| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.122394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0520864 |
| LDHA | lactate dehydrogenase A | 0.0509787 |
| GRAMD1B | GRAM domain containing 1B | 0.0410272 |
| ASPH | aspartate beta-hydroxylase | 0.0386581 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0305106 |
| PKM | pyruvate kinase, muscle | 0.029066 |
| MCL1 | myeloid cell leukemia 1 | 0.0287831 |
| SMAD3 | SMAD family member 3 | 0.0283505 |
| ENO1 | enolase 1, (alpha) | 0.0282535 |
| SLTM | SAFB-like, transcription modulator | 0.0280012 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0279874 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0255907 |
| MYOF | myoferlin | 0.0248168 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0247251 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0232633 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0226157 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0225687 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0225392 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0208479 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0207458 |
| CANX | calnexin | 0.0206764 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0204098 |
| PM20D1 | peptidase M20 domain containing 1 | 0.019795 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0194894 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0191142 |
| INTS6 | integrator complex subunit 6 | 0.0179317 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.017076 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0170672 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0166015 |
| PLEC | plectin | 0.0164186 |
| TXNRD1 | thioredoxin reductase 1 | 0.0163135 |
| CES1 | carboxylesterase 1 | 0.016167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0160052 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0158638 |
| HOMER1 | homer scaffolding protein 1 | 0.0157728 |
| SPAG9 | sperm associated antigen 9 | 0.015666 |
| TOP1 | topoisomerase (DNA) I | 0.0155631 |
| PCBP2 | poly(rC) binding protein 2 | 0.0155207 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.015469 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0154597 |
| ZNF638 | zinc finger protein 638 | 0.0153246 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0153144 |
| SMYD3 | SET and MYND domain containing 3 | 0.0150044 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0149761 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0148846 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0142893 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0142431 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0142405 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0140768 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.014063 |
| AHNAK | AHNAK nucleoprotein | 0.0137519 |
| RAD51B | RAD51 paralog B | 0.0134864 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0134835 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0133729 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0130198 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0129547 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0129326 |
| RNF213 | ring finger protein 213 | 0.0127411 |
| FAM13A | family with sequence similarity 13, member A | 0.0123601 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0122612 |
| GOLGB1 | golgin B1 | 0.0121621 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0116979 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0116887 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0116141 |
| ANO6 | anoctamin 6 | 0.0116138 |
| PGK1 | phosphoglycerate kinase 1 | 0.0115513 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0115036 |
| USP34 | ubiquitin specific peptidase 34 | 0.0115025 |
| DOCK1 | dedicator of cytokinesis 1 | 0.011468 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0114369 |
| HYOU1 | hypoxia up-regulated 1 | 0.0113642 |
| MAP7 | microtubule-associated protein 7 | 0.0113557 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.011285 |
| SIK3 | SIK family kinase 3 | 0.0112782 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0111772 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0111645 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.011151 |
| CALR | calreticulin | 0.0111177 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0110402 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0110169 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.010973 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0109374 |
| PYGL | phosphorylase, glycogen, liver | 0.0109288 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0106909 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0105194 |
| GPHN | gephyrin | 0.0104208 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0103797 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0103725 |
| MYO1E | myosin IE | 0.0100116 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00995004 |
| ARRDC3 | arrestin domain containing 3 | 0.00988665 |
| DSPP | dentin sialophosphoprotein | 0.00987733 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.00985688 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.00984815 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.00983577 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.00983045 |
| TPM3 | tropomyosin 3 | 0.00981286 |
