| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.386094 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.108289 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0786184 |
| YBX3 | Y box binding protein 3 | 0.073999 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.069525 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0559089 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0481529 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.041676 |
| LDHA | lactate dehydrogenase A | 0.041071 |
| GRAMD1B | GRAM domain containing 1B | 0.037778 |
| OSMR | oncostatin M receptor | 0.0370271 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0367539 |
| HMGA2 | high mobility group AT-hook 2 | 0.0365867 |
| PYGL | phosphorylase, glycogen, liver | 0.036001 |
| PDE10A | phosphodiesterase 10A | 0.0350326 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0349395 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0326134 |
| TPM4 | tropomyosin 4 | 0.0319177 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0311778 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0298901 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0297688 |
| DSPP | dentin sialophosphoprotein | 0.029746 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0296382 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0293538 |
| ATXN1 | ataxin 1 | 0.0275951 |
| VCL | vinculin | 0.0258528 |
| EGFR | epidermal growth factor receptor | 0.0254768 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0253629 |
| EXOC4 | exocyst complex component 4 | 0.0247202 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0244635 |
| RPS18 | ribosomal protein S18 | 0.0244102 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0239999 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0239414 |
| TPM3 | tropomyosin 3 | 0.0237812 |
| WWOX | WW domain containing oxidoreductase | 0.0237186 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0230522 |
| KRT18 | keratin 18, type I | 0.0229085 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0229051 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0224667 |
| FMNL2 | formin-like 2 | 0.0223252 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0221917 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0221115 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0219248 |
| TPI1 | triosephosphate isomerase 1 | 0.021545 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0215024 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0214894 |
| MT2A | metallothionein 2A | 0.0210243 |
| SVIL | supervillin | 0.0207343 |
| TRIM9 | tripartite motif containing 9 | 0.020428 |
| MCL1 | myeloid cell leukemia 1 | 0.0204223 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.019811 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0193503 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0188311 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.018593 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.018573 |
| CDCP1 | CUB domain containing protein 1 | 0.0185584 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0185484 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0183776 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0182965 |
| PRKCE | protein kinase C, epsilon | 0.0180291 |
| CUX1 | cut-like homeobox 1 | 0.0180102 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.017946 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.017683 |
| NLGN1 | neuroligin 1 | 0.0176446 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0173176 |
| STC1 | stanniocalcin 1 | 0.0171868 |
| YBX1 | Y box binding protein 1 | 0.0171523 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0171481 |
| HLA-B | major histocompatibility complex, class I, B | 0.0169372 |
| BNC2 | basonuclin 2 | 0.0164194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0160911 |
| ATP11A | ATPase, class VI, type 11A | 0.0159388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0159223 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0158499 |
| EHBP1 | EH domain binding protein 1 | 0.015633 |
| POTEF | POTE ankyrin domain family, member F | 0.015526 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0154929 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0153193 |
| LOXL2 | lysyl oxidase-like 2 | 0.015204 |
| ATP13A3 | ATPase type 13A3 | 0.0151372 |
| PRELID2 | PRELI domain containing 2 | 0.0151259 |
| TCIM | transcriptional and immune response regulator | 0.0150405 |
| RYR3 | ryanodine receptor 3 | 0.0150167 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0148259 |
| RNF213 | ring finger protein 213 | 0.0147587 |
| FAM13A | family with sequence similarity 13, member A | 0.0146876 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0145517 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0144446 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0142071 |
| SMAD3 | SMAD family member 3 | 0.0141982 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.014155 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0139974 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0139874 |
| DST | dystonin | 0.0139303 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0138499 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0138233 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0137591 |
| CANX | calnexin | 0.0137064 |
| COL5A2 | collagen, type V, alpha 2 | 0.0136954 |
| BMP5 | bone morphogenetic protein 5 | 0.0136619 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.138512 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.115139 |
| UBC | ubiquitin C | -0.108424 |
| RPS27A | ribosomal protein S27a | -0.0730817 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0687063 |
| TXNRD1 | thioredoxin reductase 1 | -0.0666811 |
| PTMA | prothymosin, alpha | -0.0576269 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0561006 |
| TMSB10 | thymosin beta 10 | -0.0549379 |
| RPL23 | ribosomal protein L23 | -0.052822 |
| RPS3 | ribosomal protein S3 | -0.0481419 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0465545 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0460566 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0449932 |
| RPS8 | ribosomal protein S8 | -0.0431721 |
| RPL37A | ribosomal protein L37a | -0.0414288 |
| RPS29 | ribosomal protein S29 | -0.0401571 |
| RPS21 | ribosomal protein S21 | -0.0390211 |
| RPL37 | ribosomal protein L37 | -0.0374572 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0374136 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0360375 |
| RPS15 | ribosomal protein S15 | -0.0350514 |
| RBM25 | RNA binding motif protein 25 | -0.0345022 |
| OGA | O-GlcNAcase | -0.0342248 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0321553 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0319895 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.031971 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0317587 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0313144 |
| RTN4 | reticulon 4 | -0.0304405 |
| PHIP | pleckstrin homology domain interacting protein | -0.0300496 |
| RPL9 | ribosomal protein L9 | -0.0298071 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0294933 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0292573 |
| RPS13 | ribosomal protein S13 | -0.0290465 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.02876 |
| RPL5 | ribosomal protein L5 | -0.0281831 |
| RPS10 | ribosomal protein S10 | -0.0280105 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0276027 |
| RPL26 | ribosomal protein L26 | -0.0271933 |
| GOLGA4 | golgin A4 | -0.027168 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0270981 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0270313 |
| RPL35A | ribosomal protein L35a | -0.0265621 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263068 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0256276 |
| BRD2 | bromodomain containing 2 | -0.0254506 |
| PCBP2 | poly(rC) binding protein 2 | -0.0246998 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0242884 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0242765 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0240614 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0232498 |
| RPL31 | ribosomal protein L31 | -0.0232173 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0231246 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0224195 |
| RPS25 | ribosomal protein S25 | -0.0220231 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0217425 |
| RPS23 | ribosomal protein S23 | -0.0216697 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0213961 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0213274 |
| RPL13A | ribosomal protein L13a | -0.021321 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0212153 |
| RPL11 | ribosomal protein L11 | -0.021129 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0208304 |
| RPLP2 | ribosomal protein, large, P2 | -0.0206921 |
| RPL12 | ribosomal protein L12 | -0.0206005 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0203428 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.0203347 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0202443 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0201461 |
| ATXN2 | ataxin 2 | -0.0200652 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0200291 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0200141 |
| XPO1 | exportin 1 | -0.0200038 |
| PLCB4 | phospholipase C, beta 4 | -0.0198936 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0198473 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0196435 |
| GPHN | gephyrin | -0.0195426 |
| RPL28 | ribosomal protein L28 | -0.0194321 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0194179 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0192508 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0191919 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0190656 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0189407 |
| CTTN | cortactin | -0.0187727 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0187341 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0186071 |
| RPL34 | ribosomal protein L34 | -0.0186066 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0185382 |
| ZNF638 | zinc finger protein 638 | -0.0184633 |
| RPL38 | ribosomal protein L38 | -0.0184146 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0184073 |
| RPL8 | ribosomal protein L8 | -0.0182891 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0182656 |
| MKI67 | marker of proliferation Ki-67 | -0.0179659 |
| SRPK2 | SRSF protein kinase 2 | -0.0179654 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0179442 |
| COG5 | component of oligomeric golgi complex 5 | -0.0179437 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0178669 |
| RPL19 | ribosomal protein L19 | -0.0176077 |
