Infigratinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Infigratinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Infigratinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.231783
FN1 fibronectin 1 0.190422
NRG1 neuregulin 1 0.180705
HMGA2 high mobility group AT-hook 2 0.162356
EXT1 exostosin glycosyltransferase 1 0.123054
TMEM156 transmembrane protein 156 0.1209
ITGA1 integrin, alpha 1 0.11339
GLIS3 GLIS family zinc finger 3 0.103504
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0983177
VCL vinculin 0.0961009
ENO1 enolase 1, (alpha) 0.085757
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0819783
IFI27 interferon, alpha-inducible protein 27 0.0805283
PKM pyruvate kinase, muscle 0.0750415
MYH9 myosin, heavy chain 9, non-muscle 0.0746586
HIPK2 homeodomain interacting protein kinase 2 0.0719787
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0710298
SQSTM1 sequestosome 1 0.0700978
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0680718
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0677223
EFNA5 ephrin-A5 0.0652001
B2M beta-2-microglobulin 0.0644192
NRP1 neuropilin 1 0.0642155
SYT1 synaptotagmin I 0.0605658
CANX calnexin 0.0587598
SFTPA2 surfactant protein A2 0.0587129
FNDC3B fibronectin type III domain containing 3B 0.0564262
AKAP12 A kinase (PRKA) anchor protein 12 0.0556192
SMAD3 SMAD family member 3 0.0555742
NTN4 netrin 4 0.054592
KLHL5 kelch-like family member 5 0.0524855
IFI6 interferon, alpha-inducible protein 6 0.0522852
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.051978
LIMCH1 LIM and calponin homology domains 1 0.0497885
SVIL supervillin 0.0488095
APLP2 amyloid beta (A4) precursor-like protein 2 0.0485487
SEPTIN9 septin 9 0.0480804
NPAS2 neuronal PAS domain protein 2 0.0475147
SMYD3 SET and MYND domain containing 3 0.0467135
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0454667
RNF213 ring finger protein 213 0.0453666
CAPN2 calpain 2, (m/II) large subunit 0.0434422
TRIO trio Rho guanine nucleotide exchange factor 0.0427768
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0425225
S100A6 S100 calcium binding protein A6 0.0423264
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.042029
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0416567
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.041207
LDHA lactate dehydrogenase A 0.0408969
RAI14 retinoic acid induced 14 0.0408929
STC2 stanniocalcin 2 0.0404104
FOXP1 forkhead box P1 0.0404071
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0402924
ETV1 ets variant 1 0.040198
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0399106
LRMDA leucine rich melanocyte differentiation associated 0.039186
MAML2 mastermind-like 2 (Drosophila) 0.0390425
PALLD palladin, cytoskeletal associated protein 0.038984
ATXN1 ataxin 1 0.0387623
LOXL2 lysyl oxidase-like 2 0.0378646
AHNAK AHNAK nucleoprotein 0.0374209
IFI44L interferon-induced protein 44-like 0.0374103
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373361
LOC102724023 ES1 protein homolog, mitochondrial 0.0365389
PDLIM5 PDZ and LIM domain 5 0.0364209
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0362824
ZBTB20 zinc finger and BTB domain containing 20 0.0361778
PDE4D phosphodiesterase 4D, cAMP-specific 0.0360097
MBD5 methyl-CpG binding domain protein 5 0.0359279
TAS2R14 taste receptor, type 2, member 14 0.0357312
LOC112694756 uncharaterized LOC112694756 0.0356355
NRIP1 nuclear receptor interacting protein 1 0.035245
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0351813
TMSB4X thymosin beta 4, X-linked 0.0346646
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0345184
DST dystonin 0.0340194
MCL1 myeloid cell leukemia 1 0.0337099
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0328298
HLA-B major histocompatibility complex, class I, B 0.0318011
VEGFC vascular endothelial growth factor C 0.0317099
PLEC plectin 0.0310419
AEBP2 AE binding protein 2 0.0307868
RAD51B RAD51 paralog B 0.0306727
MLPH melanophilin 0.030627
MACF1 microtubule-actin crosslinking factor 1 0.0304864
FHL2 four and a half LIM domains 2 0.0304766
TPM3 tropomyosin 3 0.0304703
EGFR epidermal growth factor receptor 0.0301295
RIGI RNA sensor RIG-I 0.03009
IFI16 interferon, gamma-inducible protein 16 0.029961
ETV6 ets variant 6 0.0298521
TOP1 topoisomerase (DNA) I 0.0297709
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0297217
MBNL1 muscleblind-like splicing regulator 1 0.0296685
SOX4 SRY (sex determining region Y)-box 4 0.0295678
SHB Src homology 2 domain containing adaptor protein B 0.0294775
OSMR oncostatin M receptor 0.0293607
TPI1 triosephosphate isomerase 1 0.0289935
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0285779
PRELID2 PRELI domain containing 2 0.0285082

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.125862
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0938811
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0828533
NDRG1 N-myc downstream regulated 1 -0.0551673
