Intracellular signaling by second messengers Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-9006925
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Genes

302 proteins participating in the Intracellular signaling by second messengers pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY3 adenylate cyclase 3
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADRM1 adhesion regulating molecule 1
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AGO3 argonaute RISC catalytic component 3
AGO4 argonaute RISC catalytic component 4
AHCYL1 adenosylhomocysteinase-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AREG amphiregulin
ATF2 activating transcription factor 2
ATN1 atrophin 1
BAD BCL2-associated agonist of cell death
BDNF brain-derived neurotrophic factor
BMI1 BMI1 proto-oncogene, polycomb ring finger
BTC betacellulin
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX2 chromobox homolog 2
CBX4 chromobox homolog 4
CBX6 chromobox homolog 6
CBX8 chromobox homolog 8
CD19 CD19 molecule
CD28 CD28 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CHUK conserved helix-loop-helix ubiquitous kinase
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CREB1 cAMP responsive element binding protein 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
EED embryonic ectoderm development
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPGN epithelial mitogen
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXO6 forkhead box O6
FRK fyn-related Src family tyrosine kinase
FRS2 fibroblast growth factor receptor substrate 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GRB2 growth factor receptor-bound protein 2
GRK2 G protein-coupled receptor kinase 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HBEGF heparin-binding EGF-like growth factor
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
ICOS inducible T-cell co-stimulator
IER3 immediate early response 3
IL1RAP interleukin 1 receptor accessory protein
IL33 interleukin 33
IL33R interleukin 33 receptor
INS insulin
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLB klotho beta
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LCK LCK proto-oncogene, Src family tyrosine kinase
MAF1 MAF1 homolog (S. cerevisiae)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MBD3 methyl-CpG binding domain protein 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MKRN1 makorin ring finger protein 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MOV10 Mov10 RISC complex RNA helicase
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
NBEA neurobeachin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NR2E1 nuclear receptor subfamily 2, group E, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
NRG2 neuregulin 2
NRG3 neuregulin 3
NRG4 neuregulin 4
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OTUD3 OTU deubiquitinase 3
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PHC2 polyhomeotic homolog 2 (Drosophila)
PHC3 polyhomeotic homolog 3 (Drosophila)
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCG1 phospholipase C, gamma 1
PML promyelocytic leukemia
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKX protein kinase, X-linked
PRR5 proline rich 5 (renal)
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RCOR1 REST corepressor 1
REST RE1-silencing transcription factor
RHEB Ras homolog enriched in brain
RHOG ras homolog family member G
RICTOR RPTOR independent companion of MTOR, complex 2
RING1 ring finger protein 1
RNF146 ring finger protein 146
RNF2 ring finger protein 2
RPS27A ribosomal protein S27a
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SALL4 spalt-like transcription factor 4
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEM1 SEM1 26S proteasome subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A9 solute carrier family 38, member 9
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STRN striatin, calmodulin binding protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TGFA transforming growth factor, alpha
THEM4 thioesterase superfamily member 4
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNRC6A trinucleotide repeat containing 6A
TNRC6B trinucleotide repeat containing 6B
TNRC6C trinucleotide repeat containing 6C
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TRIB3 tribbles pseudokinase 3
TRIM27 tripartite motif containing 27
TSC2 tuberous sclerosis 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAV1 vav 1 guanine nucleotide exchange factor
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase