| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Infigratinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Infigratinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0465027 |
| HDAC9 | histone deacetylase 9 | 0.0412804 |
| ZNF292 | zinc finger protein 292 | 0.0333843 |
| POTEF | POTE ankyrin domain family, member F | 0.0287487 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0262039 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0233799 |
| TPM3 | tropomyosin 3 | 0.023119 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0213348 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0194902 |
| RPL23 | ribosomal protein L23 | 0.0190197 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0189913 |
| CANX | calnexin | 0.0188568 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0185301 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0179284 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0177022 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0173499 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0168545 |
| MATR3 | matrin 3 | 0.0167393 |
| LDHA | lactate dehydrogenase A | 0.0164667 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0161217 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0154615 |
| APP | amyloid beta (A4) precursor protein | 0.015311 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0152773 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0152355 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0150834 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0148051 |
| RPL12 | ribosomal protein L12 | 0.0147191 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0146687 |
| MRTFA | myocardin related transcription factor A | 0.014642 |
| RHEB | Ras homolog enriched in brain | 0.0145959 |
| UBAP2 | ubiquitin associated protein 2 | 0.0145192 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0142977 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0141712 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0141267 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.014104 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0140593 |
| TSPAN12 | tetraspanin 12 | 0.0139867 |
| TMSB4X | thymosin beta 4, X-linked | 0.0138559 |
| RPL3 | ribosomal protein L3 | 0.0138171 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0136334 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0134639 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0133922 |
| RPS4X | ribosomal protein S4, X-linked | 0.013387 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0132895 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0131356 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0130706 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0130122 |
| YAP1 | Yes-associated protein 1 | 0.0129946 |
| RYBP | RING1 and YY1 binding protein | 0.0129365 |
| CALU | calumenin | 0.0128147 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0127873 |
| XPO1 | exportin 1 | 0.0127112 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0125345 |
| YBX1 | Y box binding protein 1 | 0.0124766 |
| NEK7 | NIMA-related kinase 7 | 0.012471 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0124434 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0124421 |
| ANXA5 | annexin A5 | 0.0123824 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.012354 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0122341 |
| QKI | QKI, KH domain containing, RNA binding | 0.0121685 |
| MEMO1 | mediator of cell motility 1 | 0.0120838 |
| PTMS | parathymosin | 0.0120805 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0120397 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0120315 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.012015 |
| PCDH18 | protocadherin 18 | 0.0120019 |
| ARRDC3 | arrestin domain containing 3 | 0.0118793 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0117736 |
| RPS18 | ribosomal protein S18 | 0.0117095 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0116428 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0115853 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.0115727 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0114802 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.011432 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.011379 |
| PCBP2 | poly(rC) binding protein 2 | 0.0113005 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0112973 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0111915 |
| SFPQ | splicing factor proline/glutamine-rich | 0.011184 |
| RPS26 | ribosomal protein S26 | 0.011151 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0110508 |
| DSTN | destrin (actin depolymerizing factor) | 0.011009 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0109545 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.010936 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0109037 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 0.0109009 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0108982 |
| RPLP0 | ribosomal protein, large, P0 | 0.010845 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0107556 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.010709 |
| TNPO1 | transportin 1 | 0.0106963 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0106884 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0105668 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0105127 |
| APMAP | adipocyte plasma membrane associated protein | 0.0103946 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0101884 |
| GOLIM4 | golgi integral membrane protein 4 | 0.010157 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0100989 |
| LGMN | legumain | 0.0100841 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.252043 |
| COL11A1 | collagen, type XI, alpha 1 | -0.156743 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.135506 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.131388 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.110507 |
| CADM2 | cell adhesion molecule 2 | -0.109595 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0997867 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0959945 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0929802 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0824443 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0810211 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0771245 |
| GPC3 | glypican 3 | -0.075797 |
| PCDH9 | protocadherin 9 | -0.0739529 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0727698 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.061091 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0581046 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0557756 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0553121 |
| TENM3 | teneurin transmembrane protein 3 | -0.05489 |
| ITGAV | integrin, alpha V | -0.049386 |
| LRRC4C | leucine rich repeat containing 4C | -0.0469693 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0462986 |
| VIM | vimentin | -0.045839 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0453259 |
| NRG1 | neuregulin 1 | -0.0446169 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0421161 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.041398 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0409416 |
| PLPP1 | phospholipid phosphatase 1 | -0.0406513 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0377383 |
| PRKD1 | protein kinase D1 | -0.0376183 |
| COL3A1 | collagen, type III, alpha 1 | -0.0370146 |
| PRELID2 | PRELI domain containing 2 | -0.0364036 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0361945 |
| SHROOM3 | shroom family member 3 | -0.0357795 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0352841 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.034823 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0346174 |
| RAD51B | RAD51 paralog B | -0.0339581 |
| MEIS2 | Meis homeobox 2 | -0.0330841 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0309591 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0299524 |
| MAP4 | microtubule-associated protein 4 | -0.029888 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0298834 |
| CENPF | centromere protein F, 350/400kDa | -0.0296977 |
| PHIP | pleckstrin homology domain interacting protein | -0.0276131 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0274018 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0265143 |
| LYST | lysosomal trafficking regulator | -0.0264086 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0263786 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0262961 |
| DMD | dystrophin | -0.0258196 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0254714 |
| H1-0 | H1.0 linker histone | -0.025131 |
| CDH19 | cadherin 19, type 2 | -0.0250346 |
| DENND5B | DENN/MADD domain containing 5B | -0.0249646 |
| HSPE1 | heat shock 10kDa protein 1 | -0.0248271 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0246655 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0244087 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0238571 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0238508 |
| MYO10 | myosin X | -0.0238491 |
| HSPA1B | heat shock 70kDa protein 1B | -0.0237264 |
| TXNRD1 | thioredoxin reductase 1 | -0.0234861 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0230156 |
| EMP1 | epithelial membrane protein 1 | -0.0226846 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0226647 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | -0.0225903 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0224274 |
| MKI67 | marker of proliferation Ki-67 | -0.0223409 |
| FAM171B | family with sequence similarity 171, member B | -0.0223055 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0220328 |
| HMCN1 | hemicentin 1 | -0.0218507 |
| CACYBP | calcyclin binding protein | -0.0215388 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0215294 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0214032 |
| PRR16 | proline rich 16 | -0.0213771 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0209312 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0205424 |
| JMJD1C | jumonji domain containing 1C | -0.0205031 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0196786 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0195632 |
| FRY | furry homolog (Drosophila) | -0.0191904 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0188669 |
| WASF2 | WAS protein family, member 2 | -0.0188645 |
| THOC2 | THO complex 2 | -0.0188368 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0186835 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0184924 |
| NFIA | nuclear factor I/A | -0.0181458 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0180942 |
| METAP2 | methionyl aminopeptidase 2 | -0.0180721 |
| NHSL1 | NHS-like 1 | -0.0178675 |
| RAI1 | retinoic acid induced 1 | -0.0178095 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.017743 |
| ENAH | enabled homolog (Drosophila) | -0.0176395 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0174415 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0173746 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0172923 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0172454 |