| VMP1 | vacuole membrane protein 1 | 0.00971783 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.00966454 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0722436 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0457924 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0349496 |
| LAMC2 | laminin, gamma 2 | -0.0309181 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0273089 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0261198 |
| ACTG1 | actin gamma 1 | -0.0254846 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0219231 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0217872 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0211277 |
| RPL35A | ribosomal protein L35a | -0.0206209 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0190501 |
| FTL | ferritin, light polypeptide | -0.0185089 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0178794 |
| CST3 | cystatin C | -0.0172322 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0171945 |
| EGR1 | early growth response 1 | -0.0166892 |
| S100A10 | S100 calcium binding protein A10 | -0.0159185 |
| H1-0 | H1.0 linker histone | -0.0155691 |
| LAMA4 | laminin, alpha 4 | -0.0150033 |
| OSMR | oncostatin M receptor | -0.0145515 |
| LMO7 | LIM domain 7 | -0.0144446 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0130324 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0127705 |
| LAMB3 | laminin, beta 3 | -0.0127409 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0125692 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0124025 |
| RPL34 | ribosomal protein L34 | -0.012229 |
| PTMA | prothymosin, alpha | -0.0112571 |
| STC1 | stanniocalcin 1 | -0.0112444 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0107682 |
| RPS24 | ribosomal protein S24 | -0.0106605 |
| NDRG1 | N-myc downstream regulated 1 | -0.0103805 |
| MT2A | metallothionein 2A | -0.0100742 |
| HMGA1 | high mobility group AT-hook 1 | -0.00993511 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.00971554 |
| MT1X | metallothionein 1X | -0.00962024 |
| GNAS | GNAS complex locus | -0.00960098 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00942587 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00928852 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00916111 |
| SCEL | sciellin | -0.00900676 |
| CSTB | cystatin B (stefin B) | -0.00889646 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.00866966 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.00859149 |
| S100A9 | S100 calcium binding protein A9 | -0.0085664 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00826482 |
| MYL12B | myosin, light chain 12B, regulatory | -0.008246 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00793294 |
| RPS3 | ribosomal protein S3 | -0.00771513 |
| S100A11 | S100 calcium binding protein A11 | -0.00759248 |
| RPS21 | ribosomal protein S21 | -0.00750437 |
| RPS25 | ribosomal protein S25 | -0.00747806 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.00741544 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00739145 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0072137 |
| RPS6 | ribosomal protein S6 | -0.00700957 |
| HLA-B | major histocompatibility complex, class I, B | -0.00699962 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00693211 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00670768 |
| RPL11 | ribosomal protein L11 | -0.00653561 |
| SERF2 | small EDRK-rich factor 2 | -0.00653351 |
| PFN1 | profilin 1 | -0.00640325 |
| SMIM31 | small integral membrane protein 31 | -0.00636709 |
| RPS27A | ribosomal protein S27a | -0.00636464 |
| PERP | PERP, TP53 apoptosis effector | -0.00632385 |
| AREG | amphiregulin | -0.00608087 |
| CCNI | cyclin I | -0.00608048 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.00604368 |
| RPL37A | ribosomal protein L37a | -0.00594454 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0058814 |
| S100P | S100 calcium binding protein P | -0.00588011 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00587454 |
| S100A6 | S100 calcium binding protein A6 | -0.00586792 |
| KRT19 | keratin 19, type I | -0.00586583 |
| WASF2 | WAS protein family, member 2 | -0.00574144 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00560775 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.00553972 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.00553552 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0053817 |
| RPS13 | ribosomal protein S13 | -0.0053605 |
| RPL9 | ribosomal protein L9 | -0.00530682 |
| RPL36A | ribosomal protein L36a | -0.00527412 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.00523477 |
| RPS19 | ribosomal protein S19 | -0.00521469 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.00520079 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.00515209 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00514976 |
| MYO1D | myosin ID | -0.00511392 |
| SEC61G | Sec61 gamma subunit | -0.00508075 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00507068 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.00505564 |
| IER3 | immediate early response 3 | -0.00505208 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00497326 |
| CP | ceruloplasmin (ferroxidase) | -0.0048998 |
| RTN4 | reticulon 4 | -0.00489337 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00488945 |
| MIDN | midnolin | -0.00484338 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00483408 |
| HSPE1 | heat shock 10kDa protein 1 | -0.00481217 |
