Insulinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.|A usually benign, well circumscribed neoplasm arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin. (Experimental Factor Ontology, EFO_0000549)
External Link https://www.disgenet.org/browser/0/1/0/C0021670
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Genes

246 genes associated with the disease Insulinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACO2 aconitase 2, mitochondrial
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOR1 adiponectin receptor 1
ADM adrenomedullin
ADSS2 adenylosuccinate synthase 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPT2 angiopoietin 2
APOC2 apolipoprotein C-II
ATF6 activating transcription factor 6
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTC betacellulin
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALCA calcitonin-related polypeptide alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCNC cyclin C
CCND1 cyclin D1
CCND3 cyclin D3
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHGA chromogranin A
CIITA class II, major histocompatibility complex, transactivator
CMA1 chymase 1, mast cell
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRHR1 corticotropin releasing hormone receptor 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
DCTN4 dynactin 4 (p62)
DCTN6 dynactin 6
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIPR1 EARP complex and GARP complex interacting protein 1
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERP44 endoplasmic reticulum protein 44
ESR2 estrogen receptor 2 (ER beta)
FAS Fas cell surface death receptor
FASTK Fas-activated serine/threonine kinase
FBN1 fibrillin 1
FFAR1 free fatty acid receptor 1
FGF13 fibroblast growth factor 13
FGF21 fibroblast growth factor 21
FOXM1 forkhead box M1
G6PC glucose-6-phosphatase, catalytic subunit
G6PC2 glucose-6-phosphatase, catalytic, 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAST gastrin
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GCM2 glial cells missing homolog 2 (Drosophila)
GIP gastric inhibitory polypeptide
GLP1R glucagon-like peptide 1 receptor
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GOLGA6A golgin A6 family, member A
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR119 G protein-coupled receptor 119
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HAMP hepcidin antimicrobial peptide
HCAR2 hydroxycarboxylic acid receptor 2
HES3 hes family bHLH transcription factor 3
HK1 hexokinase 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN2 high mobility group nucleosomal binding domain 2
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IAPP islet amyloid polypeptide
IFI27 interferon, alpha-inducible protein 27
IGF2 insulin-like growth factor 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGSF9 immunoglobulin superfamily, member 9
IL10 interleukin 10
IL1B interleukin 1, beta
IL4 interleukin 4
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INS-IGF2 INS-IGF2 readthrough
INSL5 insulin-like 5
INSM1 insulinoma-associated 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KDM1A lysine (K)-specific demethylase 1A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KL klotho
KRT16 keratin 16, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LHX2 LIM homeobox 2
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPT microtubule-associated protein tau
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCTS1 malignant T cell amplified sequence 1
MDK midkine (neurite growth-promoting factor 2)
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGC57346-CRHR1 MGC57346-CRHR1 readthrough
MLH1 mutL homolog 1
MNX1 motor neuron and pancreas homeobox 1
MRC1 mannose receptor, C type 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCAM1 neural cell adhesion molecule 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NF1 neurofibromin 1
NFE2L1 nuclear factor, erythroid 2-like 1
NIT1 nitrilase 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP62 nucleoporin 62kDa
OPA1 optic atrophy 1 (autosomal dominant)
PAX4 paired box 4
PAX6 paired box 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PDHX pyruvate dehydrogenase complex, component X
PDIA2 protein disulfide isomerase family A, member 2
PDIA5 protein disulfide isomerase family A, member 5
PDX1 pancreatic and duodenal homeobox 1
PDZD2 PDZ domain containing 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRL prolactin
PRSS1 protease, serine, 1 (trypsin 1)
PSEN2 presenilin 2
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTTG1 pituitary tumor-transforming 1
RAB3A RAB3A, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RALBP1 ralA binding protein 1
RANBP2 RAN binding protein 2
RAP1A RAP1A, member of RAS oncogene family
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
REG1A regenerating islet-derived 1 alpha
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIT2 Ras-like without CAAX 2
RPS15 ribosomal protein S15
S100A8 S100 calcium binding protein A8
SCT secretin
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELENOS selenoprotein S
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC25A38 solute carrier family 25, member 38
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A10 solute carrier family 30, member 10
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNX1 sorting nexin 1
SOX6 SRY (sex determining region Y)-box 6
SQSTM1 sequestosome 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SST somatostatin
SSTR2 somatostatin receptor 2
SSTR3 somatostatin receptor 3
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
STAB1 stabilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
STOML3 stomatin (EPB72)-like 3
SYP synaptophysin
TCF19 transcription factor 19
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THBD thrombomodulin
TICAM2 toll-like receptor adaptor molecule 2
TKT transketolase
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP53 tumor protein p53
TPD52 tumor protein D52
TRABD TraB domain containing
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPAN7 tetraspanin 7
TXN thioredoxin
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WFS1 Wolfram syndrome 1 (wolframin)
WISP2 WNT1 inducible signaling pathway protein 2
YY1 YY1 transcription factor
ZC3H12A zinc finger CCCH-type containing 12A
ZGLP1 zinc finger, GATA-like protein 1