| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.126456 |
| ASPH | aspartate beta-hydroxylase | 0.0733499 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.063549 |
| LDHA | lactate dehydrogenase A | 0.0627419 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0564564 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0564275 |
| MYOF | myoferlin | 0.0525605 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0495323 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0438811 |
| KYNU | kynureninase | 0.043324 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0428322 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0379915 |
| EFNA5 | ephrin-A5 | 0.0379145 |
| SPAG9 | sperm associated antigen 9 | 0.0342356 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0329062 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0327119 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.032711 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0309856 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.029014 |
| CANX | calnexin | 0.0286384 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0272347 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0265416 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0263767 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0261998 |
| PCBP2 | poly(rC) binding protein 2 | 0.0250827 |
| ANXA2 | annexin A2 | 0.0250674 |
| MCL1 | myeloid cell leukemia 1 | 0.0249627 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0244105 |
| FNDC3B | fibronectin type III domain containing 3B | 0.024316 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0225202 |
| PGK1 | phosphoglycerate kinase 1 | 0.0217879 |
| EZR | ezrin | 0.0214621 |
| COPA | coatomer protein complex, subunit alpha | 0.0211798 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0211403 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0210098 |
| ENO1 | enolase 1, (alpha) | 0.0210065 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0209772 |
| MT2A | metallothionein 2A | 0.0201029 |
| FLNB | filamin B, beta | 0.0199322 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0196798 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.019484 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0190449 |
| ANXA1 | annexin A1 | 0.0190315 |
| VCL | vinculin | 0.0182495 |
| PKM | pyruvate kinase, muscle | 0.0181374 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0179115 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.017785 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0176752 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0173791 |
| NDRG1 | N-myc downstream regulated 1 | 0.0169503 |
| MORF4L2 | mortality factor 4 like 2 | 0.0165702 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0164557 |
| NUP58 | nucleoporin 58 | 0.0164344 |
| CALR | calreticulin | 0.016373 |
| TXNRD1 | thioredoxin reductase 1 | 0.0154069 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0152441 |
| HELZ | helicase with zinc finger | 0.0151904 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0148682 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0147985 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0147933 |
| PLCB4 | phospholipase C, beta 4 | 0.0147562 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0147107 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0146987 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0146361 |
| GRAMD1B | GRAM domain containing 1B | 0.014564 |
| AHNAK | AHNAK nucleoprotein | 0.0144421 |
| CTBP2 | C-terminal binding protein 2 | 0.0142362 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0141956 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.014169 |
| RBM39 | RNA binding motif protein 39 | 0.0140779 |
| OGA | O-GlcNAcase | 0.0140777 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0140477 |
| CALU | calumenin | 0.0139513 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0137568 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0135287 |
| ZNF292 | zinc finger protein 292 | 0.0132776 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0131614 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0131416 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0131067 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0130191 |
| TPM3 | tropomyosin 3 | 0.0129773 |
| UBC | ubiquitin C | 0.012947 |
| LMNA | lamin A/C | 0.0129147 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0129122 |
| USP34 | ubiquitin specific peptidase 34 | 0.0126936 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0126669 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0126567 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0125624 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0125515 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0125255 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0125159 |
| USP53 | ubiquitin specific peptidase 53 | 0.0123956 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0122923 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0122499 |
| NEK7 | NIMA-related kinase 7 | 0.0122411 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0121656 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0121443 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0119885 |
| ARRDC3 | arrestin domain containing 3 | 0.0119874 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0119346 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.23643 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0897548 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0804616 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0717818 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0693725 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0504591 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0498694 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0485647 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0480335 |
| FN1 | fibronectin 1 | -0.0463516 |
| VIM | vimentin | -0.0425959 |
| TMSB10 | thymosin beta 10 | -0.0399991 |
| RPS6 | ribosomal protein S6 | -0.0397808 |
| COL5A2 | collagen, type V, alpha 2 | -0.0366688 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0361337 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0338243 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0335565 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0327983 |
| TBXT | T-box transcription factor T | -0.0324838 |
| RPL37A | ribosomal protein L37a | -0.0303466 |
| CTSL | cathepsin L | -0.0296528 |
| CDH13 | cadherin 13 | -0.0291589 |
| RPS19 | ribosomal protein S19 | -0.029101 |
| RPL35A | ribosomal protein L35a | -0.0290743 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0250737 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0250521 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0244055 |
| SMYD3 | SET and MYND domain containing 3 | -0.0234351 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0232001 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0222767 |
| RPS12 | ribosomal protein S12 | -0.0221386 |
| RPLP1 | ribosomal protein, large, P1 | -0.0220568 |
| RPL9 | ribosomal protein L9 | -0.0220342 |
| RPS3 | ribosomal protein S3 | -0.0219503 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0218744 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0217223 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0212801 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0207055 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0205401 |
| RPS8 | ribosomal protein S8 | -0.0204336 |
| RPLP2 | ribosomal protein, large, P2 | -0.0200764 |
| TENM3 | teneurin transmembrane protein 3 | -0.0199331 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0193428 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0189723 |
| RPL36A | ribosomal protein L36a | -0.0186384 |
| CUX1 | cut-like homeobox 1 | -0.0181202 |
| RPS27 | ribosomal protein S27 | -0.0180299 |
| RPS27A | ribosomal protein S27a | -0.0180176 |
| NCKAP5 | NCK-associated protein 5 | -0.0177497 |
| KIAA0825 | KIAA0825 | -0.0170192 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0169599 |
| INHBA | inhibin, beta A | -0.0168503 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0167086 |
| LSAMP | limbic system-associated membrane protein | -0.0165607 |
| RPL36 | ribosomal protein L36 | -0.016068 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0157717 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0157119 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0156424 |
| RPS16 | ribosomal protein S16 | -0.0154135 |
| RPS25 | ribosomal protein S25 | -0.0153969 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0152644 |
| RPL7A | ribosomal protein L7a | -0.0151452 |
| RPS29 | ribosomal protein S29 | -0.0150621 |
| FTL | ferritin, light polypeptide | -0.015022 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0149501 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0147842 |
| PCDH15 | protocadherin-related 15 | -0.0144042 |
| RPS14 | ribosomal protein S14 | -0.0143525 |
| RPS21 | ribosomal protein S21 | -0.014305 |
| RPS23 | ribosomal protein S23 | -0.0142785 |
| RPL26 | ribosomal protein L26 | -0.0142499 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0138549 |
| GPRIN3 | GPRIN family member 3 | -0.0137689 |
| HLA-B | major histocompatibility complex, class I, B | -0.0135604 |
| CLMP | CXADR-like membrane protein | -0.0134829 |
| RPL31 | ribosomal protein L31 | -0.0134215 |
| RPL34 | ribosomal protein L34 | -0.013271 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0129288 |
| STEAP1B | STEAP family member 1B | -0.0128922 |
| RPL23 | ribosomal protein L23 | -0.0128663 |
| ZFHX3 | zinc finger homeobox 3 | -0.0127288 |
| LAMB1 | laminin, beta 1 | -0.0126409 |
| RPS24 | ribosomal protein S24 | -0.0125153 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0125041 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0124449 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0124368 |
| MAP7 | microtubule-associated protein 7 | -0.0123476 |
| STC1 | stanniocalcin 1 | -0.0123459 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0123067 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0122844 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0122772 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0122123 |
| HSPE1 | heat shock 10kDa protein 1 | -0.0122013 |
| RPS13 | ribosomal protein S13 | -0.0120976 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0120853 |
| TPM4 | tropomyosin 4 | -0.0118247 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0118241 |
| FSTL4 | follistatin-like 4 | -0.0116716 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.0113482 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0112779 |
