| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6918670 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Ingenol-3-angelate relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UPP1 | uridine phosphorylase 1 | 2.04 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 2.0 |
| DUSP5 | dual specificity phosphatase 5 | 1.85 |
| LAMC2 | laminin, gamma 2 | 1.75 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 1.7 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 1.58 |
| NRP1 | neuropilin 1 | 1.52 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 1.48 |
| FAM110C | family with sequence similarity 110, member C | 1.47 |
| NAV3 | neuron navigator 3 | 1.45 |
| NAV2 | neuron navigator 2 | 1.45 |
| LAMB3 | laminin, beta 3 | 1.43 |
| FOSL1 | FOS-like antigen 1 | 1.39 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 1.37 |
| DGKD | diacylglycerol kinase, delta 130kDa | 1.3 |
| PLAUR | plasminogen activator, urokinase receptor | 1.29 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 1.28 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 1.27 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 1.23 |
| SMTN | smoothelin | 1.23 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 1.23 |
| HAS3 | hyaluronan synthase 3 | 1.19 |
| PLAU | plasminogen activator, urokinase | 1.12 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 1.11 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 1.1 |
| APOBEC3D | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | 1.08 |
| JUNB | jun B proto-oncogene | 1.05 |
| DUSP4 | dual specificity phosphatase 4 | 1.03 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 1.0 |
| CPA4 | carboxypeptidase A4 | 0.99 |
| CD59 | CD59 molecule, complement regulatory protein | 0.98 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.98 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.97 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.91 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.9 |
| NDRG1 | N-myc downstream regulated 1 | 0.9 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.89 |
| ARG2 | arginase 2 | 0.89 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.89 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.87 |
| OPTN | optineurin | 0.87 |
| JUN | jun proto-oncogene | 0.86 |
| PLEK2 | pleckstrin 2 | 0.86 |
| ABHD2 | abhydrolase domain containing 2 | 0.84 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.83 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 0.82 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.81 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | 0.8 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.79 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.78 |
| CTSL | cathepsin L | 0.76 |
| STC2 | stanniocalcin 2 | 0.75 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.75 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.72 |
| CDK17 | cyclin-dependent kinase 17 | 0.71 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.7 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.68 |
| TXNRD1 | thioredoxin reductase 1 | 0.67 |
| ICAM1 | intercellular adhesion molecule 1 | 0.66 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.64 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.64 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.64 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.64 |
| FERMT1 | fermitin family member 1 | 0.64 |
| EFHD2 | EF-hand domain family, member D2 | 0.63 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.63 |
| WDR45 | WD repeat domain 45 | 0.63 |
| TRIML2 | tripartite motif family-like 2 | 0.63 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.63 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.62 |
| HLA-B | major histocompatibility complex, class I, B | 0.62 |
| CDC14A | cell division cycle 14A | 0.62 |
| HMOX1 | heme oxygenase 1 | 0.61 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.61 |
| AEN | apoptosis enhancing nuclease | 0.6 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 0.6 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.6 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.6 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.6 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.6 |
| SESN2 | sestrin 2 | 0.59 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.59 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.59 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.59 |
| NAGS | N-acetylglutamate synthase | 0.58 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.58 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.57 |
| RASA3 | RAS p21 protein activator 3 | 0.57 |
| HLA-A | major histocompatibility complex, class I, A | 0.57 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.57 |
| PARD6B | par-6 family cell polarity regulator beta | 0.54 |
| TSPAN5 | tetraspanin 5 | 0.54 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.54 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.54 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.53 |
| EHD4 | EH-domain containing 4 | 0.52 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.52 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.52 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKCA | protein kinase C, alpha | -2.7 |
| PRKCQ | protein kinase C, theta | -2.0 |
| PRKCB | protein kinase C, beta | -1.8 |
| PRKCG | protein kinase C, gamma | -1.4 |
| PRKCD | protein kinase C, delta | -1.36 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -1.28 |
| GDF15 | growth differentiation factor 15 | -1.24 |
| IRF2 | interferon regulatory factor 2 | -1.21 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -1.14 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -1.07 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -1.06 |
| ADAM22 | ADAM metallopeptidase domain 22 | -1.05 |
| N4BP1 | NEDD4 binding protein 1 | -0.97 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.95 |
| PEG10 | paternally expressed 10 | -0.95 |
| ULBP1 | UL16 binding protein 1 | -0.92 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.92 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.9 |
| KITLG | KIT ligand | -0.89 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.88 |
| RNF13 | ring finger protein 13 | -0.88 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -0.87 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.85 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.84 |
| VSIR | V-set immunoregulatory receptor | -0.83 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.82 |
| OGDHL | oxoglutarate dehydrogenase-like | -0.82 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.81 |
| MARCKSL1 | MARCKS-like 1 | -0.81 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | -0.81 |
| NDRG2 | NDRG family member 2 | -0.8 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -0.8 |
| ZC3H10 | zinc finger CCCH-type containing 10 | -0.79 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | -0.78 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.78 |
| TNS3 | tensin 3 | -0.77 |
| ADD3 | adducin 3 (gamma) | -0.77 |
| NEBL | nebulette | -0.75 |
| FAM120C | family with sequence similarity 120C | -0.75 |
| EME1 | essential meiotic structure-specific endonuclease 1 | -0.75 |
| SIK2 | salt-inducible kinase 2 | -0.74 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.74 |
| MBP | myelin basic protein | -0.73 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.73 |
| CLDN3 | claudin 3 | -0.73 |
| TBC1D30 | TBC1 domain family, member 30 | -0.72 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.71 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.71 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.7 |
| COL6A1 | collagen, type VI, alpha 1 | -0.7 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.69 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.69 |
| TP53 | tumor protein p53 | -0.69 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.68 |
| PALM | paralemmin | -0.68 |
| TRIM2 | tripartite motif containing 2 | -0.68 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.67 |
| GPC4 | glypican 4 | -0.67 |
| SELENOH | selenoprotein H | -0.67 |
| ABHD17C | abhydrolase domain containing 17C | -0.67 |
| TESC | tescalcin | -0.66 |
| RNF146 | ring finger protein 146 | -0.66 |
| RTN4RL2 | reticulon 4 receptor-like 2 | -0.66 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.66 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.65 |
| ACVR1B | activin A receptor, type IB | -0.65 |
| RXRG | retinoid X receptor, gamma | -0.65 |
| AJUBA | ajuba LIM protein | -0.65 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.64 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.64 |
| STMN1 | stathmin 1 | -0.64 |
| KDF1 | keratinocyte differentiation factor 1 | -0.63 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | -0.63 |
| BCL10 | B-cell CLL/lymphoma 10 | -0.63 |
| BRD8 | bromodomain containing 8 | -0.63 |
| COMMD3 | COMM domain containing 3 | -0.62 |
| PIH1D1 | PIH1 domain containing 1 | -0.62 |
| CD99 | CD99 molecule | -0.62 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.62 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.62 |
| ZNF385A | zinc finger protein 385A | -0.61 |
| FZD7 | frizzled class receptor 7 | -0.61 |
| DENND5B | DENN/MADD domain containing 5B | -0.6 |
| CADM4 | cell adhesion molecule 4 | -0.6 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.6 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.6 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.6 |
| S100A5 | S100 calcium binding protein A5 | -0.59 |
| SORT1 | sortilin 1 | -0.59 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.59 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.58 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | -0.58 |
| PPFIA3 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 | -0.58 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | -0.58 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -0.57 |
| MLXIPL | MLX interacting protein-like | -0.57 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.56 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.56 |
| ANTXR1 | anthrax toxin receptor 1 | -0.56 |
