCED1B PC-esterase domain containing 1B -0.0248321
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0247611
S100P S100 calcium binding protein P -0.0246873
PTPRR protein tyrosine phosphatase, receptor type, R -0.0245184
PDS5A PDS5 cohesin associated factor A -0.024187
KDM3A lysine (K)-specific demethylase 3A -0.024111