Intrahepatic Cholangiocarcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0345905
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Genes

422 genes associated with the disease Intrahepatic Cholangiocarcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTB actin, beta
ADAM17 ADAM metallopeptidase domain 17
ADGRE2 adhesion G protein-coupled receptor E2
ADGRE5 adhesion G protein-coupled receptor E5
ADRM1 adhesion regulating molecule 1
AFP alpha-fetoprotein
AGR3 anterior gradient 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
ANXA10 annexin A10
APC adenomatous polyposis coli
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARG1 arginase 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARSA arylsulfatase A
ASPH aspartate beta-hydroxylase
ATF2 activating transcription factor 2
AZIN2 antizyme inhibitor 2
AZU1 azurocidin 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C15ORF48 chromosome 15 open reading frame 48
C17ORF97 chromosome 17 open reading frame 97
C20ORF194 chromosome 20 open reading frame 194
CA10 carbonic anhydrase X
CALR calreticulin
CAPNS1 calpain, small subunit 1
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCHCR1 coiled-coil alpha-helical rod protein 1
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CCR7 chemokine (C-C motif) receptor 7
CD274 CD274 molecule
CD276 CD276 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD68 CD68 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHD1L chromodomain helicase DNA binding protein 1-like
CISH cytokine inducible SH2-containing protein
CKAP4 cytoskeleton-associated protein 4
CLDN18 claudin 18
CLDN4 claudin 4
COL3A1 collagen, type III, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CRYL1 crystallin, lambda 1
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL4A cullin 4A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DLEC1 deleted in lung and esophageal cancer 1
DMBT1 deleted in malignant brain tumors 1
DNER delta/notch-like EGF repeat containing
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYD dihydropyrimidine dehydrogenase
EBAG9 estrogen receptor binding site associated, antigen, 9
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC2 excision repair cross-complementation group 2
ESR2 estrogen receptor 2 (ER beta)
ESRRB estrogen-related receptor beta
ETFA electron-transfer-flavoprotein, alpha polypeptide
EYA4 EYA transcriptional coactivator and phosphatase 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FBN2 fibrillin 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGBP Fc fragment of IgG binding protein
FGF19 fibroblast growth factor 19
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FLT4 fms-related tyrosine kinase 4
FOXA2 forkhead box A2
FOXM1 forkhead box M1
FOXP3 forkhead box P3
FSCN1 fascin actin-bundling protein 1
FTO fat mass and obesity associated
GAB1 GRB2-associated binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADL1 glutamate decarboxylase-like 1
GCG glucagon
GEMIN2 gem (nuclear organelle) associated protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLP1R glucagon-like peptide 1 receptor
GLS glutaminase
GLUD1 glutamate dehydrogenase 1
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPC3 glypican 3
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GSTP1 glutathione S-transferase pi 1
H2AFZ H2A histone family, member Z
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HDAC1 histone deacetylase 1
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HDLBP high density lipoprotein binding protein
HEBP1 heme binding protein 1
HGD homogentisate 1,2-dioxygenase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHLA2 HERV-H LTR-associating 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HOMER1 homer scaffolding protein 1
HOXB7 homeobox B7
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPG2 heparan sulfate proteoglycan 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL12RB2 interleukin 12 receptor, beta 2
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL33 interleukin 33
IL4 interleukin 4
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KAT6A K(lysine) acetyltransferase 6A
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL2 kelch-like family member 2
KMT2C lysine (K)-specific methyltransferase 2C
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LATS2 large tumor suppressor kinase 2
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LOXL2 lysyl oxidase-like 2
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRK2 leucine-rich repeat kinase 2
MACC1 metastasis associated in colon cancer 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MEGF8 multiple EGF-like-domains 8
MEST mesoderm specific transcript
MFAP5 microfibrillar associated protein 5
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MOB1A MOB kinase activator 1A
MOB4 MOB family member 4, phocein
MPC1 mitochondrial pyruvate carrier 1
MSH2 mutS homolog 2
MSLN mesothelin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MUC13 mucin 13, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NEK8 NIMA-related kinase 8
NES nestin
NEUROG1 neurogenin 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP2 NLR family, pyrin domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRDC nardilysin convertase
NSD2 nuclear receptor binding SET domain protein 2
NUAK1 NUAK family, SNF1-like kinase, 1
NUMB numb homolog (Drosophila)
OGG1 8-oxoguanine DNA glycosylase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAX1 paired box 1
PBRM1 polybromo 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD1 programmed cell death 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKM pyruvate kinase, muscle
PLG plasminogen
PMEL premelanosome protein
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POSTN periostin, osteoblast specific factor
POU5F1 POU class 5 homeobox 1
PPA1 pyrophosphatase (inorganic) 1
PPARA peroxisome proliferator-activated receptor alpha
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPHLN1 periphilin 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDM5 PR domain containing 5
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
PRRT2 proline-rich transmembrane protein 2
PRSS1 protease, serine, 1 (trypsin 1)
PSG2 pregnancy specific beta-1-glycoprotein 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTK7 protein tyrosine kinase 7 (inactive)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAB1A RAB1A, member RAS oncogene family
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM45 RNA binding motif protein 45
RBP1 retinol binding protein 1, cellular
RBP5 retinol binding protein 5, cellular
RCOR3 REST corepressor 3
REG1A regenerating islet-derived 1 alpha
REG4 regenerating islet-derived family, member 4
RMDN1 regulator of microtubule dynamics 1
RMDN2 regulator of microtubule dynamics 2
RMDN3 regulator of microtubule dynamics 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RNF43 ring finger protein 43
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPL41 ribosomal protein L41
RPS4X ribosomal protein S4, X-linked
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
S100A1 S100 calcium binding protein A1
S100A11 S100 calcium binding protein A11
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
SATB1 SATB homeobox 1
SCAF11 SR-related CTD-associated factor 11
SDC1 syndecan 1
SDC2 syndecan 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SETD2 SET domain containing 2
SFRP1 secreted frizzled-related protein 1
SGMS1 sphingomyelin synthase 1
SHBG sex hormone-binding globulin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRT3 sirtuin 3
SLBP stem-loop binding protein
SLC12A9 solute carrier family 12, member 9
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX4 synovial sarcoma, X breakpoint 4
SSX4B synovial sarcoma, X breakpoint 4B
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIL SCL/TAL1 interrupting locus
STK11 serine/threonine kinase 11
STYK1 serine/threonine/tyrosine kinase 1
SYBU syntabulin (syntaxin-interacting)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAZ tafazzin
TBX3 T-box 3
TEP1 telomerase-associated protein 1
TET1 tet methylcytosine dioxygenase 1
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
THY1 Thy-1 cell surface antigen
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRAF4 TNF receptor-associated factor 4
TRIM44 tripartite motif containing 44
TUG1 taurine up-regulated 1 (non-protein coding)
TYMS thymidylate synthetase
UBE2F ubiquitin-conjugating enzyme E2F (putative)
UBE2M ubiquitin-conjugating enzyme E2M
UGDH UDP-glucose 6-dehydrogenase
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VASH1 vasohibin 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIM vimentin
VTA1 vesicle (multivesicular body) trafficking 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR20 WD repeat domain 20
WNT3A wingless-type MMTV integration site family, member 3A
WT1 Wilms tumor 1
WWOX WW domain containing oxidoreductase
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZEB2 zinc finger E-box binding homeobox 2
ZGLP1 zinc finger, GATA-like protein 1
ZHX2 zinc fingers and homeoboxes 2