HILPDA hypoxia inducible lipid droplet-associated -0.0547066
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0456217
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0453209
FTL ferritin, light polypeptide -0.0446581
WDR45B WD repeat domain 45B -0.0385624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0337586
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0333737
NAMPT nicotinamide phosphoribosyltransferase -0.0329692
RAB1A RAB1A, member RAS oncogene family -0.0322316
LCORL ligand dependent nuclear receptor corepressor-like -0.0316862
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314442
RNF145 ring finger protein 145 -0.0305585
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.030412
SOD2 superoxide dismutase 2, mitochondrial -0.0301797
TPT1 tumor protein, translationally-controlled 1 -0.0301242
RBM39 RNA binding motif protein 39 -0.0300186
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0290635
NUP58 nucleoporin 58 -0.0286667
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0284391
OGA O-GlcNAcase -0.0277634
HELZ helicase with zinc finger -0.0275285
ZNF292 zinc finger protein 292 -0.0274774
CD109 CD109 molecule -0.0272086
RLF rearranged L-myc fusion -0.0255844
WAC WW domain containing adaptor with coiled-coil -0.0254864
MARCHF6 membrane associated ring-CH-type finger 6 -0.0253513
TRA2A transformer 2 alpha homolog (Drosophila) -0.0248539
RPS6 ribosomal protein S6 -0.0248026
IFRD1 interferon-related developmental regulator 1 -0.0247547
SUCO SUN domain containing ossification factor -0.0247484
QKI QKI, KH domain containing, RNA binding -0.0245093
RAB6A RAB6A, member RAS oncogene family -0.024478
ACBD3 acyl-CoA binding domain containing 3 -0.0243602
SPAG9 sperm associated antigen 9 -0.0242204
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0234517
MT2A metallothionein 2A -0.0233722
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0228251
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.022445
GARS1 glycyl-tRNA synthetase 1 -0.0220667
UGCG UDP-glucose ceramide glucosyltransferase -0.0219864
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0218596
NEK7 NIMA-related kinase 7 -0.0212833
TENT2 terminal nucleotidyltransferase 2 -0.0209481
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0205877
UBC ubiquitin C -0.0203845
GOLGA4 golgin A4 -0.020364
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0203376
TFG TRK-fused gene -0.019991
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0198649
MT1X metallothionein 1X -0.0198165
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0196781
USP3 ubiquitin specific peptidase 3 -0.0195971
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0194876
COG5 component of oligomeric golgi complex 5 -0.0194348
SDCBP syndecan binding protein (syntenin) -0.0193711
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0191365
TXNIP thioredoxin interacting protein -0.0191359
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0189946
NOP58 NOP58 ribonucleoprotein -0.0189592
MXI1 MAX interactor 1, dimerization protein -0.0189197
RHEB Ras homolog enriched in brain -0.0188374
GOLT1B golgi transport 1B -0.0186911
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0186263
FAM13A family with sequence similarity 13, member A -0.0186215
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0183156
AFTPH aftiphilin -0.0182217
RIOK3 RIO kinase 3 -0.0180964
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.017541
BHLHE40 basic helix-loop-helix family, member e40 -0.0174686
DDIT4 DNA-damage-inducible transcript 4 -0.0174117
CACUL1 CDK2-associated, cullin domain 1 -0.0173497
SRP54 signal recognition particle 54kDa -0.0172915
TPD52 tumor protein D52 -0.0170974
MIS18BP1 MIS18 binding protein 1 -0.0170738
KDM5B lysine (K)-specific demethylase 5B -0.0168277
WDFY1 WD repeat and FYVE domain containing 1 -0.0167499
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.016747
KDM3A lysine (K)-specific demethylase 3A -0.0167281
ESYT2 extended synaptotagmin-like protein 2 -0.0167063
PNPLA8 patatin-like phospholipase domain containing 8 -0.0165751
HSPA1A heat shock 70kDa protein 1A -0.0164835
COPA coatomer protein complex, subunit alpha -0.01648
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0163589
RTN4 reticulon 4 -0.0163173
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0159551
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0158252
WTAP Wilms tumor 1 associated protein -0.0157395
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0157383
MRPS6 mitochondrial ribosomal protein S6 -0.0157366
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0155849
ODR4 odr-4 GPCR localization factor homolog -0.0155742
KCTD9 potassium channel tetramerization domain containing 9 -0.0155389
SEC24A SEC24 family member A -0.015419
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0151501
NPEPPS aminopeptidase puromycin sensitive -0.0151032
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0150855