| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.0771537 |
| EXT1 | exostosin glycosyltransferase 1 | 0.069552 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0663941 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0663801 |
| EFNA5 | ephrin-A5 | 0.0507818 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0444146 |
| FBXO32 | F-box protein 32 | 0.04203 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0373067 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0359995 |
| LMO7 | LIM domain 7 | 0.0354049 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0353184 |
| RAI14 | retinoic acid induced 14 | 0.0345344 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0309418 |
| RNF213 | ring finger protein 213 | 0.0305137 |
| GOLGB1 | golgin B1 | 0.0284694 |
| MYO1E | myosin IE | 0.0280888 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0276748 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0269596 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0254239 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0252629 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0248926 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0244274 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0239716 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0239185 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0238179 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0236648 |
| ETV6 | ets variant 6 | 0.0234239 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0230876 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0226974 |
| MX2 | MX dynamin-like GTPase 2 | 0.0224415 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0223565 |
| MYO6 | myosin VI | 0.0219954 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0219469 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0218823 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0217288 |
| RAD51B | RAD51 paralog B | 0.0208891 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0208784 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0208691 |
| CEP350 | centrosomal protein 350kDa | 0.0208013 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0207759 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0206697 |
| MACC1 | metastasis associated in colon cancer 1 | 0.020587 |
| CSTB | cystatin B (stefin B) | 0.0202918 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0202466 |
| VCL | vinculin | 0.020105 |
| RIGI | RNA sensor RIG-I | 0.0200089 |
| FNIP1 | folliculin interacting protein 1 | 0.0195983 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0194738 |
| ERBIN | erbb2 interacting protein | 0.0189742 |
| FBXO34 | F-box protein 34 | 0.0189235 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0188315 |
| HLA-B | major histocompatibility complex, class I, B | 0.0188071 |
| TMEM165 | transmembrane protein 165 | 0.0188027 |
| RBM47 | RNA binding motif protein 47 | 0.0183989 |
| MCU | mitochondrial calcium uniporter | 0.0182184 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0179533 |
| UBAP1 | ubiquitin associated protein 1 | 0.0175153 |
| SCFD1 | sec1 family domain containing 1 | 0.0174905 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0172048 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0167803 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0167578 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0167552 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0166259 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.016602 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0164168 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0161651 |
| RCOR1 | REST corepressor 1 | 0.0161323 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.0160452 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0159011 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0158293 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0155063 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0154329 |
| PLSCR1 | phospholipid scramblase 1 | 0.0149391 |
| TBC1D22A | TBC1 domain family, member 22A | 0.01487 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0147426 |
| FRMD5 | FERM domain containing 5 | 0.0147303 |
| CUX1 | cut-like homeobox 1 | 0.0146567 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0146566 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0141783 |
| JUP | junction plakoglobin | 0.0141773 |
| SNX6 | sorting nexin 6 | 0.014128 |
| AOPEP | aminopeptidase O (putative) | 0.014116 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.014075 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0140718 |
| DTNA | dystrobrevin, alpha | 0.0139763 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0139597 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0138828 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0138062 |
| RSF1 | remodeling and spacing factor 1 | 0.0137846 |
| ATOSA | atos homolog A | 0.0136852 |
| VEGFA | vascular endothelial growth factor A | 0.0136785 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0136483 |
| DSPP | dentin sialophosphoprotein | 0.0135984 |
| MX1 | MX dynamin-like GTPase 1 | 0.0135624 |
| SRP54 | signal recognition particle 54kDa | 0.0135361 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0132438 |
| TMF1 | TATA element modulatory factor 1 | 0.0132109 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0131961 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0130992 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0130657 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.273767 |
| UBC | ubiquitin C | -0.203027 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.174766 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.142273 |
| FN1 | fibronectin 1 | -0.12661 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.113217 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102251 |
| ASPH | aspartate beta-hydroxylase | -0.0919054 |
| NDRG1 | N-myc downstream regulated 1 | -0.08024 |
| TMSB10 | thymosin beta 10 | -0.0757619 |
| FTL | ferritin, light polypeptide | -0.0730032 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.067319 |
| RPS27A | ribosomal protein S27a | -0.0616222 |
| S100A6 | S100 calcium binding protein A6 | -0.0589036 |
| PTMA | prothymosin, alpha | -0.0547074 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0546747 |
| RPL23 | ribosomal protein L23 | -0.0524147 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0522726 |
| ENO1 | enolase 1, (alpha) | -0.0505059 |
| RPS3 | ribosomal protein S3 | -0.0462528 |
| HMGA1 | high mobility group AT-hook 1 | -0.046086 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0444801 |
| TXNRD1 | thioredoxin reductase 1 | -0.0440092 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0413163 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.040634 |
| PCBP2 | poly(rC) binding protein 2 | -0.0375197 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0370944 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0370046 |
| RPL8 | ribosomal protein L8 | -0.0364606 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0362774 |
| RACK1 | receptor for activated C kinase 1 | -0.0360649 |
| HMGB2 | high mobility group box 2 | -0.0360432 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0358293 |
| CALR | calreticulin | -0.0357792 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0356921 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0356775 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0353869 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0343838 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0338187 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0335772 |
| RPS8 | ribosomal protein S8 | -0.033224 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.033203 |
| TFG | TRK-fused gene | -0.0331859 |
| G0S2 | G0/G1 switch 2 | -0.0330979 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0327125 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0323348 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0322162 |
| POTEF | POTE ankyrin domain family, member F | -0.0314956 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.031271 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0308934 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0308488 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0307353 |
| UPP1 | uridine phosphorylase 1 | -0.030681 |
| RPS23 | ribosomal protein S23 | -0.0305379 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0302208 |
| MT2A | metallothionein 2A | -0.0299857 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0298539 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0295548 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0292524 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0287212 |
| KRT7 | keratin 7, type II | -0.028591 |
| AHNAK | AHNAK nucleoprotein | -0.0285832 |
| LAMC2 | laminin, gamma 2 | -0.0285491 |
| LAMB3 | laminin, beta 3 | -0.0285482 |
| RPLP2 | ribosomal protein, large, P2 | -0.0284998 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0282314 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0274055 |
| RHOA | ras homolog family member A | -0.0268012 |
| CCNI | cyclin I | -0.0267344 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0258798 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0257646 |
| S100A10 | S100 calcium binding protein A10 | -0.025699 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0256667 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0256267 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0253402 |
| RHEB | Ras homolog enriched in brain | -0.0251655 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0250682 |
| RTN4 | reticulon 4 | -0.024976 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0249727 |
| EPCAM | epithelial cell adhesion molecule | -0.0247626 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0241083 |
| RPS19 | ribosomal protein S19 | -0.0240955 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0240629 |
| RPL5 | ribosomal protein L5 | -0.0238766 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.0238602 |
| RPL19 | ribosomal protein L19 | -0.0237719 |
| SDC4 | syndecan 4 | -0.0231509 |
| RPL9 | ribosomal protein L9 | -0.0229013 |
| RPL32 | ribosomal protein L32 | -0.0227394 |
| RYBP | RING1 and YY1 binding protein | -0.0226623 |
| PAPOLA | poly(A) polymerase alpha | -0.0226588 |
| MATR3 | matrin 3 | -0.0225354 |
| RNF145 | ring finger protein 145 | -0.0225209 |
| AREG | amphiregulin | -0.0224322 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0223638 |
| ZNF292 | zinc finger protein 292 | -0.0221986 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0221083 |
| RPS5 | ribosomal protein S5 | -0.0219441 |
| RPL37A | ribosomal protein L37a | -0.0219352 |
| CCNL1 | cyclin L1 | -0.021842 |
