| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.222882 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0768827 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0676477 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0641461 |
| LDHA | lactate dehydrogenase A | 0.0630153 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0559649 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0497472 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.049674 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0487104 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0465865 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0451266 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0450507 |
| HLA-B | major histocompatibility complex, class I, B | 0.0440685 |
| S100A6 | S100 calcium binding protein A6 | 0.0377191 |
| PYGL | phosphorylase, glycogen, liver | 0.0375202 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0367611 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0362913 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0359524 |
| IER3 | immediate early response 3 | 0.0354224 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0351678 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0343478 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0333163 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0328626 |
| EGFR | epidermal growth factor receptor | 0.03235 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0320227 |
| CMIP | c-Maf inducing protein | 0.0299807 |
| NDRG1 | N-myc downstream regulated 1 | 0.0295575 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.028936 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0287928 |
| RPL35A | ribosomal protein L35a | 0.028719 |
| FMNL2 | formin-like 2 | 0.0282855 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.027438 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0270317 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0270312 |
| RPL31 | ribosomal protein L31 | 0.0266878 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0266721 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0264883 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0263486 |
| MCL1 | myeloid cell leukemia 1 | 0.0260338 |
| FLNB | filamin B, beta | 0.0255318 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0254934 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0254549 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0253405 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0242778 |
| HLA-A | major histocompatibility complex, class I, A | 0.0240573 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.023351 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0231873 |
| ANGPTL4 | angiopoietin-like 4 | 0.0226878 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0224231 |
| RPS8 | ribosomal protein S8 | 0.0221234 |
| MYO1E | myosin IE | 0.0220803 |
| ATXN1 | ataxin 1 | 0.0218267 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0214774 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.02143 |
| SVIL | supervillin | 0.0207946 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0199085 |
| NF1 | neurofibromin 1 | 0.0197068 |
| ASPH | aspartate beta-hydroxylase | 0.0196777 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0194629 |
| FAM107B | family with sequence similarity 107, member B | 0.0193933 |
| RPLP1 | ribosomal protein, large, P1 | 0.0191675 |
| USP34 | ubiquitin specific peptidase 34 | 0.0191249 |
| VIM | vimentin | 0.0190425 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0189706 |
| COPA | coatomer protein complex, subunit alpha | 0.0189583 |
| RPL37A | ribosomal protein L37a | 0.0186339 |
| B2M | beta-2-microglobulin | 0.0185256 |
| UTRN | utrophin | 0.0185204 |
| GOLGA4 | golgin A4 | 0.0180152 |
| NEBL | nebulette | 0.0177819 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0177623 |
| S100A10 | S100 calcium binding protein A10 | 0.0177613 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0176869 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0176517 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0175282 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0172549 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0171978 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0170883 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0169871 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0168774 |
| ACTG1 | actin gamma 1 | 0.0167676 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0165841 |
| SNX14 | sorting nexin 14 | 0.0164864 |
| EHBP1 | EH domain binding protein 1 | 0.0164184 |
| RPS6 | ribosomal protein S6 | 0.0163686 |
| PARD3 | par-3 family cell polarity regulator | 0.016286 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0161587 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0160768 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0160087 |
| RAD51B | RAD51 paralog B | 0.0159414 |
| INTS6 | integrator complex subunit 6 | 0.0158885 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.015662 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0156405 |
| RPS27 | ribosomal protein S27 | 0.0156341 |
| KYNU | kynureninase | 0.0156293 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0155302 |
| SBF2 | SET binding factor 2 | 0.0154727 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0154544 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0154203 |
| CTBP2 | C-terminal binding protein 2 | 0.0151961 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.101135 |
| GRAMD1B | GRAM domain containing 1B | -0.0928677 |
| TXNRD1 | thioredoxin reductase 1 | -0.0879651 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0649525 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0543258 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0498201 |
| UBC | ubiquitin C | -0.0464753 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0402531 |
| RPS27A | ribosomal protein S27a | -0.0393751 |
| FGB | fibrinogen beta chain | -0.0383551 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0355409 |
| RTN4 | reticulon 4 | -0.0351553 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0322529 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0282102 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0278384 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0260781 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0253497 |
| MKI67 | marker of proliferation Ki-67 | -0.0252768 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0231591 |
| TMSB10 | thymosin beta 10 | -0.0227334 |
| TPM3 | tropomyosin 3 | -0.0220965 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0205875 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0191875 |
| PTMA | prothymosin, alpha | -0.0191273 |
| KLF6 | Kruppel-like factor 6 | -0.0190612 |
| ANLN | anillin, actin binding protein | -0.0190217 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0189351 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0186471 |
| YBX1 | Y box binding protein 1 | -0.0179773 |
| RPL23 | ribosomal protein L23 | -0.0179533 |
| SLC38A2 | solute carrier family 38, member 2 | -0.017919 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0178468 |
| CENPF | centromere protein F, 350/400kDa | -0.0176187 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0174412 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0173906 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0173321 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0169468 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0169292 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0169018 |
| RPL4 | ribosomal protein L4 | -0.0168527 |
| TPX2 | TPX2, microtubule-associated | -0.0168519 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0165758 |
| RHEB | Ras homolog enriched in brain | -0.0164742 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.014903 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0147864 |
| YBX3 | Y box binding protein 3 | -0.0146562 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0146193 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0144912 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0144778 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0144606 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0144075 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0143433 |
| ECT2 | epithelial cell transforming 2 | -0.0143041 |
| WDR43 | WD repeat domain 43 | -0.0140705 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0139162 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0138589 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0136475 |
| USP3 | ubiquitin specific peptidase 3 | -0.0135089 |
| TNPO1 | transportin 1 | -0.0132552 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0132355 |
| RHOA | ras homolog family member A | -0.0131623 |
| CENPE | centromere protein E, 312kDa | -0.0129641 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0125677 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0124177 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0123998 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0117486 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0115378 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0114158 |
| MORF4L1 | mortality factor 4 like 1 | -0.0113783 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | -0.011079 |
| FAM168A | family with sequence similarity 168, member A | -0.0110647 |
| FTL | ferritin, light polypeptide | -0.0110171 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0109874 |
| XPO1 | exportin 1 | -0.010809 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0108061 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0107785 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0107145 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.010705 |
| ENAH | enabled homolog (Drosophila) | -0.0106919 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0106342 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0105145 |
| HSPA4 | heat shock 70kDa protein 4 | -0.010467 |
| TUBB | tubulin, beta class I | -0.010459 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0104165 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0102426 |
| TMEM123 | transmembrane protein 123 | -0.0102271 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0101981 |
| FGG | fibrinogen gamma chain | -0.0100867 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0100506 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0100034 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.00995286 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.00991352 |
| VMP1 | vacuole membrane protein 1 | -0.00983033 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.00978657 |
| NTN4 | netrin 4 | -0.0097046 |
| HSPA1B | heat shock 70kDa protein 1B | -0.00966391 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.00962389 |
| HMGB1 | high mobility group box 1 | -0.009579 |
| ZNF292 | zinc finger protein 292 | -0.00956283 |
| AREG | amphiregulin | -0.00956248 |
