Infigratinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Infigratinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109741
PCBP2 poly(rC) binding protein 2 0.0952018
NAMPT nicotinamide phosphoribosyltransferase 0.0695525
SOD2 superoxide dismutase 2, mitochondrial 0.0652164
FNDC3B fibronectin type III domain containing 3B 0.0627852
GRB10 growth factor receptor-bound protein 10 0.0623492
SMAD3 SMAD family member 3 0.0601293
KDM2A lysine (K)-specific demethylase 2A 0.0559035
CD44 CD44 molecule (Indian blood group) 0.0496948
GOLGA4 golgin A4 0.0489993
ELL2 elongation factor, RNA polymerase II, 2 0.0479209
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0476741
RICTOR RPTOR independent companion of MTOR, complex 2 0.0432348
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0430696
LDHA lactate dehydrogenase A 0.0426509
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0423087
ATP13A3 ATPase type 13A3 0.0379671
FTH1 ferritin, heavy polypeptide 1 0.0369234
RBM39 RNA binding motif protein 39 0.0369107
FAM13A family with sequence similarity 13, member A 0.0366072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0362868
APLP2 amyloid beta (A4) precursor-like protein 2 0.0345453
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0340638
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0338708
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0338591
UBA6 ubiquitin-like modifier activating enzyme 6 0.0337771
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0335402
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03288
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0328753
LOX lysyl oxidase 0.0322671
ZNF292 zinc finger protein 292 0.0321066
CANX calnexin 0.0316338
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0313783
PDIA3 protein disulfide isomerase family A, member 3 0.0308726
LMAN1 lectin, mannose-binding, 1 0.0303551
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0299361
SPAG9 sperm associated antigen 9 0.0289602
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0287114
HELZ helicase with zinc finger 0.0285715
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0281114
MBNL1 muscleblind-like splicing regulator 1 0.0277317
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0277197
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0267698
USP3 ubiquitin specific peptidase 3 0.0267146
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0262657
WAC WW domain containing adaptor with coiled-coil 0.0262575
YBX1 Y box binding protein 1 0.0261573
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.026029
RUNX1 runt-related transcription factor 1 0.0258471
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0250715
RIOK3 RIO kinase 3 0.0244876
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0239706
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0236766
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0232009
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0229153
FN1 fibronectin 1 0.0227629
PIAS2 protein inhibitor of activated STAT, 2 0.0223718
COPA coatomer protein complex, subunit alpha 0.0223083
EEF2 eukaryotic translation elongation factor 2 0.0220981
CTNND1 catenin (cadherin-associated protein), delta 1 0.0216659
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0215479
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0214755
SBF2 SET binding factor 2 0.0213694
MAP1B microtubule-associated protein 1B 0.0212738
DPYSL3 dihydropyrimidinase-like 3 0.0212611
PKM pyruvate kinase, muscle 0.0212469
BASP1 brain abundant, membrane attached signal protein 1 0.021175
PARD3 par-3 family cell polarity regulator 0.0211644
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0211442
RAB8B RAB8B, member RAS oncogene family 0.0210119
YBX3 Y box binding protein 3 0.020806
HILPDA hypoxia inducible lipid droplet-associated 0.0206089
BIRC3 baculoviral IAP repeat containing 3 0.0205938
KMT2C lysine (K)-specific methyltransferase 2C 0.0205683
SRP54 signal recognition particle 54kDa 0.0204649
ERRFI1 ERBB receptor feedback inhibitor 1 0.0204241
MYH9 myosin, heavy chain 9, non-muscle 0.0202371
EZR ezrin 0.0201382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0200726
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0200133
SYAP1 synapse associated protein 1 0.0198807
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0198207
OGA O-GlcNAcase 0.0196854
TRIO trio Rho guanine nucleotide exchange factor 0.0196648
MYO10 myosin X 0.019462
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0193511
ANKRD28 ankyrin repeat domain 28 0.0192974
SLTM SAFB-like, transcription modulator 0.0190355
ANXA2 annexin A2 0.0189603
BHLHE40 basic helix-loop-helix family, member e40 0.018828
FAM107B family with sequence similarity 107, member B 0.0187594
ESYT2 extended synaptotagmin-like protein 2 0.0185131
RNF145 ring finger protein 145 0.0184448
KIF5B kinesin family member 5B 0.018374
CD109 CD109 molecule 0.0183677
APP amyloid beta (A4) precursor protein 0.018355
SEC23A Sec23 homolog A (S. cerevisiae) 0.0182822
SIK3 SIK family kinase 3 0.0182514
ASPH aspartate beta-hydroxylase 0.0181671
FBXL13 F-box and leucine-rich repeat protein 13 0.0181334

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.068567
CDH13 cadherin 13 -0.0581491
TPT1 tumor protein, translationally-controlled 1 -0.0574937
TFPI2 tissue factor pathway inhibitor 2 -0.0500602
RPL35A ribosomal protein L35a -0.041453
SDK1 sidekick cell adhesion molecule 1 -0.0395416
STC1 stanniocalcin 1 -0.0390299
MTSS1 metastasis suppressor 1 -0.0388325
NRG1 neuregulin 1 -0.0373013
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.036945
FAM20C family with sequence similarity 20, member C -0.0315192
ZMYND8 zinc finger, MYND-type containing 8 -0.030765
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0272513
RPLP1 ribosomal protein, large, P1 -0.0265592
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0261731
HLA-B major histocompatibility complex, class I, B -0.0260512
RPL37A ribosomal protein L37a -0.0256174
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0252259
GLCCI1 glucocorticoid induced 1 -0.0247791
PRRX1 paired related homeobox 1 -0.0247152
RPS29 ribosomal protein S29 -0.0246177
RPS24 ribosomal protein S24 -0.0243019
CLMP CXADR-like membrane protein -0.023731
TM4SF1 transmembrane 4 L six family member 1 -0.0224396
RPL31 ribosomal protein L31 -0.022372
DIAPH2 diaphanous-related formin 2 -0.0223527
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0219207
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0216347
RPLP2 ribosomal protein, large, P2 -0.0213356
DPYD dihydropyrimidine dehydrogenase -0.0212985
VIM vimentin -0.0212919
RPL38 ribosomal protein L38 -0.0212744
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0212612
ENO2 enolase 2 (gamma, neuronal) -0.0211222
RPS6 ribosomal protein S6 -0.0209123
ZNF804A zinc finger protein 804A -0.0200622
IL1B interleukin 1, beta -0.01993
HMGA2 high mobility group AT-hook 2 -0.0195789
RPS13 ribosomal protein S13 -0.0193216
BTG1 B-cell translocation gene 1, anti-proliferative -0.0192097
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0189502
WSB1 WD repeat and SOCS box containing 1 -0.0189247
RPL34 ribosomal protein L34 -0.0187496
HM13 histocompatibility (minor) 13 -0.0186233
EXT1 exostosin glycosyltransferase 1 -0.0180134
PTMA prothymosin, alpha -0.0178237
DNER delta/notch-like EGF repeat containing -0.0173715
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0171703
ATG7 autophagy related 7 -0.0168954
IFI6 interferon, alpha-inducible protein 6 -0.0168886
IER3 immediate early response 3 -0.0166716
CDK14 cyclin-dependent kinase 14 -0.0164919
RPS11 ribosomal protein S11 -0.0163761
ANXA10 annexin A10 -0.0162779
TPST1 tyrosylprotein sulfotransferase 1 -0.0161313
ARL4C ADP-ribosylation factor-like 4C -0.016125
EIF1 eukaryotic translation initiation factor 1 -0.0157848
FRMD4A FERM domain containing 4A -0.0157261
RPS12 ribosomal protein S12 -0.0156606
CAVIN1 caveolae associated protein 1 -0.015653
IGFBP3 insulin-like growth factor binding protein 3 -0.0155098
MSRB3 methionine sulfoxide reductase B3 -0.0153545
RPS8 ribosomal protein S8 -0.0152972
MAML3 mastermind-like 3 (Drosophila) -0.0151762
ACTG1 actin gamma 1 -0.015121
RPL7A ribosomal protein L7a -0.0151065
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0150887
TRIOBP TRIO and F-actin binding protein -0.015051
NUMB numb homolog (Drosophila) -0.0149331
PCNX4 pecanex 4 -0.0148411
SP100 SP100 nuclear antigen -0.0148162
THBD thrombomodulin -0.0147352
NLK nemo-like kinase -0.0147115
RPS25 ribosomal protein S25 -0.0146617
SH3RF3 SH3 domain containing ring finger 3 -0.0146101
CP ceruloplasmin (ferroxidase) -0.0145405
THSD4 thrombospondin, type I, domain containing 4 -0.0144398
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0143642
WNT2B wingless-type MMTV integration site family, member 2B -0.0141881
ENOSF1 enolase superfamily member 1 -0.0141636
BMERB1 bMERB domain containing 1 -0.014117
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0140829
NAP1L1 nucleosome assembly protein 1-like 1 -0.0140829
RPL9 ribosomal protein L9 -0.0140696
TMEM165 transmembrane protein 165 -0.0140509
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0136089
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0135418
RPL28 ribosomal protein L28 -0.0134932
EFCAB13 EF-hand calcium binding domain 13 -0.013426
RPL37 ribosomal protein L37 -0.0132226
RPS23 ribosomal protein S23 -0.0131898
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0131186
EFNA5 ephrin-A5 -0.0129809
ARHGAP22 Rho GTPase activating protein 22 -0.0129637
RPS16 ribosomal protein S16 -0.0128873
RPS27A ribosomal protein S27a -0.0127951
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0127712
RAI14 retinoic acid induced 14 -0.0127443
RPS19 ribosomal protein S19 -0.0127343
BMAL2 basic helix-loop-helix ARNT like 2 -0.0126516