Insulin secretion Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. (Gene Ontology, GO_0030073)
External Link https://www.kegg.jp/entry/hsa04911
Similar Terms
Downloads & Tools

Genes

81 proteins participating in the Insulin secretion pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ATF4 activating transcription factor 4
ATF6B activating transcription factor 6 beta
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
C1QTNF1 C1q and tumor necrosis factor related protein 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCKAR cholecystokinin A receptor
CHRM3 cholinergic receptor, muscarinic 3
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
FFAR1 free fatty acid receptor 1
FXYD2 FXYD domain containing ion transport regulator 2
GCG glucagon
GDNF glial cell derived neurotrophic factor
GLP1R glucagon-like peptide 1 receptor
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GPR119 G protein-coupled receptor 119
INS insulin
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNU1 potassium channel, subfamily U, member 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
PCLO piccolo presynaptic cytomatrix protein
PDHX pyruvate dehydrogenase complex, component X
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
RAB3A RAB3A, member RAS oncogene family
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RIMS2 regulating synaptic membrane exocytosis 2
RIPK2 receptor-interacting serine-threonine kinase 2
RYR2 ryanodine receptor 2 (cardiac)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
STX1A syntaxin 1A (brain)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)